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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Nephrogenic diabetes insipidus(NDI):clinical,laboratory and genetic characterization of five Brazilian patients显示文摘 | Vaisbich MH Carneiro J Boson W | | 0，，： | 1 |
| 3 | A detailed investigation of HPGe detector response for improved Monte Carlo efficiency calculations显示文摘 | BOSON J AGREN G JOHANSSON L | 2008 | Nucl Instrum Methods A2008，587，： | 1 |
| 4 | Induction of neutralising antibodies by virus-like particles harbouring surface proteins from highly pathogenic H5N1 and H7N1 influenza viruses显示文摘 | Szécsi J Boson B Johnsson P | 2006 | Virol J2006，3，： | 1 |
| 5 | Nephrogenic diabetes insipidus ( NDI) : clinical, laboratory and genetic characterization of five Brazilian patients 显示文摘 | Vaisbich MH Carneiro J Boson W | 2009 | Clinics (Sao Paulo)2009，64，5： | 1 |
| 6 | Lycopene is a more potent inhibitor of human cancer cell proliferation than either alofacarotene or beta-carotene显示文摘 | LEVY J BOSON E FELDMAN B | 1995 | Nutrition and Cancer1995，24，： | 1 |
| 7 | Deep vein thrombosis in elderly patients hospitalized in subacute care facilities:a multicenter cross-sectional study of risk factors,prophylaxis,and prevalence显示文摘 | Boson JL Labarere J Sevestre MA | 2003 | Arch intern Med2003，163，： | 1 |
| 8 | Deep vein thrombosis in elderly patients hospitalized in subacute care facilities : A multi center cross sec- tional study of risk factors, prophylaxis and prevalence 显示文摘 | Boson JL Labarere J Sevestre MA | 2003 | Archintern Med2003，163，21： | 1 |
| 9 | Induction of neu- tralising antibodies by virus-like particles harbouring surface proteins from highly pathogenic HSN1 and HTN1 influenza viruses显示文摘 | Szecsi J Boson B Johnsson P | 2006 | Virol J2006，3，： | 1 |
| 10 | A detailed investiga- tion of HPGe detector response for improved Monte Carlo efficiency calculations 显示文摘 | Boson J gren G Johansson L | 2008 | Nuclear Instruments and Methods in Physics Research Section A:Accelera- tors Spectrometers Detectors and Associated Equip- ment2008，587，2： | 1 |
| 11 | Induction of neutralising anti- bodies by virus-like particles harbouring surface pro- teins from highly pathogenic H5N1 and H7N1 infuenza viruscs显示文摘 | Szecsi J Boson B | 2006 | J Virol2006，370，： | 1 |
| 12 | Induction of neutralising antibodies by virus-like particles harbouring surface proteins from highly pathogenic H5N1 and H7N1 influenza viruses显示文摘 | Szécsi J Boson B Johnsson P | 2006 | Virol J2006，3，： | 1 |
| 13 | Deep vein thrombosis in elderly patients hospitalized in subacute care facilities:A multi centercross -sectional study of risk factors, prophylaxis and prevalence显示文摘 | Boson JL Labarere J Sevestre MA | 2003 | Arch intern Med2003，163，21： | 1 |
| 14 | Lycopene is a more potent inhibitor of human cancer cell proliferation than either alofacarotene or beta-carotene 显示文摘 | Levy J Boson E Feldman B | 1995 | Nutrition and Cancer1995，24，： | 1 |
| 15 | Evaluatien of Monte Carlo-based calibrations of HPGe detectors for in situ gamma-ray spectrometry 显示文摘 | Boson J Plamboeck A H Rameback H | 2009 | Journal of Environmental Radioactivity2009，，100： | 1 |
| 16 | A detailed investigation of HPGe detector response for improved Monte Carlo efficiency calculations 显示文摘 | Boson J Agren G Johansson L | 2008 | Nucl Instrum Methods A2008，587，23： | 1 |
| 17 | Lycopene is a more potent inhibitor of human cancer cell:proliferation than either alpha-carotene or beta-carotene显示文摘 | Levy J Boson E Feldman B | 1995 | Nutrition and Cancer1995，24，4： | 1 |
| 18 | Induction of neutralising antibodies by virus-like particles harbouring surface proteins from highly pathogenic H5N1 and H7N1 influenza viruses显示文摘 | Szecsi J Boson B Johnsson P | 2006 | Virol J2006，3，1： | 1 |
| 19 | Viral and cellular determinants of the hepatitis C virus envelope-heparan sulfate interaction显示文摘 | Barth H Schnober E K Zhang F Linhardt R J Depla E Boson B Cosset F L Patel A H Blum H E Baumert T F | 2006 | J Virol2006，80，10： | 1 |
| 20 | A de-tailed investigation of HPGe detector response for improved Monte Carlo efficiency calculations显示文摘 | BOSON J 樻GREN G JOHANSSON L | | 0，，： | 1 |
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