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| 1 | nor-NOHA逆转自发性高血压大鼠血管重构显示文摘目的探讨精氨酸酶抑制剂nor-NOHA对自发性高血压大鼠(SHR)血管重构的影响。方法WKY大鼠作为对照组,SHR随机分为模型组与受试组,受试组每天腹腔注射nor-NOHA(40mg/kg),定期测量大鼠收缩压和体质量,10周后,采用酶谱法检测心、肾及胸主动脉组织中活性MMP-2的含量,并对胸主动脉进行Tricrome-Masson,Picric-Siriusred及Orcein组织特染观察中膜厚度(MT)、管腔内径(LD)、径腔比(M/L)、Ⅰ型和Ⅲ型胶原及弹力纤维面积百分比值等。结果受试组收缩压显著下降、左心室MMP-2较SHR组含量显著降低(P<0.05),胸主动脉的MT、M/L、Ⅰ型和Ⅲ型胶原蛋白均下降(P<0.05)。结论nor-NOHA可能通过抑制MMP-2活性及降低Ⅰ型和Ⅲ型胶原的合成而缓解SHR血管重构。 | 马玲 Demougeot C Bagnost T Berthelot A | 2009 | 基础医学与临床2009，29，11： | 4 |
| 2 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 3 | Dysfunctions of the Iga system:a common link between intestinal and renal diseases显示文摘Immunoglobulin A(Iga)-isotype antibodies play an important role in immunity owing to their structure,glycosylation,localization and receptor interactions.Dysfunctions in this system can lead to multiple types of pathology.This review describes the characteristics of Iga and discusses the involvement of abnormalities in the Iga system on the development of celiac disease and Iga nephropathy. | Christina Papista Laureline Berthelot Renato C Monteiro | 2011 | Cellular & Molecular Immunology2011，8，2： | 3 |
| 4 | Birth of piglets after OPS vitrification and transfer of compacted morula stage embryos with intact zona pellucida显示文摘 | Berthelot F Martinat-Botte F Perreau C | 2001 | Reprod Nutr Dev2001，41，： | 1 |
| 5 | Regulatory B cells play a key role in immune system balance 显示文摘 | Berthelot JM Jamin C Amrouche K | 2013 | Joint Bone Spine2013，80，1： | 1 |
| 6 | Chromatographic study of magnesium and calcium binding to immobilized human serum albumin显示文摘 | Guillaume Y C Peyrin E Berthelot A | 1999 | J Chromatography B1999，728，： | 1 |
| 7 | Usefulness of 2‐[<sup>18</sup>F]‐fluoro‐2‐deoxy‐ d ‐glucose–Positron Emission Tomography/Computed Tomography for Staging and Evaluation of Treatment Response in IgG4‐Related Disease: A Retrospective Multicenter Study显示文摘 | Mikael Ebbo Aurélie Grados Eric Guedj Delphine Gobert Cécile Colavolpe Mohamad Zaidan Agathe Masseau Fanny Bernard Jean‐Marie Berthelot Nathalie Morel Fran?ois Lifermann Sylvain Palat Julien Haroche Xavier Mariette Bertrand Godeau Emmanuelle Bernit Nathal | 2014 | Arthritis Care & Research2014，，1： | 1 |
| 8 | Cheese flavour formation by amino acid catabolism显示文摘 | YVON M BERTHELOT S GRIPON J C | 2001 | International Dairy Journal2001，11，47： | 1 |
| 9 | New insights into the vascular mechanisms underlying the beneficial effect of swimming training on the endotheli- al vasodilator function in apolipoprotein E - deficient mice 显示文摘 | Pellegrin M Berthelot A Houdayer C | 2007 | Atherosclerosis2007，190，： | 1 |
| 10 | Regulatory B cells play a key role in immune system balance显示文摘 | Berthelot JM Jamin C Amrouche K | 2013 | Joint Bone Spine2013，80，： | 1 |
| 11 | Regulatory B cells play a key role in immune system balance 显示文摘 | Berthelot JM Jamin C Amrouche K | 2013 | Joint Bone Spine2013，80，1： | 1 |
| 12 | Electrochemical investigation of the P2-NaxCo O2 phase diagram显示文摘 | BERTHELOT R CARLIER D DELMAS C | 2011 | Nature Materials2011，10，1： | 1 |
| 13 | A model for estimating the costs and burdens of breast cancer diagnosis and treatment in Canada显示文摘 | WILL BP BERTHELOT J M HOULE C | 1993 | Health Res1993，5，4： | 1 |
| 14 | Modulation of eukaryotic mRNA stability via the cap-binding translation complex eIF4F 显示文摘 | Ramirez CV Vilela C Berthelot K | 2002 | J Mol Biol2002，318，4： | 1 |
| 15 | Reinitiation and recycling are distinct processes occurring downstream of translation termination in yeast显示文摘 | Rajkowitsch L Vilela C Berthelot K | 2004 | J Mol Biol2004，335，1： | 1 |
| 16 | Piglets born after non-surgical deep intrauterine transfer of vitrified blastocysts in silts显示文摘 | Berthelot F Martinat-Botte F | 2005 | Anim Reprod Sci2005，85，： | 1 |
| 17 | New insights into the vascular mechanisms underlying the beneficial effect of swimming training on the endothelial vasodilator function in apolipoprotein E-deficient mice显示文摘 | Pellegrin M Berthelot A Houdayer C | 2007 | Atherosclerosis2007，190，： | 1 |
| 18 | Affinity chromatography study of magnesium and calcium binding to human serum albumin: pH and temperature variations显示文摘 | GUILLAUME Y C GUINCHARD C BERTHELOT A | 2000 | Talanta2000，53，： | 1 |
| 19 | Regulatory B cells play a key role in immune system balance显示文摘 | Berthelot JM Jamin C Amrouche K | 2013 | Joint Bone Spine2013，80，1： | 1 |
| 20 | Inverted repeat nucleotide sequences in the genomes of Marek disease virus and the herpesvirus of the turkey 显示文摘 | Cebrian J Kaschka-Dierich C Berthelot N | 1982 | Proc Natl Acad Sci USA1982，79，2： | 1 |
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