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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | The weibull distribution function and wind power statistics显示文摘 | Bowden G J Barker P R Shestopal V O | 1983 | Wind Engineering1983，7，： | 1 |
| 3 | Identification in the self-managing organization: Characteristics of target and tenure显示文摘 | Barker J R Tompkins P K | 1994 | Human Communication Research1994，21，： | 1 |
| 4 | Hybrid-ion a lithium-ion cell based on a sodium insertion material显示文摘 | Barker J Gover R K B Burns P | 2006 | Electrochemical and Solid-State Letters2006，9，4： | 1 |
| 5 | Liberation of staling aldehydes during storage of beer 显示文摘 | Barker R L Gracey D E F Irwin A J Pipasts P Leiska E | 1983 | J Inst Brew1983，89，： | 1 |
| 6 | The Weibull distribution function and wind power statistics显示文摘 | Bowden G J Barker P R Shestopal V O | 1983 | Wind Engineering1983，，7： | 1 |
| 7 | The weibull distribution function and wind power statistics,wind engineering 显示文摘 | BOWDEN G J BARKER P R SHESTOPAL V O et ol | 1983 | (7): 85-981983，，7： | 1 |
| 8 | Pulmonary lymphangiectasia: diagnosis and clinical course显示文摘 | Esther C R Jr Barker P M | 2004 | Pediatr Pulmonol2004，38，4： | 1 |
| 9 | LiVP2O7:a viable litnium-ion cathode materials显示文摘 | BARKER J GOVER R K B BURNS P | 2005 | Electrchemical and Solid-State Letters2005，8，9： | 1 |
| 10 | The Weibull distribution function and wind power statistics显示文摘 | Bowden G J Barker P R Shestopal V O | 1983 | Wind Engineering1983，7，： | 1 |
| 11 | The Weibull distribution function and wind power statistics显示文摘 | BOWDEN G J BARKER P R SHESTOPAL V O | | 0，，02： | 1 |
| 12 | The effect of Al sub-stitution on the electrochemical insertion properties of the lithi-um vanadium phosphate,Li3V2(PO4)3显示文摘 | Barker J Gover R K B P Burns | 2007 | J Electrochem Soc2007，154，4： | 1 |
| 13 | The Weibull distribution function and wind power statisties 显示文摘 | BOWDEN G J BARKER P R SHESTOPAL V O | 1983 | Wind Engineering1983，7，2： | 1 |
| 14 | The Weibull distribution function and wind power statistics显示文摘 | Bowden G J Barker P R Shestopal V O | 1983 | Wind Engineering1983，7，2： | 1 |
| 15 | Proton MR spectroscopic and diffusion tensor brain MR imaging in X-linked adrenoleukodystrophy:initial experience显示文摘 | Eichler F Itoh R Barker P | 2002 | Radiology2002，225，1： | 1 |
| 16 | Determining the impact of distributed generation on power systems in radial distribution systems显示文摘 | Barker P P Melio R W D | 2000 | IEEE Power Engineering Society Summer Meeting2000，3，： | 1 |
| 17 | Cost-effectiveness of interventions to prevent and control diabetes mellitus: a systematic review显示文摘 | Li R Zhang P Barker LE | 2010 | Diabetes Care2010，33，8： | 1 |
| 18 | The Weibull Distribution Function and Wind Power Statisties显示文摘 | Bowden G J Barker P R ShestoPal V O | 1983 | Wind Engineering1983，7，2： | 1 |
| 19 | Modeling Converging Hazards in Survival Analysis显示文摘 | BARKER P HENDERSON R | 2004 | Lifetime Data Analysis2004，10，： | 1 |
| 20 | Weibull distribution function and wind power statistics显示文摘 | Bowden G J Barker P R Shestopal V O | 1983 | Control and Decision Wind Engineering1983，7，2： | 1 |
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