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| 1 | Recombinant streptokinase vs hydrocortisone suppositories in acute hemorrhoids:A randomized controlled trial显示文摘AIM: To compare the efficacy and safety of recombinant streptokinase(rSK) vs hydrocortisone acetate-based suppositories in acute hemorrhoidal disease.METHODS: A multicenter(11 sites), randomized(1:1:1), open, controlled trial with parallel groups was performed. All participating patients gave their written,informed consent. After inclusion, patients with acute symptoms of hemorrhoids were centrally randomized to receive, as outpatients, by the rectal route, suppositories of rSK 200000 IU of one unit every 8 h(first 3 units)and afterwards every 12 h until 8 administrations were completed(schedule A), one unit every 8 h until 6 units were completed(schedule B), or 25 mg hydrocortisone acetate once every 8 h up to a maximum of 24 administrations. Evaluations were performed at 3, 5,and 10 d post-inclusion. The main end-point was the 5thday response(disappearance of pain and bleeding, and≥ 70% reduction of the lesion size). Time to response and need for thrombectomy were secondary efficacy variables. Adverse events were also evaluated.RESULTS: Groups were homogeneous with regards to demographic and baseline characteristics. Fifth day complete response rates were 156/170(91.8%; 95%CI:87.3-96.2), 155/170(91.2%; 95%CI: 86.6%-95.7%),and 46/170(27.1%; 95%CI: 20.1%-34.0%) with rSK(schedule A and B) and hydrocortisone acetate suppositories, respectively. These 64.6% and 63.9%differences(95%CI: 56.7%-72.2% and 55.7%-72.0%)were highly significant(P < 0.001). This advantage was detected since the early 3rd day evaluation(68.8% and64.1% vs 7.1% for the rSK and active control groups,respectively; P < 0.001) and was maintained even at the late 10 th day assessment(97.1% and 93.5% vs67.1% for rSK and hydrocortisone acetate, respectively;P < 0.001). Time to response was 3 d(95%CI: 2.9-3.1)for both rSK groups and 10 d(95%CI: 9.3-10.7) in the hydrocortisone acetate group. This difference was highly significant(P < 0.001). All subgroup stratified analyses(with or without thrombosis and hemorrhoid classification) showed a statistically significant advantage for the rSK groups. Thrombectomy was necessary in4/251 and 14/133 patients with baseline thrombosis in the rSK and hydrocortisone acetate groups, respectively(P < 0.001). There were no adverse events attributable to the experimental treatment.CONCLUSION: rSK suppositories showed a significant advantage over a widely-used over-the-counter hydrocortisone acetate preparation for the treatment of acute hemorrhoidal illness, as well as having an adequate safety profile. | Francisco Hernández-Bernal Georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-Alvarez Osmany Martínez-Serrano Odalys C Lazo-Diago Cimara H Bermúdez-Badell José R Causa-García Juan E Domínguez-Suárez Pedro A López-Saura 无 | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 2 | Analysis of factors for conversion of laparoscopic to open cholecystectomy: a prospective study of 703 patients with acute cholecystitis显示文摘 | Domínguez LC Rivera A Bermúdez C | 2011 | Cir Esp2011，89，5： | 1 |
| 3 | Targeted treatments for cervical cancer:a review显示文摘 | PERALTA-ZA RAGOZA O BERM(U)DEZ-MORALES VH P(E)REZ-PLASENCIA C | | 0，，03： | 1 |
| 4 | Spectrophometric Color Matching Based on Two constant Kubelka-Munk Theory显示文摘 | WALOW ITW MC CARTHY C J BERMS R S | 1988 | Col Res App l1988，13，6： | 1 |
| 5 | Hospitalized Patients with Novel Influenza A (H1N1) Virus Infection - California, April-May, 2009显示文摘 | Louie J Winter K Harriman K Vugia D Glaser C Matyas B Schnurr D Guevara H Pan C Y Saguar E Berumen R Hunley E Messenger S Preas C Hatch D Chavez G Kriner P Lopez K Sunega D Rexin D Roach S Kempf J Gonzalez R Morgan L Barnes N Berm | 2009 | MMWR Morbidity and Mortality Weekly Report2009，，19： | 1 |
| 6 | Immunomodulatory effects of IL-12 secreted by Lactococcus lactis on Th1/Th2 balance in ovalbumin (OVA)-induced asthma model mice显示文摘 | Wu C Y Yang G Bermúdez-Humarán L G | 2006 | Int Immunopharmacol2006，6，4： | 1 |
| 7 | Second trimester maternal serum analytes in triploid pregnancies:correlation with phenotype and sex chromosome complement显示文摘 | Berm PA Gainey A Ingardia C J | 2001 | Prenat Diagn2001，21，8： | 1 |
| 8 | Modeling,system identification and robust control of a coaxial micro helicopter显示文摘 | Schafroth D Bermes C Bouabdallah S | 2010 | Control Engineering Practice2010，18，7： | 1 |
| 9 | Influence of phosphorus on Cu sorption kinetics:Stirred flow chamber experiments显示文摘 | P(E)REZ-NOVO C FERN(A)NDEZ-CALV(I)NO D BERM (U)DEZ-COUSO A | | 0，，： | 1 |
| 10 | Association between apoliprotein E gene polymorphism snd hypercholesterolemic phenotype io Maracaibo,Zulia state,Venezuela显示文摘 | Arráiz N Bermúdez V Prieto C | | 0，，： | 1 |
| 11 | Nonlinear Lamb waves for the detection of material nonlinearity 显示文摘 | Bermes C Kim J Y Qu J M Jaeobs L J | 2008 | Mechanical Systems and Signal Processing2008，22，： | 1 |
| 12 | Hysteretic linear and nonlinear acoustic responses from pressed interfaces显示文摘 | KIM J Y BALTAZAR A Hid J W BERMES C | 2006 | International Journal of Solids and Structures2006，43，21： | 1 |
| 13 | Current status of clinical islet transplantation显示文摘 | Korsgren O Nilsson B Berme C | 2005 | Transplantation2005，79，10： | 1 |
| 14 | Nonlinear Lamb waves for the detection of material nonlinearity显示文摘 | BERMES C KIM J Y QU J | 2008 | Mechanical Systems and Signal Processing2008，22，4： | 1 |
| 15 | Current status of clinical islet transplantation显示文摘 | Korsgren O Nilsson B Berme C | 2005 | Transplantation2005，79，10： | 1 |
| 16 | Plane stress yield function for aluminum alloy sheets显示文摘 | Berm J C | 2003 | International Journal of Plasticity2003，19，9： | 1 |
| 17 | Nonlinear Lamb waves for the detection of material nonlinearity显示文摘 | BERMES C KIM J Y QU J JACOBS L J | 2008 | Mechanical Systems and Signal Processing2008，22，4： | 1 |
| 18 | Nonlinear Lamb waves for the detection of material nonlinearity显示文摘 | BERMES C KIM J Y QU Jianmin | 2008 | Mechanical Systems and Signal Processing2008，22，： | 1 |
| 19 | Analysis of factors for conversion of laparoscopic to open cholecystectomy:a prospective study of 703 patients with acute cholecystitis显示文摘 | Domíngnez LC Rivers A Bermúdez C | 2011 | Cir Esp2011，89，5： | 1 |
| 20 | Analysis of factor for conversion of laparoscopic to open cholecystectomy:a prospective study of 703 patients with acute cholecystitis显示文摘 | Domínguez LC Rivera A Bermúdez C | 2011 | Cir Esp2011，89，5： | 1 |
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