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您的检索式：作者名="Axel Mosig"
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| 1 | An Image Skeletonization-Based Tool for Pollen Tube Morphology Analysis and Phenotyping显示文摘The mechanism underlying pollen tube growth involves diverse genes and molecular pathways. Alterations in the regulatory genes or pathways cause phenotypic changes reflected by cellular morphology, which can be captured using fluorescence microscopy. Determining and classifying pollen tube morphological phenotypes in such microscopic images is key to our understanding the involvement of genes and pathways. In this context, we propose a computational method to extract quantitative morphological features, and demonstrate that these features reflect morphological differences relevant to distinguish different defects of pollen tube growth. The corresponding software tool furthermore includes a novel semi-automated image segmentation approach, allowing to highly accurately identify the boundary of a pollen tube in a microscopic image. | Chaofeng Wang Cai-Pinq Gui Hai-Kuan Liu Dong Zhang Axel Mosig | 2013 | Journal of Integrative Plant Biology2013，55，2： | 1 |
| 2 | Fragrep: An Efficient Search Tool for Fragmented Patterns in Genomic Sequences显示文摘Many classes of non-coding RNAs (ncRNAs; including Y RNAs, vault RNAs, RNase P RNAs, and MRP RNAs, as well as a novel class recently discovered in Dictyostelium discoideum) can be characterized by a pattern of short but well- conserved sequence elements that are separated by poorly conserved regions of sometimes highly variable lengths. Local alignment algorithms such as BLAST are therefore ill-suited for the discovery of new homologs of such ncRNAs in genomic sequences. The Fragrep tool instead implements an efficient algorithm for detect- ing the pattern fragments that occur in a given order. For each pattern fragment, the mismatch tolerance and bounds on the length of the intervening sequences can be specified separately. Furthermore, matches can be ranked by a statistically well-motivated scoring scheme. | Axel Mosig Katrin Sameith Peter Stadler | 2006 | Genomics, Proteomics & Bioinformatics2006，4，1： | 1 |
| 3 | U7 snRNAs:A Computational Survey显示文摘U7 small nuclear RNA (snRNA) sequences have been described only for a handful of animal species in the past. Here we describe a computational search for func-tional U7 snRNA genes throughout vertebrates including the upstream sequence elements characteristic for snRNAs transcribed by polymerase Ⅱ. Based on the results of this search,we discuss the high variability of U7 snRNAs in both se-quence and structure,and report on an attempt to find U7 snRNA sequences in basal deuterostomes and non-drosophilids insect genomes based on a combination of sequence,structure,and promoter features. Due to the extremely short se-quence and the high variability in both sequence and structure,no unambiguous candidates were found. These results cast doubt on putative U7 homologs in even more distant organisms that are reported in the most recent release of the Rfam database. | Manja Marz Axel Mosig Brbel M.R.Stadler Peter F.Stadler | 2007 | Genomics, Proteomics & Bioinformatics2007，5，3： | 0 |
| 4 | Commuting between Two Worlds显示文摘China is one of the fastest growing economies worldwide. Are science and research also in the fast lane? We talked with LUO Yuan, scientist at the Institute of Coal Chemistry in Shanxi, and Axel Mosig, Professor at Ruhr University in Bochum, who has first-hand experience working and living in China. | LUO Yuan Axel Mosig | 2014 | Bulletin of the Chinese Academy of Sciences2014，28，2： | 0 |
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