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| 1 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 2 | NAC Transcription Factor ORE1 and Senescence- Induced BIFUNCTIONAL NUCLEASE1 (BFN1) Constitute a Regulatory Cascade in Arabidopsis显示文摘老朽是包含很多抄写因素的行动的一个高度调整的过程。NAC 抄写因素 ORE1 (ANAC092 ) 最近被显示了在断然在 Arabidopsis thaliana 控制老朽起一个关键作用;然而,它通过施加它的分子的功能的直接目标基因都没以前被识别。这里,我们报导那 BIFUNCTIONAL NUCLEASE1 (BFN1 ) ,著名提高老朽的基因,被 ORE1 直接调整。我们已经检测了 BFN1 的提高的表示在在 estradiol 可诱导的 ORE1 overexpression 线的 ORE1 的正式就职以后的 2 h 和在有 35S:ORE1 的 Arabidopsis 叶肉房间原物的 transfection 以后的 6 h 构造。当在衰老的叶子和成熟的花机关的截去地区的 BFN1 表示在 ore1 异种背景是几乎不在的时, ORE1 和 BFN1 表示模式大部分重叠,由 promoterreporter 显示出基因(GUS ) 熔化。在 vitro 绑定地点试金揭示了一个由两部组成的 ORE1 有约束力的地点,类似于 ORS1 的, ORE1 的 paralog。一个由两部组成的 ORE1 有约束力的地点在 BFN1 倡导者被识别;变异在全身的 BFN1 倡导者的上下文以内的 cis 元素急速地减少了调停 ORE1 的 transactivation 能力在短暂地 transfected Arabidopsis 叶肉房间原物。而且,染色质 immunoprecipitation (薄片) 在 ORE1 有约束力的 vivo 示威到 BFN1 倡导者。我们也在 vivo 表明 ORE1 的绑定到二另外的联系老朽的基因的倡导者,也就是 SAG29/SWEET15 和 SINA1,在老朽期间支持 ORE1 的中央角色。 | Lilian R Matallana-Ramirez Mamoona Rauf Sarit Farage-Barhom Hakan Dortay Gang-Ping Xue Wolfgang Droge-Laser Amnon Lers Salma Balazadeh Bernd Mueller-Roeber | 2013 | Molecular Plant2013，6，5： | 8 |
| 3 | Noninvasive detection and evaluation of atherosclerotic coronary plaques with multislice computed tomography 1 1 This study was performed without additional financial support.显示文摘 | Stephen Schroeder Andreas F Kopp Andreas Baumbach Christoph Meisner Axel Kuettner Christian Georg Bernd Ohnesorge Christian Herdeg Claus D Claussen Karl R Karsch | 2001 | Journal of the American College of Cardiology2001，，5： | 3 |
| 4 | Quantification of human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) mRNA in testicular tissue of infertile patients显示文摘Aim: To evaluate the quantitative detection of human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) mRNA as diagnostic parameters in the workup of testicular tissue specimens from patients presenting with non-obstructive azoospemia. Methods: hTR and hTERT mRNA expression were quantified in 38 cryopreserved testicular tissue specimens by fluorescence real-time reverse transcription- polymerase chain reaction (RT-PCR)in a LightCycler(r). This was paralleled by conventional histological workup in all tissue specimens and additional semithin sectioning preparation in cases with maturation arrest ( n = 12) and Sertoli-cell-only syndrome ( n = 12). Results: The average normalized hTERT expression (NhTERT) Was 131.9 ± 48.0 copies (mean ± SD) in tissue specimens with full spermatogenesis, NhTERT = 51.2 ± 17.2 copies in those with maturation arrest and NhTERT = 2.7 ± 2.4 copies in those with Sertoli-cell-only syndrome (SCOS). The discriminant analysis showed that detection of NhTERT (NhTR) had a predictive value of 86.8 % (55.3 % ) for correct classification in one of the three histological subgroups.Conclusion: Our results demonstrate that quantitative detection of hTERT mRNA expression in testicular tissue enables a molecular-diagnostic classification of gametogenesis. Quantitative detection of hTERT in testicular biopsies is thus well suited for supplementing the histopathological evaluation. | Mark Schrader Markus Müller Rüdiger Heicappell Bernd Straub Kurt Miller | 2001 | Asian Journal of Andrology2001，3，4： | 3 |
| 5 | Uncoupled eNOS annihilates neuregulin-1β-induced cardioprotection: a novel mechanism in pharmacological postconditioning in myocardial infarction显示文摘 | Bernd Ebner Stefan A. Lange Thomas Eckert Clementine Wischniowski Annette Ebner Rüdiger C. Braun-Dullaeus Christof Weinbrenner Carsten Wunderlich Gregor Simonis Ruth H. Strasser | 2013 | Molecular and Cellular Biochemistry2013，，1： | 2 |
| 6 | Measuring velocity dispersion and attenuation in the exploration seismic frequency band显示文摘 | Langqiu F S Bernd M Douglas R S | 2009 | Geophysics2009，72，2： | 1 |
| 7 | Fairness as a constraint on trust in reciprocity:earned property rights in a reciprocal exchange experiment显示文摘 | FAHR R BERND I | 2000 | Economics Letters2000，66，3： | 1 |
| 8 | C-reactive protein and red cell aggregation correlate with late venous function after acute deep venous thrombosis显示文摘 | Elisabeth Krieger Bernd van Der Loo Beatrice R | 2004 | J Vasc Surg2004，40，4： | 1 |
| 9 | StGCPRP,a potato gene strongly expressed in stomatal guard cells,defines a novel type of repetitive proline-rich proteins显示文摘 | Menke U Nathalie R Bernd M R | 2000 | Plant physiology2000，122，3： | 1 |
| 10 | In vitro and in vivo studies on blends of isotactic and atactic poly (3-hydroxybutyrate) for development of a dura substitute material显示文摘 | Kunze C Edgar Bernd H Androsch R Nischan C Freier T Kramer S | 2006 | Biomaterials2006，27，： | 1 |
| 11 | Integrating manufacturing and logistic systems along global supply chains显示文摘 | Bernd S R Frazzon E M Thomas M | 2010 | CIRP Journal of Manufacturing Science and Technology2010，，2： | 1 |
| 12 | Fairness as a constrain on trust in reciprocity: earned property rights in a reciprocal exchange experiment显示文摘 | Fahr R Bernd I | 2000 | Economics Letters2000，66，3： | 1 |
| 13 | The contribution of biomass in the future global energy supply:a review of 17 studies显示文摘 | Berndes G Hoogwijk M Broek R | 2003 | Biomass and Bioenergy2003，1，： | 1 |
| 14 | Biomass burning-a review of organic tracers for smoke from incomplete combustion 显示文摘 | Simoneit Bernd R T | 2002 | Applied Geochemistry2002，17，3： | 1 |
| 15 | Mechanical spectroscopy of polymer :nagnelile composites 显示文摘 | Bernd W Werner R Lei Q H | 2004 | Materials Science and Engineering A2004，370，12： | 1 |
| 16 | Severe leukopenia in a rheumatoid arthritis patient treated with a methotrexate/leflunomide combination 显示文摘 | TOTH P BERND R | 2014 | Rev Bras Reumatol2014，5，2： | 1 |
| 17 | Supercritical fluid extracts from brown coal lithotypes and their group components-molecular composition of non-polar compounds显示文摘 | Franciszek Czechowski Marek Stolarski Bernd R T Simoneit | 2002 | Fuel2002，81，： | 1 |
| 18 | Continuous in-line gasfication/vitrification process for thermal waste treatment :Process technology and current status of projects 显示文摘 | Bernd Calaminus Stahlberg R | 1998 | Waste Management1998，18，： | 1 |
| 19 | A review of current applications of mass spectrometry for biomarker/ molecular tracer elucidations显示文摘 | SIMONEIT BERND R T | 2005 | Mass Spectrom Rev2005，24，5： | 1 |
| 20 | Experimental evaluation of numerical simulation of cavitating flow around hydrofoil显示文摘 | Dular M Bachert R Bernd S | 2005 | European Joumal of Mechanics B: Fluids2005，24，12： | 1 |
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