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| 1 | 胃癌预防亚太地区共识指南显示文摘背景与目的:胃癌是亚太地区的主要健康负担之一,但对其预防策略尚缺乏共识。本共识会议旨在评价预防胃癌的策略。方法:多学科专家组应用德尔菲(Delphi)法制订共识条文,提呈相关数据,对证据等级、推荐强度以及共识水平予以分级。结果:幽门螺杆菌(H.pylori)感染是非贲门胃腺癌必要但非充分的致病因子。盐的高摄入与胃癌强烈相关。新鲜果蔬对胃癌具有预防作用,但维生素和其他饮食补充并不能预防胃癌。H.pylori感染中的宿主-细菌相互作用导致不同类型的胃炎和胃酸分泌,从而决定疾病结局。胃癌阳性家族史是一个重要的危险因素。低血清胃蛋白酶原反映胃萎缩程度,可作为检出胃癌高危人群的标志物。H.pylori筛查和治疗被推荐作为减少高危人群胃癌危险性的一种策略,该策略在萎缩性胃炎发生前实施最为有效,但并不排除对胃癌高危人群的内镜监测。对胃癌低危人群不推荐行H.pylori筛查。H.pylori感染的一线治疗应遵循国家治疗指南。结论:高危人群中H.pylori筛查和根除策略可能会减少胃癌的发生率,本共识根据现有证据予以推荐。 | Kwong Ming Fock Nick Talley Paul Moayyedi Richard Hunt Takeshi Azuma Kentaro Sugano Shu Dong Xiao Shiu Kum Lam Khean Lee Goh Tsutomu Chiba Naomi Uemura Jae G Kim Nayoung Kim Tiing Leong Ang Varocha Mahachai Hazel Mitchell Abdul Aziz Rani Jyh Ming Liou Ratha-korn Vilaichone Jose Sollanor 钱本余 | 2008 | 胃肠病学2008，13，4： | 37 |
| 2 | Endoscopic diagnosis of extrahepatic bile duct carcinoma:Advances and current limitations显示文摘The accurate diagnosis of extrahepatic bile duct carcinoma is difficult,even now.When ultrasonography(US)shows dilatation of the bile duct,magnetic resonance cholangiopancreatography followed by endoscopic US(EUS)is the next step.When US or EUS shows localized bile duct wall thickening,endoscopic retrograde cholangiopancreatography should be conducted with intraductal US(IDUS)and forceps biopsy.Fluorescence in situ hybridization increases the sensitivity of brush cytology with similar specificity.In patients with papillary type bile duct carcinoma,three biopsies are sufficient.In patients with nodular or infiltrating-type bile duct carcinoma,multiple biopsies are warranted,and IDUS can compensate for the limitations of biopsies.In preoperative staging,the combination of dynamic multidetector low computed tomography(MDCT)and IDUS is useful for evaluating vascular invasion and cancer depth infiltration.However,assessment of lymph nodes metastases is difficult.In resectable cases,assessment of longitudinal cancer spread is important.The combination of IDUS and MDCT is useful for revealing submucosal cancer extension,which is common in hilar cholangiocarcinoma.To estimate the mucosal extenextension,which is common in extrahepatic bile duct carcinoma,the combination of IDUS and cholangioscopy is required.The utility of current peroral cholangioscopy is limited by the maneuverability of the“baby scope”.A new baby scope(10 Fr),called“SpyGlass”has potential,if the image quality can be improved.Since extrahepatic bile duct carcinoma is common in the Far East,many researchers in Japan and Korea contributed these studies,especially,in the evaluation of longitudinal cancer extension. | Kiichi Tamada Jun Ushio Kentaro Sugano | 2011 | World Journal of Clinical Oncology2011，2，5： | 26 |
| 3 | 早胃的癌症用的程度的诊断灵活光谱成像颜色改进显示文摘 The demarcation line between the cancerous lesion and the surrounding area could be easily recognized with flexible spectral imaging color enhancement (FICE) system compared with conventional white light images. The characteristic f inding of depressed-type early gastric cancer (EGC) in most cases was revealed as reddish lesions distinct from the surrounding yellowish non-cancerous area without magnification. Conventional endoscopic images provide little information regarding depressed lesions located in the tangential line, but FICE produces higher color contrast of such cancers. Histological f indings in depressed area with reddish col- or changes show a high density of glandular structure and an apparently irregular microvessel in intervening parts between crypts, resulting in the higher color con- trast of FICE image between cancer and surrounding area. Some depressed cancers are shown as whitish lesion by conventional endoscopy. FICE also can pro- duce higher color contrast between whitish cancerous lesions and surrounding atrophic mucosa. For nearly flat cancer, FICE can produce an irregular structuralpattern of cancer distinct from that of the surrounding mucosa, leading to a clear demarcation. Most elevated-type EGCs are detected easily as yellowish lesions with clearly contrasting demarcation. In some cases, a partially reddish change is accompanied on the tumor surface similar to depressed type cancer. In addition, the FICE system is quite useful for the detection of minute gastric cancer, even without magnif ication. These new contrasting images with the FICE system may have the potential to increase the rate of detection of gastric cancers and screen for them more effectively as well as to determine the extent of EGC. | Hiroyuki Osawa Hironori Yamamoto Yoshimasa Miura Mitsuyo Yoshizawa Keijiro Sunada Kiichi Satoh Kentaro Sugano | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，8： | 11 |
| 4 | Clinical outcomes of enteroscopy using the double-balloon method for strictures of the small intestine显示文摘AIM: To evaluate the clinical outcome of enteroscopy, using the double-balloon method, focusing on the involvement of neoplasms in strictures of the small intestine.METHODS: Enteroscopy, using the double-balloon method, was performed between December 1999 and December 2002 at Jichi Medical School Hospital, Japan and strictures of the small intestine were found in 17 out of 62 patients. These 17 consecutive patients were subjected to analysis.RESULTS: The double-balloon enteroscopy contributed to the diagnosis of small intestinal neoplasms found in 3out of 17 patients by direct observation of the strictures as well as biopsy sampling. Surgical procedures were chosen for these three patients, while balloon dilation was chosen for the strictures in four patients diagnosed with inflammation without involvement of neoplasm.CONCLUSION: Double-balloon enteroscopy is a useful method for the diagnosis and treatment of strictures in the small bowel. | Keijiro Sunada Hironori Yamamoto Hiroto Kita Tomonori Yano Hiroyuki Sato Yoshikazu Hayashi Tomohiko Miyata Yutaka Sekine Akiko Kuno Michiko Iwamoto Hirohide Ohnishi Kenichi Ido Kentaro Sugano | 2005 | World Journal of Gastroenterology2005，11，7： | 6 |
| 5 | Non-steroidal anti-inflammatory drug-induced small bowel injuries identified by double-balloon endoscopy显示文摘AIM: To clarify clinical features of the NSAID-induced small bowel lesions using a new method of endoscopy.METHODS: This is a retrospective study and we analyzed seven patients with small bowel lesions while taking NSAIDs among 61 patients who had undergone doubleballoon endoscopy because of gastro-intestinal bleeding or anemia between September 2000 and March 2004, at Jichi Medical School Hospital in Japan. Neither conventional EGD nor colonoscopy revealed any lesions of potential bleeding sources including ulcerations. Double-balloon endoscopy was carried out from oral approach in three patients, from anal approach in three patients, and from both approaches in one patient.RESULTS: Ulcers or erosions were observed in the ileum in six patients and in the jejunum in one patient, respectively.The ulcers were multiple in all the patients with different features from tiny punched out ulcers to deep ulcerations with oozing hemorrhage or scar. All the patients recovered uneventfully and had full resolution of symptoms after suspension of the drug.CONCLUSION: NSAIDs can induce injuries in the small bowel even in patients without any lesions in both the stomach and colon. | Yoshikazu Hayashi Hironori Yamamoto Hiroto Kita Keijiro Sunada Hiroyuki Sato Tomonori Yano Michiko Iwamoto Yutaka Sekine Tomohiko Miyata Akiko Kuno Takaaki Iwaki Yoshiyuki Kawamura Hironari Ajibe Kenichi Ido Kentaro Sugano | 2005 | World Journal of Gastroenterology2005，11，31： | 6 |
| 6 | Clinical outcomes of double-balloon endoscopy for the diagnosis and treatment of small-intestinal diseases显示文摘 | Hironori Yamamoto Hiroto Kita Keijiro Sunada Yoshikazu Hayashi Hiroyuki Sato Tomonori Yano Michiko Iwamoto Yutaka Sekine Tomohiko Miyata Akiko Kuno Hironari Ajibe Kenichi Ido Kentaro Sugano | 2004 | Clinical Gastroenterology and Hepatology2004，，11： | 2 |
| 7 | Total enteroscopy with a nonsurgical steerable double-balloon method显示文摘 | Hironori Yamamoto Yutaka Sekine Yukihiro Sato Toshihiko Higashizawa Tomohiko Miyata Satoru Iino Kenichi Ido Kentaro Sugano | 2001 | Gastrointestinal Endoscopy2001，，2： | 2 |
| 8 | Total enteroscopy with a nonsurgical steerable double-balloon method显示文摘 | Hironori Yamamoto Yutaka Sekine Yukihiro Sato Toshihiko Higashizawa Tomohiko Miyata Satoru Iino Kenichi Ido Kentaro Sugano | 2001 | Gastrointestinal Endoscopy2001，，2： | 2 |
| 9 | The revised Japanese clinical diagnostic criteria for chronic pancreatitis显示文摘 | Tooru Shimosegawa Keisho Kataoka Terumi Kamisawa Hiroyuki Miyakawa Hirotaka Ohara Tetsuhide Ito Satoru Naruse Naohiro Sata Koichi Suda Morihisa Hirota Yoshifumi Takeyama Keiko Shiratori Takashi Hatori Makoto Otsuki Yutaka Atomi Kentaro Sugano Masao Tanaka | 2010 | Journal of Gastroenterology2010，，6： | 2 |
| 10 | Success rate of curative endoscopic mucosal resection with circumferential mucosal incision assisted by submucosal injection of sodium hyaluronate显示文摘 | Hironori Yamamoto Hiroshi Kawata Keijiro Sunada Kiichi Satoh Yoshinari Kaneko Kenichi Ido Kentaro Sugano | 2002 | Gastrointestinal Endoscopy2002，，4： | 2 |
| 11 | Nonsurgical management of small-bowel polyps in Peutz–Jeghers syndrome with extensive polypectomy by using double-balloon endoscopy显示文摘 | Hirotsugu Sakamoto Hironori Yamamoto Yoshikazu Hayashi Tomonori Yano Tomohiko Miyata Naoyuki Nishimura Hakuei Shinhata Hiroyuki Sato Keijiro Sunada Kentaro Sugano | 2011 | Gastrointestinal Endoscopy2011，，2： | 2 |
| 12 | Changes in plasma ghrelin levels, gastric ghrelin production, and body weight after Helicobacter pylori cure显示文摘 | Hiroyuki Osawa Hiroto Kita Hirohide Ohnishi Masamitsu Nakazato Yukari Date Christopher L. Bowlus Yumiko Ishino Eiko Watanabe Tomomi Shiiya Hiroaki Ueno Hiroko Hoshino Kiichi Satoh Kentaro Sugano | 2006 | Journal of Gastroenterology2006，，10： | 1 |
| 13 | Optimal band imaging system can facilitate detection of changes in depressed-type early gastric cancer显示文摘 | Hiroyuki Osawa Mitsuyo Yoshizawa Hironori Yamamoto Hiroto Kita Kiichi Satoh Hirohide Ohnishi Hidetoshi Nakano Masahiro Wada Masayuki Arashiro Mamiko Tsukui Kenichi Ido Kentaro Sugano | 2008 | Gastrointestinal Endoscopy2008，，2： | 1 |
| 14 | Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capacity of nuclear factor-κB显示文摘 | Hiroyuki Mutoh Hiroko Hayakawa Hirotsugu Sakamoto Kentaro Sugano | 2007 | Journal of Gastroenterology2007，，9： | 1 |
| 15 | Role of double-balloon endoscopy in the diagnosis of small-bowel tumors: the first Japanese multicenter study显示文摘 | Keigo Mitsui Shu Tanaka Hironori Yamamoto Tsuyoshi Kobayashi Akihito Ehara Tomonori Yano Hidemi Goto Hiroshi Nakase Shinji Tanaka Toshiyuki Matsui Mitsuo Iida Kentaro Sugano Choitsu Sakamoto | 2009 | Gastrointestinal Endoscopy2009，，3： | 1 |
| 16 | Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal metaplasia显示文摘 | Akashi Eda Hiroyuki Osawa Ichiro Yanaka Kiichi Satoh Hiroyuki Mutoh Ken Kihira Kentaro Sugano | 2002 | Journal of Gastroenterology2002，，2： | 1 |
| 17 | A case of successful enteroscopic balloon dilation for late anastomotic stricture of choledochojejunostomy after living donor liver transplantation显示文摘 | Hidenori Haruta Hironori Yamamoto Koichi Mizuta Yoshiaki Kita Takeji Uno Satoshi Egami Shuji Hishikawa Kentaro Sugano Hideo Kawarasaki | 2005 | Liver Transpl2005，，12： | 1 |
| 18 | Risk factor profiles, drug usage, and prevalence of aspirin-associated gastroduodenal injuries among high-risk cardiovascular Japanese patients: the results from the MAGIC study显示文摘 | Naomi Uemura Kentaro Sugano Hideyuki Hiraishi Kazuyuki Shimada Shinya Goto Shinichiro Uchiyama Yasushi Okada Hideki Origasa Yasuo Ikeda | 2014 | Journal of Gastroenterology2014，，： | 1 |
| 19 | Rationale in diagnosis and screening of atrophic gastritis with stomach-specific plasma biomarkers显示文摘 | Lars Agréus Ernst J Kuipers Limas Kupcinskas Peter Malfertheiner Francesco Di Mario Marcis Leja Varocha Mahachai Niv Yaron Martijn van Oijen Guillermo Perez Perez Massimo Rugge Jukka Ronkainen Mikko Salaspuro Pentti Sipponen Kentaro Sugano Joseph Sung | 2012 | Scandinavian Journal of Gastroenterology2012，，2： | 1 |
| 20 | Disease trends after Helicobacter pylori eradication based on Japanese nationwide claims and the health check-up database显示文摘BACKGROUND Helicobacter pylori(H.pylori)infection is a risk factor for many diseases,including peptic ulcer disease and gastric cancer.While H.pylori eradication therapy can prevent these diseases,potentially unfavorable effects of eradication therapy have also been reported in some diseases,such as gastroesophageal reflux disease(GERD),Barrett’s esophagus(BE),inflammatory bowel disease(IBD),allergic diseases,and metabolic diseases.Consequently,both positive and negative impacts should be considered when assessing the effects of H.pylori eradication therapy.AIM To compare the incidence of these diseases before and after H.pylori eradication and to comprehensively assess its effects.METHODS This retrospective cohort study used a Japanese nationwide health claims database(April 2009-March 2020),developed by the Japanese Ministry of Health,Labour and Welfare.The database contained almost all health insurance claims data issued in Japan,and specific health check-up data for individuals who took the check-ups.Descriptive statistics were used for the analyses.Patients who received primary eradication therapy were defined as those prescribed medication for H.pylori eradication.New diagnoses,defined as incidence of upper gastrointestinal diseases and IBD,and prevalence of allergic diseases were compared before and after eradication.The incidence and prevalence of each disease were also compared between the 3-year period before eradication(from the 4th to the 2nd year prior to the year of eradication)and the 3-year period after eradication(from the 1st to the 3rd year after the year of eradication)based on the age category and calendar year and month.Changes in body mass index and proportion of patients with metabolic syndrome(MS)were examined before and after eradication.RESULTS We identified 5219731 patients who received primary eradication therapy.The 65-69 years age group had the greatest number of patients in both sexes.There was no significant increase in the incidence of GERD after eradication when considering the effects of aging and reporting period.However,the incidence of BE was higher in the 3-year period after eradication than in the 3-year period before eradication for all age categories(0.02%-0.10%vs<0.01%-0.05%).The incidence of IBD and prevalence of allergic disease were also higher after eradication.In contrast,the incidence of gastric and duodenal ulcers and gastritis was reduced after eradication.In patients with at least one entry of health check-up data(1701111 patients),the percentage of patients with MS showed a slight increase following eradication(11.0%in the year of eradication and 12.2%after 5 years).CONCLUSION The results suggest that H.pylori eradication therapy reduces peptic ulcers and gastritis;however,it is associated with increased incidence of several other chronic diseases. | Kazuhiro Mizukami Kentaro Sugano Tomomi Takeshima Kazunari Murakami | 2023 | World Journal of Gastroenterology2023，29，4： | 1 |
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