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| 1 | From the stomach to other organs:Helicobacter pylori and the liver显示文摘Many recent studies have examined the importance of Helicobacter pylori(H. pylori) infection in the pathogenesis of the diseases outside the stomach and explored the significance of this bacterium in the pathogenesis of some metabolic and cardiovascular diseases. Recent studies have provided evidence that H. pylori is also involved in the pathogenesis of some liver diseases. Many observations have proved that H. pylori infection is important in the development of insulin resistance, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, liver fibrosis and cirrhosis. The worsening of liver inflammation of different origins also occurs during H. pylori infection. Some studies have indicated that H. pylori infection induces autoimmunological diseases in the liver and biliary tract. The potential significance of this bacterium in carcinogenesis is unclear, but it is within the scope of interest of many studies. The proposed mechanisms through which H. pylori impacts the development of hepatobiliary diseases are complex and ambiguous. The importance of other Helicobacter species in the development of hepatobiliary diseases is also considered because they could lead to the development of inflammatory, fibrotic and necrotic injuries of the liver and, consequently, to hepatocellular carcinoma. However, many contrary viewpoints indicate that some evidence is not convincing, and further studies of the subject are needed. This review presents the current knowledge about the importance of H. pylori in the pathogenesis of liver and in biliary diseases. | Marek Waluga Michal Kukla Michal Zorniak Agata Bacik Rafal Kotulski | 2015 | World Journal of Hepatology2015，7，18： | 11 |
| 2 | Graphene oxide paper as a saturable absorber for Er-and Tm-doped fiber lasers显示文摘In this work pulse generation in both the 1.5 and 2 μm spectral ranges using a graphene oxide(GO)-paper-based saturable absorber in Er-and Tm-doped fiber lasers is presented. The article describes the fabrication method of GO paper and its characterization. The performance of both lasers is discussed in detail. Stable, mode-locked operation provides 613 fs and 1.36 ps soliton pulses centered at 1565.9 and 1961.6 nm in Er-and Tm-doped fiber lasers, respectively. Furthermore, scaling of spectral width, and hence the pulse duration, by increasing the number of GO paper layers in the Er-doped laser is described. The versatility and simplicity of GO paper fabrication combined with the possibility of scaling the optical spectrum full width at half-maximum are essential features that make it a good candidate for ultrafast low-power mode-locked lasers operating in different spectral regions. | Jakub Boguslawski Jaroslaw Sotor Grzegorz Sobon Rafal Kozinski Krzysztof Librant Magdalena Aksienionek Ludwika Lipinska Krzysztof MAbramski | 2015 | Photonics Research2015，3，4： | 5 |
| 3 | Isolated right posterior bile duct injury following cholecystectomy:Report of two cases显示文摘Anatomic variations of the right biliary system are one of the most common risk factors for sectoral bile duct injury(BDI)during cholecystectomy.Isolated right posterior BDI may in particular be a challenge for both diagnosis and management.Herein we describe two cases of isolated right posterior sectoral BDI that took place during laparoscopic cholecystectomy.Despite effective external biliary drainage from the liver hilum in both cases,there was a persistent biliary leak observed which was not visible on endoscopic retrogradecholangiogram.Careful evaluation of images from both endoscopic and magnetic resonance cholangiograms revealed the diagnosis of an isolated right posterior sectoral BDI.These were treated with a delayed bisegmental(segments 6 and 7)liver resection and a Roux-en-Y hepaticojejunostomy respectively with good outcomes at 24 and 4 mo of follow-up.This paper discusses strategies for prevention of such injuries along with the diagnostic and therapeutic challenges it offers. | Maciej Wojcicki Waldemar Patkowski Tomasz Chmurowicz Andrzej Bialek Anna Wiechowska-Kozlowska Rafal Stankiewicz Piotr Milkiewicz Marek Krawczyk | 2013 | World Journal of Gastroenterology2013，19，36： | 5 |
| 4 | Microarray-based identification of tomato microRNAs and time course analysis of their response to Cucumber mosaic virus infection显示文摘A large number of plant microRNAs (miRNAs) are now documented in the miRBase, among which only 30 are for Solanum lycopersicum (tomato). Clearly, there is a far-reaching need to identify and profile the expression of miRNAs in this important crop under various physiological and pathological conditions. In this study, we used an in situ synthesized custom microarray of plant miRNAs to examine the expression and temporal presence of miRNAs in the leaves of tomato plants infected with Cucumber mosaic virus (CMV). Following computational sequence homology search and hairpin structure prediction, we identified three novel tomato miRNA precursor genes. Our results also show that, in accordance with the phenotype of the developing leaves, the tomato miRNAs are differentially expressed at different stages of plant development and that CMV infection can induce or suppress the expression of miRNAs as well as up-regulate some star miRNAs (miRNA*s) which are normally present at much lower levels. The results indicate that developmental anomalies elicited by virus infection may be caused by more complex biological processes. | Qiu-lei LANG Xiao-chuan ZHOU Xiao-lin ZHANG Rafal DRABEK Zhi-xiang ZUO Yong-liang REN Tong-bin LI Ji-shuang CHEN Xiao-lian GAO | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，2： | 3 |
| 5 | Land use and land cover changes in small Carpathian catchments between the mid-19^th and early 21^st centuries and their record on the land surface显示文摘Land use and land cover(LULC) changes and their impact on the mountain environment were studied in six catchments(~10 km^2 each) in the Polish Western Carpathians from the mid-19^(th) century to the early 21^(st) century. The analysis of cadastral and orthophoto maps indicates that during the investigated period, the forest area increased, quantified by an annual change index(Annch), between +0.12% to +0.27%, with a decrease of arable land index to –0.45% and –2.28% in the analysed catchments. LULC changes were accompanied by a continuous increase in settlement developments(residential and farming houses) by 50%-140% as well as significant changes related to their spatial distribution. Abandonment of arable land and forest succession have resulted in the geomorphological transformation of hillslopes, which predominantly includes a decrease in used road density, their transformation to road cuts and gorges. Overpopulation and the domination agriculture in the past caused the expansion of unpaved roads density and then the fragmentation of hillslopes, as well as the development of agricultural terraces. | Rafal KROCZAK Joanna FIDELUS-ORZECHOWSKA Anna BUCALA-HRABIA Tomasz BRYNDAL | 2018 | Journal of Mountain Science2018，15，12： | 3 |
| 6 | Invasion of the raccoon dog Nyctereutes procyonoides in Europe: History of colonization, features behind its success, and threats to native fauna显示文摘 | Kaarina KAUHALA Rafal KOWALCZYK | 2011 | Current Zoology2011，57，5： | 3 |
| 7 | Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans显示文摘 | Omenetti Alessia Porrello Alessandro Jung Youngmi Yang Liu Popov Yury Choi Steve S Witek Rafal P Alpini Gianfranco Venter Juliet Vandongen Hendrika M Syn Wing-Kin Baroni Gianluca Svegliati Benedetti Antonio Schuppan Detlef Diehl Anna Mae | 2008 | Journal of Clinical Investigation2008，，10： | 3 |
| 8 | Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia显示文摘 | Daniel Gackowski Rafal Rozalski Agnieszka Siomek Tomasz Dziaman Krzysztof Nicpon Maciej Klimarczyk Aleksander Araszkiewicz Ryszard Olinski | 2007 | Journal of the Neurological Sciences2007，，1： | 3 |
| 9 | Interleukin-1 beta induces the expression and production of stem cell factor by epithelial cells: crucial involvement of the PI-3K/mTOR pathway and HIF-1 transcription complex显示文摘在发炎和白血球过多症之间的潜在的交叉连接有一段时间被讨论了,但是支持这教义的试验性的证据是少见的。特别地,由煽动性的调停人理解为 proto-oncogenic 生长因素表情的潜在的 upregulation 负责的机制是重要的。这里,我们调查了高度煽动性的 cytokine interleukin-1 贝它的能力(IL-1β) 到导致干细胞因素(SCF ) 的生产,它是在造血的 myeloid 细胞的恶意的转变之上控制尖锐 myeloid 白血球过多症的前进的一个主要造血的生长因素。我们发现了那人的 IL-1β在 MCF-7 人的上皮的乳癌房间和那导致了 SCF 的表示 / 分泌物这个过程取决于组织缺氧可诱导的因素 1 (HIF-1 ) 抄写建筑群。我们也表明了 phosphatidylinositol-3 kinase (PI-3K ) 的一个关键角色 rapamycin (mTOR ) 的 /mammalian 目标在 IL-1β 的小径;导致的 HIF-1α在 MCF-7 房间的累积。重要地, mTOR 也被发现在 IL-1β 起一个作用;导致的 SCF 生产。而且,为 IL-1β 的积极关联的一个趋势;并且在健康人的施主的血浆的 SCF 层次被观察。总的来说,我们的结果表明那 IL-1β,它通常衔接天生、适应的免疫,通过 PI-3K/mTOR 小径和 HIF-1 抄写建筑群导致主要 haematopoietic/proleukaemic 生长因素 SCF 的生产。这些调查结果强烈支持在发炎和尖锐 myeloid 白血球过多症之间的串音。 | Rafal W Wyszynski Bernhard F Gibbs Luca Varani Daniela Iannotta Vadim V Sumbayev | 2016 | Cellular & Molecular Immunology2016，13，1： | 2 |
| 10 | Emission of BTEX and PAHs from molding sands with furan cold setting resins containing different contents of free furfuryl alcohol during production of cast iron显示文摘At present, furan resin is the largest selling no-bake system of moulding sands. The most commonly used furan no-bake binders(FNB) are condensation products of furfuryl alcohol(FA) urea, formaldehyde and phenol. They are generally cured by exposure to organic sulfonic acids. FNB provide excellent mold and core strength, cure rapidly and allow the sand to be reclaimed at fairly high yields, generally 75%-80%, especially in applications where due allowance is made for the need to keep total sulfur content below 0.1%. However, due to probable carcinogenic properties of furfuryl alcohol, the EU Directive limits the content of this substance(in a monomer form in resin) to 25%. The classification of furfuryl alcohol and the resulting furan resin products has changed from 'harmful' to 'toxic by inhalation'. The aim of this study was to determine the effect of free furfuryl alcohol content in the resin on the emission of harmful substances from the BTEX(Benzene Toluene Ethylbenzene & Xylene) and PAHs(polycyclic aromatic hydrocarbon) group exposed to high temperature and how it affects the emissions allowance of reclaimed sand in the matrix. Three resins from a leading manufacturer were examined, which contain a free furfuryl alcohol content of 71%-72%, about 50% and < 25%, respectively. The hardener for each resin was 65% aqueous solution of paratoluenesulfonic acid. Tests were carried out in semi-industrial conditions where liquid cast-iron was poured into sample sand mold at 1,350 °C. The matrix of the studied sands was reclaimed in the amount of 0, 50%, 100%, respectively.With the increase of free furfuryl alcohol content, the volume of evolved gases decreased. For all resins the main component from the BTEX group dominating in the emitted gases was benzene; however toluene also appeared in the amount of a few percentages. In contrast, ethylbenzene and xylenes occurred only in the gases emitted from resin-bonded sands with the largest furfuryl alcohol content. The increase in the share of reclaimed sands resulted in very significant increase in the volume of gas generated and participation of benzene in these gases. In terms of emission of compounds from the PAHs group virtually for all resins, the total content of these substances was comparable(within the limits of error). The main components were: fluoranthene, pyrene and benzo(a) anthracene. | Mariusz Holtzer Sylwia Zymankowska–Kumon Angelika Kmita Rafal Dańko | 2015 | China Foundry2015，12，6： | 2 |
| 11 | Hedgehog-Mediated Epithelial-to-Mesenchymal Transition and Fibrogenic Repair in Nonalcoholic Fatty Liver Disease显示文摘 | Wing–Kin Syn Youngmi Jung Alessia Omenetti Manal Abdelmalek Cynthia D. Guy Liu Yang Jiangbo Wang Rafal P. Witek Caitlin M. Fearing Thiago A. Pereira Vanessa Teaberry Steve S. Choi J. Conde–Vancells Gamze F. Karaca Anna Mae Diehl | 2009 | Gastroenterology2009，，4： | 2 |
| 12 | Sphincter-preserving R0 total mesorectal excision with resection of internal genitalia combined with pre-or postoperative chemoradiation for T4 rectal cancer in females显示文摘AIM: To evaluate the impact of chemoradiation admi- nistered pre- or postoperatively on prognosis in females following R0 extended resection with sphincter- preserving total mesorectal excision (TME) for locally advanced rectal cancer and to assess the association between chemoradiation and intra- and postoperative variables. METHODS: Twenty-one females were treated for locally advanced but preoperatively assessed as primarily resectable rectal cancer involving reproductive organs. Anterior resection with TME and excision of internal genitalia was combined with neo- or adjuvant chemoradiation. Two-year disease-free survival analysis was performed with the Kaplan-Meier method and log- rank test. The association between chemoradiation and other variables was evaluated with the Fisher’s exact test and Mann-Whitney test. RESULTS: Survival rate decreased in anaemic females (51.5% vs 57.4%), in patients older than 60 years (41.8% vs 66.7%) with poorly differentiated cancers (50.0% vs 55.6%) and tumors located ≤ 7 cm from the anal verge (42.9% vs 68.1%) but with the lack of importance. Patients with negative lymph nodes and women chemoradiated preoperatively had significantly favourable prognosis (85.7% vs 35.7%; P= 0.03 and 80.0% vs 27.3%; P = 0.01, respectively). Preoperative chemoradiation compared to adjuvant radiochemotherapy was not significantly associated with the duration of surgery, incidence of intraoperative bowel perforation and blood loss ≥ 1 L, rate of postoperative bladder and anorectal dysfunction, and minimal distal resection margin. It significantly influenced minimal radial margin (mean 4.2 mm vs 1.1 mm; P < 0.01). CONCLUSION: Despite involving internal genitalia, long-term disease-free survival and sphincter preservation may be achieved with combined-modality therapy for females with T4 locally advanced rectal carcinoma. Neoadjuvant chemoradiation does not compromise functional results and may significantly improve oncological outcomes probably due to enhanced radial clearance. | Bartlomiej Szynglarewicz Rafal Matkowski Piotr Kasprzak Daniel Sydor Jozef Forgacz Marek Pudelko Jan Kornafel | 2007 | World Journal of Gastroenterology2007，13，16： | 2 |
| 13 | Topiramate select ively protects against seizures induced by ATPA,a GluR5 kainme receptor agonist显示文摘 | Rafal M Kaminski MB Rogawski MA | 2004 | Neuropharmacology2004，46，： | 1 |
| 14 | Shifting visual attention between object and locations: evidence from normal and parietal lesion subjects 显示文摘 | Egly R Driver J Rafal R | 1994 | J Exp Psychol Gen1994，123，1： | 1 |
| 15 | Bone Marrow–Derived Hepatic Oval Cells Differentiate Into Hepatocytes in 2-Acetylaminofluorene/Partial Hepatectomy–Induced Liver Regeneration显示文摘 | Seh–Hoon Oh Rafal P. Witek Si–Hyun Bae Donghang Zheng Youngmi Jung Anna C. Piscaglia Bryon E. Petersen | 2007 | Gastroenterology2007，，： | 1 |
| 16 | Application of organic forms of zinc, copperand manganese in the first three months of dairy cow lactation and their effect on the yield, composition and quality of milk显示文摘 | Stefania Kinal Rafal Bodarski Adolf Kofniewicz | 2005 | Bull Vet Inst Pulawy2005，49，： | 1 |
| 17 | Embryogenesis and plant regeneration from maize zygotes by in vitro culture of fertilized embryo sacs显示文摘 | Rafal Mol Elisabeth Matthys-Rochon Christian Dumas | 1995 | Plant Cell Reports1995，，12： | 1 |
| 18 | Optimal selection of ensemble classifiers using measures of competence and diversity of base clas- sifiers 显示文摘 | RAFAL L MAREK K TOMASZ W | 2014 | Neurocomputing2014，，： | 1 |
| 19 | Peptide specificity of thy- mic selection for CD4^+ ,CD25^+T cell 显示文摘 | Rafal P Piofr K Lesze K I | 2002 | J Immunol2002，168，2： | 1 |
| 20 | Derangement of body representa- tion in complex regional pain syndrome: report of a case treated with mirror and prisms显示文摘 | Bultitude JH Rafal RD | 2010 | Exp Brain Res2010，204，40： | 1 |
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