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| 1 | Reversibility of minimal hepatic encephalopathy following liver transplantation in Egyptian cirrhotic patients显示文摘AIM To evaluate the reversibility of minimal hepatic encephalopathy(MHE) following liver transplantation(LT) in Egyptian cirrhotic patients. METHODS This prospective study included twenty patients with biopsy-proven liver cirrhosis listed for LT and twenty ageand sex-matched healthy control subjects. All underwent neuro-psychiatric examination, laboratory investigations, radiological studies and psychometric tests including trail making test A(TMT A), TMT B, digit symbol test and serial dotting test. The psychometric hepatic encephalopathy score(PHES) was calculated for patients to diagnose MHE. Psychometric tests were repeated six months following LT in the cirrhotic patient group. RESULTS Before LT, psychometric tests showed highly significant deficits in cirrhotic patients in comparison to controls(P < 0.001). There was a statistically significant improvement in test values in the patient group after LT; however, their values were still significantly worse than those of the controls(P < 0.001). The PHES detected MHE in 16 patients(80%) before LT with a median value of -7 ± 3.5. The median PHES value was significantly improved following LT, reaching-4.5 ± 5(P < 0.001), and the number of patients with MHE decreased to 11(55%). The pre-transplant model for end-stage liver disease(MELD) score ≥ 15 was significantly related to the presence of post-transplant MHE(P = 0.005). More patients in whom reversal of MHE was observed had a pre-transplant MELD score < 15.CONCLUSION Reversal of MHE in cirrhotic patients could be achieved by LT, especially in those with a MELD score < 15. | Mahmoud A Osman Moataz M Sayed Khaled A Mansour Shereen A Saleh Wesam A Ibrahim Sara M Abdelhakam Mohamed Bahaa Wael A Yousry Hosam S Elbaz Reginia N Mikhail Azza M Hassan Ehab H Elsayed Dalia A Mahmoud | 2016 | World Journal of Hepatology2016，8，30： | 11 |
| 2 | High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation:Role of endoplasmic-reticulum-stress显示文摘AIM To elucidate how high diet-induced endoplasmic reticulum-stress upregulates thioredoxin interacting protein expression in Müller cells leading to retinal inflammation. METHODS Male C57Bl/J mice were fed either normal diet or 60% high fat diet for 4-8 wk. During the 4 wk study, mice received phenyl-butyric acid(PBA); endoplasmic reticulum-stress inhibitor; for 2 wk. Insulin resistance was assessed by oral glucose tolerance. Effects of palmitate-bovine serum albumin(BSA)(400 μmol/L) were examined in retinal Müller glial cell line and primary Müller cells isolated from wild type and thioredoxin interacting protein knock-out mice. Expression of thioredoxin interacting protein, endoplasmic reticulum-stress markers, mi R-17-5p m RNA, as well as nucleotide-binding oligomerization domain-like receptor protein(NLRP3) and IL1β protein was determined.RESULTS High fat diet for 8 wk induced obesity and insulin resistance evident by increases in body weight and impaired glucose tolerance. By performing quantitative real-time polymerase chain reaction, we found that high fat diet triggered the expression of retinal endoplasmic reticulum-stress markers(P < 0.05). These effects were associated with increased thioredoxin interacting protein and decreased mi R-17-5p expression, whichwere restored by inhibiting endoplasmic reticulumstress with PBA(P < 0.05). In vitro, palmitate-BSA triggered endoplasmic reticulum-stress markers, which was accompanied with reduced mi R-17-5p and induced thioredoxin interacting protein m RNA in retinal Müller glial cell line(P < 0.05). Palmitate upregulated NLRP3 and IL1β expression in primary Müller cells isolated from wild type. However, using primary Müller cells isolated from thioredoxin interacting protein knock-out mice abolished palmitate-mediated increase in NLRP3 and IL1β.CONCLUSION Our work suggests that targeting endoplasmic reticulumstress or thioredoxin interacting protein are potential therapeutic strategies for early intervention of obesityinduced retinal inflammation. | Maha Coucha Islam N Mohamed Sally L Elshaer Osinakachuk Mbata Megan L Bartasis Azza B El-Remessy | 2017 | World Journal of Diabetes2017，8，2： | 8 |
| 3 | Thioredoxin interacting protein,a key molecular switch between oxidative stress and sterile inflammation in cellular response显示文摘Tissue and systemic inflammation have been the main culprit behind the cellular response to multiple insults and maintaining homeostasis.Obesity is an independent disease state that has been reported as a common risk factor for multiple metabolic and microvascular diseases including nonalcoholic fatty liver disease(NAFLD),retinopathy,critical limb ischemia,and impaired angiogenesis.Sterile inflammation driven by high-fat diet,increased formation of reactive oxygen species,alteration of intracellular calcium level and associated release of inflammatory mediators,are the main common underlying forces in the pathophysiology of NAFLD,ischemic retinopathy,stroke,and aging brain.This work aims to examine the contribution of the pro-oxidative and pro-inflammatory thioredoxin interacting protein(TXNIP)to the expression and activation of NLRP3-inflammasome resulting in initiation or exacerbation of sterile inflammation in these disease states.Finally,the potential for TXNIP as a therapeutic target and whether TXNIP expression can be modulated using natural antioxidants or repurposing other drugs will be discussed. | Islam N Mohamed Luling Li Saifudeen Ismael Tauheed Ishrat Azza B El-Remessy | 2021 | World Journal of Diabetes2021，12，12： | 6 |
| 4 | Comprehensive risk assessment of heavy metals in surface sediments along the Egyp- tian Red Sea coast显示文摘 | Dalia M S A S Azza K Ahmed E N | 2014 | The Egyptian Journal of Aquatic Research2014，40，4： | 1 |
| 5 | Floating mats: their occurrence and influence on shoreline distribution of emergent vegetation显示文摘 | Azza N Denny P Koppel J V | 2006 | Freshwater Biology2006，51，： | 1 |
| 6 | Floating mats: their occurrence and influence on shoreline distribution of emergent vegetation显示文摘 | Azza N Denny P Koppel J V Kansiime F | 2006 | FreshwaterBiology2006，51，： | 1 |
| 7 | Application of infrared spectros- copy in the study of polymorphism of hydrogenated canola oil显示文摘 | AZZA N M DEMAN J M | 1985 | J Am Oil Chem Soc1985，62，10： | 1 |
| 8 | Polymorphism of hydrogenated canola oil 显示文摘 | AZZA N M DEMAN J M | 1985 | J Am Oil Chem Soc1985，62，4： | 1 |
| 9 | Polymorphism of hydrogenated canola oil 显示文摘 | AZZA N M DEMAN J M | 1985 | J Am Oil Chem Soc1985，62，4： | 1 |
| 10 | Polychlorinated biphenyls and chlorinated pestiddes in mussels from the Egyptian Red Sea coast显示文摘 | AZZA K AHMED E N TAREK O S | | 0，，： | 1 |
| 11 | Preparation and some properties of immobilized Penicillium funiculosum 258 dextranase显示文摘 | MOHAMED A A N ISMAIL A M S AZZA M A F | 1999 | Process Biochemistry1999，34，4： | 1 |
| 12 | Floating mats; theiroccurrence and influence on shoreline distribution of emergentvegetation显示文摘 | Azza N Denny P Van de Koppel J | 2006 | Freshwater Biology2006，51，7： | 1 |
| 13 | Polychlorinated biphenyls and chlorinated pesticides in mussels from the Egyptian Red Sea coast显示文摘 | Azza K Ahmed E N Tarek O S | 2004 | Chemosphere2004，54，： | 1 |
| 14 | Floating mats: their occurrence and influence on shoreline distribution of emergent vegetation 显示文摘 | AZZA N DENNY P KOPPEL J V | 2006 | Freshwater Biol2006，51，： | 1 |
| 15 | Floating mats: their occurrence and influence on shoreline distribution of emergent vegetation显示文摘 | Azza N Denny p Koppel J V | 2006 | FreshwaterBiology2006，51，： | 1 |
| 16 | Provirophages and transpovirons as the diverse mobilome of giant viruses 显示文摘 | Desnues C La Scola B Yutin N Fournous G Robert C Azza S Jardot P Monteil S Campocasso A Koon-in E V Raouh D | 2012 | PNAS2012，109，18： | 1 |
| 17 | Polychlorinated biphenyls and chlorinated pesticides in mussels from the Egyptian Red Sea coast显示文摘 | AZZA K AHMED E N TAREK O S | 2004 | Chemosphere2004，4，： | 1 |
| 18 | Effect of girradiation on the occurrence of pathogenic microorganisms and nutritive value of four principal cereal grains显示文摘 | AZIZ N H SOUZAN R M SHAHIN A AZZA | | 0，，： | 1 |
| 19 | Giant Marseillevirus Highlights the Role of Amoebae as a Melting Pot in Emergence of Chimeric Microorganisms显示文摘 | Boyer M Yutin N Pagnier I Barrassi L Fournous G Espinosa L Robert C Azza S Sun S Rossmann MG Suzan-Monti M La Scola B Koonin EV Raoult D | | 0，，51： | 1 |
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