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| 1 | Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer显示文摘胃的癌症是世界范围的最普通的恶意之一;然而,在 tumorigenesis 的分子的机制仍然需要探索。BCL2L11 属于 BCL-2 家庭,并且充当内在的 apoptotic 串联的一个中央管理者并且调停房间 apoptosis。尽管 miRNAs 被报导了涉及癌症开发的每个阶段,在 GC 的 miR-24 的角色还没被报导。在现在的学习,当 BCL2L11 的表示在 GC 的肿瘤纸巾被禁止时, miR-24 被发现起来调整。研究从在 vitro 并且在显示出的 vivo,那 miR-24 调整 BCL2L11 表示由与 mRNA 的 3UTR 直接有约束力,因此支持房间生长,移植当禁止房间 apoptosis 时。因此, miR-24 是能是为未来的潜在的药目标的新奇 onco-miRNA 临床的使用。 | Haiyang Zhang Jingjing Duan Yanjun Qu Ting Deng Rui Liu Le Zhang Ming Bai Jialu Li Tao Ning Shaohua Ge Xia Wang ZhenzhenWang~ Qian Fan Hongli Li Guoguang Ying Dingzhi Huang Yi Ba | 2016 | Protein & Cell2016，7，2： | 11 |
| 2 | Correlation of the temporal and spatial expression patterns of HQT with the biosynthesis and accumulation of chlorogenic acid in Lonicera japonica flowers显示文摘Hydroxycinnamoyl-CoA quinate transferase(HQT)is one of the key enzymes in the biosynthesis of chlorogenic acid(CGA)in the flowers of Lonicera japonica.However,the spatiotemporal expression patterns of HQT and its relationship to the dynamics of CGA biosynthesis,transport,and storage remain largely unknown.In this study,we collected L.japonica flower samples at different growth stages(S1–S6)and examined the spatiotemporal expression pattern of HQT and the dynamic accumulation patterns of CGA using a combination of molecular and cytological techniques.Our results suggest that the spatiotemporal expression pattern of HQT is directly correlated with dynamic changes in CGA accumulation and distribution in L.japonica flowers.We further show that CGA is synthesized primarily in the cytoplasm and chloroplasts.CGA synthesized in the cytoplasm first accumulates in specialized vesicles and is then transferred to large central vacuoles for storage by fusion of CGA-containing vesicles with vacuoles.Furthermore,CGA synthesized in the chloroplasts appears to be transferred into the vacuoles for storage by direct membrane fusion between the tonoplast and the disrupted chloroplast membranes.Collectively,our results suggest that CGA is synthesized in chloroplasts and cytoplasm and finally transferred to the vacuole for long-term storage. | Yanqun Li Dexin Kong Mei Bai Hanjun He Haiyang Wang Hong Wu | 2019 | Horticulture Research2019，6，1： | 7 |
| 3 | Giant enhancement of magnetocaloric effect in metallic glass matrix composite显示文摘The magnetocaloric effect (MCE) has made great success in very low temperature refrigeration, which is highly desirable for application to the extended higher tem-perature range. Here we report the giant enhancement of MCE in the metallic glass composite. The large magnetic refrigerant capacity (RC) up to 103 J·kg-1 is more than double the RC of the well-known crystalline magnetic refrigerant compound Gd5Si2Ge1.9Fe0.1 (357 J·kg-1) and MnFeP0.45As0.55 (390 J·kg-1)(containing either ex-orbitant-cost Ge or poisonous As). The full width at half maximum of the magnetic entropy change (ΔSm) peak almost spreads over the whole low-temperature range (from 303 to 30 K), which is five times wider than that of the Gd5Si2Ge1.9Fe0.1 and pure Gd. The maximum ΔSm approaches a nearly constant value in a wide tem-perature span over 100 K, and however, such a broad table-like region near room temperature has seldom been found in alloys and compounds. In combination with the intrinsic amorphous nature, the metallic glass composite may be potential for the ideal Ericsson-cycle magnetic refrigeration over a broad temperature range near room temperature. | WANG YongTian BAI HaiYang PAN MingXiang ZHAO DeQian WANG WeiHua | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，4： | 5 |
| 4 | Toward an ideal electrical resistance strain gauge using a bare and single straight strand metallic glassy fiber显示文摘Electrical resistance strain gauges(SGs) are useful tools for experimental stress analysis and the strain sensing elements in many electromechanical transducers including load cells,pressure transducers,torque meters,accelerometers,force cells,displacement transducers and so forth.The commonly used commercial crystalline strain sensing materials of SGs are in the form of wire or foil of which performance and reliability is not good enough due to their low electrical resistivity and incapacity to get thin thickness.Smaller SGs with single straight strand strain sensing materials,which are called ideal SG,are highly desirable for more than seven decades since the first SG was invented.Here,we show the development of a type of minuscule length scale strain gauge by using a bare and single straight strand metallic glassy fiber(MGF) with high resistivity,much smaller lengthscale,high elastic limits(2.16%) and especially the super piezoresistance effect.We anticipate that our metallic glassy fiber strain gauge(MGFSG),which moves toward the ideal SGs,would have wide applications for electromechanical transducers and stress analysis and catalyze development of more micro-and nanoscale metallic glass applications. | YI Jun HUO LiShan ZHAO DeQian PAN MinXiang BAI HaiYang WANG WeiHua | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，4： | 4 |
| 5 | Room-temperature production of silver-nanofiber film for large-area, transparent and flexible surface electromagnetic interference shielding显示文摘A kind of pollution known as electromagnetic interference(EMI),which results from ubiquitous usage of various electronic communication and military radar equipment,has been receiving increasing attention recently.However,large-area EMI shielding on transparent and/or curved surfaces,including building windows,curved glass wall,and special requirements spaces(SRSs),remains hard to achieve.In this paper,a silver nanofiber(AgNF)based flexible and transparent EMI shielding film was successfully assembled via a room-temperature roll-to-roll production method.For transparent application scenario,AgNF with 89%transmittance in visible range and 1μm thickness shows~20 dB shielding efficiency(EMI SE).On the other hand,total shielding(>50 dB)is obtained when the thickness of AgNF increases to 10μm,while its transmittance in visible range remains higher than 75%.Considering the facile and scale-free production technology,this material can be readily applied in large-scale,transparent,and/or SRSs EMI shielding. | Sen Lin Haiyang Wang Fan Wu Qingmin Wang Xiaopeng Bai Di Zu Jianan Song Dong Wang Zhenglian Liu Ziwei Li Nian Tao Kai Huang Ming Lei Bo Li Hui Wu | 2019 | npj Flexible Electronics2019，3，1： | 4 |
| 6 | Co-application of energy uncoupling and ultrafiltration in sludge treatment:Evaluations of sludge reduction,supernatant recovery and membrane fouling control显示文摘Energy uncoupling is often used for sludge reduction because it is easy to operate and does not require a significant amount of extra equipments(i.e.no additional tank required).However,over time the supernatant extracted using this method can deteriorate,ultimately requiring further treatment.The purpose of this study was to determine the effect of using a low-pressure ultrafiltration membrane process for sludge water recovery after the sludge had undergone an energy uncoupling treatment(using 3,3’,4’,5-tetrachlorosalicylanilide(TCS)).Energy uncoupling was found to break apart sludge floe by reducing extracellular polymeric substances(EPS)and adenosine triphosphate(ATP)content.Analysis of supernatant indicated that when energy uncoupling and membrane filtration were coapplied and the TCS dosage was below 30 mg/L,there was no significant deterioration in organic component removal.However,ammonia and phosphate concentrations were found to increase as the concentration of TCS added increased.Additionally,due to low sludge concentrations and EPS contents,addition of 30-60 mg/L TCS during sludge reduction increased the permeate flux(two times higher than the control)and decreased the hydraulic reversible and cake layer resistances.In contrast,high dosage of TCS aggravated membrane fouling by forming compact fouling layers.In general,this study found that the co-application of energy uncoupling and membrane filtration processes represents an effective alternative method for simultaneous sludge reduction and sludge supernatant recovery. | An Ding Yingxue Zhao Zhongsen Yan Langming Bai Haiyang Yang Heng Liang Guibai Li Nanqi Ren | 2020 | Frontiers of Environmental Science & Engineering2020，14，4： | 3 |
| 7 | Highly energetic and flammable metallic glasses显示文摘Energetic materials are solids that release a large amount of energy in combustion. The evaluation depends on both combustion heat and ignition temperature. Conventional non-metallic materials have low ignition temperature but small combustion heat,whereas metals have large combustion heat but high ignition temperatures. We show that many metallic glasses, combining the merits of both metals and non-metals, have large combustion heat, approximately twice that of the non-metals, and low ignition temperature that is several hundreds of Kelvin lower than that of the metals. The ease in igniting metallic glass results from the low thermal conductivity of the materials and the storage of energy in their liquid-like atomic structure. Metallic glass ribbons outweigh metallic nanoparticles due to their high production efficiency, low cost and nontoxicity. The findings suggest that metallic glasses are alternative energetic materials. | BangSheng Yu YongHao Sun HaiYang Bai WeiHua Wang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，7： | 3 |
| 8 | Exosomal miR-155 from gastric cancer induces cancerassociated cachexia by suppressing adipogenesis and promoting brown adipose differentiation via C/EPBβ显示文摘Objective:The aim of this research was to identify whether exosomes were involved in impairing adipogenesis in cancer-associated cachexia(CAC)by detecting the adipodifferentiation capacity and the expressions of adipogenic proteins in gastric cancer(GC)-associated adipocytes.Methods:Western blotting and RT-PCR were used to investigate the expressions of C/EPBβ,C/EPBα,PPARγ,and UCP1 in adipose mesenchymal stem cells(A-MSCs)to evaluate the function of exosomal miR-155.BALB/c nude mice were intravenously injected in vivo with GC exosomes with different levels of miR-155 to determine changes in adipodifferentiation of A-MSCs.Results:Exosomes derived from GC cells suppressed adipogenesis in A-MSCs as characterized by decreased lipid droplets.Similarly,A-MSCs co-cultured with GC exosomes exhibited increased ATP production through brown adipose differentiation characterized by highly dense mitochondria and enhanced UCP1 expression(P<0.05).Mechanistically,exosomal miR-155 secreted from GC cells suppressed adipogenesis and promoted brown adipose differentiation by targeting C/EPBβ,accompanied by downregulated C/EPBαand PPARγand upregulated UCP1(P<0.05).Moreover,overexpression of miR-155 in GC exosomes improved CAC in vivo,which was characterized by fat loss,suppressed expressions of C/EPBβ,C/EPBα,and PPARγin A-MSCs,and high expression of UCP1(P<0.05).Decreasing the level of miR-155 in injected GC exosomes abrogated the improved CAC effects.Conclusions:GC exosomal miR-155 suppressed adipogenesis and enhanced brown adipose differentiation in A-MSCs by targeting C/EPBβof A-MSCs,which played a crucial role in CAC. | Ying Liu Meng Wang Ting Deng Rui Liu Tao Ning Ming Bai Guoguang Ying Haiyang Zhang Yi Ba | 2022 | Cancer Biology & Medicine2022，19，9： | 3 |
| 9 | 1.3 μm InAs/GaAs quantum dot lasers on silicon with GaInP upper cladding layers显示文摘We report on the first electrically pumped continuous-wave(CW) In As/Ga As quantum dot(QD) laser grown on Si with a GaInP upper cladding layer. A QD laser structure with a Ga_(0.51)In_(0.49)P upper cladding layer and an Al_(0.53)Ga_(0.47)As lower cladding layer was directly grown on Si by metal–organic chemical vapor deposition. It demonstrates the postgrowth annealing effect on the QDs was relieved enough with the GaInP upper cladding layer grown at a low temperature of 550°C. Broad-stripe edge-emitting lasers with 2-mm cavity length and 15-μm stripe width were fabricated and characterized. Under CW operation, room-temperature lasing at ~1.3 μm has been achieved with a threshold density of 737 A∕cm^2 and a single-facet output power of 21.8 mW. | JUN WANG HAIYANG HU HAWING YIN YIMING BAI JIAN LI XIN WEI YUANYUAN LIU YONGQING HUANG XIAOMIN REN HUIYUN LIU | 2018 | Photonics Research2018，6，4： | 2 |
| 10 | Taking advantage of glass:capturing and retaining the helium gas on the moon显示文摘Helium-3(3He)is a noble gas that has critical applications in scientific research and promising application potential as clean fusion energy.It is thought that the lunar regolith contains large amounts of helium,but it is challenging to extract because most helium atoms are reserved in defects of crystals or as solid solutions.Here,we find large amounts of helium bubbles in the glassy surface layer of ilmenite particles that were brought back by the Chang’E-5 mission.The special disordered atomic packing structure of glasses should be the critical factor for capturing the noble helium gas.The reserves in bubbles do not require heating to high temperatures to be extracted.Mechanical methods at ambient temperatures can easily break the bubbles.Our results provide insights into the mechanism of helium gathering on the moon and offer guidance on future in situ extraction. | Ao Li Xiao Chen Lijian Song Guoxin Chen Wei Xu Juntao Huo Meng Gao Ming Li Lei Zhang Bingnan Yao Min Ji Yan Zhang Shaofan Zhao Wei Yao Yanhui Liu Jun-Qiang Wang Haiyang Bai Zhigang Zou Mengfei Yang Weihua Wang | 2022 | Materials Futures2022，1，3： | 2 |
| 11 | Glassy metallic plastics显示文摘This paper reports a class of bulk metallic glass including Ce-, LaCe-, CaLi-, Yb-, and Sr-based metallic glasses, which are regarded as glassy metallic plastics because they combine some unique properties of both plastics and metallic alloys. These glassy metallic plastics have very low glass transition temperature (Tg^25oC to 150oC) and low Young’s modulus (~20 GPa to 35 GPa). Similar to glassy plastics, these metallic plastics show excellent plastic-like deformability on macro-, micro- and even nano-scale in their supercooled liquid range and can be processed, such as elongated, compressed, bent, and imprinted at low temperatures, in hot water for instance. Under ambient conditions, they display such metallic properties as high thermal and electric conductivities and excellent mechanical properties and other unique properties. The metallic plastics have potential applications and are also a model system for studying issues in glass physics. | LI JianFu, WANG JunQiang, LIU XiaoFeng, ZHAO Kun, ZHANG Bo, BAI HaiYang, PAN MingXiang & WANG WeiHua Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，3： | 2 |
| 12 | High Efficient Numerical Simulation of Infrared Radiation from a Hot Exhaust Nozzle显示文摘A coupled model,capable of simulating transonic flow,solid heat conduction,species transport,and gas radiation,is developed that provides better computational treatment of infrared radiation from hot exhaust nozzles.The modeling of gas radiation is based on a statistical narrow-band correlated-k analysis,whose parameters are deduced from the HITEMP line-by-line database.To improve computational efficiency,several methods are employed.A mixed analytical-numerical algorithm is described for the stiffness of the two-equation turbulence model and an alternating direction implicit pretreatment for the ill-conditioned matrix appearing in the coupled problem of flow and solid heat conduction.Moreover,an improved multigrid method and a symmetry plane treatment of the radiation transfer-energy equations are also introduced.Four numerical simulations are given to confirm the efficiency and accuracy of the numerical method.Finally,an account of the aerothermodynamics and infrared characteristics for two types of nozzles are presented.The infrared radiation intensity of the Chevron ejecting nozzle is clearly smaller than that of the common axisymmetric ejecting nozzle.All computations can be performed on a personal computer. | Haiyang Hu Peng Bai Qiang Wang | 2012 | Communications in Computational Physics2012，11，4： | 2 |
| 13 | Ag nanoparticles preparation and their light trapping performance显示文摘Ag nanoparticles were fabricated on Si substrates by radio-frequency magnetron sputtering and thermal annealing treatments.It was found that Ag nanoparticles are ellipsoid at low annealing temperature,but the axis ratio decreases with the increase of annealing temperature,and a shape transformation from ellipsoid to sphere occurs when the temperature increases to a critical point.The experimental results showed that the surface plasmon resonances depend greatly on the nanoparticles'shape and size,which is in accordance with the theoretical calculation based on discrete dipole approximation.The results of forward-scattering efficiency(FSE) and light trapping spectrum(LTS) showed that Ag nanoparticles annealed at 400°C could strongly enhance the light harvest than those annealed at 300 and 500°C,and that the LTS peak intensity of the former is 1.7 and 1.5 times stronger than those of the later two samples,respectively.The conclusions obtained in this paper showed that Ag ellipsoid nanoparticles with appropriate size is more favorable for enhancing the light trapping. | BAI YiMing WANG Jun YIN ZhiGang CHEN NuoFu ZHANG XingWang FU Zhen YAO JianXi LI Ning HE HaiYang GULI MiNa | 2013 | Science China(Technological Sciences)2013，56，1： | 2 |
| 14 | Friedel-crafts hydroxyalkylation of anisole over oxalic acid modifed Hfl ze olite 显示文摘 | BAI Guoyi DOU Haiyang QIU Mande | 2010 | Catalysis Letters2010，138，34： | 1 |
| 15 | Carbon-addition-induced bulk ZrTiCuNiBe amorphous matrix composite containing ZrC particles 显示文摘 | Wang Weihua Bai Haiyang | 2000 | Materials Letters2000，44，： | 1 |
| 16 | Formation of new Zr-Ti-Cu-Ni-Be-C bulk amorphous alloy显示文摘 | Weihua Wang Wenkui Wang Haiyang Bai | 1998 | Science in China Series A: Mathematics1998，，7： | 1 |
| 17 | Friedel-Crafts hydroxyalkylation of anisole over oxalic acid modified Hβ zeolite 显示文摘 | BAI Guoyi DOU Haiyang QIU Mande | 2010 | Catalysis Letters2010，138，34： | 1 |
| 18 | Formation of new Zr-Ti-Cu-Ni-Be-C bulk amorphous alloy显示文摘 | Weihua Wang Wenkui Wang Haiyang Bai | 1998 | Science in China Series A: Mathematics1998，，7： | 1 |
| 19 | Pressure effects on nechanical properties of bulk metallic glass 显示文摘 | Yu Pu Bai Haiyang Wang Weihua | 2007 | Applied Physics Letters2007，90，05： | 1 |
| 20 | Room-temperature processing of silver submicron fiber mesh for flexible electronics显示文摘Ultrathin,patterned,conducting metallic fibers have been extensively studied as building blocks in flexible electronics.However,their scalable processing and attainment of patterns at room temperature is challenging.In this paper,we report on the patterning of ultra-long silver submicron fibers as woven mesh through the process of continuous draw spinning in the presence of ultraviolet(UV)treatment.The silver fibers can be directly intertwined on flexible substrates,such as polyethylene terephthalate(PET)and polyimide(PI).The as obtained silver submicron fiber mesh present excellent photoelectric properties(T=90%,R=9Ωsq^(−1))and outstanding flexibility and can be easily transferred on other surfaces.To demonstrate its application,flexible electrochromic smart window and infrared stealth film have been prepared. | Xiaopeng Bai Sen Lin Haolun Wang Yi Zong Haiyang Wang Ziyun Huang Donglai Li Chang Wang Hui Wu | 2018 | npj Flexible Electronics2018，2，1： | 1 |
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