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| 1 | Autophagy and cancer treatment: four functional forms of autophagy and their therapeutic applications显示文摘Cancer is the leading cause of death worldwide. Drugs play a pivotal role in cancer treatment, but the complex biological processes of cancer cells seriously limit the efficacy of various anticancer drugs. Autophagy, a self-degradative system that maintains cellular homeostasis, universally operates under normal and stress conditions in cancer cells. The roles of autophagy in cancer treatment are still controversial because both stimulation and inhibition of autophagy have been reported to enhance the effects of anticancer drugs. Thus, the important question arises as to whether we should try to strengthen or suppress autophagy during cancer therapy. Currently, autophagy can be divided into four main forms according to its different functions during cancer treatment: cytoprotective(cell survival), cytotoxic(cell death), cytostatic(growth arrest), and nonprotective(no contribution to cell death or survival). In addition, various cell death modes, such as apoptosis, necrosis, ferroptosis, senescence, and mitotic catastrophe, all contribute to the anticancer effects of drugs. The interaction between autophagy and these cell death modes is complex and can lead to anticancer drugs having different or even completely opposite effects on treatment. Therefore, it is important to understand the underlying contexts in which autophagy inhibition or activation will be beneficial or detrimental.That is, appropriate therapeutic strategies should be adopted in light of the different functions of autophagy. This review provides an overview of recent insights into the evolving relationship between autophagy and cancer treatment. | Zhaoshi BAI Yaling PENG Xinyue YE Zhixian LIU Yupeng LI Lingman MA | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，2： | 5 |
| 2 | Sensitivity analysis of the numerical study on the thermal performance of a packed-bed molten salt thermocline thermal storage system 显示文摘 | Xu Chao Wang Zhifeng He Yaling Li Xin Bai Fengwu | 2012 | Applied Energy2012，92，： | 1 |
| 3 | Effects of solid particle properties on the thermal performance of a packed-bed molten-salt thermocline thermal storage system 显示文摘 | Xu Chao Li Xin Wang Zhifeng He Yaling Bai Fengwu | 2013 | Applied ThermalEngineering2013，57，12： | 1 |
| 4 | Continuous veno-venous hemodiafiltration,impedance cardiography and critical care nephrology:a case study of chronic myeloid leukemia-associated acute renal failure显示文摘 | Iao Wang Jinsheng Xu Yaling Bai | 2011 | Crit Care Shock2011，14，： | 1 |
| 5 | Single nucleotide polymorphisms in the D-loop region of mitochondrial DNA and age-at-onset of patients with chronic kidney disease显示文摘 | Bai Yaling Guo Zhanjun Xu Jinsheng Zhang Junxia Cui Liwen Zhang Huiran Zhang Shenglei Ai Xiaolu | 2014 | Chinese Medical Journal2014，，17： | 1 |
| 6 | Acetic acid induced programmed cell death and volatile organic compounds release in Chlamydomonas reinhardtii at acidic conditions 显示文摘 | ZUO Zhaojiang ZHU Yerong BAI Yaling | 2012 | Plant Physiol Biochem2012，51，： | 1 |
| 7 | STING and TLR9 agonists synergistically enhance the immunogenicity of SARS-CoV-2 subunit vaccine显示文摘Vaccines that are reliable and efficacious are essential in the fight against the COVID-19 pandemic.In this study,we designed a dual-adjuvant system with two pathogen-associated molecular patterns(PAMPs),MnOx and CpG.This system can improve the retention of antigens at the injection site,facilitate pro-inflammatory cytokines secretion,further recruit and activate dendritic cells(DCs).As a result,antigens can be delivered to lymph nodes specifically,and adaptive immunity was strengthened.The immunized group showed an enhanced and broadened humoral and cellular immune response in systemic immunity and lung protection when combined with a tandem repeat-linked dimeric antigen version of the SARS-CoV-2 receptor binding domain(RBDdimer).Remarkably,even with a significant reduction in antigen dosage(three times lower)and a decrease in injection frequencies,our nanovaccine was able to produce the highest neutralizing antibody titers against various mutants.These titers were four-fold higher for the wild-type strain and two-fold higher for both the Beta and Omicron variants in comparison with those elicited by the Alum adjuvant group.In conclusion,our dual-adjuvant formulation presents a promising protein subunit-based candidate vaccine against SARS-CoV-2. | Yang Li Ziwei Chen Xinyi Lu Jiufeng Sun Mengyu Guo Huige Zhou Ru Bai Yuliang Zhao Chunying Chen Yaling Wang | 2023 | Nano Research2023，16，12： | 0 |
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