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	题名	作者	年代	出处	被引量
1	Hepatic glycogenosis: An underdiagnosed complication of diabetes mellitus?显示文摘Hepatic glycogenosis(HG) is characterized by excessive glycogen accumulation in hepatocytes and represents a hepatic complication of diabetes that particularly occurs in patients with longstanding poorly controlled type 1 diabetes(T1D). HG has been reported to be a very rare disease, although it is believed to be extremely underdiagnosed because it is not possible to distinguish it from non-alcoholic fatty liver disease(NAFLD) unless a liver biopsy is performed. In contrast to HG, NAFLD is characterized by liver fat accumulation and is the more likely diagnosis for patients with type 2 diabetes and metabolic syndrome. The pathogenesis of HG involves the concomitant presence of insulin and excess glucose, which increases glycogen storage in the liver. HG is characterized by a transient elevation in liver transaminases and hepatomegaly. Differentiating between these two conditions is of the utmost importance because HG is a benign disease that is potentially reversible by improving glycemic control, whereas NAFLD can progress to cirrhosis. Therefore, HG should be suspected when liver dysfunction occurs in patients with poorly controlled T1 D. The aim of this article is to review the epidemiology, clinical characteristics, pathogenesis and histology of HG.	María Teresa Julián Núria Alonso Isabel Ojanguren Eduarda Pizarro Enric Ballestar Manel Puig-Domingo	2015	World Journal of Diabetes2015，6，2：	4
2	Epigenetic differences arise during the lifetime of monozygotic twins 显示文摘	Fraga M F Ballestar E Paz M F	2005	Proc Natl Acad Sci2005，102，10：	1
3	Methyl-CpG-binding proteins. Targetingspecific gene repression显示文摘	Ballestar E Wolffe AP		0，，：	1
4	Epige- netic differences arise during the lifetime of monozy- gotic twins 显示文摘	FRAGA M F BALLESTAR E PAZ M F	2005	Proceedings of the National Academy of Sciences of the United States of America2005，102，10：	1
5	Epigenetic differences arise during the lifetime of monozygotic twins显示文摘	Fraga MF Ballestar E Paz MF	2005	Proc Natl Acad Sci USA2005，102，10：	1
6	Epigenetic differences arise during the lifetime of monozygotic twins显示文摘	Fraga M F Ballestar E Paz M F	2005	Proc Natl Acad Sd U S A2005，102，10：	1
7	Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer 显示文摘	Aguilera O Fraga M F Ballestar E	2006	Oncogene2006，25，29：	1
8	A DNA methylation signature associated with aberrant promoter DNA hypermethylation of DNMT3B in human colorectal cancer显示文摘	Covadonga Huidobro Rocío G. Urdinguio Ramón María Rodríguez Cristina Mangas Vincenzo Calvanese Pablo Martínez-Camblor Cecilia Ferrero Adolfo Parra-Blanco Luis Rodrigo álvaro J. Obaya Laura Suárez-Fernández Aurora Astudillo Henar Hernando Esteban Ballestar	2011	European Journal of Cancer2011，，14：	1
9	Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer显示文摘	Fraga MF Ballestar E Villar-Garea A	2005	Nat Genet2005，37，4：	1
10	Epigenetic differences arise during the lifetime of monozygotic twins显示文摘	Fraga MF Ballestar E Paz MF		0，，：	1
11	Epigenetic differences arise during the lifetime of monozygotic twins显示文摘	Fraga MF Ballestar E Paz MF	2005	Proc Natl Acad Sci U S A2005，102，10：	1
12	Loss of acetylation at Lysl6 and trimethylation at Lys 20 of histone H4 is a common hallmark of human cancer 显示文摘	Fraga MF Ballestar E Villar-Garea A	2005	Nat Genet2005，37，4：	1
13	Epige-netic regulation of PRAME in acute myeloid leukemia is differ-ent compared to CD34+ cells from healthy donors : effect of 5-AZA treatment显示文摘	Gutierrez-CosIo S de la Rica L Ballestar E S	2012	Leuk Res2012，36，7：	1
14	Genetic unmasking of an epigenetically silenced micro RNA in human cancer cells显示文摘	Lujambio A Ropero S Ballestar E	2007	Cancer Res2007，，4：	1
15	Loss of acetylation at Lys16and trimethylation at Lys20of histone H4is a common hallmark of human cancer显示文摘	Fraga MF Ballestar E Villar-Garea A	2005	Nat Genet2005，37，4：	1
16	Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer显示文摘	Fraga MF Ballestar E Villar-Garea A		0，，：	1
17	A truncating muta- tion of HDAC2 in human cancers confers resistance to his- tone deacetylase inhibition 显示文摘	Ropero S Fraga MF Ballestar E	2006	Nat Genet2006，38，5：	1
18	Epigenetic differences arise during the life time of monozygotic twins显示文摘	Fraga M F Ballestar E Paz M F	2005	Proc Natl Acad Sci USA2005，102，10：	1
19	Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex显示文摘	Peinado H Ballestar E Esteller M	2004	Mol Cell Biol2004，24，1：	1
20	Methyl-CpG-binding proteins 显示文摘	Ballestar E Wolffe A P	2001	European Journal of Biochemistry2001，268，：	1

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