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1Management of hepatocellular carcinoma with portal vein tumor thrombosis: Review and update at 2016显示文摘Portal vein tumor thrombosis(PVTT) is a common phenomenon in hepatocellular carcinoma(HCC). Compared to HCC without PVTT, HCC with PVTT is characterized by an aggressive disease course, worse hepatic function, a higher chance of complications related to portal hypertension and poorer tolerance to treatment. Conventionally, HCC with PVTT is grouped together with metastatic HCC during the planning of its management, and most patients are offered palliative treatment with sorafenib or other systemic agents. As a result, most data on the management of HCC with PVTT comes from subgroup analyses or retrospective series. In the past few years, there have been several updates on management of HCC with PVTT. First, it is evident that HCC with PVTT consists of heterogeneous subgroups with different prognoses. Different classifications have been proposed to stage the degree of portal vein invasion/thrombosis, suggesting that different treatment modalities may be individualized to patients with different risks. Second, more studies indicate that more aggressive treatment, including surgical resection or locoregional treatment, may benefit select HCC patients with PVTT. In this review, we aim to discussthe recent conceptual changes and summarize the data on the management of HCC with PVTT.Stephen L Chan Charing CN Chong Anthony WH Chan Darren MC Poon Kenneth SH Chok 2016World Journal of Gastroenterology2016,22,32:44
2Sharing Clinical Trial Data: A Proposal from the International Committee of Medical Journal Editors显示文摘The International Committee of Medical Journal Editors (ICMJE) believes that there is an ethical obligation to responsibly share data generated by interventional clinical trials because participants have put themselves at risk.In a growing consensus,many funders around the world-foundations,government agencies,and industry-now mandate data sharing.Here,we outline ICMJE's proposed requirements to help meet this obligation.We encourage feedback on the proposed requirements.Anyone can provide feedback at www.icmje.org by April 18,2016.Darren B Taichman Joyce Backus Christopher Baethge Howard Bauchner Peter W de Leeuw Jeffrey M Drazen John Fletcher Frank Frizelle Irish Groves Abraham Haileamlak Astrid James Christine Laine Larry Peiperl Anja Pinborg Peush Sahni Si-Nan Wu 2016Chinese Medical Journal2016,,2:20
3一种新的包含可变时间效应的内生时空权重矩阵构建方法显示文摘研究目标:引入一种基于年度全局Moran指数比的内生时空权重矩阵构建方法,并评估其合理性。研究方法:基于标准化的空间权重矩阵和以年度全局Moran指数比为基础的时间权重矩阵,经过克罗内克积组合形成内生时空权重矩阵;并以两江新区辐射带动力影响因素分解问题为例,评估了内生时空权重矩阵的引入合理性。研究发现:相对于传统的外生时空权重矩阵而言,内生时空权重矩阵能够模拟空间溢出效应在时间上的动态转移和传导效应,却不会导致模型估计结果变异性质发生明显改变。研究创新:构建了一种新的内生性的、包含可变时间效应的时空权重矩阵。研究价值:为面板数据空间计量模型建模实践构建了一种更为精准的时空权重矩阵设计方式。范巧 Hudson Darren 2018数量经济技术经济研究2018,35,1:18
4Sediment fingerprinting in fluvial systems:review of tracers,sediment sources and mixing models显示文摘Suspended sediments in fluvial systems originate from a myriad of diffuse and point sources,with the relative contribution from each source varying over time and space.The process of sediment fingerprinting focuses on developing methods that enable discrete sediment sources to be identified from a composite sample of suspended material.This review identifies existing methodological steps for sediment fingerprinting including fluvial and source sampling,and critically compares biogeochcmical and physical tracers used in fingerprinting studies.Implications of applying different mixing models to the same source data are explored using data from 41 catchments across Europe,Africa,Australia,Asia,and North and South America.The application of seven commonly used mixing models to two case studies from the US(North Fork Broad River watershed) and France(BIcone watershed) with local and global(genetic algorithm) optimization methods identified all outputs remained in the acceptable range of error defined by the original authors.We propose future sediment fingerprinting studies use models that combine the best explanatory parameters provided by the modified Collins(using correction factors) and Hughes(relying on iterations involving all data,and not only their mean values) models with optimization using genetic algorithms to best predict the relative contribution of sediment sources to fluvial systems.Arman HADDADCHI Darren S.RYDER Olivier EVRARD Jon OLLEY 2013International Journal of Sediment Research2013,28,4:14
5Root-Specific Transcript Profiling of Contrasting Rice Genotypes in Response to Salinity Stress显示文摘提高的咸度强加渗透并且离子毒性在生活上强调房间并且要求大量的回答以便启用植物幸存。在在米饭( Oryza sativa )介绍抄本层次的更早的工作上造 FL478 射击,盐容忍的 indica recombinant 生来的线,和 IR29 ,盐敏感的栽培变种,抄本层次在这二就职的根以及在二另外的盐容忍的 indica 遗传型的根被比较, landrace Pokkali 和 recombinant 生来的线 IR63731 。这研究的目的是比较抄本在敏感并且容忍的线以便多半识别基因涉及工厂咸度忍耐,而非响应咸度本身。有到咸度忍耐的已知的连接的几个基因家庭的抄本侧面被描述(例如 HKT, NHX ) 。通过他们的盐应答,抄本层次,或 chromosomal 地点识别的一套基因的通常认为的功能(即在为咸度忍耐的 QTL 下面) 也被讨论。最后,在 FL478 的 Saltol 区域的父母起源进一步被调查。总的来说,介绍的数据集看起来柔韧,这个系统能为涉及咸度忍耐的新奇基因的发现提供可靠策略,似乎可能。Olivier Cotsaftis Darren Plett Alexander A.T. Johnson Harkamal Walia Clyde Wilson Abdelbagi M. Ismail Timothy J. Close Mark Tester Ute Baumann 2011Molecular Plant2011,4,1:14
6Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy显示文摘Diabetes mellitus significantly increases the risk of cardiovascular disease and heart failure in patients.Independent of hypertension and coronary artery disease,diabetes is associated with a specific cardiomyopathy,known as diabetic cardiomyopathy(DCM).Four decades of research in experimental animal models and advances in clinical imaging techniques suggest that DCM is a progressive disease,beginning early after the onset of type 1 and type 2 diabetes,ahead of left ventricular remodeling and overt diastolic dysfunction.Although the molecular pathogenesis of early DCM still remains largely unclear,activation of protein kinase C appears to be central in driving the oxidative stress dependent and independent pathways in the development of contractile dysfunction.Multiple subcellular alterations to the cardiomyocyte are now being highlighted as critical events in the early changes to the rate of force development,relaxation and stability under pathophysiological stresses.These changes include perturbed calcium handling,suppressed activity of aerobic energy producing enzymes,altered transcriptional and posttranslational modification of membrane and sarcomeric cytoskeletal proteins,reduced actin-myosin cross-bridge cycling and dynamics,and changed myofilament calcium sensitivity.In this review,we will present and discuss novel aspects of the molecular pathogenesis of early DCM,with a special focus on the sarcomeric contractile apparatus.Mark T Waddingham Amanda J Edgley Hirotsugu Tsuchimochi Darren J Kelly Mikiyasu Shirai James T Pearson 2015World Journal of Diabetes2015,6,7:10
7Historical biogeography of Melicope (Rutaceae)and its close relatives with a special emphasis on Pacific dispersals显示文摘The genus Melicope (Rutaceae)occurs on most Pacific archipelagos and is perfectly suited to study Pacific biogeography.The main goal was to infer the age,geographic origin and colonization patterns of Melicope and its relatives.We sequenced three nuclear and two plastid markers for 332specimens that represent 164species in 16genera of Rutaceae.Phylogenetic reconstruction,molecular dating,ancestral area reconstruction and diversification analyses were carried out.The two main clades (Acronychia-Melicope and Euodia)originated in Australasia and their crown ages are dated to the Miocene.Diversification rates differed among the subclades and were lowest in the Euodia lineage and highest in the Hawaiian Melicope lineage.The Malagasy and Mascarene species form a clade,which split from its SE Asian relatives in the Pliocene/P[eistocene.At least eight colonizations to the Pacific islands occurred.The timing of all colonizations except for the Hawaiian group is congruent with age of the island ages.Australia,New Guinea and New Caledonia have been the source of colonizations into the Pacific islands in the Melicope clade.Melicope shows high dispersability and has colonized remote archipelagos such as the. Austral and Marquesas Islands each twice.Colonization of islands of the Hawaiian-Emperor seamount chain likely predates the ages of the current main islands,and the initial colonization to Kaua'i occurred after the splitting of the Hawaiian.lineage into two subclades.Wider ecological niches and adaptations to bird-dispersal likely account for the much higher species richness in the Acronychia-Melicope clade compared to the Euodia clade.Marc S.Appelhans Jun Wen Marco Duretto Darren Crayn Warren L.Wagner 2018Journal of Systematics and Evolution2018,56,6:8
8Real-time PCR diagnosis of Schistosoma japonicum in low transmission areas of China显示文摘Background:Schistosomiasis in the People’s Republic of China(PRC)can be traced back to antiquity.In the past 60 years,the Chinese government has made great efforts to control this persistent disease with elimination slated by 2020 through the implementation of a comprehensive control strategy.This strategy aims to reduce the role of bovines and humans as sources of infection as a pre-requisite for elimination through transmission interruption.The goal of elimination will be achievable only by the implementation of a sustainable surveillance and control system,with sensitive diagnosis a key feature so that the true disease burden is not underestimated.Currently used diagnostics lack the necessary sensitivity to accurately determine the prevalence of Schistosoma japonicum infection in areas with low infection intensities.It is of critical importance to find and treat people and to identify animals with low-level infections if the National Control Programme for China is to achieve schistosomiasis elimination.Methods:We evaluated a real-time polymerase chain reaction(qPCR)assay using 633 human stool samples collected from five villages in Hunan,Anhui,Hubei,and Jiangxi provinces,and 182 bovine(70 cattle and 112 buffalo)stool samples obtained from four villages in Hunan,Anhui,and Jiangxi provinces in the PRC.All stool samples were subjected to the miracidium hatching test(MHT,a diagnostic procedure used in the National Schistosomiasis Control Programme)and the qPCR assay.Samples positive by MHT were subjected to either the Kato-Katz technique for humans,or the formalin-ethyl acetate sedimentation-digestion(FEA-SD)procedure for bovines,to determine infection intensities.Results:The qPCR assay exhibited a high level of sensitivity in the detection of S.japonicum infections.With both the human and bovine samples,a significantly higher prevalence was determined using the qPCR assay(11.06%humans,24.73%bovines)than with the MHT(0.93%humans,7.69%bovines).The animal contamination index(calculated using data obtained with the qPCR technique)for all positive bovines was 27618000 eggs per day,indicating a considerable amount of environmental egg contamination that would be underestimated using less sensitive diagnostic procedures.Conclusions:The qPCR assay we have evaluated will be applicable as a future field diagnostic and surveillance tool in low-transmission zones where schistosomiasis elimination is targeted and for monitoring post-intervention areas to verify that elimination has been maintained.Pei He Catherine A.Gordon Gail M.Williams Yuesheng Li Yuanyuan Wang Junjian Hu Darren J.Gray Allen G.Ross Donald Harn Donald P.McManus 2018Infectious Diseases of Poverty2018,7,1:7
9Robust nonlinear control strategy to maximize energy capture in a variable speed wind turbine with an internal induction generator显示文摘This paper proposes a control strategy to maximize the wind energy captured in a variable speed wind turbine, with an internal induction generator, at low to medium wind speeds. The proposed strategy controls the tip-speed ratio, via the rotor angular speed, to an optimum point at which the efficiency constant (or power coefficient) is maximum for a particular blade pitch angle and wind speed. This control method allows for aerodynamic rotor power maximization without exact wind turbine model knowledge. Representative numerical results demonstrate that the wind turbine can be controlled to achieve near maximum energy capture.Erhun IYASERE Mohammed H. SALAH Darren M. DAWSON John R. WAGNER Enver TATLICIOGLU 2012控制理论与应用(英文版)2012,10,2:6
10丝网印刷在太阳能电池制造中的挑战显示文摘提高太阳能电池的功率和生产力成为重要的挑战,丝网印刷工艺可以最大限度地提高制造商所寻求的因素。太阳能电池制造商当今面临的挑战正在开始两极分化成两大重点:提高太阳能电池的功率以增加单位面积的发电量;其次是无需增加相应投资而以现有的工艺提高生产力的愿望或需求。Darren Brown 2009集成电路应用2009,,8:5
11Emergency resection surgery for colorectal cancer: Patterns of recurrent disease and survival显示文摘AIM To evaluate prognostic pathological factors associated with early metachronous disease and adverse longterm survival in these patients.METHODS Clinical and histological features were analysed retrospectively over an eight-year period for prognostic impact on recurrent disease and overall survival in patients undergoing curative resection of a primary colorectal cancer. RESULTS A total of 266 patients underwent curative surgery during the study period. The median age of the study cohort was 68 year(range 26 to 91) with a followup of 7.9 years(range 4.6 to 12.6). Resection was undertaken electively in 225(84.6%) patients and emergency resection in 35(13.2%). Data on timing of surgery was missing in 6 patients. Recurrence was noted in 67(25.2%) during the study period and was predominantly early within 3 years(82.1%) and involved hepatic metastasis in 73.1%. Emergency resection(OR = 3.60, P = 0.001), T4 stage(OR = 4.33, P < 0.001) and lymphovascular invasion(LVI) (OR = 2.37, P = 0.032) were associated with higher risk of recurrent disease. Emergency resection, T4 disease and a high lymph node ratio(LNR) were strong independent predictors of adverse long-term survival. CONCLUSION Emergency surgery is associated with adverse disease free and long-term survival. T4 disease, LVI and LNR provide strong independent predictive value of longterm outcome and can inform surveillance strategies to improve outcomes.Joe Littlechild Muneer Junejo Anne-Marie Simons Finlay Curran Darren Subar 2018World Journal of Gastrointestinal Pathophysiology2018,9,1:5
12Deposition behavior of residual aluminum in drinking water distribution system:Effect of aluminum speciation显示文摘Finished drinking water usually contains some residual aluminum.The deposition of residual aluminum in distribution systems and potential release back to the drinking water could significantly influence the water quality at consumer taps.A preliminary analysis of aluminum content in cast iron pipe corrosion scales and loose deposits demonstrated that aluminum deposition on distribution pipe surfaces could be excessive for water treated by aluminum coagulants including polyaluminum chloride(PACl).In this work,the deposition features of different aluminum species in PACl were investigated by simulated coil-pipe test,batch reactor test and quartz crystal microbalance with dissipation monitoring.The deposition amount of non-polymeric aluminum species was the least,and its deposition layer was soft and hydrated,which indicated the possible formation of amorphous Al(OH)_3.Al_(13) had the highest deposition tendency,and the deposition layer was rigid and much less hydrated,which indicated that the deposited aluminum might possess regular structure and self-aggregation of Al_(13)could be the main deposition mechanism.While for Al_(30),its deposition was relatively slower and deposited aluminum amount was relatively less compared with Al_(13).However,the total deposited mass of Al_(30) was much higher than that of Al_(13),which was attributed to the deposition of particulate aluminum matters with much higher hydration state.Compared with stationary condition,stirring could significantly enhance the deposition process,while the effect of pH on deposition was relatively weak in the near neutral range of 6.7 to 8.7.Yue Zhang Baoyou Shi Yuanyuan Zhao Mingquan Yan Darren A.Lytle Dongsheng Wang 2016Journal of Environmental Sciences2016,28,4:5
13Hepatitis E virus in patients with acute severe liver injury显示文摘AIM: To examine the incidence of hepatitis E(HepE) in individuals with acute liver injury severe enough to warrant treatment at a transplant unit.METHODS: Hepatitis E virus(HEV) is an emerging pathogen in developed countries causing severe illness, particularly in immunocompromised patients or those with underlying chronic liver disease. HepE infection isoften under diagnosed, as clinicians can be reluctant to test patients who have not travelled to regions traditionally considered hyperendemic for HepE. There are few data regarding the significance of HEV in patients with very severe acute liver injury in developed countries. Eighty patients with acute severe liver injury attending the Scottish Liver Transplant unit were tested for HEV and anti-HEV IgG and IgM. Severe acute liver injury was defined as a sudden deterioration in liver function confirmed by abnormal liver function tests and coagulopathy or presence of hepatic encephalopathy. Eighty percent of these patients were diagnosed with paracetomol overdose. No patients had a history of chronic or decompensated chronic liver disease at time of sampling. IgG positive samples were quantified against the World Health Organization anti-HEV IgG standard. Samples were screened for HEV viral RNA by quantitative reverse transcription polymerase chain reaction.RESULTS: Four cases of hepatitis E were identified. Three of the four cases were only diagnosed on retrospective testing and were initially erroneously ascribed to drug-induced liver injury and decompensated chronic liver disease, with the cause of the decompensation uncertain. One case was caused by HEV genotype 1 in a traveller returning from Asia, the other three were autochthonous and diagnosed on retrospective testing. In two of these cases(where RNA was detected) HEV was found to be genotype 3, the most prevalent genotype in developed countries. Three patients survived, two of whom had been misdiagnosed as having drug induced liver injury. The fourth patient died from sepsis and liver failure precipitated as a result of hepatitis E infection and previously undiagnosed cirrhosis. Histopathology data to date is limited to mainly that seen for endemic HepE. All patients, with the exception of patient 1, demonstrated characteristics of HepE infection, as seen in previously described locally acquired cases.CONCLUSION: In patients with acute severe liver injury, HEV testing should be part of the initial diagnostic investigation algorithm irrespective of suspected initial diagnosis, age or travel history.Claire Louise Crossan Kenneth J Simpson Darren G Craig Christopher Bellamy Janice Davidson Harry R Dalton Linda Scobie 2014World Journal of Hepatology2014,6,6:4
14Management of acute spinal cord injury:A summary of the evidence pertaining to the acute management,operative and non-operative management显示文摘Acute traumatic spinal cord injury is often a lifechanging and devastating event with considerable mortality and morbidity.Over half a million people suffer from traumatic spinal cord injury annually with the majority resulting from road traffic accidents or falls.The Individual,societal and economic costs are enormous.Initial recognition and treatment of acute traumatic spinal cord injury are crucial to limit secondary injury to the spinal cord and to provide patients with the best chance of some functional recovery.This article is an overview of the management of the acute traumatic spinal cord injury patient presenting to the emergency department.We review the initial assessment,criteria for imaging and clearing the spine,and evaluate the literature to determine the optimum timing of surgery and the role of non-surgical treatment in patients presenting with acute spinal cord injury.Darren Sandean 2020World Journal of Orthopedics2020,11,12:4
15Endoscopic submucosal dissection vs endoscopic mucosal resection for colorectal polyps:A meta-analysis and metaregression with single arm analysis显示文摘BACKGROUND Endoscopic submucosal dissection(ESD)has shown to be effective in management of colorectal neoplasm in the Asian countries,while its implementation in Western countries where endoscopic mucosal resection(EMR)is preferred is still debatable.AIM To compare the surgical,histological,and oncological outcomes between ESD and EMR in the treatment of colorectal polyps,with subgroup analysis comparing the efficacy of ESD and EMR between Japan and the rest of the world.METHODS Embase and Medline databases were searched from inception to October 2020 in accordance with PRISMA guidelines for studies comparing en bloc,complete resection,margin involvement,resection time,need for additional surgery,complications,and recurrence rate of ESD with EMR.RESULTS Of 281344 colorectal polyps from 21 studies were included.When compared to EMR,the pooled analysis revealed ESD was associated with higher en bloc and complete resection rate,and lower lateral margin involvement and recurrence.ESD led to increased procedural time,need for additional surgery,and perforation risk.No significant difference in bleeding risk was found between the two groups.Meta-regression analysis suggested only right colonic polyps correlated with an increased perforation risk in ESD.Confounders including polyp size and invasion depth did not significantly influence the en bloc and complete resection rate,bleeding risk and recurrence.In subgroup analysis,Japan performed better than the rest of the world in both ESD and EMR with perforation risk of 4%and 0.0002%,respectively,as compared to perforation risk of 8%and 1%,respectively,in reports coming from rest of the world.CONCLUSION ESD resulted in better resection outcomes and lower recurrence compared to EMR.With appropriate training,ESD is preferred over EMR as the first-line therapy for resection of colorectal polyps,without restricting to lesions greater than 20 mm and those with high suspicion of submucosal invasion.Xiong Chang Lim Kameswara Rishi Yeshayahu Nistala Cheng Han Ng Snow Yunni Lin Darren Jun Hao Tan Khek-Yu Ho Choon-Seng Chong Mark Muthiah 2021World Journal of Gastroenterology2021,27,25:4
16中子衍射法研究单晶镍基高温合金热机械疲劳引起的应力和晶格错配显示文摘采用中子衍射法对热机械疲劳后的单晶镍基高温合金样品内部中心点进行了实验测量,数据处理采用了双相叠加峰和单峰分析两种方法,计算得到了样品材料的宏观等效应力、应力偏量、γ相和γ′相的等效应力和晶格错配度等.实验结果表明,两种分析方法得到的宏观等效应力基本一致.在热机械疲劳循环100周出现最大宏观等效应力和应力偏量,此时位错等微缺陷达到饱和,偏离中心点处γ′相应力减小显著;在热机械疲劳开始阶段负错配度明显减小,随循环周次增多基体塑性应变累积又使负错配度以每次8.1×10-6的速度逐渐线形增大.孙光爱 陈波 陈华 吴二冬 张俊 Vincent Ji Darren Hughes Thilo Pirling 2009物理学报2009,58,4:4
17Elucidating the Uptake and Distribution of Nanoparticles in Solid Tumors via a Multilayered Cell Culture Model显示文摘Multicellular layers(MCLs) have previously been used to determine the pharmacokinetics of a variety of different cancer drugs including paclitaxel, doxorubicin, methotrexate, and 5-fluorouracil across a number of cell lines. It is not known how nanoparticles(NPs) navigate through the tumor microenvironment once they leave the tumor blood vessel.In this study, we used the MCL model to study the uptake and penetration dynamics of NPs. Gold nanoparticles(GNPs)were used as a model system to map the NP distribution within tissue-like structures. Our results show that NP uptake and transport are dependent on the tumor cell type. MDA-MB-231 tissue showed deeper penetration of GNPs as compared to MCF-7 one. Intracellular and extracellular distributions of NPs were mapped using Cyto Viva imaging. The ability of MCLs to mimic tumor tissue characteristics makes them a useful tool in assessing the efficacy of particle distribution in solid tumors.Darren Yohan Charmainne Cruje Xiaofeng Lu Devika Chithrani 2015Nano-Micro Letters2015,7,2:3
18关于成人网络游戏玩家与未成年网络游戏玩家的比较研究显示文摘M.D.Griffiths Mark N.O.Davies Darren Chappell 范晓光 2006中国青年研究2006,,6:3
19Distal radius volar rim plate: Technical and radiographic considerations显示文摘AIM To determine technical considerations and radiographic outcomes of the Synthes volar rim distal radius plate to treat complex intra-articular fractures. METHODS This review highlights technical considerations learnt using this implant since it was introduced in a major trauma unit in November 2011, including anatomical reduction and whether this was maintained radiographically. RESULTS Twenty-six of the 382 internally fixed distal radial fractures at our unit(6.8%) were deemed to require this plate in order to achieve optimal fracture fixation between November 2011 and May 2014. A further dorsal and/or radial plate was necessary in 35% and variable angle screws were used in 54% of cases. Postoperatively, mean radial height, inclination, volar tilt and ulnar variance restored were 11.7 mm, 21o, 4.3o and-1.2 mm respectively. There were no cases of non-union or flexor/extensor tendon rupture; one case of loss of fracture reduction. Overall incidence of plate removal was 15% with one plate removed for flexor and one for extensor tendon irritation CONCLUSION The use of a rim plate enables control of challenging fardistal fracture patterns. However, additional plates were required to improve and maintain reduction. Variable angle screws were necessary in half the cases to avoid intra-articular screw penetration. If used judiciously, this implant can achieve stable fixation despite the complexity of the fracture pattern.Michelle Spiteri Darren Roberts Wayne Ng Jamie Matthews Dominic Power 2017World Journal of Orthopedics2017,8,7:3
20Results of docetaxel plus oxaliplatin (DOCOX) ± cetuximab in patients with metastatic gastric and/or gastroesophageal junction adenocarcinoma: results of a randomized phase 2 study显示文摘Donald Richards Darren M. Kocs Alexander I. Spira A. David McCollum Sami Diab Lanny I. Hecker Allen Cohn Feng Zhan Lina Asmar 2013European Journal of Cancer2013,,:3
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