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1篇 您的检索式:作者名="Katrin Sameith"
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1Fragrep: An Efficient Search Tool for Fragmented Patterns in Genomic Sequences显示文摘Many classes of non-coding RNAs (ncRNAs; including Y RNAs, vault RNAs, RNase P RNAs, and MRP RNAs, as well as a novel class recently discovered in Dictyostelium discoideum) can be characterized by a pattern of short but well- conserved sequence elements that are separated by poorly conserved regions of sometimes highly variable lengths. Local alignment algorithms such as BLAST are therefore ill-suited for the discovery of new homologs of such ncRNAs in genomic sequences. The Fragrep tool instead implements an efficient algorithm for detect- ing the pattern fragments that occur in a given order. For each pattern fragment, the mismatch tolerance and bounds on the length of the intervening sequences can be specified separately. Furthermore, matches can be ranked by a statistically well-motivated scoring scheme.Axel Mosig Katrin Sameith Peter Stadler 2006Genomics, Proteomics & Bioinformatics2006,4,1:1
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