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| 1 | Characterization of monocarboxylate transporter activity in hepatocellular carcinoma显示文摘AIM: To assess the immunoexpression of hypoxiarelated markers in samples from cirrhosis and primary and metastatic hepatocellular carcinoma(HCC).METHODS: From a total of 5836 autopsies performed at the Pathology Department- University of Sao Paulo School of Medicine Hospital- from 2003 to 2009, 188 presented primary liver tumors. Immunohistochemical reactivity for monocarboxylate transporters(MCTs)-1, 2 and 4, CD147 and glucose transporter-1(GLUT1)was assessed in necropsies from 80 cases of HCC. Data were stored and analyzed using the IBM SPSS statistical software(version 19, IBM Company, Armonk, NY). All comparisons were examined for statistical significance using Pearson's χ2 test and Fisher's exact test(when n < 5). The threshold for significant P values was established as P < 0.05.RESULTS: Plasma membrane expression of MCT4 and overall expression of GLUT1 showed progressively higher expression from non-neoplastic to primary HCC and to metastases. In contrast, overall expression of MCT2 was progressively decreased from non-neoplastic to primary HCC and to metastases. MCT1(overall and plasma membrane expression), MCT2 and CD147 plasma membrane expression were associated with absence of cirrhosis, while plasma membrane expression of CD147 was also associated with absence of HBV infection. MCT2 overall expression was associated with lower liver weight, absence of metastasis and absence of abdominal dissemination. Additionally, MCT4 plasma membrane positivity was strongly associated with Ki-67 expression. CONCLUSION: MCT4 and GLUT1 appear to play a role in HCC progression, while MCT2 is lost during progression and associated with better prognosis. | Venncio AF Alves Céline Pinheiro Filipa Morais-Santos Aloisio Felipe-Silva Adhemar Longatto-Filho Fátima Baltazar | 2014 | World Journal of Gastroenterology2014，20，33： | 11 |
| 2 | Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies显示文摘Colorectal cancer(CRC)is one of the cancer models and most of the carcinogenic steps are presently well understood.Therefore,successful preventive measures are currently used in medical practice.However,CRC is still an important public health problem as it is the third most common cancer and the fourth most frequent cause of cancer death worldwide.Nowadays,pathologic stage is a unique and well-recognized prognostic indicator,however,more accurate indicators of the biologic behavior of CRC are expected to improve the specificity of medical treatment.Angiogenesis plays an important role in the growth and progression of cancer but its role as a prognostic factor is still controversial.Probably the most important clinical implication of tumor angiogenesis is the development of anti-angiogenic therapy.The goal of this review is to critically evaluate the role of angiogenic markers,assessed by either endoglin-related microvessel density or expression of vascular endothelial growth factor family members in the CRC setting and discuss the role of these angiogenic markers in antiangiogenic therapies. | Sandra F Martins Rui M Reis Antonio Mesquita Rodrigues Fátima Baltazar Adhemar Longatto Filho | 2011 | World Journal of Clinical Oncology2011，2，6： | 9 |
| 3 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 4 | Groundwater monitoring of an open-pit limestone quarry:Water-rock interaction and mixing estimation within the rock layers by geochemical and statistical analyses显示文摘Water-rock interaction and groundwater mixing are important phenomena in understanding hydrogeological systems and the stability of rock slopes especially those consisting largely of moderately watersoluble minerals like calcite. In this study, the hydrogeological and geochemical evolutions of groundwater in a limestone quarry composed of three strata: limestone layer(covering), interbedded layer under the covering layer, and slaty greenstone layer(basement) were investigated. Water-rock interaction in the open-pit limestone quarry was evaluated using PHREEQC, while hierarchical cluster analysis(HCA)and principal component analysis(PCA) were used to classify and identify water sources responsible for possible groundwater mixing within rock layers. In addition, Geochemist's Workbench was applied to estimate the mixing fractions to clarify sensitive zones that may affect rock slope stability. The results showed that the changes in Ca2+and HCO3àconcentrations of several groundwater samples along the interbedded layer could be attributed to mixing groundwater from the limestone layer and that from slaty greenstone layer. Based on the HCA and PCA results, groundwaters were classified into several types depending on their origin:(1) groundwater from the limestone layer(LO),(2) mixed groundwater flowing along the interbedded layer(e.g., groundwater samples L-7, L-11, S-3 and S-4), and(3) groundwater originating from the slaty greenstone layer(SO). The mixing fractions of 41% LO: 59% SO, 64% LO: 36% SO, 43%LO: 57% SOand 25% LO: 75% SOon the normal days corresponded to groundwaters L-7, L-11, S-3 and S-4,respectively, while the mixing fractions of groundwaters L-7 and L-11(61% LO: 39% SOand 93% LO: 7% SO,respectively) on rainy days became the majority of groundwater originating from the limestone layer.These indicate that groundwater along the interbedded layer significantly affected the stability of rock slopes by enlarging multi-breaking zones in the layer through calcite dissolution and inducing high water pressure, tension cracks and potential sliding plane along this layer particularly during intense rainfall episodes. | Khy Eam Eang Toshifumi Igarashi Megumi Kondo Tsurugi Nakatani Carlito Baltazar Tabelin Ryota Fujinaga | 2018 | International Journal of Mining Science and Technology2018，28，6： | 6 |
| 5 | G protein-coupled estrogen receptor 1(GPER) activation triggers different signaling pathways on neurons and astrocytes显示文摘Estradiol (E2) is the most potent and prevalent form of estrogen, a well-known hormone that regulates multiple tissues and functions in humans. In the brain, E2 regulates processes as diverse as learning, memory, cognition, mood, as well as neurodevelopment and neurodegeneration. The actions of E2 are mediated by classical estrogen receptors (ERs;α and β), and by the G protein-coupled estrogen receptor 1 (GPER or GPR30)(Prossnitz and Arterburn, 2015). Classical ER are predominantly present in the nucleus and cytoplasm, with less than 2% present on the plasma membrane, and mediate genomic cellular effects that occur in the time frame of hours to days (Prossnitz and Arterburn, 2015). | Claudio Roque Graca Baltazar | 2019 | Neural Regeneration Research2019，14，12： | 3 |
| 6 | GDNF modulates HO-1 expression in substantia nigra postnatal cell cultures 显示文摘 | Saavedra A Baltazar G Carvalho CM | 2005 | Free Radic Biol Med2005，39，12： | 1 |
| 7 | Oxidation of Medium-chain acyl-CoA Esters by Extracts of Aspergillus niger: En- zymology and Characterization of Intermediates by HPLC 显示文摘 | BALTAZAR M F DICKINSON F M RATLEDGE C | 1999 | Micro- biology1999，145，1： | 1 |
| 8 | MRI of the rotator cuff and internal derangement显示文摘 | Opsha O Malik A Baltazar R | 2008 | Eur J Radiol2008，68，1： | 1 |
| 9 | Implemen- tation of a Bayesian classifier using repeated measurements for diserimina- tion of tomato fruit ripening stages 显示文摘 | Jorge I Aranda-Sanehez Arturo Baltazar | 2009 | Bio- systems Engineering2009，102，： | 1 |
| 10 | MRI of the rotator cuff and internal derangement 显示文摘 | Opsha O Malik A Baltazar R | 2008 | Eur J Radiol2008，68，1： | 1 |
| 11 | Cyclooxygenase- 2 and epidermal growth factor receptor expressions in different histological subtypes of cervical carcinomas显示文摘 | Baltazar F Filho AL Pinheiro C | 2007 | Int I Gynecol Pathol2007，26，3： | 1 |
| 12 | Influence of temperature and salinity on the yellowleg shrimp, Penaeus californieinsis Holmes, prophenoloxidase system显示文摘 | FVargas‐Albores PHinojosa‐Baltazar GPortillo‐Clark FMagallon‐Barajas | 2008 | Aquaculture Research2008，，8： | 1 |
| 13 | Topical gels of etofenamate:in vitro and in vivo evaluation显示文摘 | Marto J Baltazar D Duarte A et aI | 2014 | Pharm Dev Technol2014，5，： | 1 |
| 14 | Subclavian arterial injury associated with blunt trauma显示文摘 | Katras T Baltazar U Rush DS | 2001 | Vasc Surg2001，35，1： | 1 |
| 15 | Study of interracial stiffness ratio of a rough surface in contact using a spring model 显示文摘 | GONZALEZ-VALADEZ M BALTAZAR A DW- YER-JOYCE R S | 2010 | Wear2010，26，34： | 1 |
| 16 | Maize pollen lon- gevity and distance isolation requirements for effective pollen control显示文摘 | Luna S Figueroa V J Baltazar M B | 2001 | Crop Science2001，41，： | 1 |
| 17 | The Paradox of Participation: A Case Study on Urban Planning in Favelas and a Plea for Autonomy显示文摘 | Kapp Silke Baltazar Ana Paula | 2012 | Society for Latin American Studies2012，31，2： | 1 |
| 18 | Effect of methyl ,jasmonate on properties of intact tomato fruit mo- nitored with destructive and nondestructive tests 显示文摘 | Baltazar A Javier E L Torres I R | 2007 | Journal of Food Engineering2007，，80： | 1 |
| 19 | Influence of temperature and salinity on the yellow leg shrimp, Penaeus califoromiensis Holmes, prophenoloxidase syetem 显示文摘 | VARGAS - ALBORES F HINOJOSA - BALTAZAR P PORTI- LLO - CLARK G | 1998 | Aquaculture Research1998，29，： | 1 |
| 20 | Radiation-related arterial disease显示文摘 | Katras T Baltazar U Colvett K | 1999 | Am Surg1999，65，： | 1 |
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