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| 1 | 源于近端股骨间充质干细胞免疫抑制作用的研究显示文摘目的探讨源于成人近端股骨的间充质干细胞(MSC)是否具有免疫抑制功能,为临床移植物抗宿主病的防治寻找理想的细胞储备库。方法从全髋关节置换术患者的近端股骨中分离并培养MSC,将不同数量的细胞直接或以Transwell法加入混合淋巴细胞反应(MLR)中,检测MSC对外周血淋巴细胞(PBL)增殖水平的影响。以ELISA法及抗体中和法探讨细胞因子TGFβ1在MSC免疫调节中的作用。结果3×103、1×104、3×104、1×105个源于近端股骨的MSC对PBL增殖的抑制率分别为62%±18%、38%±4%、31%±16%、28%±12%,与采自髂骨骨髓穿刺物MSC的抑制作用相比差异无统计学意义(均P>0.05),后者对PBL的增殖抑制率为58%±12%、37%±8%、28%±6%、27%±6%;以0.2μm的微孔膜对MSC与MLR进行分隔,3×104及1×104个MSC对PBL的增殖抑制率为36%±8%和53%±12%;在ELISA实验中,MSC单独培养,MSC与MLR直接接触,或经Transwell共培养的这3种上清中转化生长因子(TGF)β1的表达水平差异无统计学意义,加入浓度递增的TGFβ1抗体不能逆转MSC对PBL增殖的抑制作用。结论源于近端股骨的MSC具有一定的免疫抑制功能,除TGFβ1外其他可溶性因子可能介导这一作用。 | 张翼鷟 Loic Fouillard Alain Chapel Morad Bensidhoum Christelle Mazurier Aish Nasef Sandrine Bouchet Manuel Lopez Dominique Thierry Norbert Cclaucle Gorin 达万明 | 2005 | 中华医学杂志2005，85，39： | 11 |
| 2 | Mechanism of friction reduction of unsaturated fatty acids as additives in diesel fuels显示文摘This paper investigates the effect of unsaturated fatty acid additives on the lubricating properties of a biodiesel,composed of a blend of fatty acid methyl esters(FAMEs)and a conventional diesel fuel.The presence of fatty acids as additives for biodiesel improves their lubricating properties at elevated temperature conditions.The formation of a protective lubricating tribochemical film on the steel contact surfaces has been evidenced.Elevated temperature conditions and possibly oxygen are needed to form this film that reduces friction and limits wear.Several analytical tools have revealed the insulating nature of the formed tribofilm and its chemical properties.Friction-induced reticulation is thought to play a major role in the growth of this insulating film. | Jean Michel MARTIN Christine MATTA Maria-Isabel De Barros BOUCHET Cyrielle FOREST Thierry Le MOGNE Thomas DUBOIS Michael MAZARIN | 2013 | Friction2013，1，3： | 7 |
| 3 | Super-low friction of ta-C coating in presence of oleic acid显示文摘Friction tests have been carried out on bearing steel friction pairs coated with a-C:H and ta-C under lubricated conditions with 1-hexadecene and pure oleic acid,respectively.Main results show that ta-C leads to the super-low regime with oleic acid(friction coefficient below 0.01)and that a-C:H is quite well lubricated by 1-hexadecen.Surface analyses by coupling X-ray photoelectron spectroscopy(XPS)and secondary ion mass spectrometry(SIMS)have been carried out in the case of oleic acid with ta-C and a-C:H coatings.Results show that tribochemical reactions have occurred.OH groups terminate the ta-C surface whereas a-C:H is covered by a thin tribofilm and is terminated by oleic acid monolayers.The superlow regime in the case of ta-C is mainly attributed to the presence of the OH-termination. | Makoto KANO Jean Michel MARTIN Kentaro YOSHIDA Maria Isabel DE BARROS BOUCHET | 2014 | Friction2014，2，2： | 6 |
| 4 | Studies on the interactions of Haemophilus parasuis with porcine epithelial tracheal cells: Limited role of LOS in apoptosis and pro-inflammatory cytokine release显示文摘 | Bénédicte Bouchet Ghyslaine Vanier Mario Jacques Eliane Auger Marcelo Gottschalk | 2008 | Microbial Pathogenesis2008，，2： | 2 |
| 5 | Interactions of Haemophilus parasuis and its LOS with porcine brain microvascular endothelial cells显示文摘 | Bouchet B Vanier G Jacques M | 2008 | Vet Res2008，39，5： | 1 |
| 6 | Mollusca Gastropoda: On a collection of Nassariidae from New Caledonian waters显示文摘 | CERNOHORSKY W O CROSNIER A BOUCHET P | 1991 | Results of Musorstom Expenditions1991，7，： | 1 |
| 7 | Structural features and potential texturising properties of lemon and maize cellulose microfibrils显示文摘 | Rondeau-Mouroa C Bouchet B Pontoire B | 2003 | Carbohydrate Polymers2003，53，： | 1 |
| 8 | Classification and nomenclator ofgastropod families 显示文摘 | Bouchet P Rocroi J | 2005 | Malacologia2005，47，1： | 1 |
| 9 | Evapotranspiration reele et potentielle, signification climatique显示文摘 | Bouchet R J | 1963 | Public General Assembly Berkeley International Association Science Hydrology Gentbrugge Belgium1963，62，： | 1 |
| 10 | Structural changes of cassava starch granules after heating at intermediate water contents显示文摘 | Garcia V Colonna R Bouchet B | 1997 | Starch1997，49，5： | 1 |
| 11 | Prognostic value of uPA, PAI- 1 and PAI - 2 mRNA expression in primary breast cancer 显示文摘 | Spyratos F Bouchet C Tozlu S | 2002 | Anticancer Res2002，22，5： | 1 |
| 12 | Toward under- standing of electrical limitations (electronic, ionic) in LiM- PO4 (M = Fe, Mn) electrode materials显示文摘 | Delacourt C Laffont L Bouchet R | 2005 | J Electrochem Soc2005，152，5： | 1 |
| 13 | Constant flowrate blocking laws and an example of their application to dead-end microfiltration of protein solutions显示文摘 | Hlavacek M Bouchet F | | 0，，03： | 1 |
| 14 | Optical wireless communications forbroadband access in home area networks 显示文摘 | LANGER KD GRUBOR J BOUCHET O | 2008 | ICTON 2008 : Proceedings2008，4，： | 1 |
| 15 | Invasion of endothelial cells by systemic and nasal strains of Haemophilus parasuis显示文摘 | Aragon V Bouchet B Gottschalk M | 2010 | The Veterinary Journal2010，186，2： | 1 |
| 16 | Muhidrug resistance gene (MDR1) polymorphisms are associated with major molecular responses to standard-dose imatinib in chronic myeloid leukemia 显示文摘 | Dulucq S Bouchet S Turcq B | 2008 | Blood2008，112，5： | 1 |
| 17 | Leukemia inhibitory factor: Role in human mesenchymal stem cells mediated immunosuppression 显示文摘 | NasefA Mazurier C Bouchet S | 2008 | Cell Immunol2008，253，12： | 1 |
| 18 | Invasion of endothelial cells by systemic and nasal strains of Haemophilus parasuis显示文摘 | Aragon V Bouchet B Gottschalk M | 2009 | Vet J2009，186，2： | 1 |
| 19 | Phenotypic diversity and association mapping for fruit quality traits in cultivated tomato and related species显示文摘 | Xu J X Nicolas R Mu(n)os S Rolland S Bouchet J P Desplat N Paslier M C Le Liang Y Brunel D Causse M | | 0，，3： | 1 |
| 20 | Evapotranspiration reelle et potentielle, signification climatique显示文摘 | Bouchet R J | 1963 | International association of hydrological science1963，62，： | 1 |
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