|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | TP53 codon 72 Arg/Arg polymorphism is associated with a higher risk for inflammatory bowel disease development显示文摘AIM: To investigate the association between tumor protein 53(TP53) codon 72 polymorphisms and the risk for inflammatory bowel disease(IBD) development.METHODS: Numerous genetic and epigenetic drivers have been identified for IBD including the TP53 gene. Pathogenic mutations in TP53 gene have only been reported in 50% of colorectal cancer(CRC) patients. A single nucleotide polymorphism(SNP) in the TP53 gene resulting in the presence of either arginine(Arg)or proline(Pro) or both at codon 72 was shown to alter TP53 tumor-suppressor properties. This SNP has been investigated as a risk factor for numerous cancers,including CRC. In this study we analyzed TP53 codon 72 polymorphism distribution in 461 IBD,181 primary sclerosing cholangitis patients and 62 healthy controls. Genotyping of TP53 was performed by sequencing and restriction fragment length polymorphism analysis of genomic DNA extracted from peripheral blood. RESULTS: The most frequent TP53 genotype in IBD patients was Arg/Arg occurring in 54%-64% of cases(and in only 32% of controls). Arg/Pro was the most prevalent genotype in controls(53%) and less common in patients(31%-40%). Pro/Pro frequency was not significantly different between controls and IBD patients. CONCLUSION: The data suggests that the TP53 codon 72 Arg/Arg genotype is associated with increased risk for IBD development. | Natalia Volodko Mohamed Salla Bertus Eksteen Richard N Fedorak Hien Q Huynh Shairaz Baksh | 2015 | World Journal of Gastroenterology2015，21，36： | 9 |
| 2 | Revealing Genetic Relationship and Prospecting of Novel Donors Among Upland Rice Genotypes Using qDTY-Linked SSR Markers显示文摘A total of 17 simple sequence repeat(SSR) markers linked to QTLs(qDTYs) governing grain yield under reproductive stage(RS) drought stress were used to assess the genetic relationship and prospecting new donors for q DTYs among 32 popular upland rice genotypes. These SSR markers generated a total of 36 alleles with an average allele count of 2.1 per locus. Polymorphic information content value of the markers ranged from 0.376 to 0.662 with an average value of 0.484. The expected heterozyogosity ranged from 0.381 to 0.632. STRUCTURE analysis divided the 32 genotypes into three sub-populations. Subsequent phenotyping revealed that all the tolerant genotypes were grouped into one sub-population, whereas the moderately tolerant and susceptible genotypes were grouped into separate sub-populations. Phylogenetic tree constructed by the unweighted neighbour-joining method also divided the genotypes into three clusters. The grouping pattern of genotypes into the clusters was similar to that into the STRUCTURE analysis, on the basis of drought tolerance level. The average value of genetic dissimilarity coefficient among the genotypes was observed to be 0.486. Furthermore, by combining genotyping data with phenotyping data, 16 new donors for 6 qDTYs were identified. | Mitadru MUKHERJEE Barada PADHY Bharathkumar SRINIVASAN Pradosh MAHADANI Sk Yasin BAKSH Ravindra DONDE Onkar Nath SINGH Lambodar BEHERA Padmini SWAIN Sushanta Kumar DASH | 2018 | Rice science2018，25，6： | 2 |
| 3 | Three-dimensional matrices of calcium polyphosphates support bone growth in vitro and in vivo显示文摘 | Baksh D Davies JE Kim S | 1998 | J Mater Sci Mater Med1998，9，12： | 1 |
| 4 | Comparison of proliferative and muhilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow 显示文摘 | Baksh D Yao R Tuan R S | 2007 | Stem Cells2007，25，6： | 1 |
| 5 | Human umbilical cord perivascular (HUCPV) cells: a source of mesenchymal progenitors 显示文摘 | Sarugaser R Lickorish D Baksh D | 2005 | Stem Cells2005，23，2： | 1 |
| 6 | comparison of proliferative and multilineage differentiation potential of human mesenchy- mal stem cells derived from umbilical cord and bone marrow 显示文摘 | Baksh D Yao R Tuan RS | 2007 | Stem Cells2007，25，6： | 1 |
| 7 | Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow显示文摘 | Baksh D Yao R Tuan RS | | 0，，06： | 1 |
| 8 | Human umbilical cord perivascular (HUCPV) cel s:a source of mesenchymal progenitors显示文摘 | Sarugaser R Lickorish D Baksh D | | 0，，02： | 1 |
| 9 | Adult mesenchymal stem cells ; characterization, differentiation, and application in cell and gene therapy显示文摘 | Baksh D Song L Tuan RS | 2004 | J cell Mol Meal2004，8，3： | 1 |
| 10 | Lumbar puncture delivery of bone marrow stromal ceils in spinal cord contusion : a novel method for minimally invasive cell transplantation显示文摘 | Baksh IA Barshinger AL | 2006 | Neurotranma2006，23，11： | 1 |
| 11 | Adult mesenchymal stem cells:characterization,differentiation,and application in cell and gene therapy显示文摘 | BAKSH D SONG L TUAN RS | | 0，，03： | 1 |
| 12 | Effects of extendedrelease niacin on lipoprotein subclass distribution显示文摘 | Morgan JM Capuzzi DM Baksh RI | | 0，，： | 1 |
| 13 | Antithrombin regulates matriptase activity involved in plasmin generation, syndecan shedding, and HGF activation in keratinocytes显示文摘 | Chen YW Xu Z Baksh AN | 2013 | PLoS One2013，8，62： | 1 |
| 14 | Adultmesenchymal stemcells:characterization,differentiation,and application in cell and genetherapy显示文摘 | Baksh D Song L Tuan RS | | 0，，03： | 1 |
| 15 | RASSF Family Proteins显示文摘 | CLARK G J BAKSH S LATIF F | 2012 | Mol Biol Int2012，2012，93： | 1 |
| 16 | Human umbilical cord perivascular (HUCPV)cells:a source of mesenchymat progenitors 显示文摘 | Sarugaser R Lickorish D Baksh D | 2005 | Stem Cells2005，23，2： | 1 |
| 17 | Adult mesenchymal stem cells:characteriazation,differentiation,and application in cell and gene therapy显示文摘 | BAKSH D SONG L TUAN R S | 2004 | J Cell Mol Med2004，8，3： | 1 |
| 18 | Pendular activity of human upper limbs during slow and normal walking 显示文摘 | Webb D Tuttle R H Baksh M | 1994 | American Journal of Physical Anthropology1994，93，4： | 1 |
| 19 | Serum Osteoprotegerin and Bone Mineral Density in Post-Menopausal Women with or without Osteoporosis显示文摘 | Rouzi A A Ardawi M S Baksh T M | 2010 | Reprod Sci2010，17，： | 1 |
| 20 | JC virus infeclion in allograft kidneys: analysis by polymerase chain reaction and immunohislochemixtry 显示文摘 | Randhawa P Baksh F Aoki N | 2003 | Transplantation2003，76，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员