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| 1 | Analysis of DC Grid Prospects in China显示文摘随着化石能源的日益枯竭,中国已将发展可再生能源提升至重要地位,并逐步实现能源结构的战略性调整。分析可再生能源发电的间歇性与不稳定性特点,以及可再生能源发电集中并网带来的稳定性问题,提出通过建设广域覆盖的直流电网以有效解决可再生能源集中并网的有功波动问题。建设全国性的直流骨干输电网,不仅可更有效地利用可再生能源,也将积极推动坚强智能电网的建设。与交流系统相比,直流电网在未来城市配电、微网等领域也有较大的优势。根据中国国情,对直流电网在中国建设的可行性进行了具体分析,并提出中国直流电网主干结构设想图,指出了直流电网建设的一些关键技术问题,为中国直流电网建设提供参考。 | WEN Jialiang WU Rui Peng Chang Wang Yu | 2012 | 中国电机工程学报2012，32，13： | 172 |
| 2 | YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA显示文摘 | Hailing Shi Xiao Wang Zhike Lu Boxuan S Zhao Honghui Ma Phillip J HSU Chang Liu Chuan He | 2017 | Cell Research2017，27，3： | 156 |
| 3 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 4 | The Chinese Society of Clinical Oncology(CSCO):Clinical guidelines for the diagnosis and treatment of gastric cancer,2021显示文摘There exist differences in the epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selections between gastric cancer patients from the Eastern and Western countries.The Chinese Society of Clinical Oncology(CSCO)has organized a panel of senior experts specializing in all sub-specialties of gastric cancer to compile a clinical guideline for the diagnosis and treatment of gastric cancer since 2016 and renews it annually.Taking into account regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted expert consensus judgment on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes in China.The 2021 CSCO Clinical Practice Guidelines for Gastric Cancer covers the diagnosis,treatment,follow-up,and screening of gastric cancer.Based on the 2020 version of the CSCO Chinese Gastric Cancer guidelines,this updated guideline integrates the results ofmajor clinical studies from China and overseas for the past year,focused on the inclusion of research data from the Chinese population for more personalized and clinically relevant recommendations.For the comprehensive treatment of non-metastatic gastric cancer,attentions were paid to neoadjuvant treatment.The value of perioperative chemotherapy is gradually becoming clearer and its recommendation level has been updated.For the comprehensive treatment of metastatic gastric cancer,recommendations for immunotherapy were included,and immune checkpoint inhibitors fromthird-line to the first-line of treatment for different patient groups with detailed notes are provided. | Feng-Hua Wang Xiao-Tian Zhang Yuan-Fang Li Lei Tang Xiu-Juan Qu Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Hong Qiu Chang Wang Miao-Zhen Qiu Mu-Yan Cai QiWu Hao Liu Wen-Long Guan Ai-Ping Zhou Yu-Jing Zhang Tian-Shu Liu Feng Bi Xiang-Lin Yuan Sheng-Xiang Rao Yan Xin Wei-Qi Sheng Hui-Mian Xu Guo-Xin Li Jia-Fu Ji Zhi-Wei Zhou Han Liang Yan-Qiao Zhang Jing Jin Lin Shen Jin Li Rui-Hua Xu | 2021 | Cancer Communications2021，41，8： | 97 |
| 5 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 6 | Characterization of Hand,Foot,and Mouth Disease in China between 2008 and 2009显示文摘Objective To investigate the epidemiological and clinical features of hand,foot and mouth disease (HFMD) since several outbreaks of HFMD caused by enteroviruses were documented in China between 2007 and 2008.Methods HFMD cases reported to the National Infectious Disease Information Management System database between May 2008 and April 2009 were assessed.Clinical features in some of the severe and fatal cases were analyzed the etiology of the outbreaks was investigated.Results 89.1% of reported HFMD cases were found in children<5 year‐old with an age‐specific incidence rate of 834.1/100 000 in the first year as the notifiable disease in China from May 2008 to April 2009.The incidence,mortality and percentage of severe cases were studied for three regions of China and found to be highest in the central region.The incidence of severe cases and mortality in rural population were significantly higher than those in urban population.Among the laboratory confirmed EV17 positive cases there were 52.6% mild,83.5% severe,and 96.1% fatal cases.More myoclonic jerks were found in the severe case group than in group that died.Tachypnea,lip purpling,pink foaming and low limb temperature occurred more frequently in the fatal cases than in the severe cases.Conclusion The epidemic of HFMD in China was characterized predominantly by EV71 infections,had relatively high mortality rates especially in the central region,and was most prevalent in young,rural populations. | ZHANG Jing SUN JunLing CHANG ZhaoRui ZHANG WeiDong WANG ZiJun FENG ZiJian | 2011 | Biomedical and Environmental Sciences2011，24，3： | 74 |
| 7 | Mesozoic subduction-accretion zone in northeastern South China Sea inferred from geophysical interpretations显示文摘A segment of Mesozoic subduction-accretion zone was inferred across the northeastern South China Sea at approximately NE45° orientation. Basic evidence includes the following: A belt of peek gross horizontal Bouguer gravity gradient (PGHGBA) is comparable in size and intensity to that of the Manila subduction-accretion zone. A belt of high positive magnetic anomalies appears to the north and sub-parallel to the PGHGBA, representing the volcanic arc associated to the subduction zone. The PGHGBA crosses obliquely both Cenozoic structures and present seafloor topography, indicating a pre-Cenozoic age. The segment is offset left-laterally by NW-running strike-slip faults, in concord with the Mesozoic stress field of South China. In addition, the existence of the subduction zone is supported by wide-angle seismic data obtained in different years by different institutions. At approximate localities, a north-dipping ramp of Moho surface is indicated by records of ocean-bottom seismometers, and a strong reflector about 8 km beneath the Moho reflector is indicated by both OBS and long-cable seismic records. The identification of a segment of Mesozoic subduction zone in NE South China Sea fills nicely the gap of the Great Late Mesozoic Circum SE Asia Subduction-acrretion Zone, which extended from Sumatra, Java, SE Kalimantan to N Palawan, and from Taiwan, Ryukyu to SW Japan. | ZHOU Di1, WANG Wanyin2, WANG Jialin3, PANG Xiong4, CAI Dongsheng5 & SUN Zhen1 1. Key Laboratory of Marginal Sea Geology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guang- zhou 510301, China 2. College of Geological and Topographical Engineering, Chang’an University, Xi’an 710054, China 3. Key Laboratory of Marine Geology, Tongji University, Shanghai 200092, China 4. China National Offshore Oil Co. Limited – Shenzhen Branch, Shenzhen 518067, China 5. China National Offshore Oil Co. Limited – Research Center, Beijing 100027, China | 2006 | Science China Earth Sciences2006，49，5： | 52 |
| 8 | Solid-pseudopapillary tumor of the pancreas: Clinical experience and literature review显示文摘AIM: To evaluate the clinical presentations of solidpseudopapillary tumor of the pancreas (SPT) and examine the diagnosis, treatment, low grade malignant potential of this rare disease.METHODS: We retrospectively reviewed a series of seven patients with SPT managed in our hospital between July 1990 and October 2003. Six females and one male with mean age of 31 years (range 13 to 50 years) were diagnosed with SPT at our institution.RESULTS: Clinical presentation included a palpable abdominal mass in two patients and vague abdominal discomfort in another two. Two patients were asymptomatic;their tumors were found incidentally on abdominal sonographic examination for other reasons. The final patient was admitted with hemoperitoneum secondary to tumor rupture. The mean diameter of the tumors in the seven patients was 10.5 cm (range 5 to 20 cm). The lesions were located in the body and tail in five cases and in the head of the pancreas in two. Surgical procedures included distal pancreatectomy (3), distal pancreatectomy with splenectomy (2), pancreaticoduodenectomy (1) and a pylorus-preserving Whipple procedure (1). There were gross adhesions or histological evidence of infiltration to the adjacent pancreas and/or splenic capsule in four cases. None of the patients received adjuvant therapy.The mean follow up was 7 years (range 0.5 to 14 years).One patient developed multiple liver metastases after 14 years of follow up.CONCLUSION: SPT is a rare tumor that behaves less aggressively than other pancreatic tumor. However, in cases with local invasion, long-term follow up is advisable. | Hsueh-Lien Huang Shou-Chuan Shih Wen-Hsiung Chang Tsang-En Wang Ming-Jen Chen Yu-Jan Chan | 2005 | World Journal of Gastroenterology2005，11，9： | 57 |
| 9 | Evaluation of the effect of partial splenic embolization on platelet values for liver cirrhosis patients with thrombocytopenia显示文摘AIM: To investigate the effect of partial splenic embolization (PSE) on platelet values in liver cirrhosis patients with thrombocytopenia and to determine the effective embolization area for platelet values improvement. METHODS: Blood parameters and liver function indicators were measured on 10 liver cirrhosis patients (6 in Child-Pugh grade A and 4 in grade B) with thrombocytopenia (platelet values < 80 × 103/μL) before embolization. Computed tomography scan was also needed in advance to acquire the splenic baseline. After 2 to 3 d, angiography and splenic embolization were performed. A second computed tomography scan was made to confirm the embolization area after 2 to 3 wk of embolization. The blood parameters of patients were also examined biweekly during the 1 year follow-up period. RESULTS: According to the computed tomography images after partial splenic embolization, we divided all patients into two groups: low (< 30%), and high (≥ 30%) embolization area groups. The platelet values were increased by 3 times compared to baseline levels after 2 wk of embolization in high embolization area group. In addition, there were significant differences in platelet values between low and high embolization area groups. GPT values decreased significantly in all patients after 2 wk of embolization. The improvement in platelet and GPT values still persisted until 1 year after PSE. In addition, 3 of 4 (75%) Child-Pugh grade B patients progressed to grade A after 2 mo of PSE. The complicationrate in < 30% and ≥ 30% embolization area groups was 50% and 100%, respectively. CONCLUSION: Partial splenic embolization is an effective method to improve platelet values and GPT values in liver cirrhosis patients with thrombocytopenia and the ≥ 30% embolization area is meaningful for platelet values improvement. The relationship between the complication rate and embolization area needs further studies. | Chi-Ming Lee Ting-Kai Leung Hung-Jung Wang Wei-Hsing Lee Li-Kuo Shen Jean-Dean Liu Chun-Chao Chang Ya-Yen Chen | 2007 | World Journal of Gastroenterology2007，13，4： | 56 |
| 10 | Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock显示文摘Inflammasomes 是触发 caspase-1 的激活和 interleukin-1β 的成熟的多蛋白质建筑群;(IL-1β) ,然而,这些建筑群的规定仍然保持糟糕描绘了。这里,我们显示出那氮的氧化物(没有) 禁止了调停 NLRP3 的 ASC pyroptosome 形成, caspase-1 激活和 IL-1β在从老鼠和人的 myeloid 房间的分泌物。同时,内长不否定地也源于 iNOS (没有 synthase 的可诱导的形式) 调整 NLRP3 inflammasome 激活。iNOS 的弄空响应 LPS 和 ATP 导致了不正常的线粒体的增加的累积,它为增加的 IL-1β 负责;生产和 caspase-1 激活。没有生产的 iNOS 缺乏或药理学抑制在 vivo 提高了 NLRP3 依赖的 cytokine 生产,因此在老鼠从导致 LPS 的败血增加死亡,它被 NLRP3 阻止缺乏。我们的结果因此经由线粒体的稳定作为 NLRP3 inflammasome 的一个批评否定管理者不识别。这研究有重要含意让新策略的设计控制 NLRP3 相关的疾病。 | Kairui Mao Shuzhen Chen Mingkuan Chen Yonglei Ma Yan Wang Bo Huang Zhengyu He Yan Zeng Yu Htl Shuhui Sun Jing Li Xiaodong Wu Xiangrui Wang Warren Strober Chang Chen Guangxun Meng Bing Sun | 2013 | Cell Research2013，23，2： | 59 |
| 11 | Mobius Isoparametric Hypersurfaces in S^(n+1) with Two Distinct Principal Curvatures | Hai Zhong LI Department of Mathematics, Tsinghua University. Beijing 100084. P. R. China Hui Li LIU Department of Mathematics, Northeastern University. Shenyang 110000. P. R. China Chang Ping WANG Key Laboratory of Pure and Applied Mathematics, School of Mathematical Sciences. Peking University, Beijing 100871, P. R. China Guo Song ZHAO Department of Mathematics, Sichuan University, Chengdu 610064. P. R. China | 2002 | Acta Mathematica Sinica,English Series2002，18，3： | 53 |
| 12 | Ultrahigh pressure (>7 GPa) gneissic K-feldspar (-bearing) garnet clinopyroxenite in the Altyn Tagh, NW China: Evi- dence from clinopyroxene exsolution in garnet显示文摘The exsolution of clinopyroxene and rutile in coarse-grain garnet is found in the gneissic K-feldspar(-bearing) garnet clinopyroxenite from Yinggelisayi in the Altyn Tagh, NW China. The maximum content of the exsolved clinopyroxene in the garnet is up to >5% by volume. The reconstructed precursor garnet (Grt1) before exsolution has a maximum Si content of 3.061 per formula uint, being of supersilicic or majoritic garnet. The peak-stage metamorphic pressure of >7 GPa is estimated using the geobarometer for volume percentage of exsolved pyroxene in garnet and the Si-(Al+Cr) geobarometer for majoritic garnet, and the temperature of about 1000℃ using the ternary alkali-feldspar geothermometer and the experimental data of ilmen- ite-magnetite solid solution. The protoliths of the rocks are intra-plate basic and intermediate ig- neous rocks, of which the geochemical features indicate that they are probably the products of the evolution of basic magma deriving from the continental lithosphere mantle. The rocks are in outcrops associated with ultrahigh pressure garnet-bearing lherzolite and ultrahigh pressure garnet granitoid gneiss. All of these data suggest that the ultrahigh pressure metamorphic rocks in the Altyn Tagh are the products of deep-subduction of the continental crust, and such deep- subduction probably reaches to >200 km in depth. This may provide new evidence for further discussion of the dynamic mechanism of the formation and evolvement of the Altyn Tagh and the other collision orogenic belts in western China. | LIU Liang1,3, CHEN Danling1, ZHANG Anda1, SUN Yong1, WANG Yan1, YANG Jiaxi1,2 & LUO Jinhai1 1. Key Laboratory of Continental Dynamics of the Ministry of Education of China, Northwest University, Xi’an 710069, China 2. College of Earth Science and Land Resources, Chang’an University, Xi’an 710054, China 3. The Laboratory of Orogen and Basin of the Ministry of Education, Peking University, Beijing 100871, China | 2005 | Science China Earth Sciences2005，48，7： | 38 |
| 13 | Relationship between phenotypes of cell-function differentiation and pathobiological behavior of gastric carcinomas显示文摘AIM To reveal the correlation between thefunctional differentiation phenotypes of gastriccarcinoma cells and the invasion and metastasisby a new way of cell-function classification.METHODS Surgically resected specimens of361 gastric carcinomas (GC) were investigatedwith enzyme-, mucin-, and tumor-related markerimmunohistochemist ry. According to thedirection of cell-function differentiation,stomach carcinomas were divided into fivefunctionally differentiated types.iation type (AFDT): there were 82 (22.7%)patients including 76 (92.7%) aged 45 years.Sixty-nine (84.1%) cases belonged to theintestinal type. Thirty-eight (46.3%) expressedCD44v6 and 9 (13.6%) of 66 male patientsdeveloped liver metastasis. The 5-year survivalrate of patients in this group (58.5%) was higherMucin secreting function differentiation type(MSFDT): 54 (15%) cases. Fifty-three (98.1%)tumors had penetrated the serosa, 12 (22.2%)expressed ER and 22 (40.7%) expressedCD44v6. The postoperative 5-year survival ratefunction differentiation type (AMPFDT): therewere 180 (49.9%) cases, including 31 (17.2%)aged yanger than 45 years. The tumor was morecommon in women (62, 34.4%,) and expressedmore frequently estrogen receptors (ER) ( 129,81.7%) than other types (P<0.01). Ovarymetastasis was found in 12 (19.4%) out of 62female subjects. The patients with this type GChad the lowest 5-year survival rate (24.7%)differentiation type (SFDT): 13 (3.6%) cases.Nine (69.2%) tumors of this type derived fromAPUD system, the other 4 (30.7%) were ofdifferent histological differentiation. Sixty percent of the patients survived at least five years.(8.9%) cases. Nineteen (59.4%) cases hadlymph node metastases but no one with liver orovary metastasis. The 5-year survival rate was28.1%.CONCLUSION This new cell-functionclassification of GC is helpful in indicating thecharacteristics of invasion and metastasis of GCwith different cell-function differentiationphenotypes. Further study is needed to disclosethe correlation between the cell-functionaldifferentiation phenotypes and the relevantgenotypes and the biological behavior of gastriccarcinoma. | Yan Xin Xiao Ling Li Yan Ping Wang Su Min Zhang Hua Chuan Zheng Dong Ying Wu Yin Chang Zhang The Fourth Laboratory of Cancer Institute, China Medical University, Shenyang 110001, Liaoning Province, China | 2001 | World Journal of Gastroenterology2001，7，1： | 38 |
| 14 | Altitude dependency of trends of daily climate extremes in southwestern China, 1961-2008显示文摘A total of 12 indices of temperature extremes and 11 indices of precipitation ex-tremes at 111 stations in southwestern China at altitudes of 285-4700 m were examined for the period 1961-2008. Significant correlations of temperature extremes and elevation in-cluded the trends of diurnal temperature range, frost days, ice days, cold night frequency and cold day frequency. Regional trends of growing season length, warm night frequency, coldest night and warmest night displayed a statistically significant positive correlation with altitude. These characteristics indicated the obvious warming with altitude. For precipitation extreme indices, only the trends of consecutive dry days, consecutive wet days, wet day precipitation and the number of heavy precipitation days had significant correlations with increasing alti-tude owing to the complex influence of atmospheric circulation. It also indicated the increased precipitation mainly at higher altitude areas, whereas the increase of extreme precipitation events mainly at lowers altitude. In addition, the clearly local influences are also crucial on climate extremes. The analysis revealed an enhanced sensitivity of climate extremes to ele-vation in southwestern China in the context of recent warming. | Li Zongxing He Yuanqing Theakstone, Wilfred H. Wang Xufeng Zhang Wei Cao Weihong Du Jiankuo Xin Huijuan Chang Li | 2012 | Journal of Geographical Sciences2012，22，3： | 36 |
| 15 | Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis显示文摘Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord injury repair. It has yet to be clarified whether ferroptosis inhibition represents the mechanism of action of Deferoxamine on spinal cord injury recovery. A rat model of Deferoxamine at thoracic 10 segment was established using a modified Allen's method. Ninety 8-week-old female Wistar rats were used. Rats in the Deferoxamine group were intraperitoneally injected with 100 mg/kg Deferoxamine 30 minutes before injury. Simultaneously, the Sham and Deferoxamine groups served as controls. Drug administration was conducted for 7 consecutive days. The results were as follows:(1) Electron microscopy revealed shrunken mitochondria in the spinal cord injury group.(2) The Basso, Beattie and Bresnahan locomotor rating score showed that recovery of the hindlimb was remarkably better in the Deferoxamine group than in the spinal cord injury group.(3) The iron concentration was lower in the Deferoxamine group than in the spinal cord injury group after injury.(4) Western blot assay revealed that, compared with the spinal cord injury group, GPX4, xCT, and glutathione expression was markedly increased in the Deferoxamine group.(5) Real-time polymerase chain reaction revealed that, compared with the Deferoxamine group, mRNA levels of ferroptosis-related genes Acyl-CoA synthetase family member 2(ACSF2) and iron-responsive element-binding protein 2(IREB2) were up-regulated in the Deferoxamine group.(6) Deferoxamine increased survival of neurons and inhibited gliosis. These findings confirm that Deferoxamine can repair spinal cord injury by inhibiting ferroptosis. Targeting ferroptosis is therefore a promising therapeutic approach for spinal cord injury. | Xue Yao Yan Zhang Jian Hao Hui-Quan Duan Chen-Xi Zhao Chao Sun Bo Li Bao-You Fan Xu Wang Wen-Xiang Li Xuan-Hao Fu Yong Hu Chang Liu Xiao-Hong Kong Shi-Qing Feng | 2019 | Neural Regeneration Research2019，14，3： | 35 |
| 16 | Normoalbuminuric diabetic kidney disease显示文摘 | Chao Chen Chang Wang Chun Hu Yachun Han Li Zhao Xuejing Zhu Li Xiao Lin Sun | 2017 | Frontiers of Medicine2017，11，3： | 38 |
| 17 | The Serum Exosome Derived MicroRNA-135a,-193b, and-384 Were Potential Alzheimer's Disease Biomarkers显示文摘Objective MicroR NAs(mi Rs) are attractive molecules to be considered as one of the blood-based biomarkers for neurodegenerative disorders such as Alzheimer's disease(AD). The goal of this study was to explore their potential value as biomarkers for the diagnosis of AD. Methods The expression levels of exosomal miR-135 a,-193 b, and-384 in the serum from mild cognitive impairment(MCI), dementia of Alzheimer-type(DAT), Parkinson's disease with dementia(PDD), and vascular dementia(VaD) patients were measured with a real-time quantitative reverse transcriptase PCR(qR T-PCR) method. Results Both serum exosome mi R-135 a and miR-384 were up-regulated while miR-193 b was down-regulated in serum of AD patients compared with that of normal controls. Exosome miR-384 was the best among the three miR s to discriminate AD, VaD, and PDD. Using the cut-off value could better interpret these laboratory test results than reference intervals in the AD diagnosis. ROC curve showed that the combination of mi R-135 a,-193 b, and-384 was proved to be better than a particular one for early AD diagnosis. Conclusion Our results indicated that the exosomal miR s in the serum were not only potential biomarker of AD early diagnosis, but might also provide novel insights into the screen and prevention of the disease. | YANG Ting Ting LIU Chen Geng GAO Shi Chao ZHANG Yi WANG Pei Chang | 2018 | Biomedical and Environmental Sciences2018，31，2： | 35 |
| 18 | The Inhibitory Effect of Oridonin on the Growth of Fifteen Human Cancer Cell Lines显示文摘OBJECTIVE To study the inhibitory effect of oridonin on the growth of cancer cells. METHODS Fifteen human cancer cell lines were subjected to various concentrations of oridonin in culture medium. The inhibitory rate of cell growth was measured by the MTT assay, and compared with a negative con- trol and 5-Fu-positive control. RESULTS The 50% inhibiting concentration (IC50) and maximal inhibition (Imax) of oridonin shown by studying the growth of the cancer cell lines were as follows: leukemias (HL60 cells: 3.9 μg/ml and 73.8%, K562 cells: 4.3 μg/ml and 76.2%); esophageal cancers(SHEEC cells: 15.4 μg/ml and 99.2%, Eca109 cells: 15.1 μg/ml and 84.6%, TE1 cells: 4.0 μg/ml and 70.2%); gastric cancers (BGC823 cells: 7.6 μg/ml and 98.7%, SGC7901 cells: 12.3 μg/ml and 85.7%); colon cancers (HT29 cells: 13.6 μg/ml and 97.2%, HCT cells: 14.5 μg/ml and 96.5%); liver cancers (Bel7402 cells: 15.2 μg/ml and 89.2%, HepG2 cells: 7.1 μg/ml and 88.3%); pancreatic cancer (PC3 cells: 11.3 μg/ml and 68.4%); lung cancer (A549 cells: 18.6 μg/ml and 98.0% ); breast cancer (MCF7 cells: 18.4 μg/ml and 84.7%); uterine cervix cancer (Hela cells: 13.7 μg/ml and 98.5%). CONCLUSION Oridonin had a relatively wide anti-tumor spectrum, and a relatively strong inhibitory effect on the growth of the 15 human cancer cells. Inhibitory effects were concentration dependent. | Junhui Chen Shaobin Wang Dongyang Chen Guisheng Chang Qingfeng Xin Shoujun Yuan Zhongying Shen | 2007 | Chinese Journal of Clinical Oncology2007，4，1： | 32 |
| 19 | Magnetism parameters characteristics of drilling deposits in Jianghan Plain and indication for forming of the Yangtze River Three Gorges显示文摘The forming time of the Yangtze River Three Gorges is considered as one of keys in the research on the Yangtze River,also is one of the most disputed hotspots.In order to solve the difficult problem,the authors adopt the internationally recognized thoughts and methods of substance tracing from source to sink.The lithologic characteristics,magnetic parameters and magnetic mineral characteristics of deposits in 2 bores are analyzed,which are both sampled from the sedimentary center of the Jianghan Plain.The results are as follows:At about 110 m depth of the core,the contents of coarse materials and stable magnetic mineral both increase significantly.Meanwhile,the magnetic susceptibility of sediment,saturation isothermal remanent magnetization and magnetic susceptibility values of anhysteretic remanent magnetism increase suddenly,which all reflect that at about 110 m depth,the important adjustment has appeared in water system of the Jianghan Plain,and the sedimentary environment and material composition have changed greatly.And it may be the horizon where the Yangtze River Three Gorges formed,its forming time reflected by the paleomagnetic dating is between 1.17 and 1.12Ma B.P. | ZHANG YuFen LI Chang'An WANG QiuLiang CHEN Liang Ma YongFa KANG ChunGuo | 2008 | Chinese Science Bulletin2008，53，4： | 34 |
| 20 | Comparison of bupivacaine, ropivacaine and levobupivacaine with sufentanil for patient-controlled epidural analgesia during labor: a randomized clinical trial显示文摘背景 Ropivacaine 和 levobupivacaine 与与 bupivacaine 相比引起更少的马达块和毒性的建议优点被介绍了进产科的止痛实践。然而,麻药是否两个都为劳动痛觉缺失相对 bupivacaine 与任何临床的利益被联系,仍然是争论的。这研究试图为控制病人的硬膜上的劳动痛觉缺失在更低的集中比较止痛功效,马达块和 bupivacaine, ropivacaine 和 levobupivacaine 的副作用。450 从未生育过者的 parturients 在这使随机化的临床的试用被注册的方法。0.05% 任何一个 bupivacaine, 0.075% , 0.1% , 0.125% 或 0.15%( 组 B ) 的集中, ropivacaine (组 R ) 或有 sufentanil 的 levobupivacaine (组 L ) 0.5 g/ml 被控制病人的痛觉缺失硬膜上地管理模式。因为一个视觉类似物规模分数是 30 公里,有效痛觉缺失被定义。为每局部麻醉的相对中部的力量用一个概率单位回归模型被计算。Parturients 人口分布,感觉并且马达封锁,产科的数据,母亲的副作用,时时,使用的局部麻醉的体积,和其它也被注意。在那里的结果不是在在有效痛觉缺失的数字的组之中的重要差别,疼痛分数,时时,局部麻醉数量使用了,感觉并且马达封锁,劳动持续时间和交货,副作用和母亲的满足的模式(P > 0.05 ) 。相对中部的力量是 bupivacaine/ropivacaine:0.828 (0.602-1.091 ) , bupivacaine/levobupivacaine:0.845 (0.617-1.12 ) , ropivacaine/levobupivacaine:1.021 (0.774-1.354 ) 分别地。然而,一少些显著地时时有效痛觉缺失并且更高数局部麻醉使用在每个组以内 0.1% 比那些在 0.05% 的集中被观察(P < 0.05 ) 。用有 sufentanil 的控制病人的硬膜上的痛觉缺失, bupivacaine 的更低的集中, ropivacaine 和 levobupivacaine 的结论为劳动痛觉缺失生产类似的痛觉缺失和马达块和安全。止痛功效主要取决于集中而非麻药的类型。 | WANG Li-zhong CHANG Xiang-yang LIU Xia HU Xiao-xia TANG Bei-lei | 2010 | Chinese Medical Journal2010，，2： | 31 |
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