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| 1 | Diagnostic performance of serum interleukin-6 in pediatric acute appendicitis:a systematic review显示文摘Background Despite the radiological and analytical advances of the last decades,there is still a significant rate of diagnostic error in pediatric acute appendicitis.In recent years,multiple biomarkers have emerged as potential diagnostic tools.This study aimed to examine the diagnostic performance of serum interleukin-6 in pediatric acute appendicitis.Methods We conducted a systematic review of the literature that involved an extensive search in the main databases of medical bibliography(Medline,PubMed,Web of Science and SciELO).Two independent reviewers selected the relevant articles based on the previously defined inclusion and exclusion criteria.Methodological quality of the selected article was rated using the QUADAS2 index.Data extraction was performed by two independent reviewers.Results The research in the medical bibliography databases resulted in 68 articles.We removed 26 duplicates.Among the remaining 42 articles,we excluded 33 following the inclusion and exclusion criteria.Of the final 9 studies included in this review,8 provided measured serum interleukin-6 values,and all of them reported significant differences between groups,but inconsistent results regarding sensitivity and specificity.Conclusions The diagnostic performance of interleukine-6 alone for the diagnosis of acute appendicitis in children is limited.The sensitivity and specificity of interleukine-6 for the diagnosis of non-complicated acute appendicitis in the pediatric population are moderate but increased in complicated appendicitis.There seems to be a direct relationship between serum level of interleukin-6 and the hours of evolution of abdominal pain in children with acute appendicitis.The increasingly widespread use of non-operative management of acute appendicitis warrants further exploration of the classificatory potential of this marker between complicated and uncomplicated appendicitis.We consider that this may be an avenue of research to explore in the future. | Javier Arredondo Montero Carlos Bardaji Pascual Monica Bronte Anaut Natalia Lopez-Andres Giuseppa Antona Nerea Martin-Calvo | 2022 | World Journal of Pediatrics2022，18，2： | 3 |
| 2 | Structural Characterization of Silver (I) Complexes (L=PPh3, PPh=Me, SC4Hs) and=AgLn=(CF=SO3) (n = 2-4), (L = PPh3, PPh2 Me) 显示文摘 | BARDAJI M CRESPO O LAGUNA A | 2000 | InorgChimActa2000，304，： | 1 |
| 3 | Hepatic involvement in pancreatitis-induced lung injury显示文摘 | Closa D Bardaji M Hotter G | 1996 | Am J Physiol1996，270，11： | 1 |
| 4 | Columnar mesomorphic organizations in cyclotriphophazenes 显示文摘 | BARBERA J BARDAJI M JIMENEZ J | 2005 | J Am Chem Soe2005，127，25： | 1 |
| 5 | Silent cerebral white matter lesions and their relationship with vascular risk factors in middle-aged predialysis patients with CKD显示文摘 | Salvado E Bardaji A | 2006 | Am J Kidney Dis2006，47，2： | 1 |
| 6 | Hepaticinvo lvement in pancrcat it is2induced lungdamage 显示文摘 | Closa D Bardaji M Hotter G | 1996 | AmJ Physio l1996，270，11： | 1 |
| 7 | Cystatin C and cardiac hyper- tropthy in primary hypertension显示文摘 | Prats M Font R Bardaji A etal | 2010 | Blood Press2010，19，1： | 1 |
| 8 | Silent cerebral white matter lesions and their relationship with vascular risk factors in middle-aged predialysis patients with CKD显示文摘 | Martinez-Vea A Salvado E Bardaji A | | 0，，02： | 1 |
| 9 | Use of the dithiasuccinoyl (Dts) amino protecting group for solid-phase synthesis of protected peptide nucleic acid (PNA) oligomers 显示文摘 | Planas M Bardaji E Jensen KJ | 1999 | J Org Chem1999，64，10： | 1 |
| 10 | Hepatic involvement in pancreatitis-induced lung damage显示文摘 | Closa D Bardaji M Hotter G | 1996 | Am J Physiol1996，270，11： | 1 |
| 11 | Malaria prevention with IPTp during pregnancy reduces neonatal mortality显示文摘 | Menendez C Bardaji A Sigauque B | 2010 | PLoS ONE2010，5，2： | 1 |
| 12 | Hepatic involvement in pancreatitis-inducod lung damage显示文摘 | BARDAJI CDM PRATS HN FERNANDEZ-CRUZ EGL | 1996 | Am J Physiol1996，270，： | 1 |
| 13 | Retrospective evaluation of carcinoid tumors of the appendix in children显示文摘 | San VB Bardaji C Riqol S | 2009 | Cir Pediatr2009，22，2： | 1 |
| 14 | Cystatin C and cardiac hypertropthy in primary hypertension显示文摘 | Prats M Font R Bardaji A | 2010 | Blood Press2010，19，1： | 1 |
| 15 | Cystatin C and cardiac hypertropthy in primary hypertension 显示文摘 | Prats M Font R Bardaji A | 2010 | Blood Press2010，19，1： | 1 |
| 16 | 显示文摘 | Bardaji M Caminade A M Majoral J P | 1997 | Organometallics1997，16，15： | 1 |
| 17 | Cystatin C and cardiac hypert ropt hy in primary hypertension显示文摘 | Prat s M Font R Bardaji A | 2010 | Blood Press2010，19，1： | 1 |
| 18 | Cystatin C and cardiac hypertropthy in primary hypertension显示文摘 | Prats M Font R Bardaji A | | 0，，01： | 1 |
| 19 | Mother-to-child transmis- sion of HIV-1 :association with malaria prevention,anaemia and pla- cental malaria显示文摘 | Naniche D Lahuerta M Bardaji A | 2008 | HIV Med2008，9，9： | 1 |
| 20 | Columnar mesomorphic organizations in cyclotriphosphazenes显示文摘 | BARBERA J BARDAJI M JIMENEZ J | 2005 | J Am Chem Soc2005，127，25： | 1 |
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