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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | Li-O2 and Li-S batteries with high energy storage 显示文摘 | Bruce P G Freunberger S A Hardwick L J | 2012 | Nat Mater2012，11，1： | 1 |
| 3 | Environmental lead exposure during early childhood显示文摘 | BRUCE P L RICHARD H MONA H | 2002 | J Pediatr2002，，： | 1 |
| 4 | 查看详情显示文摘 | H L Nguyen P N Horton M B Hursthouse C Legon D W Bruce | | 0，，： | 1 |
| 5 | Analysis of alkylphenol ethoxylate metabolites in the aquatic environment using liquid chromatography - electrospray spectrometry 显示文摘 | Ferguson P L Charles R I Bruce J B | 2000 | Analytical Chemistry2000，72，18： | 1 |
| 6 | Predicting fracture in cold upset forging by finite element methods显示文摘 | John L F Bruce R P | 1989 | J Material Shaping Technology1989，7，1： | 1 |
| 7 | Li-O2 and Li-S batteries with high energy storage显示文摘 | Bruce P G Freunberger S A Hardwick L J | 2012 | Nature Materials2012，11，1： | 1 |
| 8 | New Sand Additive Alternative for Veining in Thin-walled Castings显示文摘 | P L Zajac J Bruce | 1999 | AFS Transactions1999，107，： | 1 |
| 9 | Propylene Polymerization with Unbridge Metallocenes:Ligarid Effects in the Selectivity for Elastomeric Polypropylene显示文摘 | Maciejewsk J L Bruce P M D Waymouth R M | 1997 | Organometallics1997，16，： | 1 |
| 10 | Gravity-scaled tests on blast-induced soil-structure interaction显示文摘 | BRUCE L Kutter L MOQUETTE O'LEARY P Y | 1988 | Journal of Geotechnieal engineering American Society of Civil Engineering1988，144，4： | 1 |
| 11 | Succinylcholine-induced postoperative sore throat显示文摘 | CAPON L M BRUCE D L PATEL K P | 1983 | Anesthesiology1983，59，3： | 1 |
| 12 | Adaptive disk spin-down for mobile computers显示文摘 | David P Helmbold Darrell D E Long Tracey L Sconyers Bruce Sherrod | 2000 | Mobile Networks and Applications2000，5，4： | 1 |
| 13 | Major depression in elderly home health care atients显示文摘 | Bruce M L McAvay G J Raue P J | 2002 | Am J Psychiatry2002，59，8： | 1 |
| 14 | Li-O2 and Li-S batteries with high energy storage显示文摘 | Bruce P G Freunberger S A Hardwick L J | 2012 | Nat Mater2012，11，： | 1 |
| 15 | Low-level environmental lead exposure and children' s intellectual function: An international pooled analysis 显示文摘 | Bruce P L Richard H Jane K | 2005 | Environ Health Perspect2005，113，7： | 1 |
| 16 | Post-pollination hybridization barriers in Nicotiana section Alatae显示文摘 | Christopher B L Lawrence E P Bruce A M | | 0，，3： | 1 |
| 17 | Electrochemical extraction of lithium from LiMn2O4显示文摘 | Johnson P J de Picciotto L Bruce P G | 1984 | Materials Research Bulletin1984，19，2： | 1 |
| 18 | A bilateral comparison of spectral responsivity measurements in the spectral range 250 nm to 1800 nm between the NIST(USA)and the NRC(Canada)显示文摘 | Bruce S S | 2003 | Metrologia2003，40，： | 1 |
| 19 | Li-O2 and Li-S batteries with high energy storage显示文摘 | Bruce P G Freunberger S A Hardwick L J Tarascon J M | 2010 | Nature Materials2010，11，1： | 1 |
| 20 | Electrochemical extraction of lithium from LiMn2O4 显示文摘 | THACKERAY M M JOHNSON P J de PICCIOTTO L A BRUCE P G GOODENOUGH J B | 1984 | Materials Research Bulletin1984，19，2： | 1 |
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