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| 1 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 2 | Requirement for cyclin D3 in germinal center formation and function显示文摘第二等的淋巴的纸巾的幼芽的中心(GC ) 对装高亲密关系的体液的有免疫力的回答批评。当多样化他们的抗体基因时,在 GC 以内的 B 房间经历快速的同种细胞的扩大和选择。尽管 GC B 房间采用一个唯一的 proliferative 程序提供这些进程,这通常被相信,很少联系 GC 的房间周期怎么被安排被知道。D 类型 cyclins 组成使房间能对生理的变化作出回应的房间周期引擎的一个重要部件。房间类型 -- 并且 D 类型 cyclins 的发展阶段特定的角色被描述了,但是 cyclin D 要求没在 GC 反应期间被探讨。在这研究,我们报导 cyclin D3 为切换的增长和 Ig 班大部分是非必需的在 vitro 激活的 B 房间。相反,在 Ccnd3 的 GC 开发 ?/ ?老鼠显著地被损害,作为是 T 房间依赖者抗体反应。在 GC 以内,尽管切换, unswitched B 房间被 cyclin D3 inactivation 影响, IgM?水池更严重地被减少。有趣地尽管有 cyclin D2 表示的补偿增加, Ccnd3 的一个重要数字 ?/ ?GC B 房间处于静止 G0 状态积累。最后,尽管 cyclin D3 inactivation 没在 GC B 房间破坏 BCL6 表示,支持 BCL6 overexpression 的效果完全堵住了 GC,建议 cyclin D3 调整 GC 形成的 BCL6 下游地行动。这是 cyclin D3 玩的第一示范在 B 房间开发的 GC 阶段的一个重要、唯一的角色。 | Jonathan U Peled J Jessica Yu Jeganathan Venkatesh Enguang Bi B Belinda Ding Melissa Krupski-Downs Rita Shaknovich Piotr Sicinski Betty Diamond Matthew D Scharff B Hilda Ye | 2010 | Cell Research2010，20，6： | 3 |
| 3 | Application of soft landing to the process control of chemical mechanical polishing显示文摘 | Chiu J B Yu C C Shen S H | 2003 | Microelectronic Engineering2003，65，3： | 2 |
| 4 | 显示文摘 | Shekunov B Yu Baldyga J York P | 2001 | Chemical Engineering Science2001，56，： | 2 |
| 5 | Fine mapping of a C-terminal linear epitope highly conserved among the major envelope gly coprotein E2 (gpS1 to gp54) of different pestiviruses显示文摘 | Yu M Wang L F Shiell B J Morrissy C J Westbury H A | 1996 | Virology1996，222，： | 1 |
| 6 | Protective action of bacterial melanin against DNA damage in full UV spectrums by a sensitive plasmid-based noncellular system显示文摘 | Geng J Yu S B Wan X | 2008 | Journal of Biochemical and Biophysical Methods2008，，： | 1 |
| 7 | Development of nanophase CeO2- Pt/C cathode catalyst for direct methanol fuel cell 显示文摘 | YU H B KIM J Y LEE H l | 2005 | J Power Sources2005，140，： | 1 |
| 8 | Robust fuzzy control of nonlinear fuzzy impulsive systems with time - varying delay 显示文摘 | Jiang H B Yu J J Zhou C G | 2008 | IET control theory and applications2008，8，2： | 1 |
| 9 | Neural model adaptation and predictive control of a chemical process rig显示文摘 | YU D L YU D W GOMM J B | 2006 | IEEE Transactions on Control Systems Technoogy2006，14，5： | 1 |
| 10 | Study of local three-dimensional conformal radiotherapy combined with transcatheter arterial chemoembolization for patients with stage Ⅲ hepatocellular carcionma显示文摘 | Yu J Wang L | 2003 | Am J Clin Oncol2003，26，4： | 1 |
| 11 | Modified generalized Lorenz system and fold chaotic attractors显示文摘 | Bao B C Liu Z Yu J B | 2009 | International Journal of Bifurcation and Chaos2009，19，8： | 1 |
| 12 | Kinetic basis for the substrate specificity during hydrolysis of phospholipids by secreted phospholipase A2 显示文摘 | ROGERS J YU B Z SERVES S V | 1996 | Biochemistry1996，35，29： | 1 |
| 13 | Posttraurmatic stress disorder in patients with burn injuries显示文摘 | Yu B H Dimsdale J E | 1999 | J Bum Care Rehabil1999，20，5： | 1 |
| 14 | Genetic bases of appearance quality of rice grains in Shanyou 63, an elite rice hybrid显示文摘 | Tan Y F Li J X Yu S B et a1 | 2000 | Theor Appl Genet2000，101，56： | 1 |
| 15 | Chem显示文摘 | Yu M F Yakobson B I and Ruoff R S Phys J | 2000 | B2000，104，： | 1 |
| 16 | Pro-and antiinflammatory eytokine signaling:reciprocal antagonism regulates interferongamma production by human natural killer cells显示文摘 | YU J WEI M BECKNELL B | 2006 | Immunity2006，24，5： | 1 |
| 17 | Modeling Discontinuous Liquid Flow in a Blast Furnace显示文摘 | Wang G X Chew S J Yu A B | 1997 | Metallurgical and Materials Transactions1997，28，2： | 1 |
| 18 | Synthesis of three diosgenyl saponins:dioscin polyphyllin D,and balanitin 7显示文摘 | DENG S J YU B HUI Y Z | 1999 | Carbohydrate Research1999，317，： | 1 |
| 19 | Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development显示文摘 | Hanson R D Hess J L Yu B D | 1999 | Proc Natl Acad Sci U S A1999，96，14： | 1 |
| 20 | Role of wide contacts in the ac response of a double-barrier structure显示文摘 | QUAN J YU Y B TANG Y H | 2006 | Phys Rev B2006，73，19： | 1 |
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