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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Determination of the Complex Young and Shear Dynamic Moduli of Viscoelastic Materials 显示文摘 | Willis R L Wu L Berthelot Y H | 2001 | Journal of the Acoustical Society of America2001，109，2： | 1 |
| 3 | Petri nets theory for the connection of protocols显示文摘 | Terrat R | 1982 | IEEE Transactions on Communications1982，30，12： | 1 |
| 4 | Electrochemical investigation of the P2-NaxCo O2 phase diagram显示文摘 | BERTHELOT R CARLIER D DELMAS C | 2011 | Nature Materials2011，10，1： | 1 |
| 5 | Septicemia due to Pasteurella pneumotropiea:16S rRNA sequencing for diagnosis confirmation显示文摘 | Frebourg NB Berthelot G Hocq R | 2002 | J Clin Mierobiol2002，40，2： | 1 |
| 6 | Determination ofthe complex Young and shear dynamic moduli of vis-coelastic materials显示文摘 | Willis R L Wu L Berthelot Y H | 2001 | The Journal of the AcousticalSociety of America2001，109，2： | 1 |
| 7 | Electrochemical inves- tigation of the P2-NaCoO2 phase diagram显示文摘 | Berthelot R Carlier D Delmas C | 2011 | Nature Ma- terials2011，10，： | 1 |
| 8 | Electrochemical investigation of the P2-Na= CoO2 phase diagram 显示文摘 | Berthelot R Carlier D Delmas C | 2011 | Nat Mater2011，10，1： | 1 |
| 9 | The use of wetlands in the Mississippi Delta for wastewater assimilation:a re- view显示文摘 | Bean R Berthelot G Brantley | 2004 | Ocean & Coastal Management2004，47，1112： | 1 |
| 10 | Electrochemical investigation of the P2-NaCoO2 phase diagram 显示文摘 | Berthelot R Carlier D Delmas C | 2011 | Nature Materials2011，10，： | 1 |
| 11 | Petri nets theory for the correctness of protocols显示文摘 | BERTHELOT G TERRAT R | 1982 | IEEE Trans on Communications1982，30，12： | 1 |
| 12 | Na-ion intercalation cathode with high rate and excellent structural stability显示文摘 | Berthelot R Carlier D Delmas C | 2010 | Nature Materials2010，148，： | 1 |
| 13 | Mechanistic laboratory evaluation and field construction of recycled concrete materials for use in road substructures显示文摘 | BERTHELOT C HAICHERT R PODBORO- CHYNSKI D | 2010 | Transportation Re- search Record2010，2167，： | 1 |
| 14 | Reduction of nets and parallel programs显示文摘 | Berthelot G Roucairol G Valk R | 1980 | Lecture Notes in Computer Science1980，84，15： | 1 |
| 15 | Determination of the complex young and shear dynamic moduli of viscoelastic materials显示文摘 | Willis R L Wu L Berthelot Y H | | 0，，： | 1 |
| 16 | Fabrication and Prop- erties of Low-Temperature ( ≤ 600℃ ) Processed n-Type Nanocrysta/line SiC/p-Type Crysta/line Si Heterojunction Diodes显示文摘 | Kerdiles S Berthelot A Rizk R | 2002 | Applied Physics Letters2002，80，20： | 1 |
| 17 | Electrochemical investigation of the P2-NaxCoO2 phase diagram显示文摘 | Berthelot R Carlier D Delmas C | 2011 | Nature Materials2011，10，1： | 1 |
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