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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Anomalous temperature dependence of photoluminescence in MBE-grown GaInNAs/GaAs QWs 显示文摘 | Liang X G Jiang D S Bian L F | 2002 | Chinese Physics Letter2002，19，： | 2 |
| 3 | Cauchy Integral Formula and Plemelj Formula of Bihypermonogenic Functions in Real Clifford Analysis 显示文摘 | BIAN X ERIKSSON S L LI J | 2009 | Complex Variables and Elliptic Equations2009，54，10： | 1 |
| 4 | Preparation and properties of rare earth oxide/polyimide hybrids显示文摘 | BIAN L J QIAN X F YIN J | 2002 | Polymer Testing2002，21，： | 1 |
| 5 | Dicofol application resulted in high DDTs residue in cotton fields from northern Jiangsu province, China显示文摘 | Yang X L Wang S S Bian Y R | 2008 | J Hazard Mater2008，150，1： | 1 |
| 6 | Peptide hormone ghrelin enhances neuro?nal excitability by inhibition of Kv7IKCNQ channels显示文摘 | Shi L Bian X Qu Z | 2013 | Nat Com?mun2013，54，： | 1 |
| 7 | 查看详情显示文摘 | Bian C L Jiang G X Cheng Y X Xie Z Y Wang L X | | 0，，03： | 1 |
| 8 | Using immobilized G-proteincoupled receptors to screen bioactive traditional Chinese medi- cine compounds with multiple targets显示文摘 | Zhao X Li Q Bian L | 2012 | J Pharm Biomed A- nal2012，70，： | 1 |
| 9 | Analyses of turbulence parameters in the near-surface layer at Qamdo of the southeastern Tibetan Plateau显示文摘 | Bian L X Xu L Lu | 2003 | Adv Atmos Sci2003，20，3： | 1 |
| 10 | Analyzing optimal timing ofmerger and acquisition under cooperation opportunism inreal options and game-theoretic framework显示文摘 | Bian L Hu W X Zhang J P | 2009 | Mot2009 :Proceedings of Zhengzhou Confemce on Management oftechnology Volss I and II2009，，： | 1 |
| 11 | Preparation and characterization ofZnO/ polyethersulfone (PES ) hybrid membranes 显示文摘 | L Shen X Bian X Lu | 2012 | Desalination2012，293，8： | 1 |
| 12 | Influence of aged conductor surface conditions on AC corona discharge with a corona cage 显示文摘 | Bian X M Yu D M Chert L etal | 2011 | IEEE Transactions on Dielectrics and Electrical Insulation2011，18，3： | 1 |
| 13 | Positive corona inception voltages and corona currents for air at various pressures and humidities 显示文摘 | Bian X Wang L MacAlpine J M K | 2010 | IEEE Transac- tions on Dielectrics and Electrical Insulation2010，17，1： | 1 |
| 14 | 显示文摘 | Bian J M Li X M Zhang L D | 2004 | Appl Phys Lett2004，84，： | 1 |
| 15 | Effects of Acanthopanax senticosus polysaccharide supplementation on growth performance,immunity,blood parameters and expression of pro-inflammatory cytokines genes in challenged weaned piglets显示文摘 | Han J Bian L Liu X | 2014 | Asian-Australas J Anim Sci2014，27，7： | 1 |
| 16 | Effect of quenching temperature on the chemical short-range order in Al-Fe-Ce amorphous alloys 显示文摘 | Zhang L Wu Y S Bian X F | 1999 | J Mater Sci Lett1999，18，： | 1 |
| 17 | Influence of aged conductor surface conditions on ac corona discharge with a corona cage显示文摘 | Bian X M Yu D M Chen L | 2011 | IEEE Transactions on Dielectric and Electrical Insulation2011，18，3： | 1 |
| 18 | Molecular characteristics of the tubeworm, Ridgeia piscesae, from the deep-sea hydrother- real vent 显示文摘 | Ruan L W Bian X F Wang X | 2008 | Extremophiles2008，12，5： | 1 |
| 19 | Impact of surface roughness on corona discharge for 30-year operating conductors in 500kV AC power transmission line显示文摘 | Bian X M Chen L Yu D M | 2012 | IEEE Transactions on Power Delivery2012，27，3： | 1 |
| 20 | Broadband circularly polarized annular-ring microstfip antenna显示文摘 | Guo Y X Bian L Shi X Q | 2009 | Antennas and Propagation IEEE Transactions on2009，57，8： | 1 |
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