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| 1 | Burden of Clostridium difficile infection between 2010 and 2013:Trends and outcomes from an academic center in Eastern Europe显示文摘AIM:To analyze the incidence and possible risk factors in hospitalized patients treated with Clostridium difficile infection(CDI).METHODS:A total of 11751 patients were admitted to our clinic between 1 January 2010 and 1 May2013.Two hundred and forty-seven inpatients were prospectively diagnosed with CDI.For the risk analysis a 1:3 matching was used.Data of 732 patients matched for age,sex,and inpatient care period and unit were compared to those of the CDI population.Inpatient records were collected from an electronic hospital database and comprehensively reviewed.RESULTS:Incidence of CDI was 21.0/1000 admissions(2.1%of all-cause hospitalizations and 4.45%of total inpatient days).The incidence of severe CDI was 12.6%(2.63/1000 of all-cause hospitalizations).Distribution of CDI cases was different according to the unit type,with highest incidence rates in hematology,gastroenterology and nephrology units(32.9,25 and24.6/1000 admissions,respectively) and lowest rates in 1.4%(33/2312) in endocrinology and general internal medicine(14.2 and 16.9/1000 admissions)units.Recurrence of CDI was 11.3%within 12 wk after discharge.Duration of hospital stay was longer in patients with CDI compared to controls(17.6 ± 10.8d vs 12.4 ± 7.71 d).CDI accounted for 6.3%of allinpatient deaths,and 30-d mortality rate was 21.9%(54/247 cases).Risk factors for CDI were antibiotic therapy[including third-generation cephalosporins or fluoroquinolones,odds ratio(OR) = 4.559;P < 0.001],use of proton pump inhibitors(OR = 2.082,P< 0.001),previous hospitaiization within 12 mo(OR = 3.167,P < 0.001),previous CDI(OR = 15.32;P < 0.001),while presence of diabetes mellitus was associated with a decreased risk for CDI(OR = 0.484;P< 0.001).Treatment of recurrent cases was significantly different from primary infections with more frequent use of vancomycin alone or in combination(P < 0.001),and antibiotic therapy duration was longer(P < 0.02).Severity,mortality and outcome of primary infections and relapsing cases did not significantly differ.CONCLUSION:CDI was accounted for significant burden with longer hospitaiization and adverse outcomes.Antibiotic,PPI therapy and previous hospitaiization or CDI were risk factors for CDI. | Zsuzsanna Kurti Barbara D Lovasz Michael D Mandel Zoltan Csima Petra A Golovics Bence D Csako Anna Mohas Lorant Gnczi Krisztina B Gecse Lajos S Kiss Miklos Szathmari Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，21： | 6 |
| 2 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Takamaru Ashikaga Donald L Weaver Barbara J Miller Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Denise M Mammolito David R McCready Eleftherios P Mamo | 2007 | Lancet Oncology2007，，10： | 2 |
| 3 | Conditions for stability of the extended Kalman filter and their application to the frequency trackingproblem显示文摘 | Barbara F Scala L Robert R B | 1995 | Mathematics of Control Signals and Systems1995，8，1： | 1 |
| 4 | Patterns in nutrient availability and plant diversity of temperate North American wetlands显示文摘 | Barbara L B Mark RW Allison A | 1999 | Ecology1999，7，： | 1 |
| 5 | An inter- laboratory study to test the ability of amendments to reduce the availability of Cd, Pb, and Zn in situ 显示文摘 | Sally B Barbara C Enzo L | 2005 | Environmental Pollution2005，138，： | 1 |
| 6 | Demonstration of TCDD-attenuated P450 steroidogenic enzyme mRNA levels in rat granulosa cells in vitro using competitive RT-PCR显示文摘 | Asok K D Barbara A B W Amanda L T | 2000 | Mol Cell Endocrinol2000，164，： | 1 |
| 7 | Stillbirth following previous cesarean section in Bavaria/Germany 1987 -2005 显示文摘 | Maximilian B F Nicholas L Barbara S | 2009 | Archives of Gynecology and Obstetrics2009，279，： | 1 |
| 8 | Discontinuing antithyroid drug therapy before ablation with radioiodine in Graves disease显示文摘 | Henry B Burch MD Barbara L | 1994 | Ann Intern Med1994，121，8： | 1 |
| 9 | Comparison of Optimization Formulations for Waste- load Allocations显示文摘 | Donald H B Barbara J L | 1992 | Journal of Environmental Engineering Division1992，188，4： | 1 |
| 10 | Neon isotopes constrain convection and volatile origin in the Earth's mantle显示文摘 | Chris J B Bernard M Barbara S L Martin C | 2005 | Nature2005，433，： | 1 |
| 11 | Soluble and insoluble fractions of heavy metals in wet and dry atmospheric depositions in Bologna,Italy显示文摘 | MORSELLI L OLIVIERI P BARBARA B | | 0，，03： | 1 |
| 12 | Patterns in nutrient availability and plant diversity of temperate North American wetlands 显示文摘 | Barbara L B Mark R W and Allison A | 1999 | Ecology1999，7，： | 1 |
| 13 | Rheology and functional properties of starches isolated from five improved rice varieties from West Africa显示文摘 | OLAYIDE S L ROMANO L BARBARA B | 2011 | Food Hydrocolloids2011，25，7： | 1 |
| 14 | The Kasai portoenterostomy for biliary atresia: a review of a 27-year experience with 81 patients显示文摘 | Barbara E Wildhaber Arnold G Coran Robert A Drongowski Ronald B Hirschl James D Geiger Joseph L Lelli Daniel H Teitelbaum | 2003 | Journal of Pediatric Surgery2003，，10： | 1 |
| 15 | Comparison of optimization formula- tions for waste-load allocations显示文摘 | Donald H B Barbara J L | 1992 | Journal of Environmental En- gineering1992，188，4： | 1 |
| 16 | The R gene product of bacteri- ophage X is the murein transglycosylase显示文摘 | Nrystyna B Barbara L | 1981 | Molecular and General Genetics1981，184，： | 1 |
| 17 | Conditions for stability of the extended Kalman filter and their application to the frequency tracking problem显示文摘 | Barbara F Scala L Robert R B | 1995 | Mathematics of Control Signals and Systems1995，8，1： | 1 |
| 18 | Neural development of selective attention and response inhibition显示文摘 | James R Booth Douglas D Burman Joel R Meyer Zhang Lei Barbara L Trommer Nicholas D Davenport Wei Li Todd B Parrish Darren R Gitelman M.Marsel Mesulam | 2003 | Neuroimage2003，，2： | 1 |
| 19 | Starchmethylcellulose based edible films:Theological properties of film-forming dispersions显示文摘 | Donatella P Barbara B Romano L | 2003 | Journal of Food Engineering2003，59，： | 1 |
| 20 | Comparison of optimization formulations for waste-load allocation 显示文摘 | Donald H B Barbara J L | 1992 | Journal of Environmental Engineering1992，188，4： | 1 |
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