|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis显示文摘Estrogens play important roles in the development and progression of multiple tumor types.Accumulating evidence points to the significance of estrogen action not only in tumors of hormonally regulated tissues such as the breast,endometrium and ovary,but also in the development of colorectal cancer(CRC).The effects of estrogens in physiological and pathophysiological conditions are mediated by the nuclear estrogen receptorsαandβ,as well as the membranebound G protein-coupled estrogen receptor(GPER).The roles of GPER in CRC development and progression,however,remain poorly understood.Studies on the functions of GPER in the colon have shown that this estrogen receptor regulates colonic motility as well as immune responses in CRC-associated diseases,such as Crohn’s disease and ulcerative colitis.GPER is also involved in cell cycle regulation,endoplasmic reticulum stress,proliferation,apoptosis,vascularization,cell migration,and the regulation of fatty acid and estrogen metabolism in CRC cells.Thus,multiple lines of evidence suggest that GPER may play an important role in colorectal carcinogenesis.In this review,we present the current state of knowledge regarding the contribution of GPER to colon function and CRC. | Damian Jacenik Ellen J Beswick Wanda M Krajewska Eric R Prossnitz | 2019 | World Journal of Gastroenterology2019，25，30： | 6 |
| 2 | NADH/NADPH oxidase and enhanced superoxide production in the mineralocorticoid hypertensive rat显示文摘 | Beswick R A Dorrance A M Leite R | 2001 | Hypertension2001，38，5： | 1 |
| 3 | Differential release of superoxide anions by macrophages treated with long and short fibre amosite asbestos is a consequence of differential affinity for opsonin 显示文摘 | Hill I M Beswick P H Donaldson K | 1995 | Occup Environ Med1995，52，2： | 1 |
| 4 | Exogenous TERC alone can enhance proliferative potential, telomerase activity and te- lomere length in lymphocytes from dyskeratosis congenita patients显示文摘 | Kirwan M Beswick R Vulliamy T | 2009 | Br J Haematol2009，144，5： | 1 |
| 5 | TINF2 mutations result in very short telomeres:analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes显示文摘 | Walne AJ Vulliamy T Beswick R Kirwan M Dokal I | | 0，，09： | 1 |
| 6 | The Effect of Chromium on High Carbon Bering Steels显示文摘 | Beswick J M | 1989 | Metallurgical and Materials Transactions A1989，，： | 1 |
| 7 | Fracture and Fatigue Crack Propagation Properties of Hardened 52100 Steel 显示文摘 | Beswick J M | 1989 | Metallurgical and Materials Transactions A1989，20，： | 1 |
| 8 | Application of scaffolds for bone regeneration strategies: Current trends and future directions显示文摘 | Gry Hulsart Billstr?m Ashley W. Blom Sune Larsson Andrew D. Beswick | 2013 | Injury2013，，： | 1 |
| 9 | Mutations in the telom- erase component NHP2 cause the premature ageing syndrome dyskeratosis congenita 显示文摘 | Vulliamy T Beswick R Kirwan M | 2008 | Proc Natl Acad Sci U S A2008，105，23： | 1 |
| 10 | Localizaiton of hydrogen peroxide accumulation during the hypersensitive reactive of lettuce cells to pseudomonas syringae pv phaseolicola显示文摘 | BESWICK C S BROWN L R BENNETT M H R | 1997 | The Plant Cell1997，9，： | 1 |
| 11 | Size - re- solved measurements of cloud droplet deposition velocity to a forest canopy using an eddy correlation technique 显示文摘 | Beswick K M Hargreaves K J Gallagher M W | 1991 | Quarterly Journal of the Royal Meteorological Society1991，117，： | 1 |
| 12 | 3- ( 5-Chloro-2, 4-dihydroxyphenyl )-pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone显示文摘 | BROUGH P A BARRIL X BESWICK M | 2005 | Bioorg Med Chem Lett2005，15，23： | 1 |
| 13 | Antioxidant effects of angiotensin converting enzyme inhibitors:free radical and oxidant scavenging are sulfhydryl dependent,but lipid perexidation is inhibited by both sulfhydryl and nonsulfhydryl-containing ACE inhibitors显示文摘 | Chopin M Beswick H Clapperton M | 2002 | J Cardiovase Pharmrcol2002，19，： | 1 |
| 14 | Assessment of a relaxed eddy accumulation for measurements of fluxes of biogenic volatile organic compounds:study over arable crops and a mature beech forest显示文摘 | GALLAGHER M W CLAYBOROUGH R BESWICK K M | | 0，，： | 1 |
| 15 | 4- Amino derivatives of the Hspg0 inhibitor CCT018159显示文摘 | BARRIL X BESWICK M C COLLIER A | 2006 | Bioorg Med Chem Lett2006，16，9： | 1 |
| 16 | 查看详情显示文摘 | Bear M Beswick J A | | 0，，： | 1 |
| 17 | Mutations in the teloalerase component NHP2 cause the premature ageing syndrome dyskeratosis congenita 显示文摘 | Vulliamy T Beswick R Kirwan M | 2008 | Proc Natl Acad Sci USA2008，105，23： | 1 |
| 18 | Infant temperament,maternal personality,and parenting stress as contributors to infant developmental outcomes显示文摘 | Molfese V J Rudasill K M Beswick J L | 2010 | Merrill-Palmer Quarterly2010，56，1： | 1 |
| 19 | Infant temperament, maternal personality, and parenting stress as contributors to infant developmental outcomes显示文摘 | Molfese V J Rudasill K M Beswick J L | 2010 | Merrill-Palmer Quarterly2010，56，1： | 1 |
| 20 | Assessment of a relaxed eddy accumulation for measurements of fluxes of biogenic volatile organic compounds: study over amble crops and a mature beech forest显示文摘 | GALLAGHER M W CLAYBOROUGH R BESWICK K M | 2000 | Atmospheric Environment2000，34，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员