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| 1 | OPG对TNF诱导的成骨细胞凋亡的抑制作用显示文摘目的 探讨TNF α能否诱导成骨类细胞凋亡及OPG能否抑制其凋亡 ,开辟一条防治骨质疏松的新路。方法 将人间充质干细胞在分化培养液中培养 2 1天使之成为成骨细胞 ,与MG6 3一起用于凋亡实验。鼠WEHI 16 4细胞系用于阳性对照。AnnexinV和TUNEL分析方法检测成骨类细胞凋亡。结果 和FasL诱导细胞凋亡一样 ,TNF α能引起MG6 3骨肉瘤细胞、间充质干细胞和成骨细胞的凋亡 ,并表现为明显的浓度依赖和时间依赖。低浓度TNF α(170~ 5 0 0 pmol/L)作用于细胞 2~ 4h就显示了较明显的凋亡 ,而 0 4 5~1 5nmol/LOPG几乎完全抑制了 5 0 0 pmol/LTNF α诱导的凋亡。结论 OPG能够抑制TNF α诱导的成骨类细胞凋亡。 | 步荣发 李亚男 Jennifer I Oakley Harry C Blair | 2004 | 解放军医学杂志2004，29，4： | 4 |
| 2 | Bone and high-density lipoprotein:The beginning of a beautiful friendship显示文摘There is a tight link between bone and lipid metabolic pathways.In this vein,several studies focused on the exploration of high-density lipoprotein(HDL)in the pathobiology of bone diseases,with emphasis to the osteoarthritis(OA)and osteoporosis,the most common bone pathologies.Indeed,epidemiological and in vitro data have connected reduced HDL levels or dysfunctional HDL with cartilage destruction and OA development.Recent studies uncovered functional links between HDL and OA fueling the interesting hypothesis that OA could be a chronic element of the metabolic syndrome.Other studies have linked HDL to bone mineral density.Even though at epidemiological levels the results are conflicting,studies in animals as well as in vitro experiments have shown that HDL facilitates osteoblastogensis and bone synthesis and most probably affects osteoclastogenesis and osteoclast bone resorption.Notably,reduced HDL levels result in increased bone marrow adiposity affecting bone cells function.Unveiling the mechanisms that connect HDL and bone/cartilage homeostasis may contribute to the design of novel therapeutic agents for the improvement of bone and cartilage quality and thus for the treatment of related pathological conditions. | Dionysios J Papachristou Harry C Blair | 2016 | World Journal of Orthopedics2016，7，2： | 3 |
| 3 | Two rules for deducing valid inequalities for 0-1 problems显示文摘 | BLAIR C | 1976 | SIAM Journal on Applied Mathematics1976，31，4： | 1 |
| 4 | A cross-validation of safety climate scale using confirmatory factor analytic approach 显示文摘 | Seo D C Torabi M R Blair E H | 2004 | Journal of Safety Research2004，35，4： | 1 |
| 5 | Early intervention for low birth weight,preterm in- fants: the role of negative emotionality in the specification of effects显示文摘 | Blair C | 2002 | Dev Psychopathol2002，14，2： | 1 |
| 6 | Morphological and electrophoretic investigations of selected species of Chaetomorpha (Chlorophyta,Cladophorales)显示文摘 | Blair S M Matheieson A C Cheney D P | 1982 | Phycologia1982，21，： | 1 |
| 7 | Analysis of compressive fracture in rock using statistical techniques : Part II : effect of mi- croscale heterogeneity on macroscopic deformation 显示文摘 | Blair S C Cook N G | 1998 | International Journal of Rock Mechanics and Mining Sciences 8< Geomechanics Abstracts1998，35，7： | 1 |
| 8 | Hydroxylated and methoxylated polybrorninated diphenyl ethers in a Canadian Arctic marine food web 显示文摘 | KELLY B C IKONOMOU M G BLAIR J D | 2008 | Environmental Science & Technolo- gy2008，42，19： | 1 |
| 9 | 3-D Printing of open source appropriate technologies for self-directed sustainable development显示文摘 | Pearce JM Morris Blair C Laciak KJ Andrews R Nosrat A Zelenika-Zovko I | 2010 | J Sustain Dev2010，3，4： | 1 |
| 10 | Regional trabecular bone matrix degeneration and osteocyte death in femora of glucocorticoid-treated rabbits显示文摘 | EBERHARDT AW YEAGER-JONES A BLAIR H C | 2001 | Endocrinology2001，142，3： | 1 |
| 11 | Forced response of bladed disk assemblies-a survey 显示文摘 | Slater J C Minkiewicz G R Blair A J | 1999 | The Shock and Vibration Digest1999，31，1： | 1 |
| 12 | Alluvial-Fans and TheirNatural Distinction from Rivers Based on Morpholo-gy, Hydraulic Iocesses, Sedimentary Processes,and Facies Assemblages 显示文摘 | Blair T C Mcpherson J G | 1994 | Journal of SedimentaryResearch1994，64，： | 1 |
| 13 | Bom to run:competition enhances the spread of genes from crops to wild relatives 显示文摘 | Wolfe L M Blair A C | 2007 | New Phytolo- gist2007，173，3： | 1 |
| 14 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 15 | Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in hutchinson-gilford progeria syndrome cells显示文摘 | Cao K Graziotto J J Blair C D | 2011 | Sci Transl Med2011，3，89： | 1 |
| 16 | Structure-guided development of affinity probes for tyrosine kinases using chemical genetics 显示文摘 | Blair J A Rauh D Kung C | 2007 | Nat Chem Biol2007，3，4： | 1 |
| 17 | Proresorptive actions of FSH and bone loss显示文摘 | Zaidi M Blair H C Iqbal J | 2007 | Ann N Y Acad Sci2007，1116，6： | 1 |
| 18 | Carbon remineralization in the Amazon-Guianas mobile mudbelt: a sedimentary incinerator显示文摘 | ALLER R C BLAIR N E | 2006 | Continental Shelf Research2006，26，： | 1 |
| 19 | IGFs and IGFBPs in GH insensitivity 显示文摘 | SAVAGE M O BLAIR J C JORGE A J | 2005 | Endocr Dev2005，9，： | 1 |
| 20 | Defining thyrotropin dependent and independent steps of thyroid hormone synthesis by using thyrotropin receptor null mice显示文摘 | Marians R C Ng L Blair H C | | 0，，： | 1 |
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