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| 1 | Three-dimensional neurostereoendoscopy: subjective and objective comparison to 2D显示文摘 | Fraser JF Allen B Anand VK Schwartz TH | 2009 | 中国神经肿瘤杂志2009，7，1： | 6 |
| 2 | Diagnosis of focal liver lesions with deep learning-based multichannel analysis of hepatocyte-specific contrast-enhanced magnetic resonance imaging显示文摘BACKGROUND The nature of input data is an essential factor when training neural networks.Research concerning magnetic resonance imaging(MRI)-based diagnosis of liver tumors using deep learning has been rapidly advancing.Still,evidence to support the utilization of multi-dimensional and multi-parametric image data is lacking.Due to higher information content,three-dimensional input should presumably result in higher classification precision.Also,the differentiation between focal liver lesions(FLLs)can only be plausible with simultaneous analysis of multisequence MRI images.AIM To compare diagnostic efficiency of two-dimensional(2D)and three-dimensional(3D)-densely connected convolutional neural networks(DenseNet)for FLLs on multi-sequence MRI.METHODS We retrospectively collected T2-weighted,gadoxetate disodium-enhanced arterial phase,portal venous phase,and hepatobiliary phase MRI scans from patients with focal nodular hyperplasia(FNH),hepatocellular carcinomas(HCC)or liver metastases(MET).Our search identified 71 FNH,69 HCC and 76 MET.After volume registration,the same three most representative axial slices from all sequences were combined into four-channel images to train the 2D-DenseNet264 network.Identical bounding boxes were selected on all scans and stacked into 4D volumes to train the 3D-DenseNet264 model.The test set consisted of 10-10-10 tumors.The performance of the models was compared using area under the receiver operating characteristic curve(AUROC),specificity,sensitivity,positive predictive values(PPV),negative predictive values(NPV),and f1 scores.RESULTS The average AUC value of the 2D model(0.98)was slightly higher than that of the 3D model(0.94).Mean PPV,sensitivity,NPV,specificity and f1 scores(0.94,0.93,0.97,0.97,and 0.93)of the 2D model were also superior to metrics of the 3D model(0.84,0.83,0.92,0.92,and 0.83).The classification metrics of FNH were 0.91,1.00,1.00,0.95,and 0.95 using the 2D and 0.90,0.90,0.95,0.95,and 0.90 using the 3D models.The 2D and 3D networks'performance in the diagnosis of HCC were 1.00,0.80,0.91,1.00,and 0.89 and 0.88,0.70,0.86,0.95,and 0.78,respectively;while the evaluation of MET lesions resulted in 0.91,1.00,1.00,0.95,and 0.95 and 0.75,0.90,0.94,0.85,and 0.82 using the 2D and 3D networks,respectively.CONCLUSION Both 2D and 3D-DenseNets can differentiate FNH,HCC and MET with good accuracy when trained on hepatocyte-specific contrast-enhanced multi-sequence MRI volumes. | Róbert Stollmayer Bettina K Budai Ambrus Tóth IldikóKalina Erika Hartmann Péter Szoldán Viktor Bérczi Pál Maurovich-Horvat Pál N Kaposi | 2021 | World Journal of Gastroenterology2021，27，35： | 6 |
| 3 | 在现实生活中,有与无人值守时血压测量的差异显示文摘关于收缩压干预试验(systolic blood pressure intervention trial,SPRINT)的研究结果 是否具有普遍性的争论,引起了人们对无人值守诊室血压测量技术相当大的兴趣。现实世界中,与在熟悉的诊室里进行的传统血压测量方法相比,无人值守的血压测量值是否更低,尚无定论。 | 叶超毅 叶鹏 Bauer F Seibert FS Rohn B Bauer KAR Rolshoven E Babel N Westhoff TH | 2018 | 中华高血压杂志2018，26，3： | 5 |
| 4 | Comparison of different lymph node staging systems in prognosis of gastric cancer:a bi-institutional study from Hungary显示文摘Objective: The Union for International Cancer Control(UICC) Node(N) classification is the most common used staging method for the prognosis of gastric cancer. It demands adequate, at least 16 lymph nodes(LNs) to be dissected; therefore different staging systems were invented.Methods: Between March 2005 and March 2010, 164 patients were evaluated at the Department of General Surgery in the Kenézy Gyula Hospital and at the Department of General, Thoracic and Vascular Surgery in the Kaposi Mór Hospital. The 6th, 7th and 8th UICC N-staging systems, the number of examined LNs, the number of harvested negative LNs, the metastatic lymph node ratio(MLR) and the log odds of positive LNs(LODDS) were determined to measure their 5-year survival rates and to compare them to each other.Results: The overall 5-year survival rate for all patients was 55.5% with a median overall survival time of 102 months. The tumor stage, gender, UICC N-stages, MLR and the LODDS were significant prognostic factors for the 5-year survival with univariate analysis. The 6th UICC N-stage did not follow the adequate risk in comparing N2 vs. N0 and N3 vs. N0 with multivariate investigation. Comparison of performances of the residual N classifications proved that the LODDS system was first in the prediction of prognosis during the evaluation of all patients and in cases with less than 16 harvested LNs. The MLR gave the best prognostic prediction when adequate(more than or equal to 16) lymphadenectomy was performed.Conclusions: We suggest the application of LODDS system routinely in western patients and the usage of MLR classification in cases with extended lymphadenectomy. | dezso tóth adrienn bíró zsolt varga miklós torok péterárkosy | 2017 | Chinese Journal of Cancer Research2017，29，4： | 4 |
| 5 | 一般人群中腹型肥胖和新发心房颤动的关系显示文摘已知身高越高,体质量越大,心房颤动发生风险越高。然而,心房颤动的风险是否与腹型肥胖有关尚不清楚。Baek等纳入韩国国民健康保险计划全国样本队列中基线无心房颤动的成人501 690人,年龄(47.6±14.3)岁,女性250 664人,占50%。测定其体质量指数(body mass index,BMI)和腰围,将BMI〈18.5kg/m2定义为低体质量,18.5~〈25.0kg/m2定义为正常体质量;25.0~〈30.0kg/m2定义为超重;≥30.0kg/m2定义为肥胖;将腰围≥90(男性)和≥80cm(女性)定义为腹型肥胖。 | 刘莉 叶鹏 Baek YS Yang PS Kim TH Uhm JS Park J Pak HN Lee MH Joung B | 2017 | 中华高血压杂志2017，25，9： | 4 |
| 6 | Structure of the Microbial Communities in Coniferous Forest Soils in Relation to Site Fertility and Stand Development Stage显示文摘 | T. Pennanen J. Liski E. B??th V. Kitunen J. Uotila C.J. Westman H. Fritze | 1999 | Microbial Ecology1999，，2： | 2 |
| 7 | Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia–reperfusion: Therapeutic potential of mitochondrially targeted antioxidants显示文摘 | Partha Mukhopadhyay B?la Horváth Zsuzsanna Zsengell?r Sándor Bátkai Zongxian Cao Malek Kechrid Eileen Holovac Katalin Erd?lyi Galin Tanchian Lucas Liaudet Isaac E. Stillman Joy Joseph Balaraman Kalyanaraman Pál Pacher | 2012 | Free Radical Biology and Medicine2012，，5： | 2 |
| 8 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 9 | The evolution of microstructure in a laser clad TiB-Ti composite coating 显示文摘 | KOOI B J PEI Y T DE HOSSON J Th M | 2003 | Acta Mater2003，51，2： | 2 |
| 10 | The use of phospholipid fatty acid analysis to estimate bacterial and fungal biomass in soil显示文摘 | A. Frosteg?rd E. B??th | 1996 | Biology and Fertility of Soils (-)1996，，1： | 2 |
| 11 | Ultraharmonic myocardial contrast imaging: in vivo experimental and clinical data from a novel technique显示文摘 | Kuersten B Murthy TH Li P | 2001 | J Am Soc Echocardiogr2001，14，9： | 2 |
| 12 | Peptide aggregation and pore formation in a lipid bilayer:a combined coarse-grained and all atom molecular dynamics study显示文摘 | Th(o)gersen L Schi(o)tt B Vosegaard T | | 0，，09： | 1 |
| 13 | Single injection of naked plasmid encoding alpha-melanocyte- stimulating hormone protects against thioacetamide-induced acute liver failure in mice 显示文摘 | WANG CH JAWAN B LEE TH | 2004 | Biochem Biophys Res Commun2004，322，1： | 1 |
| 14 | DC-SIGN (CD209) mediates Dengue virus infection of human dendritic cells显示文摘 | Tassaneetrithep B Burgess TH Granelli-Piperno A | 2003 | J Exp Med2003，197，： | 1 |
| 15 | Inhibitors of the PI3-kinase/Akt pathway induce mitotic catastrophe in non-small cell lung cancer cells 显示文摘 | Hemstrom TH Sandstrom M Zhivotovsky B | 2006 | Int J Cancer2006，119，5： | 1 |
| 16 | Farfield impact of water injection dredging in the Crouch River 显示文摘 | Winterwerp J C Wang Z B Kester J A Th M van | 2002 | Water & maritime engineering2002，，4： | 1 |
| 17 | Syphilitic uveitis in pa- tients infected with human immunodeficiency virus显示文摘 | Tran TH Cassoux N Bodaghi B | 2005 | Graefes Arch Clin Exp Ophthalmol2005，243，： | 1 |
| 18 | Management of acute osteoporotic vertebral fractures:a nonrandomized trial comparing percutaneous vertebroplasty with conservative therapy显示文摘 | Diamond TH Champion B Clark WA | | 0，，04： | 1 |
| 19 | The use of phospholipid fatty acid analysis to estimate bacterial and fungal biomass in soil显示文摘 | Frosteg(a)rd A E B(a)(a)th | 1996 | Biology and Fertility of Soils1996，22，1： | 1 |
| 20 | Antiepi- leptic drug intoxication factors and their significance 显示文摘 | Manon-Espaillat R Burnstine TH Remler B | 1991 | Epilepsia1991，32，： | 1 |
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