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| 1 | Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation显示文摘AIM:To investigate large tumor suppressor 1 (LATS1 ) expression, promoter hypermethylation, and microsatellite instability in colorectal cancer (CRC).METHODS:RNA was isolated from tumor tissue of 142 CRC patients and 40 colon mucosal biopsies of healthy controls. After reverse transcription, quantitative polymerase chain reaction (PCR) was performed, and LATS1 expression was normalized to expression of the ACTB and RPL32 housekeeping genes. To analyze hypermethylation, genomic DNA was isolated from 44 tumor CRC biopsies, and methylation-specific PCR was performed. Microsatellite instability (MSI) status was checked with PCR using BAT26, BAT25, and BAT40 markers in the genomic DNA of 84 CRC patients, followed by denaturing gel electrophoresis. RESULTS:Decreased LATS1 expression was found in 127/142 (89.4%) CRC cases with the average ratio of the LATS1 level 10.33 ± 32.64 in CRC patients vs 32.85 ± 33.56 in healthy controls. The lowest expression was found in Dukes' B stage tumors and G1 (welldifferentiated) cells. Hypermethylation of the LATS1 promoter was present in 25/44 (57%) CRC cases analyzed. LATS1 promoter hypermethylation was strongly associated with decreased gene expression; methylated cases showed 162× lower expression of LATS1 than unmethylated cases. Although high-grade MSI (mutation in all three markers) was found in 14/84 (17%) cases and low-grade MSI (mutation in 1-2 markers) was found in 30/84 (36%) cases, we found no association with LATS1 expression. CONCLUSION:Decreased expression of LATS1 in CRC was associated with promoter hypermethylation, but not MSI status. Such reduced expression may promote progression of CRC. | Piotr M Wierzbicki Krystian Adrych Dorota Kartanowicz Marcin Stanislawowski Anna Kowalczyk Janusz Godlewski Iwona Skwierz-Bogdanska Krzysztof Celinski Tomasz Gach Jan Kulig Bartlomiej Korybalski Zbigniew Kmiec | 2013 | World Journal of Gastroenterology2013，19，27： | 8 |
| 2 | Laser-induced white-light emission from graphene ceramics–opening a band gap in graphene显示文摘Recent theoretical and experimental studies have indicated the existence of a new stable phase of carbon with mixed sp^(2) and sp^(3) hybridized bonds—diaphite.Such a two-layered structure with sp^(2)/sp^(3) bonds may be observed after the photostimulation of highly oriented pyrolytic graphene with femtosecond laser pulses.This hidden multistability of graphene may be used to create a semiconducting phase immersed in the semimetallic continuum,resulting in bandgap opening.We demonstrate that bandgap opening and light emission from graphene is possible using continuous-wave laser beams with wavelengths from the visible(405 nm)to the near-infrared range(975 nm).We demonstrate that without the application of cooling,the effective temperature of the emitting sample remains lower than 900 K,which is far below the value predicted by the theory of black-body radiation.Moreover,light emission from a graphene sample may be observed at temperatures as low as 10 K. | Wieslaw Strek Bartlomiej Cichy Lukasz Radosinski Pawel Gluchowski Lukasz Marciniak Mikolaj Lukaszewicz Dariusz Hreniak | 2015 | Light(Science & Applications)2015，4，1： | 6 |
| 3 | Shape control over microwave hydrothermally grown Y2O3:Eu by europium concentration adjustment显示文摘Two-step synthesis of Y2O3:Eu nanostructures was performed.It includes microwave driven hydrothermal and calcination stages.Performed route results in crystallization of Y4O(OH)g(NO3):Eu crystals initially,then Y2O3:Eu crystals after calcination.Arranged Eu contents in relation to overall cation quantity were set to 2 mol%,10 mol%and 20 mol%.Varying europium concentrations influence habit of obtained Y4O(OH)g(NO3):Eu crystals from needle-like to plate-like and as a result,also shapes of final Y2O3:Eu nanostructures.Additionally,certain amount of Eu2+ions was detected in as-grown material using laser spectroscopy and decay kinetics measurements.Obtained material was calcined at 1200°C in the air,which results in oxidation of Eu2+ions and crystallization of small number of cubic EU2 O3 nanocrystals.Characterization of obtained materials was performed using XRD,SEM,TEM,EDX,CL,Raman and photoluminescence spectroscopy. | Jaroslaw Kaszewski Julita Rosowska Bartlomiej S.Witkowski Lukasz Wachnicki Karolina Wenelska Ewa Mijowska Lev-Ivan Bulyk Damian Wlodarczyk Andrzej Suchocki Boleslaw Kozankiewicz Marek Godlewski | 2019 | Journal of Rare Earths2019，37，11： | 3 |
| 4 | Coherent supercontinuum generation in soft glass photonic crystal fibers显示文摘An overview of the progress on pulse-preserving, coherent, nonlinear fiber-based supercontinuum generation is presented. The context encompasses various wavelength ranges and pump sources, starting with silica photonic crystal fibers pumped with 1.0 μm femtosecond lasers up to chalcogenide step-index and microstructured fibers pumped from optical parametric amplifiers tuned to mid-infrared wavelengths. In particular, silica and silicatebased all-normal dispersion(ANDi) photonic crystal fibers have been demonstrated for pumping with femtosecond lasers operating at 1.56 μm with the recorded spectra covering 0.9–2.3 μm. This matches amplification bands of robust fiber amplifiers and femtosecond lasers. The review therefore focuses specifically on this wavelength range, discussing glass and nonlinear fiber designs, experimental results on supercontinuum generation up to the fundamental limit of oxide glass fiber transmission around 2.8 μm, and various limitations of supercontinuum bandwidth and coherence. Specifically, the role of nonlinear response against the role of dispersion profile shape is analyzed for two different soft glass ANDi fibers pumped at more than 2.0 μm. A spatio-temporal interaction of the fundamental fiber mode with modes propagating in the photonic lattice of the discussed ANDi fibers is shown to have positive effects on the coherence of the supercontinuum at pump pulse durations of 400 fs. Finally, the design and development of graded-index, nanostructured core optical fibers are discussed.In such structures the arbitrary shaping of the core refractive index profile could significantly improve the engineering flexibility of dispersion and effective mode area characteristics, and would be an interesting platform to further study the intermodal interaction mechanisms and their impact on supercontinuum coherence for subpicosecond laser pumped setups. | MARIUSZ KLIMCZAK BARTLOMIEJ SIWICKI ALEXANDER HEIDT RYSZARD BUCZYNSKI | 2017 | Photonics Research2017，5，6： | 3 |
| 5 | Stewart-Treves syndrome angiosarcoma expresses phenotypes of both blood and lymphatic capillaries显示文摘 | Marek Stanczyk Magdalena Gewartowska Marcin Swierkowski Bartlomiej Grala Marek Maruszynski | 2013 | Chinese Medical Journal2013，，2： | 2 |
| 6 | Sphincter-preserving R0 total mesorectal excision with resection of internal genitalia combined with pre-or postoperative chemoradiation for T4 rectal cancer in females显示文摘AIM: To evaluate the impact of chemoradiation admi- nistered pre- or postoperatively on prognosis in females following R0 extended resection with sphincter- preserving total mesorectal excision (TME) for locally advanced rectal cancer and to assess the association between chemoradiation and intra- and postoperative variables. METHODS: Twenty-one females were treated for locally advanced but preoperatively assessed as primarily resectable rectal cancer involving reproductive organs. Anterior resection with TME and excision of internal genitalia was combined with neo- or adjuvant chemoradiation. Two-year disease-free survival analysis was performed with the Kaplan-Meier method and log- rank test. The association between chemoradiation and other variables was evaluated with the Fisher’s exact test and Mann-Whitney test. RESULTS: Survival rate decreased in anaemic females (51.5% vs 57.4%), in patients older than 60 years (41.8% vs 66.7%) with poorly differentiated cancers (50.0% vs 55.6%) and tumors located ≤ 7 cm from the anal verge (42.9% vs 68.1%) but with the lack of importance. Patients with negative lymph nodes and women chemoradiated preoperatively had significantly favourable prognosis (85.7% vs 35.7%; P= 0.03 and 80.0% vs 27.3%; P = 0.01, respectively). Preoperative chemoradiation compared to adjuvant radiochemotherapy was not significantly associated with the duration of surgery, incidence of intraoperative bowel perforation and blood loss ≥ 1 L, rate of postoperative bladder and anorectal dysfunction, and minimal distal resection margin. It significantly influenced minimal radial margin (mean 4.2 mm vs 1.1 mm; P < 0.01). CONCLUSION: Despite involving internal genitalia, long-term disease-free survival and sphincter preservation may be achieved with combined-modality therapy for females with T4 locally advanced rectal carcinoma. Neoadjuvant chemoradiation does not compromise functional results and may significantly improve oncological outcomes probably due to enhanced radial clearance. | Bartlomiej Szynglarewicz Rafal Matkowski Piotr Kasprzak Daniel Sydor Jozef Forgacz Marek Pudelko Jan Kornafel | 2007 | World Journal of Gastroenterology2007，13，16： | 2 |
| 7 | Optical performance monitoring of phase-modulated signals using asynchronous amplitude histogram analysis 显示文摘 | Bartlomiej Kozicki Ohara Takuya Takara Hidehiko | 2008 | Journal of Lightwave Technology2008，26，10： | 1 |
| 8 | Coexisting polymorphisms of and genes as a risk factor for persistent platelet activation with clopidogrel 显示文摘 | Malek LA Bartlomiej MD Spiewak M | 2008 | Circulation2008，72，7： | 1 |
| 9 | Investigations ofunderwater FHPP for welding steel overlap joints 显示文摘 | Andraej Ambroziak Bartlomiej Gul | 2007 | Archives of Civil and Mechanical Engineering2007，5，2： | 1 |
| 10 | Decision-aware data suppression in wireless sensor networks for target tracking applications显示文摘 | Bartlomiej PLACZEK | 2017 | Frontiers of Computer Science2017，11，6： | 1 |
| 11 | Experimental demonstration of spectrum-sliced elastic optical path network (SLICE)显示文摘 | BARTLOMIEJ K HIDEHIKO T YUKIO T | 2010 | Optics Express2010，18，22： | 1 |
| 12 | Surgical resection for persistent seroma,following modified radical mastectomy 显示文摘 | Marek S Bartlomiej G Tomasz Z | 2007 | World Journal of Surgical Oncology2007，5，： | 1 |
| 13 | Microcalorimetry as a possible tool for phenanthrene toxicity evaluation to eukaryotic cells显示文摘 | Katarzyna L Bartlomiej P Jerzy D | 2004 | Therm Acta2004，411，2： | 1 |
| 14 | Applicability of surface directional wells for upper Silesia Basin coal seams' drainage ahead of mining显示文摘Methods of exploitation drainage, which is presently applied in polish hard coal mines in Upper Silesian Coal Basin(Poland), are not effective enough, high risk of methane hazard can be observed, and production capacity of the mining plant is not fully used. Methane hazard, which may occur during planned coal exploitation, is presented in this paper. Following parameters are taken into consideration in the forecasts: coal extraction parameters, geological and mining conditions, deposit's methane saturation degree and impact of coal exploitation on the degasification coefficient of the seams, which are under the influence of relaxation zone. This paper presents the results of the analysis aiming to verify applicability of drainage ahead of mining of the coal seams by using surface directional wells. Based on the collected data(coal seams' structural maps, profiles of the exploratory wells, geological cross-sections), the lab tests of drilling cores and direct wells' tests, static model of the deposit was constructed and suitable grid of directional wells from the surface was designed. Comparison of forecasted methane emission volume between the two methods is investigated. The results indicated the necessity of performing appropriate deposit's stimulations in order to increase effectiveness of drainage ahead of mining. | Jura Bartlomiej Skiba Jacek Wierzbinski Krystian | 2014 | International Journal of Mining Science and Technology2014，24，3： | 1 |
| 15 | Idendification oflactic acid bacteria using FTIR spectroscopy and cluster analysis显示文摘 | BARTLOMIEJ D ANDRZEJ B DOROTA N ea al | 2007 | International Dairy Journal2007，17，： | 1 |
| 16 | Optical path ag- gregation for 1-Tbit/s transmission in spectrum-sliced elastic optical path network显示文摘 | BARTLOMIEJ K HIDEHIKO T YOSHIAKE S | 2010 | IEEE Photonics Technology Letters2010，22，17： | 1 |
| 17 | First report of intro- ducing population - based breast cancer screening in Poland : ex- perience of the 3 -million population region of Lower Silesia显示文摘 | RAFAL MATKOWSKI BARTLOMIEJ | 2011 | Cancer epidemiology2011，35，6： | 1 |
| 18 | Development of measurement techniques for determination main and hazardous components in biogas utilised for energy purposes显示文摘 | GRZEGORZ Piechota BARTLOMIEJ Iglifiski ROMAN Buczkowski | 2013 | Energy Conversion and Management2013，68，： | 1 |
| 19 | Photoconductance and inverse photoconductance in films of functionalized metal nanoparticles 显示文摘 | HIDEYUKI N KYLE J M B BARTLOMIEJ K | 2009 | Nature2009，460，37： | 1 |
| 20 | Mechano-chemlstry diffusion in multiocomponent compressible mixtures 显示文摘 | Mare Danielewski Bartlomiej Wierzba | 2008 | Physica2008，387，： | 1 |
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