维普期刊资源整合服务平台（V6.5）

92篇 您的检索式：作者名="BIGARD"

选中清除导出查看参考文献查看引证文献引用追踪共5页首页上一页第1页下一页末页 /5 跳转

	题名	作者	年代	出处	被引量
1	Adalimumab induction therapy for ulcerative colitis with intolerance or lost response to infliximab: An open-label study显示文摘AIM: To evaluate the efficacy of adalimumab induction therapy in patients with ulcerative colitis who previously responded to infliximab and then lost response or became intolerant. METHODS: Ten patients with ulcerative colitis were enrolled in a 4-wk open-label trial. The patients received a loading dose of 160 mg adalimumab at wk 0 followed by 80 mg at wk 2. The primary efficacy measure was clinical improvement at wk 4, as defined by a decrease in clinical activity index (CAI) of more than 4. RESULTS: Four of 10 patients (40%) benefited from subsequent adalimumab therapy; one patient achieved remission (CAI < 4) and 3 had clinical improvement at wk 4. 6 patients had no response (60%); 2 of 6 (33.3%) subsequently underwent colectomy. This was accompanied by a decrease in median CRP concentration from 16.8 mg/mL at baseline to 3.85 mg/mL at wk 4, excluding two patients who underwent colectomy after two infusions of adalimumab. Among the 6 patients with severe colitis (CAI > 12) at baseline, none achieved remission and only one patient had clinical improvement at wk 4. CONCLUSION: The small advantage of adalimumab in patients with mild to moderate ulcerative colitis and lost response or intolerance to infliximab needs to be confirmed in randomised, double-blind, placebo- controlled trials.	Laurent Peyrin-Biroulet Cécile Laclotte Xavier Roblin Marc-André Bigard	2007	World Journal of Gastroenterology2007，13，16：	2
2	Adaptation of cardiac myosin and creatine kinase to chronic hypoxia:role of anorexia and hypertension显示文摘	Pissarek M Bigard X Mateo P	1997	Am J Physiol Heart Circ Physiol1997，41，4：	1
3	Beneficial effects ofendurance training on cardiac and skeletal muscle energy me-tabolism in heart failure显示文摘	Ventura-Clapier R Mettauer B Bigard X	2007	Cardiovasc Res2007，73，1：	1
4	Sodium citrate ingestion and muscle performance in acute hypobaric hypoxia显示文摘	Hausswirth C Bigard A X Lepers R	1995	Eur J Appl Physiol1995，71，4：	1
5	Changes in diet- ary protein intake fail to prevent decrease in muscle growth induced by severe hypoxia in rats 显示文摘	BIGARD AX DOUCE P MERINO D	1996	J Appl Physiol (1985)1996，80，1：	1
6	Changes in myosin heavy chain profile of mature regenerated muscle with endurance training in rat显示文摘	Bigard A X Janmot C Sanchez H	1999	Acta Physiol Scand1999，165，2：	1
7	Effects of chronic hypoxia and endurance training on muscle capillarity in rats显示文摘	BIGARD A X BRUNET A GUEZENNEC C Y	1991	Pflugers Arch1991，419，34：	1
8	Skeletal muscle changes after endurance training at high altitude显示文摘	BIGARD AX	1991	J Appl Phsiol1991，71，6：	1
9	Skeletal muscle changes after endurance training at high altitude显示文摘	BIGARD A X BRUNET A GUEZENNEC C Y	1991	J Appl Physiol1991，71，6：	1
10	Adaptation of cardiac myosin and creatine kinase to chronic hypoxia: role of anorexia and hypertension显示文摘	Pissarek M Bigard X Mateo P	1997	Am J Physiol1997，272，42：	1
11	Myosin heavy chain composition of skeletal muscles in young rats growing under hypobaric hypoxia conditions 显示文摘	Bigard AX Sanchez H Birot O	2000	J Appl Physiol2000，88，：	1
12	Thyroid hormones and muscle phenotype : involvement of new signaling pathways 显示文摘	Bigard AX Koulmann N Bahi L	2008	J SocBio2008，202，2：	1
13	Effects of hindlimb suspension and androgen treatment on testosterone receptors in rat skeletal muscles显示文摘	Bricout VA Serrurier BD Bigard AX	1999	Eur J Appl Physiol Occup Physiol1999，79，：	1
14	Effects of prolonged exercise on brain ammonia and amino acids显示文摘	Guezennec CY Abdelmalki A Serrurier B Merino D Bigard X Berthelot M	1998	Int J Sports Med1998，19，5：	1
15	Muscle damage induced by running training during recovery from hindlimb suspension:the effect of dantrolene sodium显示文摘	Bigard AX Merino D Lienhard F	1997	Eur J Appl Physiol Occup Physiol1997，76，5：	1
16	Branched-chain amino acid supplementation during repeated prolonged skiing exercises at altitude显示文摘	Bigard AX Satabin P Lavier P	1996	Int J Sport Nutr1996，6，3：	1
17	Skeletal muscle changes after endurance training athigh altitude显示文摘	BIGARD A X BRUNET A GUEZENNEC C Y	1991	J Appl Physiol1991，71，6：	1
18	Posture control after prolonged exercise显示文摘	Romuald Lepers André X. Bigard Jean-Pierre Diard Jean-Fran?ois Gouteyron Charles Y. Guezennec	1997	European Journal of Applied Physiology and Occupational Physiology1997，，1：	1
19	Changes in Dietary Protein Intake Fail to Prevent Decrease in Muscle Growth Induced by Severe Hypoxia in Rats 显示文摘	BIGARD A X DOUCE P MERINO D	1996	J Appl Physiol1996，80，1：	1
20	Interaction between signalling pathways involved in skeletal muscle responses to endurance exercise显示文摘	KOULMANN N BIGARD A	2006	Pflügers Archiv-European Journal of Physiology2006，，02：	1

返回顶部每页显示：

共5页首页上一页第1页下一页末页 /5 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示