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| 1 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 2 | 2-Week triple therapy for Helicobacter pylori infection is better than 1-week in clinical Practice: a large prospective single-center randomized st udy显示文摘 | Paoluzi P Iacopini F Crispino P Nardi F Bella A Rivera M Rossi P Gurnari M Caracciolo F Zippi M Pica R | 2006 | Helicobacter2006，11，： | 1 |
| 3 | Glass-basah/epoxy hybrid composites for marine applications显示文摘 | Fiore V Di Bella G Valenza A | 2011 | Materials & Design2011，32，4： | 1 |
| 4 | Impact of diabetes on overall and cancer- specific mortality in colorectal cancer patients显示文摘 | Bella F Minicozzi P Giacomin A | 2013 | J Cancer Res Clin Oncol2013，139，8： | 1 |
| 5 | Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity : a key mechanism in osteoporosis显示文摘 | D' Amelio P Grimaldi A Di Bella S | 2008 | Bone2008，43，1： | 1 |
| 6 | Phytopathol显示文摘 | BELLA A WHEELER M H | 1986 | ANN REV1986，24，： | 1 |
| 7 | Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28显示文摘 | Di Bella D Lazzaro F Brusco A | 2010 | Nat Genet2010，42，4： | 1 |
| 8 | Approach to 3-aminoindolin-2-ones via oxime ether functionalized carbamoylcyclohexadienes 显示文摘 | BELLA A F SLAWIN A M WALTON J C | 2004 | J Org Chem2004，69，18： | 1 |
| 9 | Intrathecal baclofen therapy in patients with severe spasticity显示文摘 | Marra G A Aleo G Di Bella P | 2007 | Aeta Neuroehir Suppl2007，97，1： | 1 |
| 10 | Association of IL-10 polymorphism with severity of illness in community acquired pneumonia 显示文摘 | GALLAGHER P M LOWE G BELLA A ctal | 2003 | J Throax2003，58，2： | 1 |
| 11 | Human lymphocyte stimula-tion with pouchitis flora is greater than with flora from a healthypouch but is suppressed by metronidazole显示文摘 | BELLA J NICHOLLS R J FORBES A | 2004 | Gut2004，53，： | 1 |
| 12 | Aberrant nuclear factor-kB/Rel expression and the pathogenesis of breast cancer显示文摘 | SOVAK M A BELLAS R E KIM D W | 1997 | J Clln Invest1997，100，12： | 1 |
| 13 | Structure-performance correlation of nanocellulose-based polymer electrolytes for efficient quasi-solid DSSCs显示文摘 | Chiappone A Bella F Nair J R | 2014 | Chemelectrochem2014，1，8： | 1 |
| 14 | Sulfide production in anaerobic microcosms显示文摘 | Ramn A E D A Bella | 1974 | Limnol Oceanogr1974，19，1： | 1 |
| 15 | T-shaped shunt and intracavernous tunneling for prolonged ischemic priapism 显示文摘 | Brant WO Garcia MM Bella A J | 2009 | J Urol2009，181，： | 1 |
| 16 | Genome-wide linkage mapping for valve calcification susceptibility loci in hypertensive sibships:the Hypertension Genetic Epidemiology Network Study显示文摘 | Bella JN Tang W Kraja A | 2007 | Hypertension2007，49，： | 1 |
| 17 | Poor sperm mor- phology-is it only ICSI, or is there another alternative? 显示文摘 | Adler A La Bella PA Mc Caffrey C | 2000 | Fertil Steril2000，74，3： | 1 |
| 18 | Flow characterization of a high performance SI engine intake system - Part 2: numerical analysis显示文摘 | Bella G Maio A De Grimaldi C N | 2003 | SAE2003，，： | 1 |
| 19 | Evaluation of biodiesel storage stability using reference methods 显示文摘 | BONDIOLI P GASPAROLI A BELLA L D | 2004 | Eur J Lipid Sci Technol2004，104，12： | 1 |
| 20 | 显示文摘 | BELLA S D FRAGALA I GUERRI A | 2004 | Inorg Chim Acta2004，357，4： | 1 |
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