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| 1 | Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy显示文摘Oral dichloroacetate sodium(DCA) has been investigated as a novel metabolic therapy for various cancers since 2007, based on data from Bonnet et al that DCA can trigger apoptosis of human lung, breast and brain cancer cells. Response to therapy in human studies is measured by standard response evaluation criteria for solid tumours definitions, which define 'response' by the degree of tumour reduction, or tumour disappearance on imaging. However, Blackburn et al have demonstrated that DCA can also act as a cytostatic agent in vitro and in vivo, without causing apoptosis(programmed cell death). A case is presented in which oral DCA therapy resulted in tumour stabilization of stage 4 colon cancer in a 57 years old female for a period of nearly 4 years, with no serious toxicity. Since the natural history of stage 4 colon cancer consists of steady progression leading to disability and death, this case highlights a novel use of DCA as a cytostatic agent with a potential to maintain long-term stability of advanced-stage cancer. | Akbar Khan Douglas Andrews Anneke C Blackburn | 2016 | World Journal of Clinical Cases2016，4，10： | 4 |
| 2 | Patients undergoing infrainguinal bypass to treat atherosclerotic vascular disease are underprescribed cardioprotective medications: effect on graft patency, limb salvage, and mortality显示文摘 | Peter K Henke Susan Blackburn Mary C Proctor Jeri Stevens Debabrata Mukherjee Sanjay Rajagopalin Gilbert R Upchurch James C Stanley Kim A Eagle | 2004 | Journal of Vascular Surgery2004，，： | 2 |
| 3 | Ranolazine,a partial fatty acid oxidation inhibitor,reduce myocardialinfarct size and cardic troponin T release in the rat显示文摘 | Zacharowski K Blackburn B Thienmermann C | 2001 | Eur J Pharmacol2001，418，12： | 1 |
| 4 | Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H) ones as inhibitors of the fatty acid transporter FATP4显示文摘 | Blackburn C Guan B Brown J | 2006 | Bioorg Med Chem Lett2006，16，13： | 1 |
| 5 | Towards the remote sensing of matorral vegetation physiology:relationships between spectral reflectance,pigment,and biophysical characteristics of semiarid bushland canopies显示文摘 | Blackburn G A Steele C M | | 0，，3： | 1 |
| 6 | Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging显示文摘 | BLACKBURN E H GREIDER C W SZOSTAK J W | 2006 | Nat Med2006，12，10： | 1 |
| 7 | A complementary numerical and physical investigation of vortex-induced vibration显示文摘 | Blackburn M Govardhan R N Williamson C H K | 2001 | Journal of Fluids and Structures2001，15，： | 1 |
| 8 | Separation and detection of Salmonellae using immunornagnetie particles显示文摘 | Blackburn C de W Patel PD Gibbs PA | 1991 | Biofouling1991，5，： | 1 |
| 9 | Salicylate hydroxylation as an indicator of hydroxyl radical generation in dextran sulfate-induced colitis 显示文摘 | BLACKBURN A C DOE W F BUFFINTON G D | 1998 | Free Radio Biol Med1998，25，3： | 1 |
| 10 | Isolation of Mycoplasma bovis from cattle in Northern Ireland from 1999 to 2005 显示文摘 | BLACKBURN P BROOKS C MCCONNELL W | 2007 | Vet Rec2007，161，13： | 1 |
| 11 | Turbulent Pipe Flow at ReT ?1000:A Comparison of Wall-resolved Large-eddy Simulation, Direct Numerical Simulation and Hot-wire Experiment显示文摘 | Chin C Ng H C H Blackburn H Mj | 2015 | Computers & Fluids2015，122，： | 1 |
| 12 | The influence of auto- clave steam on polymer and organic fibre modified ceramic shells显示文摘 | YUAN C JONES S BLACKBURN S | 2005 | Journal of the European Ceramic Society2005，25，： | 1 |
| 13 | Identification of a specific telomere terminal transferase activity in Tetrahymena extracts显示文摘 | Grieder C Blackburn E | 1985 | Cell1985，43，： | 1 |
| 14 | A role for the transcriptional repressor Blimp-] in CD8+ T cell exhaustion during chronic viral infection 显示文摘 | Shin H Blackburn SD Intlekofer AM Kao C Angelosan- to JM Reiner SL Wherry El | 2009 | Immunity2009，31，2： | 1 |
| 15 | Identification of a specific telomere terminal transferase activity in tetrahymena extracts 显示文摘 | Greider C W Blackburn E H | 1985 | Cell1985，43，： | 1 |
| 16 | Tenidap in rheumatoid arthritis:a 24-week double-blind comparison with hydroxychloroquine-plus-piroxicam,and piroxicam alone显示文摘 | Prupas H M Silverfield J C | 1995 | Arthritis Rheum1995，38，10： | 1 |
| 17 | One-solvent polymorph screen of carbamazepine显示文摘 | Getsoian A Lodaya R M Blackburn A C | 2008 | International Journal of Pharmaceutics2008，348，12： | 1 |
| 18 | Phase Transformations in Ti-Mo and Ti-V alloys显示文摘 | BLACKBURN M J WILLIAMS J C | 1968 | Transactions of TMS-AIME1968，242，： | 1 |
| 19 | A telomeric sequence in the RNA of tetrahymena telomerase required for telomere repeat synthesis 显示文摘 | Greider C W Blackburn E H | 1989 | Nature1989，337，： | 1 |
| 20 | Identification of a specific telomere terminal transferase activity in Tetrahymena extracts显示文摘 | Blackburn E H | 1985 | Cell1985，43，： | 1 |
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