|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Influence of Eutrophication on the Distribution of Total Mercury and Methylmercury in Hydroelectric Reservoirs显示文摘 | Meng Bo Feng X B Chen C X Qiu G L Sommar J Guo Y N Liang P Wan Q | 2010 | EN2010，，5： | 2 |
| 3 | The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis 显示文摘 | Khanna C Wan X Bose S | 2004 | Nat Med2004，10，2： | 1 |
| 4 | Protective action of bacterial melanin against DNA damage in full UV spectrums by a sensitive plasmid-based noncellular system显示文摘 | Geng J Yu S B Wan X | 2008 | Journal of Biochemical and Biophysical Methods2008，，： | 1 |
| 5 | Preparation and characterization of gelatin gel with a gradient structure 显示文摘 | Wang Y L Cheng G X Yao K D | 2000 | Polymer Int2000，49，12： | 1 |
| 6 | Mechanism of proton doping in polyaniline显示文摘 | Yang J P | 1995 | J Appli Polym Sci1995，55，： | 1 |
| 7 | Cellular alternans:a mechanism linking calcium cycling proteins to cardiac arrhythmogenesis显示文摘 | WAN X ROSENBAUM DS | 2006 | Ann NYAcad Sci2006，1080，10： | 1 |
| 8 | Preparation of epoxy-silica-acrylate hybrid coatings 显示文摘 | WAN T LIN J H LI X J | 2008 | Polymer Bulletin2008，59，6： | 1 |
| 9 | The preventive effect of adjuvant-free administration of TNF-PADRE autovaccine on collagen-Ⅱ-induced rheumatoid arthritis in mice显示文摘 | Wan Y Yuan S Xue X | 2009 | Cell Immunol2009，258，1： | 1 |
| 10 | Genetic analysis of a novel dominant rice dwarf mutant 986083D显示文摘 | Qin R Z Qiu Y Cheng Z J Shan X Y Guo X P Zhai H Q Wan J M | 2008 | Euphytica2008，160，： | 1 |
| 11 | Attitudes of Ch-inesemedical students towardthe IIME GlobalMinimum Essential Require-ments显示文摘 | Zhang X Li X Wan X Zeng C Scott CS Schaad DC | 2004 | Teaching and Learning in Medicine2004，16，2： | 1 |
| 12 | Metal directed assembly of 1 - D and 2 --D coordination polymers with f luconazole and dicyanamide co --ligand显示文摘 | Zhao X J Wan g Q Du M | | Inorg Chim Act a0，，： | 1 |
| 13 | Paleocene-Eocene record of ophiolite obduction and initial India-Asia collision,south central Tibet显示文摘 | DING L PAUL K WAN X | 2005 | Tectonics2005，24，： | 1 |
| 14 | The membrane-eytoskeleton linker ezrin is necessary for osteosareoma metastasis 显示文摘 | Khanna C Wan X Bose S | 2004 | Nat Med2004，10，2： | 1 |
| 15 | Statics of a gillnet placed in a uniform current 显示文摘 | Wan R Huang W Q Song X F | 2004 | Ocean Engineering2004，31，： | 1 |
| 16 | Neck circumference positively related with central obesity, overweight, and metabolic syndrome in Chinese subjects with type 2 diabetes: Beijing Community Diabetes Study 4 显示文摘 | Yang G R Yuan S Y Fu H J Wan G Zhu L X Bu X L | 2010 | Diabetes Care2010，33，： | 1 |
| 17 | Silicon isotope fractionation in bamboo and its significance to the biogeochemical cycle of silicon显示文摘 | DING T P ZHOU J X WAN D F | 2008 | Geochimica et Cosmochimica Acta2008，72，5： | 1 |
| 18 | Factors effecting the prognosis of patients with delayed encephalopathy alter acute carbon monoxide poisoning 显示文摘 | Hu H Pan X Wan Y | 2011 | American Journal of Emergency Medicine2011，29，3： | 1 |
| 19 | Data-Driven Facial Expression Synthesis via Laplacian Deformation显示文摘 | Wan X M Jin X G | 2012 | Multimedia Tools and Applications2012，58，1： | 1 |
| 20 | Microbial pretreatment of corn stover with Ceriporiopsis subvermispora for enzymatic hydrolysis and ethanol production显示文摘 | Wan C X Li Y B | | 0，，16： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员