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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | The mycobiota of the weed Mikania micrantha in southern Brazil with particular reference to fungal pathogens for biological control显示文摘 | Barreto R W Evans H C | 1995 | Mycol Res1995，，3： | 1 |
| 3 | K/DOQI- recommended intact PTH levels do not prevent low-turnover bone disease in hemodialysis patients 显示文摘 | Barreto F C Barreto D V MoysOs R M | 2008 | Kidney Int2008，73，6： | 1 |
| 4 | MS222 does not induce primary DNA damage in fish显示文摘 | BARRETO R E GONTIJO A M M C ALVES - DE - LIMA R O | 2007 | Aquac2007，15，2： | 1 |
| 5 | Monocrotaline pyrrol is cytotoxic and alters the patterns of GFAP expression on astrocyte primary cultures显示文摘 | Barreto R A Sousa C S Silva V D A | 2008 | Toxic in Vitro2008，22，： | 1 |
| 6 | Assessment of a small sawdust gasification unit 显示文摘 | WANDER P R ALTAFINI C R BARRETO R M | 2004 | Biomass and Bioenergy2004，27，： | 1 |
| 7 | The mycobiota of the weed Mikania micrantha in south Brazil with particular reference to fungal pathogens for biological control显示文摘 | Barreto R W Evans H C | 1995 | Mycol Rec1995，99，3： | 1 |
| 8 | The mycobiota of the weed Mikania micrantha in southern Brazil with particular reference to fungal pathogens for biological control显示文摘 | Barreto R W Evans H C | 1995 | Mycol Res1995，，3： | 1 |
| 9 | Decay rates for viscoelastic plates with memory显示文摘 | Lapa E C Barreto R | 1996 | J of Elasticity1996，44，1： | 1 |
| 10 | Decay rates for viscoelastic plates with memory显示文摘 | Lapa E C Barreto R | 1996 | J of Elasticity1996，44，1： | 1 |
| 11 | Large-scale ecological restoration of high-diversity tropical forests in Se Brazil显示文摘 | Rodrigues R R Gandolfi S Nave A G Aronson J Barreto T E Vidal C Y Brancalion P H | 2011 | Forest Ecology and Management2011，261，10： | 1 |
| 12 | Swim training does not protect mice from skeletal muscle oxidative damage following a maximum exercise test显示文摘 | Barreto T O Cleto L S Gioda C R | 2012 | Eur J Appl Physiol2012，112，7： | 1 |
| 13 | The mycobiota of the weed Mikania micrantha in southern Brazil with particular reference to fungal pathogens for biological control 显示文摘 | Barreto R W Evans H C | 1995 | Mycological Research1995，99，3： | 1 |
| 14 | Decay rates for viscoelastic plates with memory显示文摘 | Rivera J M Lapa E C Barreto R | 1996 | J of Elasticity1996，44，1： | 1 |
| 15 | Decay rates for viscoelastic plates with memory显示文摘 | RIVERA J E M LAPA E C BARRETO R | 1996 | Journal of Elasticity1996，44，1： | 1 |
| 16 | Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids 显示文摘 | Barreto M C Pinto R E Arrabaca J D | 2003 | Toxicol Lett2003，146，1： | 1 |
| 17 | Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids显示文摘 | BARRETO M C PINTO R E ARRABACA J D | 2003 | Toxi Lett2003，146，1： | 1 |
| 18 | Monocrotaline pyr - rol is cytotoxic and alters the patterns of GFAP expression on as- trocyte primary cultures显示文摘 | Barreto R A Sousa C S Silva V D A | 2008 | Toxic in Vitro2008，，22： | 1 |
| 19 | Biochimica et Biophysica Acta显示文摘 | Antunes F Marinho H S Barreto M C Pavao M L Pinto R E | 2003 | 1624:112003，1624，： | 1 |
| 20 | The impact of soil management on aggregation,carbon stabilization and carbon loss as CO_2 in the surface layer of a Rhodic Ferralsol in Southern Brazil显示文摘 | BARRETO R C MADARI B E MADDOCK J E L | 2009 | Agriculture Ecosystems&Environment2009，132，34： | 1 |
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