|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Competitive allele specific TaqMan PCR for KRAS , BRAF and EGFR mutation detection in clinical formalin fixed paraffin embedded samples显示文摘 | Audrey Didelot Delphine Le Corre Armelle Luscan Aurélie Cazes Karine Pallier Jean-Fran?ois Emile Pierre Laurent-Puig Hélène Blons | 2012 | Experimental and Molecular Pathology2012，，3： | 1 |
| 2 | Sex differences in learning deficits induced by prenatal stress in juvenile rats显示文摘 | Michèle G Audrey B Johann M | 2004 | Behavioural Brain Research2004，150，： | 1 |
| 3 | Bedside sonographie measurement of optic nerve sheath diameter as a predictor of increased intracranial pressure in children 显示文摘 | Audrey Le Mary Ellen Hoehn Mary E Smith | 2009 | Annals of Emergency Medicine2009，53，6： | 1 |
| 4 | Brain tumor imaging using small-angle x-ray scattering tomography显示文摘 | Torben H Jensen Martin Bech Oliver Bunk Maria Thomsen Andreas Menzel Audrey Bouchet Géraldine Le Duc Robert Feidenhans’l Franz Pfeiffer | 2011 | Physics in Medicine and Biology2011，，： | 1 |
| 5 | O<sup>6</sup>‐methylguanine‐DNA methyltransferase (MGMT) promoter methylation and low MGMT‐encoded protein expression as prognostic markers in glioblastoma patients treated with biodegradable carmustine wafer implants after initial surgery fol显示文摘 | Emmanuèle Lechapt‐Zalcman Guéna?lle Levallet Audrey Emmanuelle Dugué Anne Vital Marie‐Danièle Diebold Philippe Menei Philippe Colin Philippe Peruzzy Evelyne Emery Myriam Bernaudin Fran?oise Chapon Jean‐Sébastien Guillamo | 2012 | Cancer2012，，18： | 1 |
| 6 | Gene expression profiling improves prognostication by nomogram in patients with soft-tissue sarcomas显示文摘Dear Editor,Surgery remains the cornerstone of treatment for softtissue sarcomas(STS)[1].However,despite adequate locoregional treatment,30%-40%of the patients eventually develop metastases[2,3].Accurate risk assessment is crucial to tailor therapeutic strategies and to identify high-risk patients who may benefit from perioperative chemotherapy.Hence,several efforts have been made to develop prognostic nomograms that enable individual prognosis prediction;representing an important decision-making aid for oncologists and surgeons involved in sarcoma care[4-6]. | Amandine Crombé Mariella Spalato-Ceruso Audrey Michot Yech’an Laizet Carlo Lucchesi Maud Toulmonde Kevin Bourcier Francois Le Loarer Antoine Italiano | 2022 | Cancer Communications2022，42，6： | 0 |
| 7 | Prognostic impact of circulating tumor cells in patients with soft-tissue sarcomas:a prospective study显示文摘Dear Editor,Sarcomas represent a heterogenous group of tumors accounting for about 1%of cancer in adults and 15%in children[1].However,despite adequate locoregional treatment,up to 40%of patients develop metastatic disease.Drugs used in the advanced setting have very limited efficacy,with a response rate of<10%and progression-free survival of<4 months and are mainly used for palliative purposes[1].It is,therefore,important to monitor individual therapy responses to avoid inefficient therapy and unnecessary toxicity.Such monitoring is currently based on repeated CT imaging which may represent an important burden for patients with advanced disease[2]. | Julie Blanchi Audrey Laroche-Clary Francois Le Loarer Benjamin Bonhomme Antoine Italiano | 2023 | Cancer Communications2023，43，3： | 0 |
| 8 | Do astrocytes respond to light,sound,or electrical stimulation?显示文摘Astrocytes are not only the most populous cell type in the human brain,but they also have the most extensive and dive rse sets of connections,across synapses,axons,blood vessels,as well as having their own internal network.Unsurprisingly,they are associated with many brain functions;from the synaptic transmission to energy metabolism and fluid homeostasis,and from cerebral blood flow and blood-brain barrier maintenance to neuroprotection,memory,immune defenses and detoxification,slee p,and early development.And yet,notwithstanding these key roles,so many current therapeutic approaches to a range of brain disorders have largely neglected their potential involvement.In this review,we consider the role of astrocytes in three brain therapies;two are emerging treatments(photobiomodulation and ultrasound),while the other is well-established(deep brain stimulation).In essence,we explore the issue of whether external sources,such as light,sound,or electricity,can influence the function of astrocytes,as they do neurons.We find that,when taken all together,each of these external sources can influence many,if not,all of the functions associated with astrocytes.These include influencing neuronal activity,prompting neuroprotection,reducing inflammation(astrogliosis) and potentially increasing cerebral blood flow and stimulating the glymphatic system.We suggest that astrocytes,just like neurons,can respond positively to each of these external applications and that their activation co uld each impart many beneficial outcomes on brain function;they are likely to be key playe rs underpinning the mechanisms behind many therapeutic strategies. | Audrey Le Naour Emilien Beziat Jaimie Hoh Kam Pierre Magistretti Alim-Louis Benabid John Mitrofanis | 2023 | Neural Regeneration Research2023，18，11： | 0 |
| 9 | Added value of molecular karyotype in childhood acute lymphoblastic leukemia显示文摘Background:Thanks to an improved therapeutic regimen in childhood B-cell precursor acute lymphoblastic leukemia(BCP-ALL),5 year-overall survival now exceeds 90%.Unfortunately,the 25%of children who relapse have an initial poor prognosis,potentially driven by pre-existing or emerging molecular anomalies.The latter are initially and essentially identified by cytogenetics.However,some subtle alterations are not visible through karyotyping.Methods:Single nucleotide polymorphisms(SNP)array is an alternative way of chromosomal analysis allowing for a more in-depth evaluation of chromosomal modifications such as the assessment of copy number alterations(CNA)and loss of heterozygosity(LOH).This method was applied here in retrospective diagnosis/relapse paired samples from seven children with BCP-ALL and in a prospective cohort of 38 newly diagnosed childhood cases.Results:In the matched study,compared to the initial karyotype,SNP array analysis reclassified two patients as poor prognosis cases.Modulation during relapse was seen for 4 CNA and 0.9 LOH.In the prospective study,SNP reclassified the 10 patients with intermediate karyotype as 7 good prognosis and 3 poor prognosis.Ultimately,in all the children tested,SNP array allowed to identify additional anomalies compared to conventional karyotype,refine its prognostic value and identify some druggable anomalies that could be used for precision medicine.Overall,the anomalies detected could be segregated in four groups respectively involved in B-cell development,cell proliferation,transcription and molecular pathways.Conclusion:SNP therefore appears to be a method of choice in the integrated diagnosis of BCP ALL,especially for patients initially classified as intermediate prognosis.This complementary method of both cytogenetics and high throughput sequencing allows to obtain further classified information and can be useful in case of failure of these techniques. | Margaux Camuset Baptiste Le Calvez Olivier Theisen Catherine Godon Audrey Grain Caroline Thomas Marie-Laure Couec Marie C.Béné Fanny Rialland Marion Eveillard | 2023 | Cancer Innovation2023，2，6： | 0 |
| 10 | Endothelin increases the proliferation of rat olfactory mucosa cells显示文摘The olfactory mucosa holds olfactory sensory neurons directly in contact with an aggressive environment. In order to maintain its integrity, it is one of the few neural zones which are continuously renewed during the whole animal life. Among several factors regulating this renewal, endothelin acts as an anti-apoptotic factor in the rat olfactory epithelium. In the present study, we explored whether endothelin could also act as a proliferative factor. Using primary culture of the olfactory mucosa, we found that an early treatment with endothelin increased its growth. Consistently, a treatment with a mixture of BQ123 and BQ788(endothelin receptor antagonists) decreased the primary culture growth without affecting the cellular death level. We then used combined approaches of calcium imaging, reverse transcriptase-quantitative polymerase chain reaction and protein level measurements to show that endothelin was locally synthetized by the primary culture until it reached confluency. Furthermore, in vivo intranasal instillation of endothelin receptor antagonists led to a decrease of olfactory mucosa cell expressing proliferating cell nuclear antigen(PCNA), a marker of proliferation. Only short-term treatment reduced the PCNA level in the olfactory mucosa cells. When the treatment was prolonged, the PCNA level was not statistically affected but the expression level of endothelin was increased. Overall, our results show that endothelin plays a proliferative role in the olfactory mucosa and that its level is dynamically regulated. This study was approved by the Comité d’éthique en expérimentation animale COMETHEA(COMETHEA C2 EA-45;protocol approval #12-058) on November 28, 2012. | Bertrand Bryche Audrey Saint-Albin Claire Le Poupon Schlegel Christine Baly Patrice Congar Nicolas Meunier | 2020 | Neural Regeneration Research2020，15，2： | 0 |
| 11 | High-elevation hypoxia impacts perinatal physiology and performance in a potential montane colonizer显示文摘Climate change is generating range shifts in many organisms,notably along the elevational gradient in mountainous environments.However,moving up in elevation exposes organisms to lower oxygen availability,which may reduce the successful reproduction and development of oviparous organisms.To test this possibility in an upwardcolonizing species,we artificially incubated developing embryos of the viperine snake(Natrix maura)using a split-clutch design,in conditions of extreme high elevation(hypoxia at 2877 m above sea level;72%sea-level equivalent O2 availability)or low elevation(control group;i.e.normoxia at 436 m above sea level).Hatching success did not differ between the two treatments.Embryos developing at extreme high elevation had higher heart rates and hatched earlier,resulting in hatchlings that were smaller in body size and slower swimmers compared to their siblings incubated at lower elevation.Furthermore,post-hatching reciprocal transplant of juveniles showed that snakes which developed at extreme high elevation,when transferred back to low elevation,did not recover full performance compared to their siblings from the low elevation incubation treatment.These results suggest that incubation at extreme high elevation,including the effects of hypoxia,will not prevent oviparous ectotherms from producing viable young,but may pose significant physiological challenges on developing offspring in ovo.These early-life performance limitations imposed by extreme high elevation could have negative consequences on adult phenotypes,including on fitness-related traits. | Jérémie SOUCHET Eric J.GANGLOFF Gaëlle MICHELI Coralie BOSSU Audrey TROCHET Romain BERTRAND Jean CLOBERT Olivier CALVEZ Albert MARTINEZ-SILVESTRE Elodie DARNET Hugo LE CHEVALIER Olivier GUILLAUME Marc MOSSOLL-TORRES Laurent BARTHE Gilles POTTIER HervéPHILIPPE Fabien AUBRET | 2020 | Integrative Zoology2020，15，6： | 0 |
| 12 | Use of a specific questionnaire and perineal electromyography to assess neuropathic pain after radical retropubic prostatectomy显示文摘Objective:Prostate cancer is the most frequent cancer in men and radical retropubic prostatectomy(RRP)is one of the first-line treatment.However,RRP has some side effects and can lead to chronic perineal pain.The objective of the study was to determine in patients suffering from perineal pain after RRP the possibility of a neurogenic damage by means of a specific questionnaire dedicated to track down neuropathic pain.Methods:Forty patients were explored by a specific and validated questionnaire,the Neuropathic Pain Symptom Inventory(NPSI).Patients were divided into two groups:Group A with an NSPI score≥4 was considered as suffering from neuropathic pain,and Group B was considered as a control group without neuropathic pain(NSPI score<4).All patients had a perineal electrophysiological testing to confirm the possibility of a neurogenic damage.Results:Group A was composed by 13 men and Group B by 27 men,with mean age 72.45 years and mean duration of pain 2.7 years.In Group A,the most frequent symptoms were burning sensation,electrical shock and numbness.Location of the pain was global perineal area(8/13),anus(10/13),penis(5/13)and glans penis(2/13).Electromyography(EMG)findings confirmed the presence of denervation and neurogenic damages compared with controls(p<0.001).Conclusion:One third of the patients consulting for chronic pain following RRP had probably a neuropathic lesion leading to a chronic perineal pain as suggested by an NSPI score≥4 and EMG alterations. | Nicolas Turmel Samer Sheikh Ismael Camille Chesnel Audrey Charlanes Claire Hentzen Frédérique Le Breton Gérard Amarenco | 2019 | Asian Journal of Urology2019，6，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员