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| 1 | Gut bless you:The microbiota-gut-brain axis in irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is a common clinical label for medically unexplained gastrointestinal symptoms,recently described as a disturbance of the microbiota-gut-brain axis.Despite decades of research,the pathophysiology of this highly heterogeneous disorder remains elusive.However,a dramatic change in the understanding of the underlying pathophysiological mechanisms surfaced when the importance of gut microbiota protruded the scientific picture.Are we getting any closer to understanding IBS’etiology,or are we drowning in unspecific,conflicting data because we possess limited tools to unravel the cluster of secrets our gut microbiota is concealing?In this comprehensive review we are discussing some of the major important features of IBS and their interaction with gut microbiota,clinical microbiota-altering treatment such as the low FODMAP diet and fecal microbiota transplantation,neuroimaging and methods in microbiota analyses,and current and future challenges with big data analysis in IBS. | Eline Margrete Randulff Hillestad Aina van der Meeren Bharat Halandur Nagaraja Ben RenéBjørsvik Noman Haleem Alfonso Benitez-Paez Yolanda Sanz Trygve Hausken Gülen Arslan Lied Arvid Lundervold Birgitte Berentsen | 2022 | World Journal of Gastroenterology2022，28，4： | 15 |
| 2 | PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus显示文摘地岬在许多细胞的活动起一个枢轴的作用,并且它的 subcellular 区分提供空间、时间的选择。这里,我们报导由二高度相应的蛋白质 PAQR10 和孕激素和 AdipoQ 受体家庭的 PAQR11 在 Golgi 仪器发信号的地岬的空间规定的一个模式。PAQR10 和 PAQR11 在 Golgi 仪器是只局部性的。PAQR10/PAQR11 的 Overexpression 刺激基础、导致 EGF 的英皇家空军之阶级最低之兵 phosphorylation 并且以一种剂量依赖者方式增加英皇家空军之阶级最低之兵目标基因的表示。PAQR10/PAQR11 的 Overexpression 显著地提高 HRas, NRas 和 KRas4A 的 Golgi 本地化,然而并非 KRas4B。PAQR10 和 PAQR11 罐头也与 HRas, NRas 和 KRas4A 交往,然而并非 KRas4B。在由 PAQR10/PAQR11 的 overexpression 的 Golgi 仪器的增加的地岬蛋白质处于一个活跃状态。一致地, PAQR10 和 PAQR11 还原剂击倒在 Golgi 仪器的刺激 EGF 的英皇家空军之阶级最低之兵 phosphorylation 和地岬激活。有趣地, PAQR10 和 PAQR11 能与 RasGRP1,地岬的 guanine 核苷酸交换蛋白质,和 RasGRP1 的增加 Golgi 本地化交往。RasGRP1 的 C1 领域为和 PAQR10/PAQR11 的 RasGRP1 的相互作用必要、足够。由 overexpressed PAQR10/PAQR11 的英皇家空军之阶级最低之兵 phosphorylation 的模拟被 RasGRP1 的 downregulation 废除。而且, PC12 房间的区别被 PAQR10/PAQR11 的 overexpression 显著地提高。一起,这研究揭开由 PAQR10 和 PAQR11 在 Golgi 仪器发信号的地岬的空间规定的一个新范例。 | Ting Jin Qiurong Ding Heng Huang Daqian Xu Yuhui Jiang Ben Zhou Zhenghu Li Xiaomeng Jiang Jing He Weizhong Liu Yixuan Zhang Yi Pan Zhenzhen Wang Walter G Thomas Yan Chen | 2012 | Cell Research2012，22，4： | 6 |
| 3 | Prediction of genetic value for sweet cherry fruit maturity among environments using a 6K SNP array显示文摘The timing of fruit maturity is an important trait in sweet cherry production and breeding.Phenotypic variation for phenology of fruit maturity in sweet cherry appears to be under strong genetic control,but that control might be complicated by phenotypic instability across environments.Although such genotype-by-environment interaction(G×E)is a common phenomenon in crop plants,knowledge about it is lacking for fruit maturity timing and other sweet cherry traits.In this study,1673 genome-wide SNP markers were used to estimate genomic relationships among 597 weakly pedigree-connected individuals evaluated over two seasons at three locations in Europe and one location in the USA,thus sampling eight‘environments’.The combined dataset enabled a single meta-analysis to investigate the environmental stability of genomic predictions.Linkage disequilibrium among marker loci declined rapidly with physical distance,and ordination of the relationship matrix suggested no strong structure among germplasm.The most parsimonious G×E model allowed heterogeneous genetic variance and pairwise covariances among environments.Narrow-sense genomic heritability was very high(0.60–0.83),as was accuracy of predicted breeding values(>0.62).Average correlation of additive effects among environments was high(0.96)and breeding values were highly correlated across locations.Results indicated that genomic models can be used in cherry to accurately predict date of fruit maturity for untested individuals in new environments.Limited G×E for this trait indicated that phenotypes of individuals will be stable across similar environments.Equivalent analyses for other sweet cherry traits,for which multiple years of data are commonly available among breeders and cultivar testers,would be informative for predicting performance of elite selections and cultivars in new environments. | Craig M.Hardner Ben J.Hayes Satish Kumar Stijn Vanderzande Lichun Cai Julia Piaskowski JoséQuero-Garcia JoséAntonio Campoy Teresa Barreneche Daniela Giovannini Alessandro Liverani Gérard Charlot Miguel Villamil-Castro Nnadozie Oraguzie Cameron P.Peace | 2019 | Horticulture Research2019，6，1： | 5 |
| 4 | A chemical method to graft carbon nanotubes onto a carbon fiber显示文摘 | Abdelghani Laachachi Alexandre Vivet Gérard Nouet Bessem Ben Doudou Christophe Poilane Jun Chen Jin Bo bai M’Hamed Ayachi | 2007 | Materials Letters2007，，3： | 3 |
| 5 | Bacteriocin-based strategies for food biopreservation显示文摘 | Antonio Gálvez Hikmate Abriouel Rosario Lucas López Nabil Ben Omar | 2007 | International Journal of Food Microbiology2007，，1： | 2 |
| 6 | Influence of the temperature on the properties of sputtered titanium oxide films显示文摘 | Ben Amor S Guedri L Baud G | 2003 | Materials Chemistry and Physics2003，77，3： | 1 |
| 7 | Diagnostic accuracy of clinical symptoms and signs in children w:th meningitis 显示文摘 | Amarilyo G Alper A Ben - Tov A | 2011 | Pediatr Errverg Care2011，27，3： | 1 |
| 8 | Contributions fromglacially derived sediment to the global iron(oxyhydroxide)cy-cle:Implications for iron delivery to the oceans显示文摘 | Raiswell R Tranter M Benning L G | 2006 | Geochimicaet Cosmochimica Acta2006，70，11： | 1 |
| 9 | Simulation of IR images of natural backgrounds显示文摘 | Ben Y N Rahat B Feigin G | 1983 | Applied Optics1983，22，1： | 1 |
| 10 | Use of Genetic Algorithms for Neural Networks to Predict Community-acquired Pneumonia显示文摘 | Paul S H Ben S G Thomas G T | 2004 | Artificial Intelligence in Medicine2004，30，： | 1 |
| 11 | Characterization of Zireonia Films Deposited by RF Magnetron Sputtering 显示文摘 | Ben Amor S Rogier B Baud G | 1998 | Materials Science and Engineering: B1998，7，1： | 1 |
| 12 | Three-dimensional structure of myosin subfragment-1 : a molecular motor显示文摘 | Rayment I Rypniewski WR Schmidt-Base K Smith R Tomchik DR Benning MM Winkelmann DA Wesenberg G Holden HM | 1993 | Science1993，261，： | 1 |
| 13 | Hydrosulphide complexing of Au (Ⅰ)in hydrothermal solutions from 150-400℃ and 500-1500 bar显示文摘 | Benning L G Seward T M | 1996 | Geochimica et Cosmochimica Acta1996，60，11： | 1 |
| 14 | ILAE Treatment Guidelines:evidence-based analysis of antiepileptic drug efficacy andeffectiveness as initial monotherapy for epileptic seizures andsyndromes显示文摘 | Tracy G Ben M Blaise B | 2006 | Epilepsia2006，47，7： | 1 |
| 15 | Communication between multiple drug binding sites on P - glycoprotein 显示文摘 | Martin C Ben'idge G Higgins CF | 2000 | Mol Pharmacol2000，58，3： | 1 |
| 16 | Structural and optical properties of sputtered ZnO films显示文摘 | BACHARI E M BAUD G BEN AMOR S JACQUET M | 1999 | Thin Solid Films1999，348，12： | 1 |
| 17 | Functional efficacy of glatiramer acetate treatment for laser - induced retinal damage in rats 显示文摘 | Belokopytov M Ben -Shlomo G Bosner M | 2008 | Lasers Surg Med2008，40，： | 1 |
| 18 | DNA topoisomerase IIstructures and anthracycline activity: insights into ternary com-plex formation显示文摘 | Dal Ben D Palumbo M Zagotto G | 2007 | Curr Pharm Des2007，13，27： | 1 |
| 19 | Overview of flotation deinking显示文摘 | Dorris G Ben Y Ricard M | 2011 | Progress in paper recycling2011，20，1： | 1 |
| 20 | Calcium channels activatd by hydrogen peroxide mediate abscisic acid signaling in guard cells 显示文摘 | Pei Z M Murata Y Benning G | 2000 | Nature2000，406，： | 1 |
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