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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | 用于电力系统仿真的潮流控制器模型显示文摘本文描述了—族基于可关断晶闸管(GTO)电压源逆变器的电力系统控制装置,介绍了静补(STATCON)、串联潮流控制器(SPFC)和统一潮流控制器(UPC)的稳态模型。静补是由美国的EPRI、TVA和西屋科技中心联合开发的基于逆变器的并联装置、不久它将被安装在TVA的16lkV输电系统上用于控制线路电压。而串联潮流控制器和统一潮流控制器则代表了静补在串联应用方面的拓展。这些装置的建模可以结合到现有的大型电力系统分析程序之中供系统稳态研究使用。IEEE的30母线试验系统的仿真结果证明了这些电压源潮流控制装置的稳态性能。UPFC具有能同时对线路的有功与无功潮流独立地进行控制的能力,可以认为它特别适用厂输电潮流控制。 | J. Bian Meniber T. A Lemak Member(Power benration Business Unit Science and Technology CenterWestinghouse Electric Corporation. Pittsburrgh, PA, USA)K J. Nelson Member D. G. Ramey Aenior Member(Power Genration Business UnitWestinghouse Electric Corporat | 1995 | 电网技术1995，19，9： | 3 |
| 3 | A simplified cloning strategy for the generation of an endothelial cell sdective recombinant adenovirus vector 显示文摘 | MAHANIVONG C KRUGER J A BIAN D | 2006 | USA J Virol Methods2006，135，1： | 1 |
| 4 | Non-crossing cumulants of type B显示文摘 | Biane P Goodman F Nica A | 2003 | Transactions of the American Mathematical Society2003，355，6： | 1 |
| 5 | InP Based passive ring resonator coupler lasers显示文摘 | Bian Z Liu B Shakouri A | 2003 | IEEE J Quantum Electron2003，39，7： | 1 |
| 6 | sBAFF mutants induce neutralizing antibodies against BAFF显示文摘 | Gao H Bian A Zheng Y | 2007 | FEBS Letters2007，581，4： | 1 |
| 7 | The effect of atypical antipsychotics,perospirone,ziprasidone and quetiapine on microglial activation induced by interferon-gamma显示文摘 | Bian Q Kato T Monji A | 2008 | Prog Neuropsychopharmacol Biol Psychiatry2008，32，1： | 1 |
| 8 | Nonlinear State Estimation and Model Predictive Control of Nitrogen Purification Columns 显示文摘 | BIAN S HENSON M A BELANGER P | 2005 | Industrial and Engineering Chemistry Research2005，44，1： | 1 |
| 9 | Effects of biocharamendment on soil quality,crop yield and greenhouse gasemission in a Chinese rice paddy:a field study of 2 consecutiverice growing cycles显示文摘 | Zhang A F Bian R J Pan G X ei al | 2012 | Field Crops Research2012，127，： | 1 |
| 10 | Phase control of multichannel molecular high-order harmonic generation by the asymmetric diatomic molecule HeH2+ in two-color laser fields显示文摘 | Bian X B Bandrauk A D | 2011 | Phys Hev A2011，83，02： | 1 |
| 11 | Compartmental Modeling of High Purity Air Separation Columns显示文摘 | BIAN S KHOWINIJIA S HENSON M A | 2005 | Computers and Chemical Engineering2005，29，： | 1 |
| 12 | Particulate air pollution in Mexico City: A collaborative research project 显示文摘 | Edgerton S A Bian X | 1999 | J Air & Waste Manage Assoc1999，49，： | 1 |
| 13 | A three-year experiment confirms continuous immobilization of cadmium and lead in contaminatedpaddy field with biochar amendment显示文摘 | Bian R Joseph S Cui L Pan G Li L Liu X Zhang A Rutlidge H Wong S Chia C Marjo C Gong B Munroe P Donne S | 2014 | Journal of Hazardous Materials2014，272，： | 1 |
| 14 | An LQT mutant minK alters KvLQT1 trafficking显示文摘 | Krumerman A Gao X Bian JS | 2004 | Am J Physiol Cell Physiol2004，286，6： | 1 |
| 15 | Person-to-person transmission of severe fever with thrombocytopenia syndrome bunyavirus through blood contact 显示文摘 | Gai Z Liang M Zhang Y Zhang S Jin C Wang SW Sun L Zhou N Zhang Q Sun Y Ding SJ Li C Gu W Zhang F Wang Y Bian P Li X Wang Z Song X Wang X Xu A Bi Z Chen S Li D | 2012 | Clin Infect Dis2012，54，2： | 1 |
| 16 | Expression of and cyto- kine activation by Escherichia coli curli fibers in human sepsis 显示文摘 | BIAN Z BRAUNER A LI Y | 2000 | The Journal of infectious diseases2000，181，2： | 1 |
| 17 | Human RPE-monocyte co-culture induces chemokine gene expression through activation of MAPK and NIK cascade显示文摘 | Bian ZM Elner SG Yoshida A Elner VM | 2003 | Exp Eye Res2003，76，5： | 1 |
| 18 | Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia isassociated with activation of the PI3K/Akt pathway显示文摘 | Bian Y Terse A Du J | 2009 | Cancer Res2009，69，： | 1 |
| 19 | The optimization design of the Mc Pherson strut and steering mechanism for automobiles显示文摘 | Bian X L Song B A Becker W | 2003 | Engineering Research2003，68，7： | 1 |
| 20 | Growth of the developing cerebral cortex is controlled by microRNA-7 through the p53 pathway显示文摘 | Pollock A Bian S Zhang C | 2014 | Cell Rep2014，7，4： | 1 |
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