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| 1 | 自发性脑出血管理指南 美国心脏协会/美国卒中协会针对医疗专业人员的指南显示文摘目的本指南旨在为自发性脑出血的诊断和治疗提供最新的全面推荐意见。方法利用PubMed进行规范化文献检索,检索时间至2013年8月底。撰写委员会成员通过远程电信会议讨论指南内容及推荐意见,采用美国心脏协会/美国卒中协会的疗效确定性水平和证据分级方案对推荐意见进行分级。由6位同行评议专家以及卒中委员会科学声明监督委员会和卒中委员会领导委员会成员对指南草案进行发表前审阅。结果本文为急性脑出血患者的医疗诊治提供了循证指南,重点包括诊断、凝血功能障碍和血压管理、继发性脑损伤防治、颅内压控制、外科治疗的作用、转归预测、康复、二级预防以及将来需要考虑的问题。本指南已纳入最新的3期临床试验结果。结论脑出血是一种需要进行早期积极救治的危重疾病。本指南为脑出血患者的目标导向治疗提供了一个框架。 | J. Claude Hemphill Ⅲ Steven M. Greenberg Craig S. Anderson Kyra Beckelr Bernard R. Bendok Mary Cushman Gordon L. Fung Joshua N. Goldstein R. LochMacdonald Pamela H Mitchell, Phillip A Scott,Magdy H Selim, Daniel Woo 高圆圆 徐欣 | 2015 | 国际脑血管病杂志2015，23，10： | 444 |
| 2 | 淋巴细胞减少期联合免疫重建和瘤苗免疫增强抗肿瘤免疫的机制显示文摘目的阐明向免疫重建的淋巴细胞减少小鼠(reconstituted lymphopenic mice,RLM)进行瘤苗免疫增强抗肿瘤免疫反应的机制.方法分别以放疗和环磷酰胺处理C57BL/6小鼠,建立淋巴细胞减少模型,并各设正常-非免疫组、RLM-非免疫组、正常-免疫组和RLM-免疫组等4个实验组.在免疫重建的24 h内,分别用灭活黑色素瘤细胞F10(放疗实验部分)和GM-CSF修饰的活黑色素瘤细胞D5-G 6(化疗实验部分)免疫,8~10 d后采集肿瘤疫苗部位引流淋巴结(tumor vaccine draininglymph node,TVDLN),以FACS分析细胞表型.磁珠纯化的T细胞分别经anti-CD3及anti-TCRβ刺激后,分别以[3H]-TdR掺入法和FACS检测T细胞的增殖能力和CD69的表达情况,以此反映T细胞的激活阈值.结果 RLM-免疫组TVDLN中,DC细胞和活化T细胞的频数显著增高.新鲜T细胞的体外增殖能力显著增强,激活阈值明显降低.结论放、化疗引起的淋巴细胞减少可诱导T细胞增殖活化,激活阈值降低,有助于瘤苗免疫打破机体对肿瘤的免疫耐受,增强抗肿瘤免疫反应. | 马军 王一理 HU Hong-ming Bernard A Fox 司履生 | 2005 | 中华肿瘤杂志2005，27，12： | 9 |
| 3 | Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome显示文摘We report a case of virus-induced acute respiratory distress syndrome(ARDS) treated with parenteral vitamin C in a patient testing positive for enterovirus/rhinovirus on viral screening. This report outlines the first use of high dose intravenous vitamin C as an interventional therapy for ARDS, resulting from enterovirus/rhinovirus respiratory infection. From very significant preclinical research performed at Virginia Commonwealth Universitywith vitamin C and with the very positive results of a previously performed phase Ⅰ safety trial infusing high dose vitamin C intravenously into patients with severe sepsis, we reasoned that infusing identical dosing to a patient with ARDS from viral infection would be therapeutic. We report here the case of a 20-year-old, previously healthy, female who contracted respiratory enterovirus/rhinovirus infection that led to acute lung injury and rapidly to ARDS. She contracted the infection in central Italy while on an 8-d spring break from college. During a return flight to the United States, she developed increasing dyspnea and hypoxemia that rapidly developed into acute lung injury that led to ARDS. When support with mechanical ventilation failed, extracorporeal membrane oxygenation(ECMO) was initiated. Twelve hours following ECMO initiation, high dose intravenous vitamin C was begun. The patient's recovery was rapid. ECMO and mechanical ventilation were discontinued by day-7 and the patient recovered with no long-term ARDS sequelae. Infusing high dose intravenous vitamin C into this patient with virus-induced ARDS was associated with rapid resolution of lung injury with no evidence of post-ARDS fibroproliferative sequelae. Intravenous vitamin C as a treatment for ARDS may open a new era of therapy for ARDS from many causes. | Alpha A Fowler Ⅲ Christin Kim Lawrence Lepler Rajiv Malhotra Orlando Debesa Ramesh Natarajan Bernard J Fisher Aamer Syed Christine DeWilde Anna Priday Vigneshwar Kasirajan | 2017 | World Journal of Critical Care Medicine2017，6，1： | 9 |
| 4 | SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer显示文摘 | Andreas I Papadakis Chong Sun Theo A Knijnenburg Yibo Xue Wipawadee Gremrum Michael Holzel Wouter Nijkamp Lodewyk FA Wessels Roderick L Beijersbergen Rene Bernards Sidong Huang | 2015 | Cell Research2015，25，4： | 4 |
| 5 | Effects of a 3-month vigorous physical activity intervention on eating behaviors and body composition in overweight and obese boys and girls显示文摘Purpose: This study aims to analyze the effects of a 3-month vigorous physical activity(VPA) intervention on eating behavior and body composition in overweight and obese children and adolescents.Methods: Forty-seven participants(7–16 years) took part in the study: 28 were assigned to the intervention group(IG)(10 boys and 18 girls) and19 in a control group(CG)(8 boys and 11 girls). Body composition(dual-energy X-ray absorptiometry), anthropometrics(body mass, height, and body mass index(BMI)), and eating behavior traits(Three-Factor Eating Questionnaire-R21 C) were determined before and after the VPA intervention.Results: A decrease in the percentage of body fat and BMI(-2.8% and-1.8%, respectively), and an increase in most lean mass variables were found in the IG(all p ≤ 0.05). In relation to the eating behavior traits, IG subjects showed a 14% reduction in the Emotional Eating score(p = 0.04),while Cognitive Restraint score did not change after the VPA intervention. The baseline factors of the questionnaire predicted changes in body mass and fat mass variables only in the CG.Conclusion: A 3-month VPA intervention influenced eating behaviors of overweight or obese young, especially the Emotional Eating factor, in the presence of favorable body composition changes. | María Martín-García Luis M.Alegre Beatriz Garcia-Cuartero Eleanor J.Bryant Bernard Gutin Ignacio Ara | 2019 | Journal of Sport and Health Science2019，8，2： | 4 |
| 6 | Immuno-haematologic and virologic responses and predictors of virologic failure in HIV-1 infected adults on first-line antiretroviral therapy in Cameroon显示文摘Background:Contemporary data on the immunologic,haematologic and virologic responses and predictors of virologic failure after initiation of free antiretroviral treatment in Cameroon are needed to evaluate the current treatment-monitoring algorithm and to complement efforts to scale-up and improve on the management of HIV infections.Methods:This was a cross-sectional study conducted between October 2010 and June 2012.A total of 951 participants aged 18-74 years were recruited from selected approved HIV treatment centres of the Northwest and Southwest regions.This comprised 247 males and 704 females.Demographic,self-reported risk behaviours and socioeconomic data were obtained using a structured questionnaire.Full blood and CD4+T-cell counts were done using standard automated techniques.Determination of viral load(VL)was done using Abbott RealTime HIV-1 m2000™system.Data was analysed using SPSS version 17.The statistical significance level was P<0.05.Results:The median duration of antiretroviral therapy(ART)was 24 months.The population mean CD4+T-cell count was 255.3 cells/μL[95%CI,236.8-273.9].Overall,45.9%,43.8%and 10.2%of the participants had CD4+T-cell counts of<200 cells/μL,200-499 cells/μL and>500 cells/μL respectively.Anaemia was present in 26.2%of the participants with 62.3%,25.7%and 12%described as mild,moderate and severe anaemia respectively.Virologic failure occurred in 23.2%of the participants with 12.3%having VL>10,000 RNA copies/mL.Meanwhile 76.8%of patients attained adequate viral suppression with 40.8%having undetectable viral load.The age group 18-29 years(p=0.024),co-infection with tuberculosis(p=0.014),anaemia(p=0.028)and distance from the treatment centre(p=0.011)independently predicted virologic failure.Conclusion:The majority of the participants achieved adequate viral suppression after≥6 months of ART.Despite these favourable immuno-haematologic and virologic outcomes,the National AIDS Control Program should step-up efforts to improve on antiretroviral drug distribution,as well as proper assessment and management of anaemia,foster early diagnosis and treatment of tuberculosis and enhance treatment adherence counselling especially in younger patients. | Henry D Meriki Kukwah A Tufon Mbunkah H Afegenwi Bernard A Nyindem Pascal N Atanga Damian N Anong Fidelis Cho-Ngwa Theresa Nkuo-Akenji | 2014 | Infectious Diseases of Poverty2014，3，1： | 3 |
| 7 | 伦理学与SARS:多伦多的教训显示文摘SARS的流行说明传染病在世界范围内流行是件多么容易的事,为了更好地应对下一次流行病,我们不仅要解决医学方面的问题,也同样需要解决伦理学方面的问题。 | Peter A Singer Solomon R Benatar Mark Bernstein Abdallah S Daar Bernard M Dickens Susan K MacRae Ross E G Upshur Linda Wright Randi Zlotnik Shaul 肖月 | 2004 | 英国医学杂志中文版2004，7，4： | 3 |
| 8 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 9 | The American-European consensus conference on acute respiratory distress syndrome:definitions,mechanisms,relevant outcomes,and clinical trial coordination显示文摘 | Bernard G R Artigas A Brigham K L | 1994 | Am J Respir Crit Care Med1994，151，： | 2 |
| 10 | The AmericanEuropea n consensus conference on ARDS:definitions,mechanisms,relevant outcome,and clinical trial c oordination显示文摘 | Bernard G R Artigas A Brigham K L | 1994 | Am J Respir Crit Care Med1994，149，： | 2 |
| 11 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet . 2011 (9807)2011，，9807： | 2 |
| 12 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet2011，，9807： | 2 |
| 13 | Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial显示文摘 | Robert J Motzer Bernard Escudier Stéphane Oudard Thomas E Hutson Camillo Porta Sergio Bracarda Viktor Grünwald John A Thompson Robert A Figlin Norbert Hollaender Gladys Urbanowitz William J Berg Andrea Kay David Lebwohl Alain Ravaud | 2008 | The Lancet2008，，9637： | 2 |
| 14 | Surface modification and photosensitisation of TiO2 nanocrystalline films with ascorbic acid 显示文摘 | Xagas A P Bernard M C GofA H | 2000 | J Photochem PhotobiolA : Chem2000，13，2： | 1 |
| 15 | Validation of a new method of detecting peripheral artery disease by determination of ankle-brachial index using an automatic blood pressure device显示文摘 | Bernard V Pillois X | 2004 | Angiology2004，55，： | 1 |
| 16 | Effective tumor immunotherapy directed against an oncogene-encoded produce using a vaccinia virus vector显示文摘 | Destree A McKenzies | 1987 | Proc Natl Acad Sci USA1987，84，19： | 1 |
| 17 | Galvanic sludge metals recov- ery by pyrometallurgical and hydrometallurgical treatment显示文摘 | ROSSINI G BERNARDES A M | 2006 | Journal of Hazardous Materials2006，131，123： | 1 |
| 18 | Cholinergic me-sencephalic neurons are involved in gait and postural disorders in Parkinson disease显示文摘 | Karachi C Grabli D Bernard F A | 2010 | J Clin Invest2010，120，8： | 1 |
| 19 | Increasing volume andchanging characteristics of invasive pulmonary aspergillosis onsequential thoracic computed tomography scans in patients withneutropenia显示文摘 | Caillot D Couaillier JF Bernard A | 2001 | J Clin Oncol2001，19，1： | 1 |
| 20 | The American European Consensus Conference on ARDS: definitions, mech anisms, relevant outcomes and clinical trial coordination显示文摘 | Bernard GR Artigas A Brigham KL | 1994 | Intensive Care Med1994，20，： | 1 |
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