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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Sympathetic responses to induction of anaesthesia in humans with propofol or etomidate显示文摘 | Ebert TJ Muzi M Berens R | 1992 | Anesthesiology1992，76，： | 1 |
| 3 | Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration显示文摘 | Wu Y Siadaty M S Berens M E | 2008 | Oncogene2008，27，52： | 1 |
| 4 | Molecular Mechanisms of Glioma Cell Migration and Invasion显示文摘 | Demuth T Berens M E | 2004 | Journal of Neurooncology2004，70，2： | 1 |
| 5 | Corporate associations in th?; academicliterature : Three main streams of thought in the reputation measure-ment literature 显示文摘 | BERENS G van KIEL C B M | 2004 | Corporate Reputation Review2004，7，2： | 1 |
| 6 | Sympathetic responses to induction of anesthesia in humans with propofol or etomidate显示文摘 | Ebert TJ Muzi M Berens R | 1992 | Anesthesiology1992，76，5： | 1 |
| 7 | Sympathetic responses to induction of anesthesia in humans with propofol or etomidate 显示文摘 | EBERT T J MUZI M BERENS R | 1992 | Anesthesiaology1992，76，： | 1 |
| 8 | Sympathetic responses to induction of anesthesia in humans with propofol or etomldate 显示文摘 | Ebert TJ Muzi M Berens R | 1992 | Anesthesiology1992，76，： | 1 |
| 9 | Corporate Associations and Consumer Product Responses : The Moderating Role of Corporate Brand Dominance 显示文摘 | Beren Guido Van Riel B M and Van Bruggen Gerrit | 2005 | Journal of Marketing2005，，69： | 1 |
| 10 | A Novel TetR-Regulaling Peptide Turns off rtTA Mediated Activation of Gene Expression 显示文摘 | Schmidt S Berens C Klotzsche M | 2014 | OLOS One2014，9，96： | 1 |
| 11 | Sympathetic responses to induction of anesthesia in humans with propofol or etomidate显示文摘 | Ebert TJ Muzi M Berens R | 1992 | Anesthesiology1992，76，5： | 1 |
| 12 | Stimulating Strategi-cally Aligned Behaviour Among Employees 显示文摘 | RIEL C B M van BERENS G DUKSTRA M | 2009 | Journal of Manage-ment Studies2009，，7： | 1 |
| 13 | Overlapping gene expression profiles of cell migration and tumor in- vasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regu- lators of cell migration显示文摘 | Wu Y Siadaty M S Berens M E | 2008 | Oncogene2008，27，： | 1 |
| 14 | Sympathetic responses to induction of anesthesia in humans with propofol or etomidate 显示文摘 | Ebert TJ Muzi M Berens R | 1992 | Anesthesiology1992，76，5： | 1 |
| 15 | Altered skin integrity in children admitted to a pediatric intensive care unit显示文摘 | Zollo M B Gostisha M L Berens R J | 1996 | J Nurs Care Qual1996，11，2： | 1 |
| 16 | Corporate associations in the academic literature:three main streams of thought in the reputation measurement literature显示文摘 | BERENS G VANRC B M | 2004 | Corporate Reputation Review2004，7，2： | 1 |
| 17 | Acquired mutations in TET2 are common in myelodysplastic syndromes显示文摘 | LANGEMEIJERS M KUIPER R P BEREN M | 2009 | Nat Genet2009，41，7： | 1 |
| 18 | Overlapping gene expression profiles of cell migration and tumor invasion in hum an bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration transcriptomes of bladder cancer migration显示文摘 | WU Y SIADATY M S BERENS M E | 2008 | Oncogene2008，27，52： | 1 |
| 19 | FKS06 binding protein mediates glioma cell growth and sensitivity to rapamycin treatment by regulating NF-kappaB signaling pathway显示文摘 | Jiang W Cazacu S Xiang C Zenklusen J C Fine H A Berens M | 2008 | Neoplasia2008，10，： | 1 |
| 20 | Corporate associations and consumer product responses:the moderating roleof corporate brand dominance 显示文摘 | BERENS G VAN RIEL C B M VAN BRNGGEN G tt | 2005 | Journal of marketing2005，69，3： | 1 |
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