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| 1 | Outcome in obscure gastrointestinal bleeding after capsule endoscopy显示文摘AIM: To investigate the clinical impact of capsule endoscopy(CE) after an obscure gastrointestinal bleeding(OGIB) episode, focusing on diagnostic work-up, followup and predictive factors of rebleeding. METHODS: Patients who were referred to Hospital del Mar(Barcelona, Spain) between 2007 and 2009 for OGIB who underwent a CE were retrospectively analyzed. Demographic data, current treatment with non-steroid antiinflammtory drugs or anticoagulant drugs, hemoglobin levels, transfusion requirements, previous diagnostic tests for the bleeding episode, as well as CE findings(significant or non-significant), work-up and patient out-comes were analyzed from electronic charts. Variables were compared by χ 2 analysis and Student t test. Risk factors of rebleeding were assessed by Log-rank test, Kaplan-Meier curves and Cox regression model. RESULTS: There were 105 patients [45.7% women, median age of 72 years old(interquartile range 56-79)] and a median follow-up of 326 d(interquartile range 123-641) included in this study. The overall diagnostic yield of CE was 58.1%(55.2% and 63.2%, for patients with occult OGIB and overt OGIB, respectively). In 73 patients(69.5%), OGIB was resolved. Multivariate analysis showed that hemoglobin levels lower than 8 g/dL at diagnosis [hazard ratios(HR) = 2.7, 95%CI: 1.9-6.3], patients aged 70 years and above(HR = 2.1, 95%CI: 1.2-6.1) and significant findings in CE(HR = 2.4, 95%CI: 1.1-5.8) were independent predictors of rebleeding. CONCLUSION: One third of the patients presented with rebleeding after CE; risk factors were hemoglobin levels < 8 g/dL, age ≥ 70 years or the presence of significant lesions. | Alex Caas-Ventura Lucia Márque Xavier Bessa Josep Maria DedeuDepartment of Gastroenterology Hospital del Mar Research Institute Pompeu Fabra University Marc Puigvehí Sílvia Delgado-Aros Ines Ana Ibáez Agustin Seoane Luis Barranco Felipe Bory Montserrat Andreu Begoa González-Suárez | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 4 |
| 2 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 3 | Automatic Detection of COVID-19 Infection Using Chest X-Ray Images Through Transfer Learning显示文摘The new coronavirus(COVID-19),declared by the World Health Organization as a pandemic,has infected more than 1 million people and killed more than 50 thousand.An infection caused by COVID-19 can develop into pneumonia,which can be detected by a chest X-ray exam and should be treated appropriately.In this work,we propose an automatic detection method for COVID-19 infection based on chest X-ray images.The datasets constructed for this study are composed of194 X-ray images of patients diagnosed with coronavirus and 194 X-ray images of healthy patients.Since few images of patients with COVID-19 are publicly available,we apply the concept of transfer learning for this task.We use different architectures of convolutional neural networks(CNNs)trained on Image Net,and adapt them to behave as feature extractors for the X-ray images.Then,the CNNs are combined with consolidated machine learning methods,such as k-Nearest Neighbor,Bayes,Random Forest,multilayer perceptron(MLP),and support vector machine(SVM).The results show that,for one of the datasets,the extractor-classifier pair with the best performance is the Mobile Net architecture with the SVM classifier using a linear kernel,which achieves an accuracy and an F1-score of 98.5%.For the other dataset,the best pair is Dense Net201 with MLP,achieving an accuracy and an F1-score of 95.6%.Thus,the proposed approach demonstrates efficiency in detecting COVID-19 in X-ray images. | Elene Firmeza Ohata Gabriel Maia Bezerra João Victor Souza das Chagas Aloísio Vieira Lira Neto Adriano Bessa Albuquerque Victor Hugo Cde Albuquerque Pedro Pedrosa Rebouças Filho | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，1： | 3 |
| 4 | Some Remarks on the Boundedness and Convergence Properties of Smooth Sliding Mode Controllers显示文摘Conventional sliding mode controllers are based on the assumption of switching control, but a well-known drawback of such controllers is the chattering phenomenon. To overcome the undesirable chattering effects, the discontinuity in the control law can be smoothed out in a thin boundary layer neighboring the switching surface. In this paper, rigorous proofs of the boundedness and convergence properties of smooth sliding mode controllers are presented. This result corrects flawed conclusions previously reached in the literature. An illustrative example is also presented in order to confirm the convergence of the tracking error vector to the defined bounded region. | Wallace Moreira Bessa | 2009 | International Journal of Automation and computing2009，6，2： | 3 |
| 5 | Hepatitis B surface antigen and hepatitis B core-related antigen kinetics after adding pegylated-interferon to nucleos(t)ids analogues in hepatitis B e antigen-negative patients显示文摘BACKGROUND Hepatitis B e antigen-negative chronic hepatitis B patients under nucleos(t)ids analogues(NAs)rarely achieve hepatitis B surface antigen(HBsAg)loss.AIM To evaluate if the addition of pegylated interferon(Peg-IFN)could decrease HBsAg and hepatitis B core-related antigen(HBcrAg)levels and increase HBsAg loss rate in patients under NAs therapy.METHODS Prospective,non-randomized,open-label trial evaluating the combination of Peg-IFN 180μg/week plus NAs during forty-eight weeks vs NAs in monotherapy.Hepatitis B e antigen-negative non-cirrhotic chronic hepatitis B patients of a tertiary hospital,under NAs therapy for at least 2 years and with undetectable viral load,were eligible.Patients with hepatitis C virus,hepatitis D virus or human immunodeficiency virus co-infection and liver transplanted patients were excluded.HBsAg and HBcrAg levels(log10 U/mL)were measured at baseline and during ninety-six weeks.HBsAg loss rate was evaluated in both groups.Adverse events were recorded in both groups.The kinetic of HBsAg for each treatment group was evaluated from baseline to weeks 24 and 48 by the slope of the HBsAg decline(log10 IU/mL/week)using a linear regression model.RESULTS Sixty-five patients were enrolled,61%receiving tenofovir and 33%entecavir.Thirty-six(55%)were included in Peg-IFN-NA group and 29(44%)in NA group.After matching by age and treatment duration,baseline HBsAg levels were comparable between groups(3.1 vs 3.2)(P=0.25).HBsAg levels at weeks 24,48 and 96 declined in Peg-IFN-NA group(-0.26,-0.40 and-0.44)and remained stable in NA group(-0.10,-0.10 and-0.10)(P<0.05).The slope of HBsAg decline in Peg-IFN-NA group(-0.02)was higher than in NA group(-0.00)(P=0.015).HBcrAg levels did not change.Eight(22%)patients discontinued Peg-IFN due to adverse events.The HBsAg loss was achieved in 3(8.3%)patients of the Peg-IFN-NA group and 0(0%)of the NA group.CONCLUSION The addition of Peg-IFN to NAs caused a greater and faster decrease of HBsAg levels compared to NA therapy.Side effects of Peg-IFN can limit its use in clinical practice. | Teresa Broquetas Montserrat Garcia-Retortillo Miquel Mico Lidia Canillas Marc Puigvehi Nuria Canete Susana Coll Ana Viu Juan Jose Hernandez Xavier Bessa JoseA Carrion | 2020 | World Journal of Hepatology2020，12，11： | 2 |
| 6 | Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype显示文摘 | Anna Abulí Xavier Bessa Juan Ramón González Clara Ruiz–Ponte Alejandro Cáceres Jenifer Mu?oz Victoria Gonzalo Francesc Balaguer Ceres Fernández–Rozadilla Dolors González Luisa de Castro Juan Clofent Luís Bujanda Joaquín Cubiella Josep M a Re?é Juan Diego | 2010 | Gastroenterology2010，，3： | 2 |
| 7 | Helicobacter pylori free‐living and biofilm modes of growth: behavior in response to different culture media显示文摘 | Lucinda J. Bessa Rossella Grande Donato DI Iorio Mara DI Giulio Emanuela DI Campli Luigina Cellini | 2012 | APMIS2012，，6： | 2 |
| 8 | Differential expression of cdc25 cell- cycle - activating phosphatases in human colorectal carcinoma显示文摘 | Hernandez S Bessa X Bea S | 2001 | Lab Invest2001，81，4： | 1 |
| 9 | Detection of colonic cells in peripheral blood of colorectal cancer patients by means of reverse transcription and polymerase chain reaction显示文摘 | Castells A Boix L Bessa X | 1998 | Br J Cancer1998，78，： | 1 |
| 10 | The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling显示文摘 | Bessa JM Ferreira D Melo I | | 0，，： | 1 |
| 11 | Wind power forecasting uncertainty and unit commitment 显示文摘 | Wang J Botterud A Bessa R | 2011 | Applied Energy2011，88，11： | 1 |
| 12 | Photocatalytic/H2O2 Treatment of Oil Field Produced Waters显示文摘 | Bessa E Lippel G Dezotti M | 2001 | Applied Gatalysis2001，29，2： | 1 |
| 13 | 2-Fluorophenol degradation by aerobic granular sludge in a sequencing batch reactor显示文摘 | Duque A F Bessa V S Carvalho M F | 2011 | Water Research2011，45，20： | 1 |
| 14 | Stress-induced anhedonia is associated with hypertrophy of medium spiny neurons of the nucleus accumbens显示文摘 | BESSA J M MORAIS M MARQUES F | 2013 | Translational Psychiatry2013，3，： | 1 |
| 15 | Maize and resistant starch enriched breads reduce postprandial glycemic responses in rats显示文摘 | Carla M. Brites Maria J. Trigo Belmira Carrapi?o Marcela Alvi?a Rui J. Bessa | 2011 | Nutrition Research2011，，4： | 1 |
| 16 | Clipless laparo- scopic choleeystectomy by ultrasonic dissection 显示文摘 | Bessa SS Aifayoumit A Katrik M | 2008 | J Lap- aroendosc Adv Surg Tech A2008，，4： | 1 |
| 17 | Stable Weakly Shadowable Volume-preserving Systems Are Volume-hyperbolic显示文摘We prove that any C1-stable weakly shadowable volume-preserving diffeomorphism defined on a compact manifold displays a dominated splitting E ⊕ F. Moreover, both E and F are volume-hyperbolic. Finally, we prove the version of this result for divergence-free vector fields. As a consequence, in low dimensions, we obtain global hyperbolicity. | Mrio BESSA Manseob LEE Sandra VAZ | 2014 | Acta Mathematica Sinica,English Series2014，30，6： | 1 |
| 18 | The effect of supplementation with expanded sunflower seed on carcass and meat quality of lambs raised on pasture 显示文摘 | Santos Silva J Bessa R J B Mendes I A | 2003 | Meat Science2003，65，： | 1 |
| 19 | Value of postoperative surveillance after radical surgeryfor colorectal cancer: results of a cohort study显示文摘 | Castells A Bessa X Daniels M | 1998 | Dis Colon Reclum1998，41，6： | 1 |
| 20 | Differential expression of cdc25 cell-cycle-activating phosphatases in human colorectal carcinoma显示文摘 | HERNANDEZ S BESSA X BEA S | 2001 | Lab Invest2001，81，4： | 1 |
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