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| 1 | 三江源典型区草地退化Hyperion高光谱遥感识别研究显示文摘三江源草地退化直接影响当地及长江、黄河和澜沧江中上游地区的生态安全、水资源合理利用、经济可持续发展和社会稳定,一直是人们关注的焦点问题。近年来,该地区草地群落毒杂草组分增大,退化严重。高光谱遥感具有精细识别草地种群的潜在能力,如何利用其进行草地群落组成信息探测并进行退化识别是当前研究的热点和难点问题。利用卫星高光谱Hyperion影像和地面实测高光谱遥感数据,通过多端元混合像元分解技术,提取可食牧草、毒杂草以及裸土组分信息;以此为指标对研究区草地退化程度进行分类识别,依次为:未退化、轻度退化、中度退化、重度退化和极度退化。利用野外样方实测数据验证监测结果,精度达到84.2%,表明高光谱遥感对草地退化探测具有良好的应用潜力。 | 安如 陆彩红 王慧麟 姜丹萍 孙梦秋 Jonathan Arthur Quaye Ballard | 2018 | 武汉大学学报(信息科学版)2018，43，3： | 16 |
| 2 | Gastrointestinal endoscopy biopsy derived proteomic patterns predict indeterminate colitis into ulcerative colitis and Crohn's colitis显示文摘Patients with indeterminate colitis(IC) are significantly younger at diagnosis with onset of symptoms before the age of 18 years with significant morbidity in the interim. The successful care of IC is based on microscopic visual predict precision of eventual ulcerative colitis(UC) or Crohn's colitis(CC) which is not offered in 15%-30% of inflammatory bowel disease(IBD) patients even after a combined state-of-the-art classification system of clinical, visual endoscopic, radiologic and histologic examination. These figures have not changed over the past 3 decades despite the introduction of newer diagnostic modalities. The patient outcomes after restorative proctocolectomy and ileal pouch-anal anastomosis may be painstaking if IC turns into CC. Our approach is aiming at developing a single sensitive and absolute accurate diagnostic test tool during the first clinic visit through endoscopic biopsy derived proteomic patterns. Matrix-assisted-laser desorption/ionization mass spectrometry(MS) and/or imaging MS technologies permit a histology-directed cellular test of endoscopy biopsy which identifies phenotype specific proteins, as biomarker that would assist clinicians more accurately delineate IC as beingeither a UC or CC or a non-IBD condition. These novel studies are underway on larger cohorts and are highly innovative with significances in differentiating a UC from CC in patients with IC and could lend mechanistic insights into IBD pathogenesis. | Billy Ray Ballard Amosy Ephreim M'Koma | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，7： | 7 |
| 3 | 荧光多重实时PCR检测单纯疱疹病毒显示文摘目的建立单纯疱疹病毒的荧光多重实时PCR检测及分型技术,为生殖器疱疹的诊断及病毒分型提供快捷、敏感、特异的方法.方法以细胞培养法为对照,用Smart Cycler System作为实验平台,以DNA探针荧光标记技术建立荧光多重实时PCR,用于检测生殖器疱疹患者临床标本中的1型和2型单纯疱疹病毒(HSV1、HSV2)DNA.结果荧光多重实时PCR检测HSV1和HSV2 DNA的敏感性和特异性均为100%,可检测出低至1~5拷贝的HSV DNA,30 min左右即可完成整个检测过程,而细胞培养的敏感性和特异性分别为70.10%和100%.结论基于Smart Cycler System的荧光多重实时PCR是一种易于操作、扩增效率高、封闭式的核酸扩增技术,可用一次PCR反应就能快速、敏感、准确地对临床标本中的单纯疱疹病毒进行检测和分型. | 赖维 Cheng-Yen Chen 苏向阳 黄怀球 张玉清 Ron C Ballard Stephen A Morse | 2004 | 中华皮肤科杂志2004，37，5： | 6 |
| 4 | Air quality monitoring using mobile microscopy and machine learning显示文摘Rapid,accurate and high-throughput sizing and quantification of particulate matter(PM)in air is crucial for monitoring and improving air quality.In fact,particles in air with a diameter of≤2.5μm have been classified as carcinogenic by the World Health Organization.Here we present a field-portable cost-effective platform for high-throughput quantification of particulate matter using computational lens-free microscopy and machine-learning.This platform,termed c-Air,is also integrated with a smartphone application for device control and display of results.This mobile device rapidly screens 6.5 L of air in 30 s and generates microscopic images of the aerosols in air.It provides statistics of the particle size and density distribution with a sizing accuracy of~93%.We tested this mobile platform by measuring the air quality at different indoor and outdoor environments and measurement times,and compared our results to those of an Environmental Protection Agency–approved device based on beta-attenuation monitoring,which showed strong correlation to c-Air measurements.Furthermore,we used c-Air to map the air quality around Los Angeles International Airport(LAX)over 24 h to confirm that the impact of LAX on increased PM concentration was present even at 47 km away from the airport,especially along the direction of landing flights.With its machinelearning-based computational microscopy interface,c-Air can be adaptively tailored to detect specific particles in air,for example,various types of pollen and mold and provide a cost-effective mobile solution for highly accurate and distributed sensing of air quality. | Yi-Chen Wu Ashutosh Shiledar Yi-Cheng Li Jeffrey Wong Steve Feng Xuan Chen Christine Chen Kevin Jin Saba Janamian Zhe Yang Zachary Scott Ballard Zoltán Göröcs Alborz Feizi Aydogan Ozcan | 2017 | Light(Science & Applications)2017，6，1： | 5 |
| 5 | Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts显示文摘The accumulation and aggregation of alpha-synuclein(α-syn)in several tissue including the brain is a major pathological hallmark in Parkinson’s disease(PD).In this study,we show that α-syn can be taken up by primary human cortical neurons,astrocytes and skin-derived fibroblasts in vitro.Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function,leading to cellular degeneration and cell death,provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells. | Nady Braidy Wei-Ping Gai Ying Hua Xu Perminder Sachdev Gilles J Guillemin Xing-Mai Jiang J William O Ballard Martin P Horan Zhi Ming Fang Beng H Chong Daniel Kam Yin Chan | 2013 | Translational Neurodegeneration2013，2，1： | 4 |
| 6 | Color indexing显示文摘 | Michael J. Swain Dana H. Ballard | 1991 | International Journal of Computer Vision1991，，1： | 4 |
| 7 | Advanced stereoscopic projection technology significantly improves novice performance of minimally invasive surgical skills显示文摘 | R. Smith A. Day T. Rockall K. Ballard M. Bailey I. Jourdan | 2012 | Surgical Endoscopy2012，，6： | 3 |
| 8 | 癌症筛查之未来显示文摘1引言癌症已成为美国的第二大致死病因,52%的人死于肺癌、支气管癌、女性乳腺癌、宫颈癌、结直肠癌、口腔及咽喉癌、前列腺癌和皮肤癌(黑色素瘤)。19世纪30年代,包括宫颈癌在内的子宫癌,位居美国女性癌症死亡第一位。50年代,随着巴氏涂片技术(Pap test)的应用,可以在细胞水平检测宫颈的变化,宫颈癌死亡率显著降低,这是第一个癌症筛查检测技术。此后,已有多种影像学检查(例如乳腺癌钼靶X线、内窥镜检查和计算机体层扫描)和实验室检测方法(粪便隐血试验)用于癌症筛检。 | Cheryll C.Thomas Thomas B.Richards Marcus Plescia Faye L.Wong Rachel Ballard Theodore R.Levin Bruce N.Calonge Otis W.Brawley John Iskander 徐海燕(翻译) 陆仁敏(审校) 蔡颖(审校) | 2017 | 上海预防医学2017，29，3： | 2 |
| 9 | Outcomes of submucosal(T1b) esophageal adenocarcinomas removed by endoscopic mucosal resection显示文摘AIM To investigate the outcomes and recurrences of p T1 b esophageal adenocarcinoma(EAC) following endoscopic mucosal resection(EMR) and associated treatments.METHODS Patients undergoing EMR with pathologically confirmed T1 b EAC at two academic referral centers were retrospectively identified.Patients were divided into 4 groups based on treatment following EMR:Endoscopic therapy alone(group A),endoscopic therapy with either chemotherapy,radiation or both(group B),surgicalresection(group C) or no further treatment/lost to follow-up(<12 mo)(group D).Pathology specimens were reviewed by a central pathologist.Follow-up data was obtained from the academic centers,primary care physicians and/or referring physicians.Univariate analysis was performed to identify factors predicting recurrence of EAC.RESULTS Fifty-three patients with T1 b EAC underwent EMR,of which 32(60%) had adequate follow-up ≥ 12 mo(median 34 mo,range 12-103).There were 16 patients in group A,9 in group B,7 in group C and 21 in group D.Median follow-up in groups A to C was 34 mo(range 12-103).Recurrent EAC developed overall in 9 patients(28%) including 6(38%) in group A(median:21 mo,range:6-73),1(11%) in group B(median:30 mo,range:30-30) and 2(29%) in group C(median 21 mo,range:7-35.Six of 9 recurrences were local;of the 6 recurrences,5 were treated with endoscopy alone.No predictors of recurrence of EAC were identified.CONCLUSION Endoscopic therapy of T1 b EAC may be a reasonable strategy for a subset of patients including those either refusing or medically unfit for esophagectomy. | Darren D Ballard Neel Choksi Jingmei Lin Eun-Young Choi B Joseph Elmunzer Henry Appelman Douglas K Rex Hala Fatima William Kessler John M DeWitt | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 2 |
| 10 | Spliner as embeddings for generalized cylinders显示文摘 | Shani U Ballard P H | 1984 | Computer Vision Graphics and Image Processing1984，27，： | 2 |
| 11 | 弓形虫感染引起小胶质细胞与神经元的接触以及细胞体周边抑制性突触丧失显示文摘大脑内的感染和炎症会引起神经元连通性和功能的改变。细胞内的原生动物寄生虫,弓形虫,是一种感染脑部的病原体,可引起脑炎和癫痫发作。这种寄生虫的持续感染还与行为改变和发生精神疾病(包括精神分裂症)的风险增加有关。目前来自人类和小鼠模型的研究证据表明,癫痫发作和精神分裂症均由抑制性突触的丧失或功能障碍引起。与此相符,我们最近报道了持续性弓形虫感染改变谷氨酸脱羧酶67(GAD67)的分布,该酶在抑制性突触中催化GABA的合成。这些变化可能反映突触前装置在抑制性神经元中的重新分布或抑制性神经末梢的丧失。为了直接评估后者的可能性,我们采用序列块面扫描电子显微镜(SBFSEM)并量化寄生虫感染后新皮质和海马中的细胞体周边抑制性突触。持续感染不仅导致明显的细胞体周边突触丧失,而且还诱导髓样来源的细胞对神经元细胞体的包封。免疫组织化学、遗传和超微结构分析显示,这些髓样来源的细胞包括活化的小胶质细胞。最后,超微结构分析确定了包膜于细胞体周围神经末梢的髓样来源的细胞,提示它们可能会主动置换或吞噬突触元件。因此,这些结果表明,活化的小胶质细胞有助于寄生虫感染后细胞体周围抑制突触损失,并对于弓形虫的持续感染可能如何导致癫痫发作和精神疾病提供了一种新的机制。 | Carrillo GL Ballard VA Glausen T Boone Z Teamer J Hinkson CL Wohlfert EA Blader IJ Fox MA 杜一星(编译) | 2020 | 神经损伤与功能重建2020，15，3： | 2 |
| 12 | Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c - IAP2 is under NF-kappa B control 显示文摘 | Chu Z L Mckinsey T A Lia L Gentry J J Malim M H Ballard D W | 1997 | PNAS1997，94，10： | 1 |
| 13 | Prospective follow-up study between 3 and 15 months after stroke:improvements and decline in cognitive function among dementia-free stroke survivors > 75 years of age显示文摘 | Ballard C Rowan E Stephens S | 2003 | Stroke2003，34，10： | 1 |
| 14 | Leptin enhances the calcification of vascular cells:artery wall as a target of leptin显示文摘 | Parhami F Tintut Y Ballard A | 2001 | Cire Res2001，88，9： | 1 |
| 15 | Impacts of forest management on northern forest soils显示文摘 | Ballard T M | 2000 | Forest Ecology and Management2000，133，： | 1 |
| 16 | 显示文摘 | Capema T J R G Campbell M R M Ballard | 1995 | J Nutr1995，125，： | 1 |
| 17 | Color indexing显示文摘 | Swain M J Ballard D H | 1991 | International Journal of Computer Vision1991，7，1： | 1 |
| 18 | chronic Parkinsonism in human due to aproduct of meperidine-analog synthesis 显示文摘 | Langston J W Ballard P Tetrud J W | 1983 | Science1983，219，4587： | 1 |
| 19 | Microwave - assisted extraction of phenolic antioxidant compounds from peanut skins 显示文摘 | Ballard Tameshia S Mallikarjunan Parameswarakumar Zhou Kequan | 2010 | Food Chemistry2010，120，4： | 1 |
| 20 | Color indexing显示文摘 | Swain M J Ballard D H | 1991 | Inter- national Journal of Computer Vision1991，7，1： | 1 |
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