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| 1 | New therapeutic opportunities for Hepatitis C based on small RNA显示文摘Hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, anti-sense oligonucleotides (ASO), or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA (miR-122) in viral replication and discuss its potential for HCV molecular therapy. | Qiu-wei Pan Scot D Henry Bob J Scholte Hugo W Tilanus Harry LA Janssen Luc JW van der Laan | 2007 | World Journal of Gastroenterology2007，13，33： | 4 |
| 2 | Enhanced adsorption of natural organic matter on calcium carbonate particles through surface charge modification显示文摘 | Mustafa Bob Harold W Walker | 2001 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2001，191，12： | 1 |
| 3 | Effect of marchantins and related compounds on 5-1ipoxygenase and cyclooxygenase and their antioxidant properties a structure activity relationship study 显示文摘 | SCHWARTNEB C BOBS W MICHEL C | 1995 | Phytomedicine1995，2，2： | 1 |
| 4 | An Improved Optimization Algorithm and a Bayes Factor Termination Criterion for Sequential Projection Pursuit显示文摘 | Bobbie J M Webb-Robertson Kristin H J Scott D H Christian P Bob W W | 2005 | Chemometrics and Intelligence Laboratory Systems2005，77，12： | 1 |
| 5 | Low-temperature processing of a solution-deposited CulnSSe thin-film solar cell 显示文摘 | HOU W BOB B LI S | 2009 | Thin Solid Films2009，517，24： | 1 |
| 6 | A special fructose bisphosphate functions as a cytoplasmic regulatory metabolite in green leaves显示文摘 | Csaba C Norman F W Bob B B | 1982 | Proc Natd Acad Sci1982，79，： | 1 |
| 7 | Stabilization and complex dynamics in a predator-prey model with predator suffering from an infectious disease 显示文摘 | BOB W K GEORGE A K VAN VOORN | 2011 | Ecological Complexity2011，8，： | 1 |
| 8 | Tools for interpreting FEA results显示文摘 | BOB W | 2004 | Machine Design2004，76，19： | 1 |
| 9 | Much ado about nothing long-term memory in Pacific rim equity markets显示文摘 | Howe J S Martin D W Bob G Wood J | 1999 | International Review of Financial Analysis1999，8，2： | 1 |
| 10 | Cisplatin effects on F-ac-tin and matrix proteins precede renal tubular cell detachment andapoptosis in vitro显示文摘 | Maricke K Bob van de W Yi Z | 1998 | Cell death and Differentiation1998，5，： | 1 |
| 11 | Transurethral microwave thermotherapy for treatment of benign prostatic hyperplasia 显示文摘 | MATTIAS W BOB D | 2004 | JMHG2004，1，23： | 1 |
| 12 | The Idea of Natural History显示文摘 | Adorno Theodor W Bob Hullot-Kentor | | 0，，： | 1 |
| 13 | Stability of particle flocs upon addition of natural organic matter under quiescent conditions 显示文摘 | WALKER H W BOB M M | 2001 | Water Res2001，35，4： | 1 |
| 14 | Stability of particle flocs upon addition of natural organic matter under quiescent conditions 显示文摘 | Walker H W Bob M M | 2001 | Water Research2001，35，4： | 1 |
| 15 | Stability of particle flocs upon addition of natural organic matter under quiescent conditions 显示文摘 | Walker H W Bob M M | 2001 | Water Research2001，35，4： | 1 |
| 16 | Stability of particle flocs upon addition of natural organic matter under quiescent conditions 显示文摘 | Harold W Walker Mustafa M Bob | 2001 | Wat Res2001，35，4： | 1 |
| 17 | Stability of particle flocs upon addition of natural organic matter under quiescent conditions显示文摘 | Walker H W Bob M M | 2001 | Water Res2001，35，4： | 1 |
| 18 | Measuring Presence in Virtual Environments: A Presence Questionnaire显示文摘 | Bob G W Michael J S | 1998 | Presence: Teleoperators and Virtual Environments1998，7，3： | 1 |
| 19 | The sequence align- ment/map (SAM) format and SAMtools 显示文摘 | HENG L BOB H ALEC W | 2009 | Bioinformat- ics2009，25，： | 1 |
| 20 | Scheduling water application on drip irrigated sugar- cane 显示文摘 | Bob W | 2004 | Agricultural Water Management2004，64，： | 1 |
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