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| 1 | Colorectal cancer: From prevention to personalized medicine显示文摘Colorectal cancer(CRC)is a very heterogeneous disease that is caused by the interaction of genetic and environmental factors.CRC develops through a gradual accumulation of genetic and epigenetic changes,leading to the transformation of normal colonic mucosa into invasive cancer.CRC is one of the most prevalent and incident cancers worldwide,as well as one of the most deadly.Approximately 1235108 people are diagnosed annually with CRC,and 609051 die from CRC annually.The World Health Organization estimates an increase of77%in the number of newly diagnosed cases of CRCand an increase of 80%in deaths from CRC by 2030.The incidence of CRC can benefit from different strategies depending on its stage:health promotion through health education campaigns(when the disease is not yet present),the implementation of screening programs(for detection of the disease in its early stages),and the development of nearly personalized treatments according to both patient characteristics(age,sex)and the cancer itself(gene expression).Although there are different strategies for screening and although the number of such strategies is increasing due to the potential of emerging technologies in molecular marker application,not all strategies meet the criteria required for screening tests in population programs;the three most accepted tests are the fecal occult blood test(FOBT),colonoscopy and sigmoidoscopy.FOBT is the most used method for CRC screening worldwide and is also the primary choice in most population-based screening programs in Europe.Due to its non-invasive nature and low cost,it is one of the most accepted techniques by population.CRC is a very heterogeneous disease,and with a few exceptions(APC,p53,KRAS),most of the genes involved in CRC are observed in a small percentage of cases.The design of genetic and epigenetic marker panels that are able to provide maximum coverage in the diagnosis of colorectal neoplasia seems a reasonable strategy.In recent years,the use of DNA,RNA and protein markers in different biological samples has been explored as strategies for CRC diagnosis.Although there is not yet sufficient evidence to recommend the analysis of biomarkers such as DNA,RNA or proteins in the blood or stool,it is likely that given the quick progression of technology tools in molecular biology,increasingly sensitive and less expensive,these tools will gradually be employed in clinical practice and will likely be developed in mass. | Gemma Binefa Francisco Rodríguez-Moranta àlex Teule Manuel Medina-Hayas | 2014 | World Journal of Gastroenterology2014，20，22： | 67 |
| 2 | Local evidence aggregation for regression-based facial point detection显示文摘 | Martinez B Valstar M F Binefa X | 2013 | IEEE Trans on Pattern Analysis and Machine Intelligence2013，35，5： | 1 |
| 3 | Linking visual caes and semantic terms under specific digital video domains 显示文摘 | Sanchez J M Binefa X Vitria J | 2000 | Journal of Visual Languages and Computing2000，11，3： | 1 |
| 4 | Ostpolypectomy surveil-lance in patients with adenomas and serrated lesions : aproposal for risk stratification in the context of organizedcolorectal cancer screening programs显示文摘 | Castells A Andreu M Binefa G | 2015 | Endoscopy2015，47，1： | 1 |
| 5 | Shot partitioning based recognition of TV commercials 显示文摘 | SANCHEZ J M BINEFA X VITRIA J | 2002 | Multimedia Tools and Applications2002，15，： | 1 |
| 6 | A sparse curvature-based detec-tor of affine invariant blobs显示文摘 | Ferraz L Binefa X | 2012 | Computer Vision andImage Understanding2012，116，4： | 1 |
| 7 | Piecewise affine kernel tracking for non-planar targets 显示文摘 | Brais Martinez Xavier Binefa | 2008 | Pattern Recognition2008，41，： | 1 |
| 8 | A sparse curvature-based detector of affine invariant blobs显示文摘 | FERRAZ L BINEFA X | | 0，，04： | 1 |
| 9 | Survival changes among AIDS cases in Catalonia,Spain(1981-2001)显示文摘 | Rius C Binefa G Montoliu A | 2006 | Med Clin(Barc)2006，127，5： | 1 |
| 10 | Adherencia al programa poblacional de detección precoz de cáncer colorrectal en Catalu?a, 2000-2008显示文摘 | Núria Milà Montse García Gemma Binefa Josep Maria Borràs Josep Alfons Espinàs Víctor Moreno | 2011 | Gaceta Sanitaria2011，，3： | 1 |
| 11 | False-positive results from colorectal cancer screening in Catalonia (Spain), 2000–2010显示文摘 | Montse Garcia Núria Milà Gemma Binefa Josep Maria Borràs Josep Alfons Espinàs Víctor Moreno | 2012 | Journal of Medical Screening2012，，2： | 1 |
| 12 | Survival changes among AIDS cases in Catalonia, Spain ( 1981-2001 ) 显示文摘 | Rius C Binefa G Montoliu A | 2006 | Med Clin (Barc)2006，127，5： | 1 |
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