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| 1 | Pluronic L-81 ameliorates diabetic symptoms in db/db mice through transcriptional regulation of microsomal triglyceride transfer protein显示文摘AIM: To test whether oral L-81 treatment could im-prove the condition of mice with diabetes and to investigate how L-81 regulates microsomal triglyceride transfer protein (MTP) activity in the liver. METHODS: Genetically diabetic (db/db) mice were fed on chow supplemented with or without L-81 for 4 wk. The body weight, plasma glucose level, plasma lipid profile, and adipocyte volume of the db/db mice were assessed after treatment. Toxicity of L-81 was also evaluated. To understand the molecular mecha-nism, HepG2 cells were treated with L-81 and the effects on apolipoprotein B (apoB) secretion and mRNA level of the MTP gene were assessed.RESULTS: Treatment of db/db mice with L-81 sig-nificantly reduced and nearly normalized their body weight, hyperphagia and polydipsia. L-81 also markedly decreased the fasting plasma glucose level, improved glucose tolerance, and attenuated the elevated levels of plasma cholesterol and triglyceride. At the effective dosage, little toxicity was observed. Treatment of HepG2 cells with L-81 not only inhibited apoB secretion, but also signif icantly decreased the mRNA level of the MTP gene. Similar to the action of insulin, L-81 exerted its effect on the MTP promoter. CONCLUSION: L-81 represents a promising candidate in the development of a selective insulin-mimetic mol-ecule and an anti-diabetic agent. | Wo-Shing Au Li-Wei Lu Sidney Tam Otis King Hung Ko Billy KC Chow Ming-Liang He Samuel S Ng Chung-Man Yeung Ching-Chiu Liu Hsiang-Fu Kung Marie C Lin | 2009 | World Journal of Gastroenterology2009，15，24： | 1 |
| 2 | A six-month, supervised, erotic dressiest exercise program improves self-efficacy people with hum immunodeficiency virus: Odorized cotrolled trill显示文摘 | Fillips S Oldmedow L B Billy M J | 2006 | Aust J Physiotherapy2006，52，3： | 1 |
| 3 | Human idiopathicepiretinal membranes express NGF and NGF receptors 显示文摘 | MINCffiOTTI S STAMPACHIACCHIERE B MICERA A LAM-BIASE A RIPANDELLI G BILLI B | 2008 | fleZma2008，28，4： | 1 |
| 4 | Anti-washout admixtures in underwater concrete显示文摘 | Billy D N | 1987 | Concrete International1987，18，5： | 1 |
| 5 | Temperature extemes produced orally by hot and cold liquids显示文摘 | Palmer D S Barco M T Billy E J | 1992 | Journal of Prosthetic Dentistry1992，67，： | 1 |
| 6 | Biomechanics of lat- eral plate and pedicle screw constructs in lumbar spines in- strumented at two levels with laterally placed interbody ca- ges显示文摘 | Nayak AN Gutierrez S Billys JB | 2013 | Spine J2013，13，10： | 1 |
| 7 | Gene expression of Insulin-like growth factors (IGFs), the type I IGF receptor, and IGF-binding proteins in dexamethasone- induced fetal growth retardation 显示文摘 | Wayne A P Alan D S Billie M M | 1992 | Endocrinol1992，130，3： | 1 |
| 8 | Long term follow up after splenec tomy performed for ITP显示文摘 | Schwartz J Leber MD Billis S | 2003 | Am J Hematol2003，72，： | 1 |
| 9 | Lactate infusion at rest increases BDNF blood concentration in humans显示文摘 | Thorsten S Stefanie S Billy S | | 0，，03： | 1 |
| 10 | Production of α-1,3-galactosyltransferase knockout Pigs by nuclear transfer cloning显示文摘 | Donna K S Kwang W P Hee T C Julia L G Gi S I Melissa S Aaron B August R Billy N D Clifton N M David B C Robert J H Randall S P | 2002 | Science2002，295，5557： | 1 |
| 11 | Pathogenesis of and management strategies for postoperative delirium after hip fracture显示文摘 | Martin S Bitsch Nicolai B Foss Billy B Kristensen | 2004 | Acta Orthop Scand2004，75，4： | 1 |
| 12 | Heme metabolism after discontinued hexachlorobenzene administration in rats: Possible irreversible changes and biomarker for hexachlorobenzene persistence显示文摘 | S C Billi de Catabbi C Aldonatti L C San Martin de Viale | 2000 | Comparative biochemistry and physiology Part C2000，127，： | 1 |
| 13 | Anti-washout admixtures in underwater concrete显示文摘 | KENNETH L S BILLY D N | 1987 | Concrete International1987，9，5： | 1 |
| 14 | Experimental Determi- nation and Modeling of the Radiative Properties of Sil- ica Nanoporous Matrices 显示文摘 | LMlich S Enguehard F Billis D | 2009 | Journal of Heat Transfer2009，131，： | 1 |
| 15 | Radiative Properties of Silica Nanoporous Matrices显示文摘 | Lallieh S Enguehard F Billis D | 2008 | International Journal of Thermophysics2008，29，： | 1 |
| 16 | Multi-Dimensional Hybrid Simulation Using a Six-Actuator Self-Reaction Loading System 显示文摘 | Narutoshi N Billie F S | 2008 | The 14th World Conference on Earthquake Engineering2008，，： | 1 |
| 17 | Renal medullary carcinoma:report of seven cases from Brazil显示文摘 | Watanabe I C Billis A Guimaraes M S | 2007 | Mod Pathol2007，20，9： | 1 |
| 18 | Calculation of the vectorial field distribution in a stratified focal region of a high numerical aperture imaging system显示文摘 | NES A S BILLY L PEREIRA S F | 2004 | Opt Express2004，12，7： | 1 |
| 19 | Hybrid dynamic stabiliza- tion with posterior spinal fusion in the lumbar spine显示文摘 | Hudson W R S Gee J E Billys J B | 2011 | SAS Journal2011，5，2： | 1 |
| 20 | Summary of the AUA Guideline on management of primary vesicoureteral reflux in children显示文摘 | PETERS CA SKOOG SJ BILLY S | 2010 | J Urol2010，184，3： | 1 |
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