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| 1 | Exosomes:key players in cancer and potential therapeutic strategy显示文摘Exosomes are extracellular vesicles secreted by most eukaryotic cells and participate in intercellular communication.The components of exosomes,including proteins,DNA,mRNA,microRNA,long noncoding RNA,circular RNA,etc.,which play a crucial role in regulating tumor growth,metastasis,and angiogenesis in the process of cancer development,and can be used as a prognostic marker and/or grading basis for tumor patients.Hereby,we mainly summarized as followed:the role of exosome contents in cancer,focusing on proteins and noncoding RNA;the interaction between exosomes and tumor microenvironment;the mechanisms that epithelial-mesenchymal transition,invasion and migration of tumor affected by exosomes;and tumor suppression strategies based on exosomes.Finally,the application potential of exosomes in clinical tumor diagnosis and therapy is prospected,which providing theoretical supports for using exosomes to serve precise tumor treatment in the clinic. | Jie Dai Yangzhou Su Suye Zhong Li Cong Bang Liu Junjun Yang Yongguang Tao Zuping He Chao Chen Yiqun Jiang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 8 |
| 2 | Semaphorin 7a participants in pterygium by regulating vascular endothelial growth factor显示文摘AIM: To investigate the relationship between semaphorin 7a expression and cell proliferation and migration in pterygium fibroblasts. METHODS: Twenty-six patients with surgically diagnosed pterygium were enrolled, including 15 cases of primary pterygium and 11 cases of recurrent pterygium. In addition, 12 cases of normal conjunctival tissue were collected. The expression of semaphorin 7a in normal conjunctival tissue, primary pterygium and recurrent pterygium was detected by real-time polymerase chain reaction. Recurrent pterygium fibroblasts were isolated and cultured, and the expression of semaphorin 7a was silenced by small interfering RNA(siRNA) interference technique. Furthermore, the effects of si-semaphorin 7a interference on the mRNA and protein levels of β1-integrin, vascular endothelial growth factor A(VEGFA) and vascular endothelial growth factor receptor(VEGFR), and on fibroblast proliferation were analyzed. Transwell assay was used to detect the effect of semaphorin 7a interference on fibroblast migration. RESULTS: Semaphorin 7a was highly expressed in the primary pterygium and recurrent pterygium samples than that of the normal conjunctival tissue. Compared with the primary pterygium, the expression of semaphoring 7a in the recurrent pterygium samples was significantly increased(P<0.05). The mRNA and protein expression levels of β1-integrin, VEGFA and VEGFR were decreased after si-semaphorin 7a transfection, and as well as the cell proliferation and migration. CONCLUSION: Semaphorin 7a might play important roles in the pathogenesis of pterygium by affecting the expression of β1-integrin, VEGFA and VEGFR. | Yun-Fei Han Zhen Liu Bang Wang Wei Zhu Jing-Zhen Li Yue-Qin Qi Xiao-Jing Li Yan-Yun Xu Xiao-Xiao Dou Guo-Ying Mu | 2019 | International Journal of Ophthalmology(English edition)2019，12，6： | 6 |
| 3 | Assignment and expression patterns of porcine muscle-specific isoform of phosphoglycerate mutase gene显示文摘It has been reported that the muscle-specific isoform (type M, PGAM2) of phosphoglycerate mutase (PGAM) is a housekeeping en- zyme; it catalyzes the conversion of 3-phosphoglycerate into 2-phosphoglycerate in the glycolysis process to release energy. It is encoded by the Pgam2 gene. In this study, the cDNA of the porcine Pgam2 was cloned. This gene contains an open reading frame of 765 bp en- coding a protein of 253 residues, and the predicted protein sequences share high similarity with other mammalians, 96% identity with humans, and 94% identity with mouse and rats. Pgam2 was mapped to SSC18q13-q21 by the RH panel. In this region, there are several QTLs, such as fat ratio, lean percentage, and diameter of muslce fiber, which affect meat production and quality. The reverse transcrip- tase-polymerase chain reaction revealed that the porcine Pgam2 gene was mainly expressed in the muscle tissue (skeletal muscle and cardiac muscle), and was expressed highly at skeletal muscle development stages (embryonic periods: 33, 65, and 90 days post-conception (dpc); postnatal pigs: 4 days and adult). This indicates that the Pgam2 gene plays an important role in muscle growth and development. In addition, it was demonstrated that PGAM2 locates both in cytoplasm and nuclei, and takes part in the glycometabolism process of cyto- plasm and nuclei. | Haifang Qiu Shuhong Zhao Xuewen Xu Martine Yerle Bang Liu | 2008 | Journal of Genetics and Genomics2008，35，5： | 5 |
| 4 | Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with antiinflammatory activity in Caco-2 cells显示文摘Twenty-one protostane-type triterpenoids with diverse structures, including nine new compounds(1 e9), were isolated from the of Alisma plantago-aquatica Linn. Structurally, alisolides A-F(1 e6), composed of an oxole group coupled to a five-membered ring, represent unusual C-17 spirost protostane-type triterpenoids. Alisolide H(8) is a novel triterpenoid with an unreported endoperoxide bridge. Alisolide I(9) represents the first example of 23,24-acetal triterpenoid. Their structures were elucidated based on spectroscopic analysis, wherein the absolute configurations of 4-6, 8 were further confirmed by the Mo2(OAc)4-induced ECD method. Furthermore, all isolates were evaluated for their inhibitory effects on LPS-induced NO production in Caco-2 cells, and all the compounds showed remarkable inhibitory activities, with IC50 values in the range of 0.76 e38.20 mmol/L. | Qinghao Jin Jianqing Zhang Jinjun Hou Min Lei Chen Liu Xia Wang Yong Huang Shuai Yao Bang Yeon Hwang Wanying Wu Dean Guo | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 3 |
| 5 | Marine Mobile Wireless Channel Modeling Based on Improved Spatial Partitioning Ray Tracing显示文摘In 5G era,it is expected to achieve wireless network coverage including offshore areas.Modeling of marine wireless channels is the basis of constructing a marine communication system.In this paper,a communication scene between an unmanned aerial vehicle(UAV)and a boat is simulated to study the marine wireless channel.Firstly,an improved spatial partitioning ray tracing algorithm is proposed to track the propagation path of electromagnetic waves at sea surface.Secondly,a mobile channel is simulated and modeled based on the track results.Finally,a loss measurement is carried out in the coastal waters based on the simple wireless channel loss measuring platform,and a path loss propagation model is built.Then we compare the actual measurement data with the simulation results and find that the two are have good consistency,which further verifies the reliability of the simulation. | Zhibin Gao Bang Liu Zhipeng Cheng Canbin Chen Lianfen Huang | 2020 | China Communications2020，17，3： | 3 |
| 6 | CRISPR/Cas9-mediated mutagenesis at microhomologous regions of human mitochondrial genome显示文摘Genetic manipulation of mitochondrial DNA(mtDNA)could be harnessed for deciphering the gene function of mitochondria;it also acts as a promising approach for the therapeutic correction of pathogenic mutation in mtDNA.However,there is still a lack of direct evidence showing the edited mutagenesis within human mtDNA by clustered regularly interspaced short palindromic repeats-associated protein 9(CRISPR/Cas9).Here,using engineered CRISPR/Cas9,we observed numerous insertion/deletion(InDel)events at several mtDNA microhomologous regions,which were triggered specifically by double-strand break(DSB)lesions within mtDNA.InDel mutagenesis was significantly improved by sgRNA multiplexing and a DSB repair inhibitor,iniparib,demonstrating the evidence of rewiring DSB repair status to manipulate mtDNA using CRISPR/Cas9.These findings would provide novel insights into mtDNA mutagenesis and mitochondrial gene therapy for diseases involving pathogenic mtDNA. | Bang Wang Xiujuan Lv Yufei Wang Zhibo Wang Qi Liu Bin Lu Yong Liu Feng Gu | 2021 | Science China(Life Sciences)2021，64，9： | 3 |
| 7 | Synthesis and Characterizations of New Ferrocenyl Schiff Base with NLO Responses显示文摘A series of new stable (thermal and photochemical) ferrocenyl derivatives containing C=N bond and benzene ring in Long conjugated chains have been synthesized and characterized by 1HNMR(400MHz), IR, and elementaL anaLysis. Pull-push ferrocenyl complexes that we have prepared have strong NLO responses identified by electronic absorption spectrum. | Bang Jing LI Wan Yi LIU Tong XIE Guo Sheng HUANG Yong Xiang MA(Department of Chemisty, Lanzhou University, Lanzhou 730000) | 2000 | Chinese Chemical Letters2000，11，7： | 3 |
| 8 | Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7显示文摘The voltage-gated Na^+ channel subtype Nav1.7 is important for pain and itch in rodents and humans. We previously showed that a Nav1.7-targeting monoclonal antibody(SVmab) reduces Na+ currents and pain and itch responses in mice. Here, we investigated whether recombinant SVmab(rSVmab) binds to and blocks Nav1.7 similar to SVmab. ELISA tests revealed that SVmab was capable of binding to Nav1.7-expressing HEK293 cells,mouse DRG neurons, human nerve tissue, and the voltagesensor domain Ⅱ of Nav1.7. In contrast, rSVmab showed no or weak binding to Nav1.7 in these tests. Patch-clamp recordings showed that SVmab, but not rSVmab, markedly inhibited Na+ currents in Nav1.7-expressing HEK293 cells. Notably, electrical field stimulation increased the blocking activity of SVmab and rSVmab in Nav1.7-expressing HEK293 cells. SVmab was more effective than rSVmab in inhibiting paclitaxel-induced mechanical allodynia. SVmab also bound to human DRG neurons and inhibited their Na^+ currents. Finally, potential reasons for the differential efficacy of SVmab and rSVmab and future directions are discussed. | Sangsu Bang Jiho Yoo Xingrui Gong Di Liu Qingjian Han Xin Luo Wonseok Chang Gang Chen Sang-Taek Im Yong Ho Kim Judith A.Strong Ma-Zhong Zhang Jun-Ming Zhang Seok-Yong Lee Ru-Rong Ji | 2018 | Neuroscience Bulletin2018，34，1： | 2 |
| 9 | The MING proposal at SHINE:megahertz cavity enhanced X‑ray generation显示文摘The cavity-based X-ray free-electron laser(XFEL)has promise in producing fully coherent pulses with a bandwidth of a few meV and very stable intensity,whereas the currently existing self-amplified spontaneous emission(SASE)XFEL is capable of generating ultra-short pulses with chaotic spectra.In general,a cavity-based XFEL can provide a spectral brightness three orders of magnitude higher than that of the SASE mode,thereby opening a new door for cutting-edge scientific research.With the development of superconducting MHz repetition-rate XFEL facilities such as FLASH,European-XFEL,LCLS-II,and SHINE,practical cavity-based XFEL operations are becoming increasingly achievable.In this study,megahertz cavity enhanced X-ray generation(MING)is proposed based on China’s first hard XFEL facility-SHINE,which we refer to as MING@SHINE. | Nan‑Shun Huang Zi‑Peng Liu Bang‑Jie Deng Zi‑Han Zhu Shao‑Hua Li Tao Liu Zheng Qi Jia‑Wei Yan Wei Zhang Sheng‑Wang Xiang Yang‑Yang Lei Ya Zhu Yong‑Zhou He Qi‑Bing Yuan Fei Gao Rong‑Bing Deng Sen Sun Zhi‑Di Lei Zhi‑Qiang Jiang Meng‑Qi Duan Yuan Zhuan Xue‑Fang Huang Peng‑Cheng Dong Zhong‑Liang Li Shang‑Yu Si Lian Xue Si Chen Yong‑Fang Liu Ya‑Jun Tong Hai‑Xiao Deng Zhen‑Tang Zhao | 2023 | Nuclear Science and Techniques2023，34，1： | 2 |
| 10 | Chiral metal-organic frameworks with tunable catalytic selectivity in asymmetric transfer hydrogenation reactions显示文摘Metal-organic frameworks(MOFs)have achieved great success in the field of heterogeneous catalysis,however,ifs still challenging to design MOF catalysts with enhanced selectivity.Here,we demonstrated a combination strategy of metal design and ligand design on the enantioselectivity—that is the enantioselectivities of chiral MOF(CMOF)catalysts could be significantly enhanced by the rational choice of metal ions with higher electronegativities and introducing sterically demanding groups into the ligands.Four isostructural Ca-,Sr-and Zn-based CMOFs were prepared from enantiopure phosphono-carboxylate ligands of 1,V-biphenol that are functionalized with 2,4,6-trimethyl-and 2,4,6-trifluoro-phenyl groups at the Supposition.The uniformly distributed metal phosphonates along the channels could act as Lewis acids and catalyze the asymmetric transfer hydrogenation of heteroaromatic imines(benzoxazines and quinolines).Particularly,the Ca-based MOF 1 with 2,4,6-trimethyl groups at the substituents exhibited enhanced catalytic performance,affording the highest enantioselectivity(up to 97%).It is also the first report of the heterogeneous catalyst with chiral non-noble metal phosphonate active sites for asymmetric transfer hydrogenation reactions with Hantzsch ester as the hydrogen source.The catalyst design strategy demonstrated here is expected to develop new types of chiral materials for asymmetric catalysis and other chiral applications. | Xu Chen Zhiwei Qiao Bang Hou Hong Jiang Wei Gong Jinqiao Dong Hai-Yang Li Yong Cui Yan Liu | 2021 | Nano Research2021，14，2： | 2 |
| 11 | Effect of heat treatment on the microstructure and corrosion resistance of a Zr-Sn- Nb-Fe-Cr alloy显示文摘 | Liu Wenqing Li Qiang Zhou Bang xin | 2005 | J Nucl Mater2005，341，23： | 1 |
| 12 | Interfaciat reaction between alumina and Cu-Ti filler metal during reactive metal brazing显示文摘 | BANG K S LIU S | 1994 | Weld J1994，73，3： | 1 |
| 13 | Simultaneous enhancement of coercivity and electric resistivity of Nd-Fe-B magnets by Pr-Tb-Al-Cu synergistic grain boundary diffusion toward high-temperature motor rotors显示文摘To high-power permanent magnetic motors,it is critical for Nd-Fe-B magnets to maintain the desirable coercivity at high-temperature operating conditions.To address this,two approaches have been proven effective:(1)enhancing the room temperature coercivity;(2)reducing the eddy current loss.However,these two items are difficult to be simultaneously achieved.Here,the grain boundary diffusion(GBD)of the Pr-Tb-Al-Cu-based source is applied to enhance the coercivity and electric resistivity at room temperature from 1101 kA m-1 and 2.13×10–6Ωm to 1917 kA m-1 and 2.60×10–6Ωm,and those at 120°C from 384 kA m-1 and 4.31×10–6Ωm to 783 kA m-1 and 4.86×10–6Ωm,respectively.Such optimization is ascribed to the improved formation depth of Tb-rich 2:14:1 shells with large magnetocrystalline anisotropy and the increased intergranular Pr-based oxides with high electric resistivity,induced by the coordination effects of Tb and Pr,as proven by the atomic-scale observations and the first principles calculations.It thus results in the simultaneously improved output power and energy efficiency of the motor because of the combination of magnetic thermal stability enhancement and eddy current loss reduction,as theoretically confirmed by electromagnetic simulation. | Jiayi He Jinwen Hu Bang Zhou Haoyang Jia Xiaolian Liu Zhenhua Zhang Lin Wen Lizhong Zhao Hongya Yu Xichun Zhong Xuefeng Zhang Zhongwu Liu | 2023 | Journal of Materials Science & Technology2023，，23： | 1 |
| 14 | The influence of Auger mining excavation sequence on inter - hole pillar stability below the final highwall of a surface coal mine显示文摘 | Qian - bang zeng Guo - ming Cheng Huan - yu Liu | 2006 | International Journal of Rock Mechanics & Mining Sciences2006，43，： | 1 |
| 15 | Controllability and Observability of Linear Quaternion-valued Systems显示文摘The aim of this paper is to define an extension of the controllability and observability for linear quaternion-valued systems(QVS).Some criteria for controllability and observability are derived,and the minimum norm control and duality theorem are also investigated.Compared with real-valuedor complex-valued linear systems,it is shown that the classical Caylay-Hamilton Theorem as well as Popov-Belevitch-Hautus(PBH)type controllability and observability test do not hold for linear QVs.Hence,a modified PBH type necessary condition is studied for the controllability and observability,respectively.Finally,some examples are given to illustrate the effectiveness of the obtained results. | Bang Xin JIANG Yang LIU Kit Ian KOU Zhen WANG | 2020 | Acta Mathematica Sinica,English Series2020，36，11： | 1 |
| 16 | Molecular characterization, expression profiles of the porcine SDC2 and HSPG2 genes and their association with hematologic parameters显示文摘 | Weimin Wang Cong Tao Ping Zhou Xiang Zhou Qingde Zhang Bang Liu | 2013 | Molecular Biology Reports2013，，3： | 1 |
| 17 | Molecular characterization, expression profiles, and association analysis with hematologic parameters of the porcine HPSE and HPSE2 genes显示文摘 | Cong Tao Weimin Wang Ping Zhou Tian Xia Xiang Zhou Cuiping Zeng Qingde Zhang Bang Liu | 2013 | Journal of Applied Genetics2013，，1： | 1 |
| 18 | GTAW of Titanium Flux-coredWire with Magnesium Fluoride显示文摘 | Bang K S Chirieleison G Liu S | 2005 | Science and Technology ofWelding&Joining2005，10，5： | 1 |
| 19 | Association of two porcine reproductive and respiratory syndrome virus (PRRSV) receptor genes, CD163 and SN with immune traits显示文摘 | Fengli Wang Haifang Qiu Qingde Zhang Zhongzhen Peng Bang Liu | 2012 | Molecular Biology Reports2012，，4： | 1 |
| 20 | Crystallization of Al-based Amorphous Alloys in Good Conductivity Solution显示文摘The corrosion-induced crystallization of Al94 exNixGd6(x=6 and 10, in at.%) metallic glasses as well as phase separation, oxidation and cracking in good conductivity solution has been investigated by various techniques.The transmission electronic microscopy(TEM) result reveals that crystalline intermetallics and oxides present on the electrochemically thinned hole edge, and the phase separation occurs in the matrix of the as-spun ribbons with the circumferential speed Rcof 29.3 m/s. In addition, the bending and cracking of the samples occur after corrosion. The influence of Ni content on the phase separation, bending and cracking can be explained by the fact that the percolation of the backbone clusters in the amorphous alloy melts and glasses is enhanced by increasing the composition of Ni. | Yonggang Wang Yan Liu Yingjie Li Bang An Guanghui Cao Shifeng Jin Yimin Sun Weimin Wang | 2014 | Journal of Materials Science & Technology2014，30，12： | 1 |
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