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| 1 | Burden of Clostridium difficile infection between 2010 and 2013:Trends and outcomes from an academic center in Eastern Europe显示文摘AIM:To analyze the incidence and possible risk factors in hospitalized patients treated with Clostridium difficile infection(CDI).METHODS:A total of 11751 patients were admitted to our clinic between 1 January 2010 and 1 May2013.Two hundred and forty-seven inpatients were prospectively diagnosed with CDI.For the risk analysis a 1:3 matching was used.Data of 732 patients matched for age,sex,and inpatient care period and unit were compared to those of the CDI population.Inpatient records were collected from an electronic hospital database and comprehensively reviewed.RESULTS:Incidence of CDI was 21.0/1000 admissions(2.1%of all-cause hospitalizations and 4.45%of total inpatient days).The incidence of severe CDI was 12.6%(2.63/1000 of all-cause hospitalizations).Distribution of CDI cases was different according to the unit type,with highest incidence rates in hematology,gastroenterology and nephrology units(32.9,25 and24.6/1000 admissions,respectively) and lowest rates in 1.4%(33/2312) in endocrinology and general internal medicine(14.2 and 16.9/1000 admissions)units.Recurrence of CDI was 11.3%within 12 wk after discharge.Duration of hospital stay was longer in patients with CDI compared to controls(17.6 ± 10.8d vs 12.4 ± 7.71 d).CDI accounted for 6.3%of allinpatient deaths,and 30-d mortality rate was 21.9%(54/247 cases).Risk factors for CDI were antibiotic therapy[including third-generation cephalosporins or fluoroquinolones,odds ratio(OR) = 4.559;P < 0.001],use of proton pump inhibitors(OR = 2.082,P< 0.001),previous hospitaiization within 12 mo(OR = 3.167,P < 0.001),previous CDI(OR = 15.32;P < 0.001),while presence of diabetes mellitus was associated with a decreased risk for CDI(OR = 0.484;P< 0.001).Treatment of recurrent cases was significantly different from primary infections with more frequent use of vancomycin alone or in combination(P < 0.001),and antibiotic therapy duration was longer(P < 0.02).Severity,mortality and outcome of primary infections and relapsing cases did not significantly differ.CONCLUSION:CDI was accounted for significant burden with longer hospitaiization and adverse outcomes.Antibiotic,PPI therapy and previous hospitaiization or CDI were risk factors for CDI. | Zsuzsanna Kurti Barbara D Lovasz Michael D Mandel Zoltan Csima Petra A Golovics Bence D Csako Anna Mohas Lorant Gnczi Krisztina B Gecse Lajos S Kiss Miklos Szathmari Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，21： | 6 |
| 2 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 3 | Prevalence and predictors of hospitalization in Crohn's disease in a prospective population-based inception cohort from 2000-2012显示文摘AIM: To analyze the prevalence, length and predictors of hospitalization in the biological era in the populationbased inception cohort from Veszprem province.METHODS: Data of 331 incident Crohn's disease(CD) patients diagnosed between January 1, 2000 and December 31, 2010 were analyzed(median age at diagnosis: 28; IQR: 21-40 years). Both in- and outpatient records were collected and comprehensively reviewed.RESULTS: Probabilities of first CD-related hospitalization and re-hospitalization were 32.3%, 45.5%,53.7% and 13.6%, 23.9%, 29.8%, respectively after one, three and five years of follow-up in Kaplan-Meier analysis. First-year hospitalizations were related to diagnostic procedures(37%), surgery or disease activity(27% and 21%). Non-inflammatory disease behavior at diagnosis(HR = 1.32, P = 0.001) and perianal disease(HR = 1.47, P = 0.04) were associated with time to first CD-related hospitalization, while disease behavior change(HR = 2.38, P = 0.002) and need for steroids(HR = 3.14, P = 0.003) were associated with time to first re-hospitalization in multivariate analyses.Early CD-related hospitalization(within the year of diagnosis) was independently associated with need for immunosuppressives(OR = 2.08, P = 0.001) and need for surgeries(OR = 7.25, P < 0.001) during the disease course.CONCLUSION: Hospitalization and re-hospitalization rates are still high in this cohort, especially during the first-year after the diagnosis. Non-inflammatory disease behavior at diagnosis was identified as the pivotal predictive factor of both hospitalization and rehospitalization. | Petra A Golovics Laszlo Lakatos Michael D Mandel Barbara D Lovasz Zsuzsanna Vegh Zsuzsanna Kurti Istvan Szita Lajos S Kiss Tunde Pandur Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 4 | Coulson Rotavirus spike protein VP5 * binds a2bl integrin on the cell surface and competes with virus for cell binding and infectivity显示文摘 | Graham K L Takada Y Barbara S | 2006 | J GEN Virology2006，87，5： | 1 |
| 5 | Reversal of endocrine resistance in breast cancer:interrela- tionships among 14-3-34, FOXM1, and a gene signature associated with mitosis显示文摘 | Anna Bergamaschi Barbara L Christensen Benita S Katzenellen bogen | 2011 | Breast Cancer Research2011，13，： | 1 |
| 6 | Stillbirth following previous cesarean section in Bavaria/Germany 1987 -2005 显示文摘 | Maximilian B F Nicholas L Barbara S | 2009 | Archives of Gynecology and Obstetrics2009，279，： | 1 |
| 7 | Neon isotopes constrain convection and volatile origin in the Earth's mantle显示文摘 | Chris J B Bernard M Barbara S L Martin C | 2005 | Nature2005，433，： | 1 |
| 8 | Hospice knowledge and in- tentions among latinos using safety - net clinics显示文摘 | Claire S Barbara K Gheorghe L etal | 2012 | Journal of Palliative Medicine2012，15，9： | 1 |
| 9 | Enhancing nurses'pain management knowledge显示文摘 | Barbara L Patricia S Sonja H | 2007 | The Canadian Nurse2007，103，4： | 1 |
| 10 | Rheology and functional properties of starches isolated from five improved rice varieties from West Africa显示文摘 | OLAYIDE S L ROMANO L BARBARA B | 2011 | Food Hydrocolloids2011，25，7： | 1 |
| 11 | Efficacy of eplerenone versus enalapril as monotherapy in systemic hypertension显示文摘 | Gordon H Williams Ellen Burgess Rainer E Kolloch Luis Miguel Ruilope Joanna Niegowska Mark S Kipnes Barbara Roniker Jeffrey L Patrick Scott L Krause | 2004 | The American Journal of Cardiology2004，，： | 1 |
| 12 | Meta-Analyses of the relation between Silicone breast implants and the risk of connective-tissue diseases显示文摘 | Esther C Lawrence L Barbara S | 2000 | N Engl J Med2000，342，11： | 1 |
| 13 | GoSh: a web - based database for goat and sheep EST sequences 显示文摘 | Andrea C Barbara L Alessandra S | 2007 | Bioinformatics( Oxford England)2007，23，8： | 1 |
| 14 | lntracellular adenosine triphosphate ATP concentration a switch in decision between apoptosis and necrosis显示文摘 | Marcel L Barbara S Anna FC | 1997 | J Exp Med1997，185，8： | 1 |
| 15 | Prevalence of spontaneous hepatofugal portal flow in liver cirrhosis(letter) 显示文摘 | Gaiani S Bolondi L Barbara L | 1991 | Gastroenterology1991，101，4： | 1 |
| 16 | IFN-β pretreatment sensitizes human melanoma cells to TRAIL/Apo2 ligand-induced apoptosis显示文摘 | MAMTA C S DOUGLAS W L BARBARA S J | 2002 | J Immunol2002，169，2： | 1 |
| 17 | Intracellular adenosine triphosphate (ATP) concentration: a switch in decision between apoptosis and necrosis显示文摘 | Marcel L Barbara S Anna FC | 1997 | J Exp Med1997，185，8： | 1 |
| 18 | First human-caused extinction of a cetacean species?显示文摘 | Turvey Samuel T Pitman Robert L Taylor Barbara L Barlow Jay Akamatsu Tomonari Barrett Leigh A Zhao Xiujiang Reeves Randall R Stewart Brent S Wang Kexiong Wei Zhuo Zhang Xianfeng Pusser L.T Richlen Michael Brandon John R Wang Ding | 2007 | Biology Letters2007，，5： | 1 |
| 19 | Particulate matter de- posited on leaf of five evergreen species in Beijirtg,China: Source identification and size distribution显示文摘 | YINGSHI S BARBARA A M FENG L | 2015 | Atmospheric Environment2015，105，： | 1 |
| 20 | Work disability and productivity loss in patients with inflammatory bowel diseases in Hungary in the era of biologics显示文摘 | Mandel D. Michael Anita Bálint Barbara D. Lovász László Gulácsi Bálint Strbák Petra A. Golovics Klaudia Farkas Zsuzsanna Kürti Blanka K. Szilágyi Anna Mohás Tamás Molnár Péter L. Lakatos | 2014 | The European Journal of Health Economics2014，，1： | 1 |
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