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| 1 | 胃癌预防亚太地区共识指南显示文摘背景与目的:胃癌是亚太地区的主要健康负担之一,但对其预防策略尚缺乏共识。本共识会议旨在评价预防胃癌的策略。方法:多学科专家组应用德尔菲(Delphi)法制订共识条文,提呈相关数据,对证据等级、推荐强度以及共识水平予以分级。结果:幽门螺杆菌(H.pylori)感染是非贲门胃腺癌必要但非充分的致病因子。盐的高摄入与胃癌强烈相关。新鲜果蔬对胃癌具有预防作用,但维生素和其他饮食补充并不能预防胃癌。H.pylori感染中的宿主-细菌相互作用导致不同类型的胃炎和胃酸分泌,从而决定疾病结局。胃癌阳性家族史是一个重要的危险因素。低血清胃蛋白酶原反映胃萎缩程度,可作为检出胃癌高危人群的标志物。H.pylori筛查和治疗被推荐作为减少高危人群胃癌危险性的一种策略,该策略在萎缩性胃炎发生前实施最为有效,但并不排除对胃癌高危人群的内镜监测。对胃癌低危人群不推荐行H.pylori筛查。H.pylori感染的一线治疗应遵循国家治疗指南。结论:高危人群中H.pylori筛查和根除策略可能会减少胃癌的发生率,本共识根据现有证据予以推荐。 | Kwong Ming Fock Nick Talley Paul Moayyedi Richard Hunt Takeshi Azuma Kentaro Sugano Shu Dong Xiao Shiu Kum Lam Khean Lee Goh Tsutomu Chiba Naomi Uemura Jae G Kim Nayoung Kim Tiing Leong Ang Varocha Mahachai Hazel Mitchell Abdul Aziz Rani Jyh Ming Liou Ratha-korn Vilaichone Jose Sollanor 钱本余 | 2008 | 胃肠病学2008，13，4： | 37 |
| 2 | 信迪利单抗对比安慰剂联合化疗用于局部晚期或转移性食管鳞癌的一线治疗(ORIENT-15):一项多中心、随机、双盲、Ⅲ期临床研究显示文摘目的评价信迪利单抗对比安慰剂联合化疗(顺铂加紫杉醇或顺铂加5-氟尿嘧啶)作为不可切除的局部晚期、复发或转移性食管鳞癌一线治疗的效果。设计多中心、随机、双盲、Ⅲ期临床研究。背景2018年12月14日至2021年4月9日,国内66家研究中心,国外13家研究中心。受试者659例未曾接受过系统性治疗的成年(≥18岁)晚期或转移性食管鳞癌患者。干预受试者按1∶1的比例随机分组,每3周接受1次信迪利单抗或安慰剂(体重<60 kg者3 mg/kg,体重>60 kg者200 mg)与顺铂75 mg/m2和紫杉醇175 mg/m2的联合治疗。本研究经修订,允许研究者选择顺铂联合紫杉醇或顺铂联合5-氟尿嘧啶(800 mg/m2,第1~5天连续输注给药)化疗方案。主要结局指标所有患者和程序性细胞死亡配体1(PD-L1)表达联合阳性评分≥10的患者总生存期。结果659例患者随机分配至信迪利单抗(n=327)或安慰剂(n=332)联合化疗组。659例患者中有616例(93%)接受了信迪利单抗或安慰剂与顺铂和紫杉醇联合治疗,有43例(7%)接受了信迪利单抗或安慰剂与顺铂和5-氟尿嘧啶联合治疗。期中分析显示,在所有患者(中位总生存期16.7 vs 12.5个月,风险比0.63,95%可信区间0.51~0.78;P<0.001)和联合阳性评分≥10的患者(17.2 vs 13.6个月,0.64,0.48~0.85;P=0.002)中,信迪利单抗联合化疗组的总生存期均优于安慰剂联合化疗组。与安慰剂联合化疗相比,信迪利单抗联合化疗显著延长了所有患者(7.2 vs 5.7个月,0.56,0.46~0.68;P<0.001)和联合阳性评分≥10患者(8.3 vs 6.4个月,0.58,0.45~0.75;P<0.001)的无进展生存期。信迪利单抗联合化疗组出现治疗相关不良事件的患者人数为321/327例(98%),安慰剂联合化疗组为326/332例(98%)。在信迪利单抗联合化疗组和安慰剂联合化疗组中,3级及以上治疗相关不良事件的发生率分别为60%(196/327)和55%(181/332)。结论与安慰剂相比,信迪利单抗联合顺铂加紫杉醇作为一线治疗显著改善了晚期或转移性食管鳞癌患者的总生存期和无进展生存期。信迪利单抗联合顺铂加5-氟尿嘧啶也显示出类似的获益。临床试验注册ClinicalTrials.gov NCT03748134。 | 鲁智豪 王军业 束永前 刘连科 孔莉 杨磊 汪步海 孙国贵 姬颖华 曹国春 刘虎 崔同建 李娜 邱文生 李高峰 侯新芳 罗辉 薛丽英 张艳桥 岳文彬 刘峥 王秀问 高社干 潘跃银 Marie-Pierre Galais Aziz Zaanan 马卓 李昊宇 王岩 沈琳 ORIENT-研究团队 | 2022 | 英国医学杂志中文版2022，25，8： | 40 |
| 3 | 亚太地区胃食管反流病的处理共识:更新版显示文摘背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,并对证据质量、推荐力度和共识水平进行分级。结果:亚洲GERD发生率日益增加。其危险因素包括老年、男性、种族、家族史、社会经济地位高、体重指数增加和吸烟。对于有典型症状而无报警症状的患者,对质子泵抑制剂(PPI)试验有症状应答具有诊断意义。如PPI试验失败,停止治疗后pH监测结果阴性可排除GERD。窄带成像、胶囊内镜检查和无线pH监测的作用尚未明确。亚洲诊断策略的制定须考虑到并存的胃癌和消化性溃疡。减轻体质量和抬高床头可改善反流症状。PPIs是最有效的内科治疗手段。对于非糜烂性反流病(NERD)患者,按需治疗较为适宜。有慢性咳嗽、喉炎和典型GERD症状的患者在排除非GERD病因后,应予PPI每天两次治疗。如有经验丰富的外科医师,GERD患者可行胃底折叠术。除临床试验外,GERD不应采用内镜治疗。结论:新的诊断方法和内镜治疗的作用有待进一步研究阐明。亚洲GERD诊断策略的制定须考虑到并存的胃癌和消化性溃疡。PPIs仍为治疗的基石。 | Kwong Ming Fock Nicholas J Talley Ronnie Fass Khean Lee Goh Peter Katelaris Richard Hunt Michio Hongo Tiing Leong Ang Gerald Holtmann Sanjay Nandurkar San Ren Lin Benjamin CY Wong Francis KL Chan Abdul Aziz Rani Young-Tae Bak Jose Sollano Khek Yu Ho Sathoporn Manatsathit 钱本余 | 2008 | 胃肠病学2008，13，7： | 21 |
| 4 | Casilio: a versatile CRISPR-Cas9-Pumilio hybrid for gene regulation and genomic labeling显示文摘 | Albert W Cheng Nathaniel Jillette Phoebe Lee Dylan Plaskon Yasuhiro Fuj iwara Wenbo Wang Aziz Taghbalout Haoyi Wang | 2016 | Cell Research2016，26，2： | 19 |
| 5 | Pancreatits after endoscopic retrograde cholangio-pancreatography显示文摘Pancreatitis is the most common complication after endoscopic retrograde cholangio-pancreatography (ERCP); the reported incidence of this complication varies from less than 1% to 40%, but a rate of 4%-8% is reported in most prospective studies involving non-selected patients. Differences in criteria for defining pancreatitis, methods of data collection, and patient populations (i.e. number of high-risk patients included in the published series) are factors that are likely to affect the varying rates of post-ERCP pancreatitis. The severity of post-ERCP pancreatitis (PEP) can range from a minor inconvenience with one or two days of added hospitalization with full recovery to a devastating illness with pancreatic necrosis, multiorgan failure, permanent disability, and even death. Although, most episodes of PEP are mild (about 90%), a small percentage of patients (about 10%) develop moderate or severe pancreatitis. In the past, PEP was often viewed as an unpredictable and unavoidable complication, with no realistic strategy for its avoidance. New data have aided in stratifi cation of patients into PEP risk categories and new measures have been introduced to decrease the risk of PEP. As most ERCPs are performed on an outpatient basis, the majority of patients will not develop PEP and can be discharged. Alternatively, early detection of those patients who will go on to develop PEP can guide decisions regarding hospital admission and aggressive management. In the last decade, great efforts have been addressed toward prevention of this complication. Points of emphasis have included technical measures, pharmacological prophylaxis, and patient selection. This review provides a comprehensive, evidence-based assessment of published data on PEP and current suggestions for its avoidance. | Ayman M Abdel Aziz Glen A Lehman | 2007 | World Journal of Gastroenterology2007，13，19： | 19 |
| 6 | New technologies to investigate the brain-gut axis显示文摘Functional gastrointestinal disorders are commonly encountered in clinical practice, and pain is their commonest presenting symptom. In addition, patients with these disorders often demonstrate a heightened sensitivity to experimental visceral stimulation, termed visceral pain hypersensitivity that is likely to be important in their pathophysiology. Knowledge of how the brain processes sensory information from visceral structures is still in its infancy. However, our understanding has been propelled by technological imaging advances such as functional Magnetic Resonance Imaging, Positron Emission To-mography, Magnetoencephalography, and Electroen-cephalography (EEG). Numerous human studies have non-invasively demonstrated the complexity involved in functional pain processing, and highlighted a number of subcortical and cortical regions involved. This review will focus on the neurophysiological pathways (primary afferents, spinal and supraspinal transmission), brain- imaging techniques and the influence of endogenous and psychological processes in healthy controls and patients suffering from functional gastrointestinal dis- orders. Special attention will be paid to the newer EEG source analysis techniques. Understanding the pheno- typic differences that determine an individual's response to injurious stimuli could be the key to understanding why some patients develop pain and hyperalgesia in response to inflammation/injury while others do not. For future studies, an integrated approach is required incorporating an individual's psychological, autonomic, neuroendocrine, neurophysiological, and genetic prof ile to def ine phenotypic traits that may be at greater risk of developing sensitised states in response to gut in? am- mation or injury. | Abhishek Sharma Dina Lelic Christina Brock Peter Paine Qasim Aziz | 2009 | World Journal of Gastroenterology2009，15，2： | 15 |
| 7 | A study of rock bolting failure modes显示文摘Rock bolting has advanced rapidly during the past 4 decades due to a better understanding of load transfer mechanisms and advances made in the bolt system technology. Bolts are used as permanent and temporary support systems in tunnelling and mining operations. A review of has indicated that three systems of reinforcement devices have evolved as part of rock bolt and ground anchor while the rock is not generally thought of as being a component of the reinforcement system. A classification of rock bolting reinforcement systems is presented, followed by the fundamental theory of the load transfer mechanism. The failure mode of two phases of rock bolting system is formularised. The failure modes of cable bolting are discussed using a bond strength model as well as an iterative method. Finally, the interfacial shear stress model for ribbed bar is introduced and a closed form solution is obtained using a tri-line stress strain relationship. | Cao Chen Jan Nemcik Ren Ting Naj Aziz | 2013 | International Journal of Mining Science and Technology2013，23，1： | 14 |
| 8 | Sublethal effects of hexaflumuron on development and reproduction of the diamondback moth, Plutella xylostella (Lepidoptera: Yponomeutidae)显示文摘在 10% 致命的集中(LC10 ) 和在开发和有菱形斑纹的蛾的繁殖参数的 LC25 的 hexaflumuron 的效果, Plutella xylostella (Linnaeus, 1753 )(Lep:Yponomeutidae ) 被调查。估计的 LC50, LC10 和 P 的第三个中间形态幼虫上的 hexaflumuron 的叶剧降生物鉴定的 LC25 价值。xylostella 分别地是 1.48, 0.59 和 0.91 mg/L。Hexaflumuron 减少了在在尚不致命的集中的父母产生,但是在后代产生的蛹的重量,这效果没被观察。尚不致命的集中增加了鸡蛋,第一和第二幼虫的中间形态和蛹发展时间和成年人的弄短的寿命,但是没改变第三和第四幼虫的中间形态和蛹前发展时期。另外,女性的肥沃显著地减少了,但是处理和控制的 hatchability 是类似的。成年人前阶段的幸存率在 LC25 集中显著地衰退了。象繁殖的率(R0 ) 和尚不致命的集中的增加的内在的率那样的繁殖参数与控制相比是显著地更低的,但是在 LC10 集中的粗野繁殖率(GRR ) 被增加,它能是 hormoligosis。另外, hexaflumuron 显著地增加了双倍工资(Dt ) 。我们断定 hexaflumuron 的尚不致命的效果可能在 P 的人口动力学上展出重要效果。xylostella。 | Mohammad Mahmoudvand Habib Abbasipour Aziz Sheikhi Garjan Ali Reza Bandani | 2011 | Insect Science2011，18，6： | 13 |
| 9 | Evolution and application of in-seam drilling for gas drainage显示文摘The presence of seam gas in the form of methane or carbon dioxide presents a hazard to underground coal mining operations.In-seam drilling has been undertaken for the past three decades for gas drainage to reduce the risk of gas outburst and lower the concentrations of seam gas in the underground ventilation.The drilling practices have reflected the standards of the times and have evolved with the development of technology and equipment and the needs to provide a safe mining environment underground.Early practice was to adapt equipment from other felds,with rotary drilling being the only form of drilling available.This form of drainage allowed various levels of gas drainage coverage but with changing emphasis,research and development within the coal industry has created specifc equipment,technology and practices to accurately place in-seam boreholes to provide effcient and effective gas drainage.Research into gas content determination established a standard for the process and safe levels for mining operations to continue.Surveying technology improved from the wire-line,single-shot Eastman survey instruments which was time-dependent on borehole depth to electronic instruments located in the drill string which transmitted accurate survey data to the drilling crew without time delays.This allowed improved directional control and increased drilling rates.Directional drilling technology has now been established as the industry standard to provide effective gas drainage drilling.Exploration was identifed as an additional beneft with directional drilling as it has the ability to provide exploration data from long boreholes.The ability of the technology to provide safe and reliable means to investigate the need for inrush protection and water drainage ahead of mining has been established.Directional drilling technology has now been introduced to the Chinese coal industry for gas drainage through a practice of auditing,design,supply,training and ongoing support.Experienced drilling crews can offer site specifc gas drainage drilling services utilising the latest equipment and technology. | Frank Hungerford Ting Ren Naj Aziz | 2013 | International Journal of Mining Science and Technology2013，23，4： | 12 |
| 10 | 氟硅油合成工艺与应用性能研究进展显示文摘该文总结了氟硅油的制备方法,包括硅氢加成法、水解法、开环聚合法,并讨论了分子结构对性能的影响,包括氟硅油多种界面功能的作用机理、氟-硅协同效应等。此外,该文还综述了氟硅油作为润滑剂、消泡剂、整理剂、超疏水材料的研究应用现状。氟硅油应用过程中,以有机磷化合物、硅醇铁等为添加剂能有效地提升氟硅油的抗剪切性、抗氧化性;在分子链中引入聚醚或氨基等制备共改性硅油,能够有效地提升氟硅油的表面性能。最后,对于氟硅油的发展方向和应用前景进行了展望。 | 张德琪 Tariq Aziz 范宏 | 2016 | 精细化工2016，33，8： | 12 |
| 11 | China's Changing Trade Elasticities显示文摘中国口头的贸易作文,产品质量混合,和处理的进口内容出口的派别都在过去的十年期间实质地变化了。这显示了用总数数据估计的贸易弹性高度不稳定,与指向显著地更高的需求和价格弹性的更最近的数据。在这些参数的 Sectoral 差别也是很宽的。所有这些建议当使用历史的数据模仿中国的经济的反应到外部震动和汇率变化时,更大的小心应该被行使。分析基于有在 1980 年代和 1990 年代的中国大部分代表性的估计的系数的模型是可能的结果错误,也许平戏剧性地。 | Jahangir Aziz Xiangming Li | 2008 | China & World Economy2008，16，3： | 11 |
| 12 | 2018版腹股沟疝国际指南解读(日间手术部分)显示文摘全世界每年有超过2000万台腹股沟疝手术。为了进一步标准化、减少并发症、改善手术结果,5个洲际疝协会(欧洲疝协会、美国疝协会、亚太疝协会、非洲中东疝协会、澳洲疝协会)、国际内镜疝协会以及欧洲内镜外科协会共同签署发布了腹股沟疝治疗国际指南(2018版)。笔者重点对其中有关日间手术的部分进行详细解读。 | 宁彩虹 Bonsu Abdul Aziz 黄耿文 | 2019 | 中国普通外科杂志2019，28，10： | 11 |
| 13 | Novel association between sperm deformity index and oxidative stress-induced DNA damage in infertile male patients显示文摘Aim: To investigate the impact of abnormal sperm morphology using the sperm deformity index (SDI) on reactive oxygen species (ROS) production and its correlation with sperm DNA damage. Methods: Semen samples were collected from men undergoing infertility screening (n=7) and healthy donors (n=6). Mature spermatozoa were isolated and incubated with 5mmol/L β-nicotinamide adenine dinucleotide phosphate (NADPH) for up to 24h to induce ROS. Sperm morphology was evaluated using strict Tygerberg's criteria and the SDI. ROS levels and DNA damage were assessed using chemiluminescence and terminal deoxynucleotidyl transferase-mediated fluoresceindUTP nick end labeling (TUNEL) assays, respectively. Results: SDI values (median [interquartiles]) were higher in patients than donors (2 [1.8,2.1] vs. 1.53 [1.52, 1.58], P=0.008). Aliquots treated with NADPH showed higher ROS levels (1.22 [0.30, 1.87] vs. 0.39 [0.10, 0.57], P=0.03) and higher incidence of DNA damage than those not treated (10 [4.69, 24.85] vs. 3.85 [2.58, 5.10], P=0.008). Higher DNA damage was also seen following 24h of incubation in patients compared to donors. SDI correlated with the percentage increase in sperm DNA damage following incubation for 24h in samples treated with NADPH (r=0.7, P=0.008) and controls (r=0.58, P=0.04).Conclusion: SDI may be a useful tool in identifying potential infertile males with abnormal prevalence of oxidative stress (OS)-induced DNA damage. NADPH plays a role in ROS-mediated sperm DNA damage, which appears to be more evident in infertile patients with semen samples containing a high incidence of morphologically abnormalspermatozoa. | Tamer M.Said Nabil Aziz Rakesh K.Sharma Iwan Lewis-Jones AnthonyJ.ThomasJr AshokAgarwal | 2005 | Asian Journal of Andrology2005，7，2： | 10 |
| 14 | Levels of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 in gastric cancer显示文摘AIM:To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric cancer.METHODS:One hundred gastric cancer patients who underwent gastrectomy were enrolled in this study.The serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent assay.RESULTS:Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls (P < 0.001).Serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance,tumor size,depth of wall invasion,lymph node metastasis,liver metastasis,perineural invasion,and pathological stage.They were not significantly associated with age,gender,tumor location,or histological type.CONCLUSION:Increased MMP-1 and TIMP-1 were associated with gastric cancer.Although these markers are not good markers for diagnosis,these markers show in advanced gastric cancer. | Ozgur Kemik Ahu Sarbay Kemik Aziz Sümer Ahmet Cumhur Dulger Mine Adas Huseyin Begenik Ismail Hasirci Ozkan Yilmaz Sevim Purisa Erol Kisli Sefa Tuzun Cetin Kotan | 2011 | World Journal of Gastroenterology2011，17，16： | 10 |
| 15 | Functional brain imaging of gastrointestinal sensation in health and disease显示文摘It has since long been known, from everyday experience as well as from animal and human studies, that psychological processes-both affective and cognitive- exert an influence on gastrointestinal sensorimotor function. More specifi cally, a link between psychological factors and visceral hypersensitivity has been suggested, mainly based on research in functional gastrointestinal disorder patients. However, until recently, the exact nature of this putative relationship remained unclear, mainly due to a lack of non-invasive methods to study the (neurobiological) mechanisms underlying this relationship in non-sleeping humans. As functional brain imaging, introduced in visceral sensory neuroscience some 10 years ago, does provide a method for in vivo study of brain-gut interactions, insight into the neurobiological mechanisms underlying visceral sensation in general and the influence of psychological factors more particularly, has rapidly grown. In this article, an overview of brain imaging evidence on gastrointestinal sensation will be given, with special emphasis on the brain mechanisms underlying the interaction between affective & cognitive processes and visceral sensation. First, the reciprocal neural pathways between the brain and the gut (brain- gut axis) will be briefky outlined, including brain imaging evidence in healthy volunteers. Second, functional brain imaging studies assessing the influence of psychological factors on brain processing of visceral sensation in healthy humans will be discussed in more detail. Finally, brain imaging work investigating differences in brain responses to visceral distension between healthy volunteers and functional gastrointestinal disorderpatients will be highlighted. | Lukas Van Oudenhove Steven J Coen Qasim Aziz | 2007 | World Journal of Gastroenterology2007，13，25： | 9 |
| 16 | A New Tuning Method for Two-Degree-of-Freedom Internal Model Control under Parametric Uncertainty显示文摘内部模型控制(IMC ) 为集合点追踪产出很好的性能,但是为骚乱拒绝问题给懒惰反应。two-degree-of-freedom IMC (2DOF-IMC ) 被开发了克服软弱。然而,如果有一个无常模型,参数的背景成为一件复杂的事。现在的学习为控制器建议一个新调节方法。建议调节方法由三步组成。第一,模型无常的最糟的盒子是坚定的。第二,集合点控制器使用的参数最大的山峰(Mp ) 标准被指定,并且最后,骚乱拒绝的参数控制器使用获得边缘(美国通用汽车公司) 标准被获得。建议方法作为调节方法的 Mp 美国通用汽车公司被表示。调节方法评估了的 Mp 美国通用汽车公司并且与作为凳子标记调节节目(IMCTUNE ) 的 IMC 控制器相比的有效性。评估和比较加死了的时间(FOPDT ) 和更高的顺序过程在很多第一份订单上通过模拟被做了。测试的 FOPDT 过程在范围与可控制性比率包括过程 0.7 ~ 2.5。更高的过程包括第二份订单与欠阻尼并且有 nonminimum 阶段过程的第三份订单。尽管二更高的顺序进程被认为进程同样困难,调节方法的建议 Mp 美国通用汽车公司能甚至在进程无常下面获得好控制器参数。 | Juwari Purwo sutikno Badhrulhisham Abdul aziz Chin Sim yee Rosbi Mamat | 2013 | Chinese Journal of Chemical Engineering2013，21，9： | 9 |
| 17 | IL28B polymorphism and cytomegalovirus predict response to treatment in Egyptian HCV type 4 patients显示文摘AIM:To test whether the status of positive cytomegalovirus(CMV) DNA detection adds to the predictive value of IL28B and to further categorize C/T allele carriers.METHODS:This study included 166 chronic hepatitis C(CHC) patients who received combined interferon and ribavirin therapy for 48 wk,84 spontaneous hepatitis C virus(HCV) resolvers who were positive for IgG anti-HCV antibody and negative for HCV RNA,and 100 healthy subjects who were negative for both HCV antibodies and RNA as controls.Genomic DNA from peripheral blood was used for IL28B rs.12979860 single nucleotide polymorphism(SNP) and CMV DNA detection.A 139 bp fragment containing IL28B SNP was amplified in all subjects by polymerase chain reaction using a specifically designed primer.Then the IL28B rs.12979860 SNP was detected by restriction fragment length polymorphism(RFLP) genotyping.The presence of CMV DNA was tested by amplification of the gB1 gene using nested polymerase chain reaction.The role of CMV and IL28B rs.12979860 SNP genotypes in determining the response rate to combined interferon therapy and clinical status of patients were statistically analyzed.RESULTS:Current data showed that 67% of patients carrying the IL28B 12979860 C/C allele had a sustained viral response(SVR) while the genotypes C/T and TT were associated with lower SVR rates,50% and 48%,respectively.SVR rates for the C/C allele were lower than other HCV genotypes and/or other populations.Genotype CC was associated with the response to interferon(P = 0.025).Genotype C/C was reduced from 48% in controls to 14% in CHC patients suggesting its protective role against progression to chronicity.The majority of spontaneously cleared subjects(86%) were C/C,confirming its protective role.The C/T allele was present in 71% of CHC patients compared with 38% of controls,so the use of IL28B SNP genotyping only in these patients may be of little value as a predictor of response.CMV reactivation occurred in 40% of CHC patients.Co-infection with CMV seriously diminished the response to interferon(IFN) therapy,with SVR rates in C/C genotypes 87.5% in CMV-negative patients and 12.5% in CMV-positive patients(P < 0.0001).SVR rates among C/T carriers were reduced to < 50% in patients with positive CMV DNA while the non-response rate doubled.These data indicate that a supplemental assay for CMV viremia adds to the prognostic value of IL28B genotyping.CONCLUSION:The results suggest that both genetic(i.e.,spontaneous) and therapeutic(IFN-based therapy) arms are complementary in the battle against HCV.CMV DNA testing may be of value to better predict the response to IFN,particularly in IL28B C/T carriers. | Mostafa K El Awady Noha G Bader El Din Ashraf Tabll Yaser El Hosary Ashraf O Abdel Aziz Hesham El Khayat Mohsen Salama Tawfeek H Abdelhafez | 2013 | World Journal of Gastroenterology2013，19，2： | 8 |
| 18 | Development of a new connection for precast concrete walls subjected to cyclic loading显示文摘The Industrialized Building System(IBS) was recently introduced to minimize the time and cost of project construction.Accordingly, ensuring the integration of the connection of precast components in IBS structures is an important factor that ensures stability of buildings subjected to dynamic loads from earthquakes, vehicles, and machineries.However, structural engineers still lack knowledge on the proper connection and detailed joints of IBS structure construction.Therefore, this study proposes a special precast concrete wall-to-wall connection system for dynamic loads that resists multidirectional imposed loads and reduces vibration effects(PI2014701723).This system is designed to connect two adjacent precast wall panels by using two steel U-shaped channels(i.e., male and female joints).During casting, each joint is adapted for incorporation into a respective wall panel after considering the following conditions: one side of the steel channel opens into the thickness face of the panel; a U-shaped rubber is implemented between the two channels to dissipate the vibration effect; and bolts and nuts are used to create an extension between the two U-shaped male and female steel channels.The developed finite element model of the precast wall is subjected to cyclic loads to evaluate the performance of the proposed connection during an imposed dynamic load.Connection performance is then compared with conventional connections based on the energy dissipation, stress, deformation, and concrete damage in the plastic range.The proposed precast connection is capable of exceeding the energy absorption of precast walls subjected to dynamic load, thereby improving its resistance behavior in all principal directions. | Ramin Vaghei Farzad Hejazi Hafez Taheri Mohd Saleh Jaafar Farah Nora Aznieta Abdul Aziz | 2017 | Earthquake Engineering and Engineering Vibration2017，16，1： | 8 |
| 19 | Ever-increasing diversity of drug-induced pancreatitis显示文摘With over 100000 hospital admissions per annum,acute pancreatitis remains the leading gastrointestinal cause of hospitalization in the United States and has farreaching impact well beyond.It has become increasingly recognized that druginduced pancreatitis(DIP),despite accounting for less than 3%of all cases,represents an important and growing though often inconspicuous cause of acute pancreatitis.Nevertheless,knowledge of DIP is often curtailed by the limited availability of evidence needed to implicate given agents,especially for nonprescription medications.Indeed,the majority of available data is derived from case reports,case series,or case control studies.Furthermore,the mechanism of injury and causality for many of these drugs remain elusive as a definitive correlation is generally not established(<10%of cases).Several classification systems have been proposed,but no single system has been widely adopted,and periodic updates are required in light of ongoing pharmacologic expansion.Moreover,infrequently prescribed medications or those available over-thecounter(including herbal and other alternative remedies)are often overlooked as a potential culprit of acute pancreatitis.Herein,we review the ever-increasing diversity of DIP and the potential mechanisms of injury with the goal of raising awareness regarding the nature and magnitude of this entity.We believe this manuscript will aid in increasing both primary and secondary prevention of DIP,thus ultimately facilitating more expedient diagnosis and a decrease in DIPrelated morbidity. | Simcha Weissman Muhammad Aziz Ryan B Perumpail Tej I Mehta Rutwik Patel James H Tabibian | 2020 | World Journal of Gastroenterology2020，26，22： | 8 |
| 20 | Impacts of different drying strategies on drying characteristics,the retention of bio-active ingredient and colour changes of dried Roselle显示文摘The drying kinetics of Roselle(Hibiscus sabdariffa L) of variety Terengganu(UMKL-1) and the quality attribution of Roselle were studied. The experiments were conducted using four different drying methods, including solar greenhouse drying(SD), solar greenhouse with intermittent heat pump drying(SIHP), hot air drying(HA) and heat pump drying(HP). Among the four drying methods, HP achieved the highest drying rate at a range from0.054 g H_2 O·(g DM)^(-1) ·min^(-1) to 0.212 g H_2 O·(g DM)^(-1)·min^(-1) while SD had the lowest drying rate, measured at 0.042 g H_2 O·(g DM)^(-1)·min^(-1).The analysis on colour kinetics revealed that there is no significant colour loss(p > 0.05) observed from HP's dried Roselle. Greater amount of flavonoid compounds i.e. protocatechuic acid was found in SD and SIHP dried finished product whereas HP's dried Roselle contains higher percentage of catechin as compared to other drying methods. | Thing Chai Tham Mei Xiang Ng Shu Hui Gan Lee Suan Chua Ramlan Aziz Luqman Chuah Abdullah Sze Pheng Ong Nyuk Ling Chin Chung Lim Law | 2018 | Chinese Journal of Chemical Engineering2018，26，2： | 7 |
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