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| 1 | How virus persistence can initiate the tumorigenesis process显示文摘Human oncogenic viruses are defined as necessary but not sufficient to initiate cancer. Experimental evidence suggests that the oncogenic potential of a virus is effective in cells that have already accumulated a number of genetic mutations leading to cell cycle deregulation. Current models for viral driven oncogenesis cannot explain why tumor development in carriers of tumorigenic viruses is a very rare event, occurring decades after virus infection. Considering that viruses are mutagenic agents per se and human oncogenic viruses additionally establish latent and persistent infections, we attempt here to provide a general mechanism of tumor initiation both for RNA and DNA viruses, suggesting viruses could be both necessary and sufficient in triggering human tumorigenesis initiation. Upon reviewing emerging evidence on the ability of viruses to induce DNA damage while subverting the DNA damage response and inducing epigenetic disturbance in the infected cell, we hypothesize a general, albeit inefficient hit and rest mechanism by which viruses may produce a limited reservoir of cells harboring permanent damage that would be initiated when the vi-rus first hits the cell, before latency is established. Cells surviving virus generated damage would consequently become more sensitive to further damage mediated by the otherwise insufficient transforming activity of virus products expressed in latency, or upon episodic reactivations(viral persistence). Cells with a combination of genetic and epigenetic damage leading to a cancerous phenotype would emerge very rarely, as the probability of such an occurrence would be dependent on severity and frequency of consecutive hit and rest cycles due to viral reinfections and reactivations. | Simone Avanzi Gualtiero Alvisi Alessandro Ripalti | 2013 | World Journal of Virology2013，2，2： | 3 |
| 2 | Can the Interpedicular Distance Reliably Assess the Severity of Thoracolumbar Burst Fractures?显示文摘 | Maria Fernanda Silber Caffaro Osmar Avanzi | 2012 | Spine2012，，4： | 1 |
| 3 | Correlation between neurological deficit and spinal canal compromise in 198 patients with thoracolumbar and lumbar fractures 显示文摘 | Meves R Avanzi O | 2005 | Spine2005，30，7： | 1 |
| 4 | A systematic review of randomized clin- ical trials using posterior discectomy to treat lumbar disc her- niations显示文摘 | Gotfryd A Avanzi O | 2009 | Int Orthop2009，33，1： | 1 |
| 5 | Comparison of open discectomy with microendoscopic discectomy in lumbar disc herniations:results of a randomized controlled trail显示文摘 | Righesso O Falavigna A Avanzi O | 2007 | Neurosurgery2007，61，3： | 1 |
| 6 | Optimal dividend in the dual model显示文摘 | Avanzi B Gerber H U Shiu E S W | 2007 | Insurance: Mathematics and Economics2007，41，1： | 1 |
| 7 | The pro- tein encoded by a growth arrest-specific gene(gas6)is a new member of the vitamin K-dependent proteins related to protein S,a negative coregulator in the blood coagulation cascade显示文摘 | MANFIOLETTI G BRANCOLINI C AVANZI G | 1993 | Mol Cell Biol1993，13，8： | 1 |
| 8 | Optimal dividend in the dual model 显示文摘 | AVANZI B GERBER H U SHIU E S W | 2007 | Insurance: Mathematics and Economics2007，41，1： | 1 |
| 9 | Correlation among can alcompromise, neurologic deficit, and injury severityinthoracolumbarburstfractures显示文摘 | Meves R Avanzi O | 2006 | Spine2006，31，18： | 1 |
| 10 | Optimal dividendsin the dual model显示文摘 | B AVANZI H U GERBER ES W SHIU | 2007 | Insurance: Mathematics and Economics2007，41，1： | 1 |
| 11 | Correlation among canal compromise,neurologicdeficit,and injury severity in thoracolumbar burst fractures显示文摘 | Meves R Avanzi O | 2006 | Spine(Phila Pa 1976)2006，18，： | 1 |
| 12 | Interactions among functional groups in the cycling of, carbon, nitrogen and phosphorus in the rhizosphere of three successional species of tropical woody trees 显示文摘 | MATSUMOTO MARTINES AVANZI | 2005 | Applied Soil Ecology2005，28，1： | 1 |
| 13 | Cross - cultural adaptation and validi- ty of an adapted brazilian portuguese version of Scoliosis Research So- ciety - 30 questionnaire显示文摘 | Carrico G Meres R Avanzi O | 2012 | Spine ( Phila Pa 1976 )2012，37，1： | 1 |
| 14 | On a periodicdividend barrier strategy in the duaL model with continuousmonitoring of solvency显示文摘 | B AVANZI E C K CHEUNG B WONG etal | 2013 | Insurance: Mathematics and Eco-nomics2013，52，1： | 1 |
| 15 | Optimal dividends in the dual model显示文摘 | Avanzi B Gerber H U Shiu E S W | 2007 | Insurance:Mathematics and Economics2007，41，： | 1 |
| 16 | Correlation between neurological deficit and spinal canal compromise in 198 patients with thoracolumbar and lumbar fractures显示文摘 | Meves R Avanzi O | 2005 | Spine(Phila Pa 1976)2005，30，7： | 1 |
| 17 | Prospective evaluation of quality of life in adolescent idiopathic scoliosis before and after surgery 显示文摘 | Pellegrino LN Avanzi O | | J Spinal Disord Tech0，27，8： | 1 |
| 18 | The protein encoded by a growth arrest specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative co- regulator in the blood coagulation cascade显示文摘 | MANFIOLETTI G BRANCOLINI C AVANZI G | 1993 | Mol Cell Biol1993，13，8： | 1 |
| 19 | The importance of Injury Severity Score (ISS) in the management of thoracolumbar burst fracture 显示文摘 | Rezende R Avanzi O | 2009 | Rev Col Bras Cir2009，36，1： | 1 |
| 20 | Prospective Evaluation of Quality of Life in Adolescent Idiopathic Scoliosis before and after Surgery显示文摘 | Pel egrino LA Avanzi O | | 0，，： | 1 |
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