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| 1 | An Introduction to the Integrated Climate Model of the Center for Monsoon System Research and Its Simulated Influence of El Ni?no on East Asian–Western North Pacific Climate显示文摘This study introduces a new global climate model—the Integrated Climate Model(ICM)—developed for the seasonal prediction of East Asian–western North Pacific(EA–WNP) climate by the Center for Monsoon System Research at the Institute of Atmospheric Physics(CMSR, IAP), Chinese Academy of Sciences. ICM integrates ECHAM5 and NEMO2.3 as its atmospheric and oceanic components, respectively, using OASIS3 as the coupler. The simulation skill of ICM is evaluated here, including the simulated climatology, interannual variation, and the influence of El Nińo as one of the most important factors on EA–WNP climate. ICM successfully reproduces the distribution of sea surface temperature(SST) and precipitation without climate shift, the seasonal cycle of equatorial Pacific SST, and the precipitation and circulation of East Asian summer monsoon. The most prominent biases of ICM are the excessive cold tongue and unrealistic westward phase propagation of equatorial Pacific SST. The main interannual variation of the tropical Pacific SST and EA–WNP climate—El Nińo and the East Asia–Pacific Pattern—are also well simulated in ICM, with realistic spatial pattern and period. The simulated El Nińo has significant impact on EA–WNP climate, as in other models. The assessment shows ICM should be a reliable model for the seasonal prediction of EA–WNP climate. | HUANG Ping WANG Pengfei HU Kaiming HUANG Gang ZHANG Zhihua LIU Yong YAN Bangliang | 2014 | Advances in Atmospheric Sciences2014，31，5： | 5 |
| 2 | PSA controls hepatic lipid metabolism by regulating the NRF2 signaling pathway显示文摘The activity of proteinase is reported to correlate with the development and progression of nonalcoholic fatty liver disease(NAFLD).Puromycin-sensitive aminopeptidase(PSA/NPEPPS)is an integral nontransmembrane enzyme that functions to catalyze the cleavage of amino acids near the N-terminus of polypeptides.A previous study suggested that this enzyme acts as a regulator of neuropeptide activity;however,the metabolic function of this enzyme in the liver has not been explored.Here,we identified the novel role of PSA in hepatic lipid metabolism.Specifically,PSA expression was lower in fatty livers from NAFLD patients and mice(HFD,ob/ob,and db/db).PSA knockdown in cultured hepatocytes exacerbated diet-induced triglyceride accumulation through enhanced lipogenesis and attenuated fatty acid β-oxidation.Moreover,PSA mediated activation of the master regulator of antioxidant response,nuclear factor erythroid 2-related factor 2(NRF2),by stabilizing NRF2 protein expression,which further induced downstream antioxidant enzymes to protect the liver from oxidative stress and lipid overload.Accordingly,liver-specific PSA overexpression attenuated hepatic lipid accumulation and steatosis in ob/ob mice.Furthermore,in human liver tissue samples,decreased PSA expression correlated with the progression of NAFLD.Overall,our findings suggest that PSA is a pivotal regulator of hepatic lipid metabolism and its antioxidant function occurs by suppressing NRF2 ubiquitination.Moreover,PSA may be a potential biomarker and therapeutic target for treating NAFLD. | Bangliang Huang Xin Xiong Linlin Zhang Xiufei Liu Yuren Wang Xiaoli Gong Qian Sang Yongling Lu Hua Qu Hongting Zheng Yi Zheng | 2021 | Journal of Molecular Cell Biology2021，13，7： | 4 |
| 3 | Short-Term Test for the Induction of Lung Tumor in Mouse by Chloroprene显示文摘In a previous study by the authors,positive results from both a case-control study and acohort study were reported.In the present study a short-term test for the induction of mouselung tumor by chloroprene was conducted to confirm whether chloroprene monomer itself caninduce tumors.Kunming albino mice weaned at 2 weeks were subjected to inhaling 0,2.9±0.3,19.2±1.9,and 189.0±13.3 mg/m^3 chloroprene(GC purity,99.8%)4 h daily(except Sunday)for 7 months.All survivors were killed at the end of the 8th month or when moribund.No lungtumors were found before the 6th month.Thus,survivors at the 6th month were counted aseffective animals.Most lung tumors observed were papilloadenomas(50/57),and a few wereadenomas(7/57).The tumor incidence in the 2.9 mg/m^3 group was 8.1% in comparison to 1.3%in the control group,with the significance level at P<0.05.The higher the concentration,thehigher the incidence.Examination of the multiplicity of tumor induction also demonstrated adose-response relationship,and the number of tumors per mouse in the 189 mg/m^3 group wassignificant at P<0.01.1989 Academic Press,Inc. | DONG QINAN XIAO BANGLIANG Hu YUHUA LI SHOUQI Research Laboratory of Hygiene Toxicology,West China University of Medical Sciences,Chengdu,610044,China | 1989 | Biomedical and Environmental Sciences1989，2，2： | 2 |
| 4 | Use of simultaneous iterative reconstruction technique for electrical capacitance tomography显示文摘 | Su Bangliang Zhang Yiheng Peng Lihui | 2000 | Chemical Engineering Journal2000，77，1： | 1 |
| 5 | The use of simultaneous iterative reconstruction technique for electrical capacitance tomography显示文摘 | Su Bangliang Zhang Yiheng Peng Lihui Yao Danya Zhang Baofen | 2000 | Chemical Engineering Journal2000，77，： | 1 |
| 6 | The mechanism of the effects of the upwelling mean on the ENSO event mature phase locking显示文摘The mechanism of the effects of the upwelling mean on the ENSO event mature phase locking is ex-amined by using a mixed-mode model. The results show that the positive feedback process of the ef-fects of the seasonal variation of the upwelling mean on the Kelvin wave is the mechanism of the locking of the event mature phase to the end of the calendar year. The memory of the Rossby waves for the sign-shifting of the sea surface temperature anomaly from positive to negative 6 months before the cold peak time is the other mechanism of the locking of the La Nia event mature phase to the end of the calendar year. The results here are different from previous ones which suggest that the balance between cold and warm trends of sea surface temperature anomaly is the mechanism involved. The cold trend is caused by the upwelling Kelvin wave from upwelling Rossby wave reflected at the western boundary, excited by the westerly anomaly stress over the central Pacific and amplified by the seasonal variation of the coupled strength in its way propagating westward. The warm trend is caused by the Kelvin wave forced by the western wind stress over the middle and eastern equatorial Pacific. The cause of the differences is due to the opposite phase of the seasonal variation of the upwelling mean to that in the observation and an improper parameterization scheme for the effects of the seasonal varia-tion of the upwelling mean on the ENSO cycle in previous studies. | YAN BangLiang CMSR, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China | 2007 | Science China Earth Sciences2007，50，8： | 1 |
| 7 | MicroRNAs in esophageal cancer显示文摘 | Bin H Bangliang Y Baoxiang W | 2012 | Mol Med Rep2012，6，3： | 1 |
| 8 | Maintenance and Management Model for the Urban Stereo Landscape Forest in Chongqing Academy of Science and Technology显示文摘Based on landscaping practices in the stereo landscape demonstration project of Chongqing Academy of Science and Technology (CAST),current management and maintenance of the stereo landscapes were introduced by analyzing maintenance and management of the plants in the stereo landscape forest.The maintenance and management models were summarized according to the management styles,concrete measures and new technologies were studied,laws and key points for the maintenance and management in different seasons were given,and finally deficiencies and solutions were proposed to improve the future maintenance and management. | WANG Zhengchun CHEN Lina JIANG Haiyan HE Bangliang ZHOU Fei JIANG Xinxing CHEN Daojing YANG Bo | 2012 | Journal of Landscape Research2012，4，11： | 1 |
| 9 | The use of simultaneous iterative reconstruction technique for electrical capacitance tomography显示文摘 | Su Bangliang | 2003 | Chemical Engineering Journal2003，，77： | 1 |
| 10 | The use of simultaneous iterative reconstruction technique for electrical ca- pacitance tomography 显示文摘 | SU Bangliang ZHANG Yiheng PENG Lihui | 2000 | Chemical Engineering Joumal2000，77，12： | 1 |
| 11 | microRNAs in esophageal cancer (Review)显示文摘 | Bin He Bangliang Yin Baoxiang Wang Zhenkun Xia Chen Chen Jingqun Tang | 2012 | Molecular Medicine Reports2012，，3： | 1 |
| 12 | 凋落物年龄和氮、磷添加交互作用对杉木林土壤N_(2)O排放的影响显示文摘氧化亚氮(N_(2)O)是一种重要的温室气体,增温潜势较大,其浓度增加影响全球气候变化。由于凋落物分解影响碳和养分循环,土壤N_(2)O排放受凋落物分解作用,而凋落物年龄和氮、磷添加影响凋落物分解,潜在影响土壤N_(2)O的排放。然而,凋落物年龄和养分添加对土壤N_(2)O排放的交互作用及其机制目前还没有报道,这限制了凋落物分解对N_(2)O排放的影响评价。本研究以杉木(Cunninghamia lanceolata)不同年龄凋落物为研究对象,通过氮、磷添加处理,研究了养分和凋落物年龄对N_(2)O排放的影响及其机制。研究结果显示,幼龄凋落物主要通过调节碳氮比来影响N_(2)O排放。氮添加主要通过调节凋落物碳氮比、土壤pH以及与N_(2)O产生相关的微生物功能基因所编码的土壤酶活性来影响N_(2)O排放,整体上促进N_(2)O排放。磷添加显著降低凋落物碳氮比,进而作用于N_(2)O排放,该途径促进N_(2)O排放。同时,磷添加提高土壤有效磷水平,潜在降低N_(2)O排放,整体上降低土壤N_(2)O排放。凋落物年龄和养分添加交互作用于土壤N_(2)O排放。因此,在森林经营管理中,评价不同管理措施,尤其是间伐和选择性砍伐等导致不同凋落物输入的管理活动对土壤N_(2)O排放的影响时,应同时考虑养分输入和凋落物年龄的潜在影响。 | Shuli Wang Xi Yuan Ling Zhang Fusheng Chen Xiangmin Fang Xiaojun Liu Bangliang Deng Nasir Shad Wenyuan Zhang Xiaofei Hu Xiaomin Guo Evan Siemann | 2022 | Journal of Plant Ecology2022，15，4： | 0 |
| 13 | A novel mutation of glycogen synthase kinase-3β leads to a reduced level of GSK3βprotein in a patient with dilated cardiomyopathy显示文摘Dilated cardiomyopathy(DCM)is a frequently inherited heart condition.A familial transmission rate of 20%-35%has been documented,and most of these cases are autosomal dominant.This condition has a high rate of morbidity and mortality,which can lead to cardiac arrest and persistent heart failure. | Ke Gong Zhiping Tan Haidan Liu Xiaobo Liao Xinmin Zhou Bangliang Yin Shi Zeng Yao Yao Yifeng Yang Li Xie | 2024 | Genes & Diseases2024，11，1： | 0 |
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