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| 1 | Ethanol extract from Gynostemma pentaphyllum ameliorates dopaminergic neuronal cell death in transgenic mice expressing mutant A53T human alpha-synuclein显示文摘Gynostemma(G.) pentaphyllum(Cucurbitaceae) contains various bioactive gypenosides. Ethanol extract from G. pentaphyllum(GP-EX) has been shown to have ameliorative effects on the death of dopaminergic neurons in animal models of Parkinson’s disease(PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-and 6-hydroxydopamine. PD patients exhibit multiple symptoms, so PD-related research should combine neurotoxin models with genetic models. In the present study, we investigated the ameliorative effects of GP-EX, including gypenosides, on the cell death of dopaminergic neurons in the midbrain of A53 T α-synuclein transgenic mouse models of PD(A53 T). Both GP-EX and gypenosides at 50 mg/kg per day were orally administered to the A53 T mice for 20 weeks.α-Synuclein-immunopositive cells and α-synuclein phosphorylation were increased in the midbrain of A53 T mice, which was reduced following treatment with GP-EX. Treatment with GP-EX modulated the reduced phosphorylation of tyrosine hydroxylase, extracellular signal-regulated kinase(ERK1/2), Bcl-2-associated death promoter(Bad) at Ser112, and c-Jun N-terminal kinase(JNK1/2) due to α-synuclein overexpression. In the A53 T group, GP-EX treatment prolonged the latency of the step-through passive avoidance test and shortened the transfer latency of the elevated plus maze test. Gypenosides treatment exhibited the effects and efficacy similar to those of GP-EX. Taken together, GP-EX, including gypenosides, has ameliorative effects on dopaminergic neuronal cell death due to the overexpression of α-synuclein by modulating ERK1/2, Bad at Ser112, and JNK1/2 signaling in the midbrain of A53 T mouse model of PD. Further studies are needed to investigate GP-EX as a treatment for neurodegenerative synucleinopathies, including PD. This study was approved by the Animal Ethics Committee of Chungbuk National University(approval No. CBNUA-956-16-01) on September 21, 2016. | Hyun Jin Park Ting Ting Zhao Seung Hwan Kim Chong Kil Lee Bang Yeon Hwang Kyung Eun Lee Myung Koo Lee | 2020 | Neural Regeneration Research2020，15，2： | 5 |
| 2 | Assignment and expression patterns of porcine muscle-specific isoform of phosphoglycerate mutase gene显示文摘It has been reported that the muscle-specific isoform (type M, PGAM2) of phosphoglycerate mutase (PGAM) is a housekeeping en- zyme; it catalyzes the conversion of 3-phosphoglycerate into 2-phosphoglycerate in the glycolysis process to release energy. It is encoded by the Pgam2 gene. In this study, the cDNA of the porcine Pgam2 was cloned. This gene contains an open reading frame of 765 bp en- coding a protein of 253 residues, and the predicted protein sequences share high similarity with other mammalians, 96% identity with humans, and 94% identity with mouse and rats. Pgam2 was mapped to SSC18q13-q21 by the RH panel. In this region, there are several QTLs, such as fat ratio, lean percentage, and diameter of muslce fiber, which affect meat production and quality. The reverse transcrip- tase-polymerase chain reaction revealed that the porcine Pgam2 gene was mainly expressed in the muscle tissue (skeletal muscle and cardiac muscle), and was expressed highly at skeletal muscle development stages (embryonic periods: 33, 65, and 90 days post-conception (dpc); postnatal pigs: 4 days and adult). This indicates that the Pgam2 gene plays an important role in muscle growth and development. In addition, it was demonstrated that PGAM2 locates both in cytoplasm and nuclei, and takes part in the glycometabolism process of cyto- plasm and nuclei. | Haifang Qiu Shuhong Zhao Xuewen Xu Martine Yerle Bang Liu | 2008 | Journal of Genetics and Genomics2008，35，5： | 5 |
| 3 | The MING proposal at SHINE:megahertz cavity enhanced X‑ray generation显示文摘The cavity-based X-ray free-electron laser(XFEL)has promise in producing fully coherent pulses with a bandwidth of a few meV and very stable intensity,whereas the currently existing self-amplified spontaneous emission(SASE)XFEL is capable of generating ultra-short pulses with chaotic spectra.In general,a cavity-based XFEL can provide a spectral brightness three orders of magnitude higher than that of the SASE mode,thereby opening a new door for cutting-edge scientific research.With the development of superconducting MHz repetition-rate XFEL facilities such as FLASH,European-XFEL,LCLS-II,and SHINE,practical cavity-based XFEL operations are becoming increasingly achievable.In this study,megahertz cavity enhanced X-ray generation(MING)is proposed based on China’s first hard XFEL facility-SHINE,which we refer to as MING@SHINE. | Nan‑Shun Huang Zi‑Peng Liu Bang‑Jie Deng Zi‑Han Zhu Shao‑Hua Li Tao Liu Zheng Qi Jia‑Wei Yan Wei Zhang Sheng‑Wang Xiang Yang‑Yang Lei Ya Zhu Yong‑Zhou He Qi‑Bing Yuan Fei Gao Rong‑Bing Deng Sen Sun Zhi‑Di Lei Zhi‑Qiang Jiang Meng‑Qi Duan Yuan Zhuan Xue‑Fang Huang Peng‑Cheng Dong Zhong‑Liang Li Shang‑Yu Si Lian Xue Si Chen Yong‑Fang Liu Ya‑Jun Tong Hai‑Xiao Deng Zhen‑Tang Zhao | 2023 | Nuclear Science and Techniques2023，34，1： | 2 |
| 4 | Four new genera of the fungal family Boletaceae显示文摘Based on our previous molecular phylogenetic analyses,four new genera are described,namely Baorangia,Lanmaoa,Parvixerocomus,and Rugiboletus,and one known genus,Neoboletus,is re-delimitated.Four new species and nine new combinations are proposed.Morphological characters of each genus and related eleven species are described and illustrated.Most of species in the genera described from southwestern China are wild edible mushrooms and can be found in free markets. | Gang Wu Kuan Zhao Yan-Chun Li Nian-Kai Zeng Bang Feng Roy E.Halling Zhu L.Yang | 2016 | Fungal Diversity2016，，6： | 2 |
| 5 | Molecular genetiC diversity and population structure in Lycium accessions using SSR markers显示文摘 | Zhao W G Chung J W Cho Y I Rha W H Lee G A Ma K H Han S H Bang K H Park C B Kim S M Park Y J | 2010 | C R Bioi2010，333，： | 1 |
| 6 | Preparation of Novel Side-chain Pseudopolyrotaxanes Consisting of Cucurbituril[6] and Polyamine Salts显示文摘Pseudorotaxane monomer (VBCB) containing cucurbitutil[6] (CB[6]) and N1-(4- vinylbenzyl)-1,4-diaminobutane dihydrochloride (VBDADC) is obtained by self-assembly of cucurbituril[6] with VBDADC in water and then polymerized using potassium persulfate (KPS) as initiator to give novel water-soluble side-chain cucurbituril[6]-based pseudopolyrotaxane (PVBCB). The chemical structures of PVBCB, VBCB and VBDADC are confirmed by 1H NMR, 13C NMR spectra and elemental analysis. In VBCB, CB[6] is localized aliphatic group of the side chain and the molar ratio of CB[6] to VBDAC is 1:1 . | Zhao Sheng HOU Ye Bang TAN Kimoon KIM Qi Feng ZHOU | 2005 | Chinese Chemical Letters2005，16，8： | 1 |
| 7 | Simultaneous enhancement of coercivity and electric resistivity of Nd-Fe-B magnets by Pr-Tb-Al-Cu synergistic grain boundary diffusion toward high-temperature motor rotors显示文摘To high-power permanent magnetic motors,it is critical for Nd-Fe-B magnets to maintain the desirable coercivity at high-temperature operating conditions.To address this,two approaches have been proven effective:(1)enhancing the room temperature coercivity;(2)reducing the eddy current loss.However,these two items are difficult to be simultaneously achieved.Here,the grain boundary diffusion(GBD)of the Pr-Tb-Al-Cu-based source is applied to enhance the coercivity and electric resistivity at room temperature from 1101 kA m-1 and 2.13×10–6Ωm to 1917 kA m-1 and 2.60×10–6Ωm,and those at 120°C from 384 kA m-1 and 4.31×10–6Ωm to 783 kA m-1 and 4.86×10–6Ωm,respectively.Such optimization is ascribed to the improved formation depth of Tb-rich 2:14:1 shells with large magnetocrystalline anisotropy and the increased intergranular Pr-based oxides with high electric resistivity,induced by the coordination effects of Tb and Pr,as proven by the atomic-scale observations and the first principles calculations.It thus results in the simultaneously improved output power and energy efficiency of the motor because of the combination of magnetic thermal stability enhancement and eddy current loss reduction,as theoretically confirmed by electromagnetic simulation. | Jiayi He Jinwen Hu Bang Zhou Haoyang Jia Xiaolian Liu Zhenhua Zhang Lin Wen Lizhong Zhao Hongya Yu Xichun Zhong Xuefeng Zhang Zhongwu Liu | 2023 | Journal of Materials Science & Technology2023，，23： | 1 |
| 8 | New species and distinctive geographical divergences of the genus Sparassis (Basidiomycota): evidence from morphological and molecular data显示文摘 | Qi Zhao Bang Feng Zhu L. Yang Yu-Cheng Dai Zheng Wang B. Tolgor | 2013 | Mycological Progress2013，，2： | 1 |
| 9 | Evaluation of a new porous titanium-niobium mixed oxide for photocatalytic water decontamination显示文摘 | Saupe G B Zhao Y Bang J | 2005 | Microchemical Journal2005，81，： | 1 |
| 10 | Simultaneous perimeter measurement for multiple planar objects显示文摘 | ZHAO P QIANG N G BANG P Z | 2009 | Optics and Laser Technology2009，41，5： | 1 |
| 11 | Molecular characterization of the BTG2 and BTG3 genes in fetal muscle development of pigs显示文摘 | Zheng Feng Zhong-Lin Tang Kui Li Bang Liu Mei Yu Shu-Hong Zhao | 2007 | Gene2007，，1： | 1 |
| 12 | Simultaneous Perimeter Measurement for Multiple Planar Objects显示文摘 | ZHAO P QIANG N G BANG P Z | | 0，，05： | 1 |
| 13 | Selection of effective sin- gular values using difference spectrum and its application to fault diagnosis of headstock 显示文摘 | Zhao Xue - zhi Ye Bang -yan | 2011 | Mechanical Systems and Signal Processing2011，25，5： | 1 |
| 14 | Hydrogen Storage in Several Metal--Phosphate Molecular Sieves 显示文摘 | DONG J X BANG Z ZHAO Q | 2008 | American Institute of Chemical Engineers2008，54，11： | 1 |
| 15 | Evaluation of a new porous titanium-niobium mixed oxide for photocatalytic water decontamination 显示文摘 | Saupet G B Zhao Y Bang J | 2005 | Microchemical Journal2005，81，： | 1 |
| 16 | A novel DC capacitor voltage balance control method for cascade multilevel STATCOM 显示文摘 | LIU Zhao LIU Bang yin DUAN Shawxu | 2012 | IEEE Transactions on Power Electronics2012，27，1： | 1 |
| 17 | Evaluation of a new porous Titaniou - Niobium mixed oxide for photocatalytic water contamination 显示文摘 | Saupe G B Zhao Y Bang J | 2005 | Microchem J2005，81，： | 1 |
| 18 | 4-2 Lifetime and the Ratio of 12C3+ and 16O4+ at the CSRe显示文摘Laser cooling is the most promising method to achieve high phase-space densities, even crystalline beams for relativistic heavy ion at storage rings[1]. A test laser cooling experiment has been performed with 12C3+ ions at the CSRe. In this experiment, the 12C3+ ions were produced from an electron cyclotron resonance (ECR) ion source, and due to the residual gas and the injection gases such as CO and CO2, 16O4+ ions will be produced at the same time. | Wang Hanbing Ma Xinwen Wen Weiqiang Huang Zhongkui Zhang Dacheng Hai Bang Chuai Xiaoya Zhao Dongmei Zhu Xiaolong Yang Jie Li Jie Mao Lijun Mao Ruishi Yang Jiancheng Yuan Youjin Zhao Hongwei Laser Cooling Collaboration | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 19 | Advances in nuclear detection and readout techniques显示文摘“A Craftsman Must Sharpen His Tools to Do His Job,”said Confucius.Nuclear detection and readout techniques are the foundation of particle physics,nuclear physics,and particle astrophysics to reveal the nature of the universe.Also,they are being increasingly used in other disciplines like nuclear power generation,life sciences,environmental sciences,medical sciences,etc.The article reviews the short history,recent development,and trend of nuclear detection and readout techniques,covering Semiconductor Detector,Gaseous Detector,Scintillation Detector,Cherenkov Detector,Transition Radiation Detector,and Readout Techniques.By explaining the principle and using examples,we hope to help the interested reader underst and this research field and bring exciting information to the community. | Rui He Xiao‑Yang Niu Yi Wang Hong‑Wei Liang Hong‑Bang Liu Ye Tian Hong‑Lin Zhang Chao‑Jie Zou Zhi‑Yi Liu Yun‑Long Zhang Hai‑Bo Yang Ju Huang Hong‑Kai Wang Wei‑Jia Han Bei Cao Gang Chen Cong Dai Li‑Min Duan Rui‑Rui Fan Fang‑Fa Fu Jian‑Hua Guo Dong Han Wei Jiang Xian‑Qin Li Xin Li Zhuo‑Dai Li Yu‑Tie Liang Shun Liao De‑Xu Lin Cheng‑Ming Liu Guo‑Rui Liu Jun‑Tao Liu Ze Long Meng‑Chen Niu Hao Qiu Hu Ran Xiang‑Ming Sun Bo‑Tan Wang Jia Wang Jin‑Xiang Wang Qi‑Lin Wang Yong‑Sheng Wang Xiao‑Chuan Xia Hao‑Qing Xie He‑Run Yang Hong Yin Hong Yuan Chun‑Hui Zhang Rui‑Guang Zhao Ran Zheng Cheng‑Xin Zhao | 2023 | Nuclear Science and Techniques2023，34，12： | 0 |
| 20 | 4-6 Measurement of the Ratio of C3+ and O4+ Ions Produced by ECR Source to Prepare a Laser Cooling Experiment at Storage Rings显示文摘The cooling of heavy ions can provide high-quality beams that are especially important for high-precisionexperimental nuclear and atomic physics. The laser cooling of relativistic C3+ ion beams at the experimental coolerstorage ring (CSRe) is being currently prepared at Institute of Modern Physics (IMP) in Lanzhou. An electroncyclotron resonance ion source (ECRIS) will be used to produce C3+ ion beams. Meanwhile, O4+ ions could alsobe produced due to residual gas because of the same mass-to-charge ratio. Therefore, both C3+ and O4+ ion beamswill be injected and circulate in a storage ring during the laser cooling experiment at the same time. A higher ratioof C3+ ions will lead to a better result for the laser cooling experiment. | Zhu Xiaolong Wen Weiqiang Ma Xinwen Li Jinyu Feng Wentian Zhang Ruitian Yan Shuncheng Guo Dalong Hai Bang Qian Dongbin Zhang Pengju Xu Shenyue Zhao Dongmei Yang Jie Zhang Dacheng Li Bin Gao Yong Huang Zhongkui Wang Hanbing | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
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