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| 1 | Genetic epidemiology of irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS) is the most common functional gastrointestinal disorder characterized by presence of abdominal pain or discomfort associated with altered bowel habits. It has three main subtypes- constipation predominant IBS(C-IBS),diarrhea predominant IBS(D-IBS) and IBS with mixed featuresof both diarrhea as well as constipation(M-IBS). Its pathophysiology and underlying mechanisms remain elusive. It is traditionally believed that IBS is a result of multiple factors including hypersensitivity of the bowel,altered bowel motility,inflammation and stress. Initial studies have shown familial aggregation of IBS suggesting shared genetic or environmental factors. Twin studies of IBS from different parts of world have shown higher concordance rates among monozygotic twins than dizygotic twins,and thus suggesting a genetic component to this disorder. Multiple studies have tried to link single-nucleotide polymorphisms(SNPs) to IBS but there is little evidence that these SNPs are functional. Various molecules have been studied and investigated by the researchers. Serotonin,a known neurotransmitter and a local hormone in the enteric nervous system,has been most extensively explored. At this time,the underlying gene pathways,genes and functional variants linked with IBS remain unknown and the promise of genetically-determined risk prediction and personalize medicine remain unfulfilled. However,molecular biological technologies continue to evolve rapidly and genetic investigations offer much promise in the intervention,treatment and prevention of IBS. | Jasbir Makker Sridhar Chilimuri Jonathan N Bella | 2015 | World Journal of Gastroenterology2015，21，40： | 20 |
| 2 | A long-term study of Pinus banksiana population dynamics 显示文摘 | Kenkel N C Hendrie M L Bella I E | 1997 | Journal of Vegetation Science1997，，8： | 1 |
| 3 | Effect of type 2 diabetes mellitus on left ventricular geometry and systolic function in hypertensive subjects 显示文摘 | Palmieri V Bella J N Arnett D K | 2001 | Circulation2001，103，1： | 1 |
| 4 | A long-term study of Pinus banksiana population dynamics显示文摘 | KENKEI N C HENDRIE M L BELLA I E | 1999 | Journal of Vegetation Science1999，，10： | 1 |
| 5 | Flow characterization of a high performance SI engine intake system - Part 2: numerical analysis显示文摘 | Bella G Maio A De Grimaldi C N | 2003 | SAE2003，，： | 1 |
| 6 | Effect of type 2 diabetes mellituson left vcntricular geometry and systolic function in hypertensive subjects: Hypertension Genetic Epidemiology Net- work(nyerGEN) study显示文摘 | PALMIERI V BELLA J N ARNETT D K | 2001 | Circulation2001，103，1： | 1 |
| 7 | Real - time fisheye lens distortion correction using automatically generated streaming accelera- tors 显示文摘 | BELLAS N CHAI S M | 2009 | IEEE Computer Soc2009，，16： | 1 |
| 8 | The impact of diabetes on left ventricular filling pattern in normotensive and hypertensive adults: the strong heart study显示文摘 | Jennifer E Liu Vittorio Palmieri Mary J Roman Jonanthan N Bella Richard Fabsitz Barbara V Howard Thomas K Welty Elisa T Lee Richard B Devereux | 2001 | Journal of the American College of Cardiology2001，，7： | 1 |
| 9 | Effect of electrocardiographic left ventricular hypertrophy on left ventricular systolic function in sys temic hypertension (the LIFE study ) 显示文摘 | WACHTELL K ROKKEDAL J BELLA J N | 2001 | Am J Cardiol2001，87，： | 1 |
| 10 | Left atrial diam- eter as an independent predictor of first clinical cardiovas- cular events in middle-aged and elderly aduhs:the Strong Heart Study(SnS) 显示文摘 | Kizer J R Bella J N Palmieri V | 2006 | Am Heart J2006，151，2： | 1 |
| 11 | Albuminuria predicts cardiovascular events independently of left ventricular mass in hypertension: a LIFE substudy显示文摘 | OLSEN M H WACHTELL K BELLA J N | 2004 | J Hum Hypertens2004，18，6： | 1 |
| 12 | Stromal stem cells and platelet-rich plasma improve bone allograft integration显示文摘 | Lucarelli E Fini M Becheroni A Giavaresi G Di Bella C Aldini N N | 2005 | Clin Or- thop Relat Res2005，435，： | 1 |
| 13 | Relationship between left ventricular diastolic relaxation and systolic function in hypertension: The hypertension genetic epidemiology network ( HyperGEN) study显示文摘 | BELLA J N PALMIERI V LIU J E | 2001 | Hypertension2001，38，： | 1 |
| 14 | Heterofunctional linking agents for the synthesis of well-defined block copolymers of dimethylsiloxane and tert-butyl methacrylate or 2-vinylpyridine显示文摘 | Bellas V Iatrou H Pitsinos E N | 2001 | Macromolecules2001，34，16： | 1 |
| 15 | FK1706 enhances the recovery of erectile function following bilateral cavernous nerve crush injury in the rat 显示文摘 | Bella AJ Hayashi N Carrion RE | 2007 | J Sex Med2007，4，2： | 1 |
| 16 | Associations of aortic and mitral regurgitation with body composition and myocardial energy expenditure in adults with hypertension: the hypertension genetic epidemiology network study显示文摘 | PALMIERI V BELLA J N ARNETY D K | 2003 | Am HeartJ2003，145，6： | 1 |
| 17 | Western analyses of preg- nancy-associated glycoprotein family (PAG) in placental extracts of various mammals 显示文摘 | Bella A Sousa N M Dehimi M L | 2007 | Theriogenology2007，68，： | 1 |
| 18 | Controlled anionic polymerization of hexamethylcyclotrisiloxane,model linear and miktoarm star Co-and terpolymers of dimethylsiloxane with styrene and isoprene显示文摘 | BELLAS V IATROU H HADJICHRISTIDIS N | 2000 | Macromolecules2000，33，19： | 1 |
| 19 | Results of a phase 2 study of bortezomib in patients with relapsed or refractory indolent lymphorna 显示文摘 | Di Bella N Taetle R Kolibaba K | 2010 | Blood2010，115，3： | 1 |
| 20 | Genetic epidemiology of irrita- ble bowel syndrome 显示文摘 | Makker J Chilimuri S Bella J N | 2015 | World J Gastroenterol2015，21，11： | 1 |
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